Three amino acids specify coactivator choice by retinoid X receptors

Molecular Endocrinology

Volumn 14, Issue 8, 2000, Pages 1198-1209

  Shao, G ^a   Heyman, R A ^a   Schulman, I G ^a  

^a EXELIXIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTATHIONE TRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RETINOID X RECEPTOR; STAT3 PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; HORMONE RECEPTOR INTERACTION; MAMMAL CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALIA; MAMMALIA;

EID: 0034463164     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.8.0495     Document Type: Article

References (41)

1. Synergistic signaling in fetal brain by STAT3-smad1 complex bridged by p300
2. Structure and specificity of nuclear receptor-coactivator interactions
3. Molecular basis of agonism and antagonism in the oestrogen receptor
4. The nuclear receptor ligand-binding domain: Structure and function
5. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
6. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
7. Molecular determinants of the estrogen receptor-coactivator interface
8. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
9. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
10. Role of CBP/P300 in nuclear receptor signaling
11. GRIP1, a transcriptional coactivator for the AF-2 trans-activation domain of steroid, thyroid, retinoid, and vitamin D receptors
12. Sequence and characterization of a coactivator for thr steroid hormone receptor superfamily
13. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
14. TIF2, a 160 kDa transcriptional mediator for ligand-dependent activation function AF-2 of nuclear receptors
15. Increasing the complexity of coactivation in nuclear receptor signaling
16. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
17. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC- 1): Multiple motifs with different binding specificities
18. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
19. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
20. The TRAP220 component of a thyroid hormone receptorassociated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
21. Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2
22. The RXR heterodimers and orphan receptors
23. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
24. Transcriptional control of adipogenesis
25. RXR agonists activate PPARα-inducible genes, lower triglycerides, and raise HDL levels in vivo
26. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARγ) heterodimers: Intermolecular synergy requires only the PPARγ hormone-dependent activation function
27. Nuclear receptors have distinct affinities for coactivators: Characterization by fluorescence resonance energy transfer
28. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation
29. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
30. Peroxisome proliferator-activated receptors and retinoid acid receptors differentially control the interactions of of retinoid X receptor heterodimers with ligands, coactivators, and corepressors
31. p300 functions as a coactivator for the peroxisome proliferator-activated receptor α
32. Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors α and β
33. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
34. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
35. The coregulator exchange in transcriptional functions of nuclear receptors
36. Nuclear receptor coactivators
37. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
38. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
39. Differential use of CREB binding protein-coactivator complexes
40. Unique response pathways are established by allosteric interactions among nuclear hormone receptors
41. The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor