Transcriptional control of adipogenesis

Current Opinion in Cell Biology

Volumn 10, Issue 2, 1998, Pages 165-173

  Fajas, Lluis ^a   Fruchart, Jean Charles ^a   Auwerx, Johan ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN KINASE; PROTEIN KINASE C; RETINOIC ACID; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL ENERGY; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TARGETING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0032054230     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80138-5     Document Type: Article

References (104)

1. Flier JS. The adipocyte: storage depot or node on the energy information superhighway. Cell. 80:1995;15-18.
2. Rosenbaum M, Leibel RL, Hirsch J. Obesity. N Engl J Med. 337:1997;396-407.
3. Bjorntorp P. Obesity. Lancet. 350:1997;423-426.
4. Smas CM, Sul HS. Control of adipocyte differentiation. Biochem J. 309:1995;697-710.
5. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem. 268:1993;6823-6826.
6. Ailhaud G, Grimaldi P, Negrel R. Hormonal regulation of adipose differentiation. Trends Endocrinol Metab. 5:1994;132-135.
7. MacDougald O, Lane D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem. 64:1995;345-373.
8. Prins JB, O'Rahilly S. Regulation of adipose cell number in man. Clin Sci. 92:1997;3-11.
9. Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell. 87:1996;377-389.
10. Guerre-Millo M, Staels B, Auwerx J. New insights into obesity genes. Diabetologia. 39:1996;1528-1531.
11. Auwerx J, Staels B. Leptin. Lancet. 1997;. in press.
12. Naggert J, Harris T, North M. The genetics of obesity. Curr Opin Genet Dev. 7:1997;398-404.
13. Green H, Kehinde O. An established cell line and its differentiation in culture II. Factors affecting adipose conversion. Cell. 5:1975;19-27.
14. Negrel R, Grimaldi P, Ailhaud G. Establishment of preadipocyte clonal cell line from epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones. Proc Natl Acad Sci USA. 75:1978;6054-6058.
15. Scott RE. Coupling of preadipocyte growth arrest and differentiation. A cell cycle model for the physiological control of cell proliferation. J Cell Biol. 94:1982;400-405.
16. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell. 79:1994;1147-1156.
17. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1994;1224-1234.
18. Christy RJ, Yang VW, Ntambi JM, Geiman DE, Landschulz WH, Friedman AD, Nakebeppu Y, Kelly TJ, Lane MD. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1989;1323-1335.
19. Freytag SO, Geddes TJ. Reciprocal regulation of adipogenesis by Myc and C/EBPα Science. 256:1992;379-382.
20. Freytag SO, Paielli DL, Gilbert JD. Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8:1994;1654-1663.
21. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol. 13:1993;4753-4759.
22. Kim JB, Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. of outstanding interest Genes Dev. 10:1996;1096-1107 Adipocyte differentiation is enhanced in cells infected with a retrovirus expressing ADD-1. Simultaneous expression of PPARγ and ADD-1 increases the transcriptional activity of the former transcription factor suggesting involvement of ADD-1 in this signaling pathway.
23. Auwerx J, Martin G, Guerre-Millo M, Staels B. Transcription, adipocyte differentiation, and obesity. J Mol Med. 74:1996;347-352.
24. Desvergne B, Wahli W. PPAR: a key nuclear factor in nutrient/gene interactions. Bauerel P. Inducible Gene Expression. 1994;142-176 Birkhauser, Boston.
25. Tontonoz P, Hu E, Spiegelman B. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ Curr Opin Genet Dev. 5:1995;571-576.
26. Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator activated receptor (PPAR) in mediating effects of fibrates and fatty acids on gene expression. J Lipid Res. 37:1996;907-925.
27. Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta. 1302:1996;93-109.
28. Schoonjans K, Martin G, Staels B, Auwerx J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr Opin Lipidol. 8:1997;159-166.
29. Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα Proc Natl Acd Sci USA. 92:1995;9856-9860.
30. Zhu Y, Qi C, Korenberg JR, Chen X-N, Noya D, Rao MS, Reddy JK. Structural organization of mouse peroxisome proliferator activated receptor γ (mPPARγ) gene; alternative promoter use and different splicing yield two mPPARγ isoforms. Proc Natl Acad Sci USA. 92:1995;7921-7925.
31. Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Salsadin R, Najib J, Laville M, Fruchart JC, Deed S, et al. Organization, promoter analysis and expression of the human PPARγ gene. of special interest J Biol Chem. 272:1997;18779-18789 A study of the organization, expression and promoter characterization of the human PPARγ gene. Expression studies showed very high expression of PPARγ in both adipose tissue and colon.
32. Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz MD, Moller DE, Berger J. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem Biophys Res Commun. 224:1996;431-437.
33. Lambe KG, Tugwood JD. A human peroxisome-proliferator activated receptor-g is activated by inducers of adipogenesis, including thiazolidinedione drugs. Eur J Biochem. 239:1996;1-7.
34. Mukherjee R, Jow L, Croston GE, Paterniti JR. Identification, characterization, and tissue distribution of human peroxisome proliferator activated receptor isoforms PPARγ2 versus PPARγ1 and activation with retinoid X agonists and antagonists. J Biol Chem. 272:1997;8071-8076.
35. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Laville M, Staels B, Auwerx J, Vidal H. Tissue distribution and quantification of the expression of PPARs and LXRa in humans: no alterations in adipose tissue of obese and NIDDM patients. Diabetes. 48:1997;1319-1327.
36. Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig A, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem. 272:1997;20230-20235.
37. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Wilson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for Peroxisome Proliferator-Activated Receptor γ (PPARγ). J Biol Chem. 270:1995;12953-12956.
38. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehman JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell. 83:1995;813-819.
39. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-Δ12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell. 83:1995;803-812.
40. Hu E, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through MAP-kinase mediated phosphorylation of PPARγ of outstanding interest Science. 274:1996;2100-2103 Covalent modification of PPARγ by phosphorylation induced by serum and growth factors inhibits its activity and alters the balance between cell growth and differentiation in the adipose cell lineage.
41. Adams M, Reginato MJ, Shao D, Lazar MA, Chatterjee VK. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem. 272:1997;5128-5132.
42. Camp HS, Tafuri SR. Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem. 272:1997;10811-10816.
43. Zhang B, Berger J, Zhou G, Elbracht A, Biswas S, White-Carrington S, Szalkowski D, Moller DE. Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 271:1996;31771-31774.
44. Glass CK, Rose DW, Rosenfeld MG. Nuclear receptor coactivators. Curr Opin Cell Biol. 9:1997;222-232.
45. DiRenzo J, Soderstrom M, Kurokawa R, Ogliastro MH, Ricote M, Ingrey S, Horlein A, Rosenfeld MG, Glass CK. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators and corepressors. of outstanding interest Mol Cell Biol. 17:1997;2166-2176 The differential recruitment of coactivators and corepressors by RAR-RXR and PPAR - RXR heterodimers provides the basis for a transcriptional switch that may be important in controlling complex programs of gene expression, such as adipocyte differentiation.
46. Hallakou S, Doare L, Foufelle F, Kergout M, Guerre-Millo M, Berthault MF, Dugail I, Morin J, Auwerx J, Ferre P. Pioglitazone induces in vivo adipocytes differentiation in obese Zucker fa/fa rat. Diabetes. 46:1997;1393-1399.
47. De Vos P, Lefebvre AM, Miller SG, Guerre-Millo M, Wong K, Saladin R, Hamann L, Staels B, Briggs MR, Auwerx J. Thiazolidinediones repress ob gene expression via activation of PPARγ J Clin Invest. 98:1996;1004-1009.
48. Zhang B, Graziano MP, Doebber TW, Leibowitz MD, White-Carrington S, Szalkowski DM, Hey PT, Wu M, Cullinan CA, Bailey P. Down-regulation of the expression of the obese gene by antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem. 271:1996;9455-9459.
49. Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA. 93:1996;5793-5796.
50. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J Biol Chem. 272:1997;5283-5290.
51. Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for tumor necrosis factor-a and its receptor during drug and dietary modulation of insulin resistance. Endocrinology. 134:1994;264-270.
52. Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, Spiegelman BM, Moller DE. Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the adipogenic effect of tumor necrosis factor-α Mol Endocrinol. 10:1996;1457-1466.
53. Ohsumi J, Sakakibara J, Yamaguchi J, Miyadai K, Yoshioka S, Fujiwara T, Horikoshi H, Serizawa N. Troglitazone prevents the inhibitory effect of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells. Endocrinology. 135:1994;2279-2282.
54. Szalkowski D, White-Carrington S, Berger J, Zhang B. Antidiabetic thiazolidinediones block the inhibitory effects of TNFα on differentiation, insulin stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology. 136:1995;1474-1481.
55. Peraldi P, Xu M, Spiegelman BM. Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signalling. of outstanding interest J Clin Invest. 100:1997;1863-1869 Thiazolidinediones improve insulin sensitivity in part by attenuating the interference of TNFα with insulin signaling.
56. Martin G, Schoonjans K, Lefebvre A, Staels B, Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein (FATP) and acyl CoA synthetase (ACS) genes by PPARα and PPARγ activators. of outstanding interest J Biol Chem. 272:1997;28210-28217 Coordinate induction by thiazolidinediones of fatty acid uptake by a tissue-selective increase in FATP and ACS gene expression in adipose tissue results in a relative decrease of fatty acid import in the muscle. This altered substrate partitioning results in a decrease in muscle fatty acid levels and will, as such, contribute in part to the improvement in glucose homeostasis after treatment with PPARγ activators.
57. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose-fatty acid cycle: its role in insulin sensitivity and metabolic disturbances of diabetes mellitus. Lancet. 1:1961;785-789.
58. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1991;1538-1552.
59. Yeh WC, Cao Z, Classon M, McKnight S. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:1995;168-181.
60. MacDougald OA, Comelius P, Lin FT, Chen SS, Lane MD. Glucocorticoids reciprocally regulate expression of the CCAAT/Enhancer-binding protein α and δ genes in 3T3-L1 adipocytes and white adipose tissue. J Biol Chem. 269:1994;19041-19047.
61. Wu Z, Xie Y, Bucher NLR, Farmer SR. Conditional ectopic expression of C/EBPγ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes Dev. 9:1995;2350-2363.
62. Wu Z, Bucher NLR, Farmer SR. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPγ, C/EBPδ, and glucocorticoids. of special interest Mol Cell Biol. 16:1996;4128-4136 Induction of PPARγ gene expression in multipotential mesenchymal stem cells is dependent on elevated levels of C/EBPβ throughout adipocyte differentiation. C/EBPδ may function by synergizing with C/EBPβ to enhance the level of PPARγ expression.
63. Lin FT, Lane MD. Antisense CCAAT/enhancer binding protein RNA suppresses coordinate gene expresion and triglyceride accumulation during differentiation of 3T3-L1 adipocytes. Genes Dev. 6:1992;533-544.
64. Wang N, Finegold MJ, Bradley A, Ou C, Abdelsayed SV, Wilde MD, Taylor LR, Wilson Dr, Darlington GJ. Impaired energy homeostasis in C/EBPα knockout mice. Science. 269:1995;1108-1112.
65. Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS. SREBP-1, a basic helix-loop-helix-leucine zipper protein that controls transcription of the LDL receptor gene. Cell. 75:1993;187-197.
66. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89:1997;331-340.
67. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1α J Clin Invest. 98:1996;1575-1584.
68. Lopez JM, Bennett MK, Sanchez HB, Rosenfeld JM, Osborne TF. Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of celular lipid. Proc Natl Acad Sci USA. 93:1996;1049-1053.
69. Bennet MK, Lopez JM, Sanchez HB, Osborne TF. Sterol regulation of fatty acid synthase promoter; coordinate feedback regulation of two major lipid pathways. J Biol Chem. 270:1995;25578-25583.
70. Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 64:1995;621-651.
71. Ihle J. STATs: signal transducers and activators of transcription. Cell. 84:1996;331-334.
72. Stephen JM, Morrison RF, Pilch PF. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. of special interest J Biol Chem. 271:1996;10441-10444 A study demonstrating the potential importance of STATs as factors driving adipocyte differentiation.
73. McAveney KM, Gimble JM, Lee LY. Prolactin receptor expression during adipocyte differentiation of bone marrow stroma. Endocrinology. 137:1996;5723-5726.
74. Zou L, Menon RK, Sperling MA. Induction of mRNAs for the growth hormone receptor gene during 3T3-L1 preadipocyte differentiation. Metabolism. 46:1997;114-118.
75. Pradines-Figueres A, Barcellini-Couget S, Dani C, Vannier C, Ailhaud G. Transcriptional control of the expression of lipoprotein lipase gene by growth hormone in preadipocyte Ob1771 cells. J Lipid Res. 31:1990;1283-1291.
76. Francis SM, Enerback S, Moller C, Enberg B, Norstedt G. A novelin vitromodel for studying signal transduction and gene regulation via growth hormone receptor. Mol Endocrinol. 7:1993;972-978.
77. Lovell-Badge R. Living with bad architecture. Nature. 376:1995;725-726.
78. Zhou X, Benson KF, Ashar HR, Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature. 376:1995;771-774.
79. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJW. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. NatGenet. 10:1995;436-443.
80. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K. Disruption of the architectural factor HMGI-C: DNA binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell. 82:1995;57-65.
