Th-2 cytokines in allergic disease

British Medical Bulletin

Volumn 56, Issue 4, 2000, Pages 956-968

  Robinson, D S ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ALLERGY; ATOPY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; EOSINOPHILIA; HELPER CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; LEISHMANIASIS; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ALLERGENS; ANIMALS; ASTHMA; CYTOKINES; DISEASE MODELS, ANIMAL; EOSINOPHILS; HUMANS; IMMUNOGLOBULIN E; IMMUNOTHERAPY; INTERLEUKIN-5; MICE; TH1 CELLS; TH2 CELLS;

EID: 0034441878     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1258/0007142001903625     Document Type: Review

References (93)

1. Two types of murine helper T cell clone. I Definition according to profiles of lymphokine activities and secreted proteins
2. Immune response to chemically modified flagellin. 3. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin
3. The role of IFN-gamma in delayed-type hypersensitivity mediated by Th-1 clones
4. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants
5. Interleukin 5, eosinophils and disease
6. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
7. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
8. Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development
9. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production
10. + T lymphocytes in atopic patients
11. Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or calcium ionophore
12. Identification of mRNA for interleukin-4 in human eosinophils with granule localization and release of the translated product
13. Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation
14. Induction of human IgE synthesis in B cells by mast cells and basophils
15. Regulation of IgE synthesis in humans
16. The human IgE network
17. Interleukin 5 enhances interleukin 4-induced IgE production by normal human B cells. The role of soluble CD23 antigen
18. Endogenous IL-6 plays an obligatory role in IL-4-induced human IgE synthesis
19. Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes
20. Induction of human IgE synthesis in B cells by mast cells and basophils
21. Interleukin-5 is a human basophilopoietin: Induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors
22. Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis
23. A human high affinity interleukin 5 receptor (IL-5R) is composed of an IL-5-specific alpha chain and a beta chain shared with the receptor for GM-CSF
24. Expression cloning of the human interleukin 3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors
25. Human interleukin 5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: Comparison and interaction with IL-1, IL-3, IL-6, and GM-CSE
26. Interleukin 5 regulates the isoform expression of its own receptor α-subunit
27. Predominant Th-2-like bronchoalveolar T-lymphocyte population in atopic asthma
28. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma
29. Allergic and non-allergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
30. Allergen exposure induces the activation of allergen-specific Th-2 cells in the airway mucosa of patients with allergic respiratory disorders
31. + T cell lines in atopic asthmatics, and atopic and non-atopic controls
32. + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics
33. Increased interleukin 10 messenger RNA expression in atopic allergy and asthma
34. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma
35. Identification of T-lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma: Relationship to symptoms and bronchial responsiveness
36. IL-4 and IL-5 mRNA and protein in bronchial biopsies from atopic and non-atopic asthmatics: Evidence against 'intrinsic' asthma being a distinct immunopathological entity
37. High affinity IgE receptor (FcεRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma
38. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients
39. + lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man
40. + T cell activation, eosinophil recruitment and interleukin 4 (IL-4), IL-5 and GM-CSF messenger RNA expression in bronchoalveolar lavage after allergen inhalation challenge of atopic asthmatics
41. Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects
42. Cytokine messenger RNA expression for IL-3, IL-4, IL-5 and granulocyte macrophage colony-stimulating factor in the nasal mucosa after allergen provocation: Relationship to tissue eosinophilia
43. Increases in activated T lymphocytes, eosinophils, and cytokine messenger RNA expression or IL-5 and GM-CSF in bronchial biopsies after allergen inhalation challenge in atopic asthmatics
44. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5 and interferon-gamma cytokine gene expression
45. Dysregulation of interleukin 4, interleukin 5, and interferon T gene expression in steroid-resistant asthma
46. Trial of cyclosporin A in corticosteroid-dependent chronic severe asthma
47. Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma
48. Inhibition of the allergen-induced late asthmatic response by cyclosporin A. Effect of cyclosporin A on the allergen-induced late asthmatic reaction
49. Randomised, doseranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
50. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen stimulated T cell cultures
51. + T cells from allergic individuals
52. + T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma
53. Interleukin-4, but not interleukin-5 or eosinophils, is required in a murine model of acute airway hyperreactivity
54. IL-5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
55. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
56. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia
57. Induction of pulmonary allergic responses by antigen-specific Th-2 cells
58. Interleukin-13: Central mediator of allergic asthma
59. Requirement for IL-13 independently of IL-4 in experimental asthma
60. Circulating, but not local lung IL-5 is required for the development of antigen-induced airways eosinophilia
61. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia and bronchial hyperresponsiveness
62. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction
63. Pulmonary expression of interleukin 13 causes inflammation, mucus hypersecretion subepithelial fibrosis, physiologic abnormalities and eotaxin production
64. The genetics of allergen-induced airway hyperresponsiveness in mice
65. Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells
66. Interleukin-9 enhances interleukin-5 receptor expression, differentiation and survival of human eosinophils
67. Co-operation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo
68. Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow
69. Cytokines induce the development of functionally heterogeneous T helper cell subsets
70. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th-1) and Th-2 cells
71. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
72. IGIF does not drive Th-1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB
73. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
74. Selective expression and functions ofinterleukin 18 receptor on T helper (Th) type 1 but not Th-2 cells
75. Genes that regulate interleukin-4 expression in T cells
76. The transcription factor GATA-3 is necessary and sufficient for Th-2 cytokine gene expression in CD4 T cells
77. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
78. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation
79. Inhibition of Th-1 development mediated by GATA-3 through an IL-4-independent mechanism
80. Gene expression of the GATA3 transcription factor is increased in atopic asthma
81. Regulation of IL-4 expression by activation of individual alleles
82. Helper T cell differentiation is controlled by the cell cycle
83. Flexible programs of chemokine receptor expression on human polarised T helper 1 and 2 lymphocytes
84. The chemokine receptor CCR8 is preferentially expressed in Th-2 but not Th-1 cells
85. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
86. Development of allergen-specific T-cell memory in atopic and normal children
87. Modulation of airway inflammation by passive transfer of allergen-specific Th-1 and Th-2 cells in a mouse model of asthma
88. Allergen-specific Th-1 cells fail to counterbalance Th-2 cell-induced hyperreactivity but cause severe airway inflammation
89. 2 in bee venom immunothetapy and recovery by IL-2 and IL-15 in vitro
90. Treatment of cat allergy with T-cell reactive peptides
91. IgE-independent MHC-restricted T cell peptide epitope-induced late asthmatics reactions
92. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta 1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
93. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis