Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver

British Journal of Cancer

Volumn 80, Issue 7, 1999, Pages 1069-1074

  Tannapfel, A ^a   Engeland, K ^a   Weinans, L ^a   Katalinic, A ^b   Hauss, J ^a   Mossner J ^a   Wittekind, Ch ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Apoptosis; Cholangiocellular carcinoma; p53; p73; Prognosis

Indexed keywords

PROTEIN P53; PROTEIN P73; TUMOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER INHIBITION; CANCER STAGING; CANCER SURVIVAL; CELL DEATH; CELL STRUCTURE; CHROMOSOME 1P; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; NUCLEAR PROTEINS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0032945080     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690465     Document Type: Article

References (18)

1. Clurman B and Groudine M (1997) Killer in search of a motive? Nature 389: 122-123
2. Harris CC (1996) Molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene. Br J Cancer 73: 261-269
3. Hui A-M, Kanai Y, Sakamoto M, Tsuda H and Hirohashi S (1997) Reduced p21WAF1/CIP1 expression and p53 mutation in hepatocellular carcinoma. Hepatology 25: 575-579
4. Jost CA, Marin MC and Kaelin WG (1997) p73 is a human p53-related protein that can induce apoptosis. Nature 389: 191-194
5. Kaghad M, Bonnet H, Yang A, Creancier L, Bisean JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F and Caput D (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90: 809-819
6. Mai M, Yokomizo A, Quian C, Yang P, Tindall DJ, Smith DI and Liu W (1998) Activation of p73 silent allele in lung cancer. Cancer Res 58: 2347-2349
7. Nomoto S, Haruki N, Kondo N, Konishi H, Takahashi T, Takahashi T and Takahashi T (1998) Search for mutations and examination of allelic expression of the p73 gene at 1p36.33 in human lung cancers. Cancer Res 58: 1380-1383
8. Ohashi K, Nakajima Y, Kanehiro H, Tsutsumi M, Taki J, Aomatsu Y, Yoshimura A, Ko S, Kin T, Yagura K, Konishi Y and Nakano H (1995) Ki-ras mutations and p53 protein expression in intrahepatic cholangiocarcinomas: relation to gross tumor morphology. Gastroenterology 109: 1612-1617
9. Orita M, Suzuki Y and Hayashi K (1989) Rapid and sensitive detection of point mutation and DNA polymorphisms using the polymerase chain reaction. Genomics 5: 874-879.
10. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual, pp E3-E4, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
11. Sun XF, Carstensen JM, Zhang H, Stal O, Wingren S, Hatschek T and Nordenskjöld B (1992) Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 340: 1369-1373.
12. Takahashi H, Ichimiya S, Nimura Y, Watanabe M, Furusato M, Wakui S, Yatani R, Aizawa S and Nakagawara A (1998) Mutation, allelotyping, and transcription analysis of the p73 gene in prostatic carcinoma. Cancer Res 58: 2076-2077.
13. Tannapfel A, Hahn H, Katalinic A, Fietkau R, Kühn R and Wittekind Ch (1996) Prognostic value of ploidy and proliferation markers in renal cell carcinoma. Cancer 77: 164-171.
14. Tannapfel A, Nüsslein S, Fietkau R, Katalinic A, Köckerling F and Wittekind C (1998) Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. Int J Radiation Oncol Biol Phys 41: 585-591.
15. Uhlman DL, Nguyen PL, Manivel C, Aeppli D, Resnick JM, Fraley EE, Zhang G and Niehans GA (1994) Association of immunostaining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma. J Natl Cancer Inst 86: 1470-1475.
16. Sobin LH and Wittekind Ch (eds) (1997) UICC: TNM Classification of Malignant Tumors, 5th edn. New York: Wiley-Liss
17. Ishak T et al (eds) (1994) WHO: Histological Typing of Tumours of the Liver, 2nd edn. Berlin: Springer Verlag
18. Wittekind C (1995) Hepatocellular carcinoma. In: Prognostic Factors in Cancer. Hennanek P, Gospodarowicz MK, Henson DE, Hutter RVP and Sobin LH (eds) Berlin: Springer Verlag