81. Negrel R, Gaillard D, Ailhaud G. Prostacyclin as a potent effector of adipose-cell differentiation. Biochem J. 257:1989;399-405.
82. Magun R, Burgering MT, Coffer PJ, Pardasani D, Lin Y, Chabot J, Sorisky A. Expression of a constitutive activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology. 137:1996;3590-3593.
83. Yeh WC, Bierer BE, McKnight S. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci USA. 92:1995;11086-11090.
84. Livneh E, Shimon T, Bechor E, Doki Y, Schieren I, Weinstein B. Linking protein kinase C to the cell cycle: ectopic expression of PKCh in NIH3T3 cells alters the expression of cyclins and cdk inhibitors and induces adipogenesis. Oncogene. 12:1996;1545-1555.
85. Williams PM, Chang DJ, Danesch U, Ringold GM, Heller RA. CCAAT/enhancer binding protein expression is rapidly extinguished in TA1 adipocyte cells treated with tumor necrosis factor. Mol Endocrinol. 6:1992;1135-1141.
86. Ron D, Brasier AR, McGehee RE, Habener J. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). J Clin Invest. 89:1992;223-233.
87. Xing H, Northrop JP, Grove JR, Kilpatrick KE, Su JL, Ringold GM. TNFα mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARγ without effects on Pref-1 expression. Endocrinology. 138:1997;2776-2783.
88. 2+ in the early stages of murine adipocyte differentiation. Differentiation. 60:1996;151-158.
89. Xue JC, Schwarz EJ, Chawla A, Lazar MA. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARγ Mol Cell Biol. 16:1996;1567-1575.
90. Schwarz EJ, Reginato MJ, Shao D, Krakow SL, Lazar MA. Retinoic acid blocks adipogenesis by inhibiting C/EBPb-mediated transcription. of special interest Mol Cell Biol. 17:1997;1552-1561 Liganded RAR inhibits adipogenesis by blocking C/EBPγ mediated induction of downstream genes.
91. Brodie AE, Manning VA, Hu CY. Inhibitors of preadipocyte differentiation induce COUP-TF binding to PPAR/RXR binding sequences. Biochem Biophys Res Commun. 228:1996;655-661.
92. Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell. 73:1993;725-734.
93. Smas CM, Chen L, Sul HS. Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation. of special interest Mol Cell Biol. 17:1997;977-988 Pref-1, a protein that inhibits adipocyte differentiation, can both act as a transmembrane protein affecting adjacent cells or can act as a soluble inhibitor of adipocyte differentiation.
94. 1. Mol Cell Biol. 8:1988;1614-1624.
95. Shao D, Lazar MA. Peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation. of outstanding interest J Biol Chem. 272:1997;21473-21478 Together with the coexpression of PPARγ and C/EBPα, permanent exit from the cell cycle establishes the irreversible commitment to adipocyte differentiation.
96. DeGregori J, Kowali T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis and G1/S-regulatory genes. Mol Cell Biol. 15:1995;4215-4224.
97. Chen P, Riley DJ, Chen Y, Lee W. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. of special interest Genes Dev. 10:1996;2794-2804 Direct and positive role for the Rb protein in terminal differentiation by enhancing the binding of C/EBPs to cognate DNA sequences and stimulating the transactivation of C/EBPβ responsive promoters in cells.
98. Higgins C, Chatterjee S, Cherington V. The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain. J Virol. 70:1996;745-752.
99. Richon V, Lyle RE, McGehee REJ. Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation. J Biol Chem. 272:1997;10117-10124.
100. Altiok S, Xu M, Spiegelman B. PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. of outstanding interest Genes Dev. 11:1997;1987-1998 Ligand activation of PPARγ is sufficient to induce growth arrest in fibroblasts and SV40 large-antigen-transformed adipogenic HIB1B cells. Decreased expression of PP2A leads to an increased phosphorylation and decreased DNA-binding activity of the E2F/DP complex leading to withdrawal from the cell cycle, which in its turn will favor adipogenesis.
101. Umek R, Friedman A, McKnight SL. CCAAT/enhancer binding protein: a component of a differentiation switch. Science. 251:1991;288-292.
102. Lin FT, Lane MD. CCAAT/enhancer binding protein a is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA. 91:1994;8757-8761.
103. Hendricks-Taylor LR, Darlington GJ. Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucl Acids Res. 23:1995;4726-4733.
104. Timchenko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ. CCAAT/enhancer-binding protein α (C/EBPα) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10:1996;804-815.