Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 2, 1996, Pages 509-514

  Lock, Sara H ^b   Kay, A Barry ^a   Barnes, Neil C ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; CORTICOSTEROID; CYCLOSPORIN A; PREDNISOLONE; SALMETEROL; THEOPHYLLINE DERIVATIVE;

ADULT; AGED; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTRICHOSIS; IMMUNOSUPPRESSIVE TREATMENT; LUNG FUNCTION TEST; MALE; ORAL DRUG ADMINISTRATION; PARESTHESIA; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEROID THERAPY;

EID: 0030071686     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.2.8564089     Document Type: Article

References (25)

1. Shiner, R. J.,A. J. Nunn, F. K.Chung, and D. M. Geddes. 1990. Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma. Lancet 336:137-140.
2. Mullarkey, G., B. A. Blumenstein, W. P. Andrade, G. A. Bailey, I. Olason, and C. E. Wetzel. 1988. Methotrexate in the treatment of corticosteroid-dependent asthma. A double-blind crossover study. N. Engl. J. Med. 318:603-607.
3. Nierop, G., W. P. Gijzel, E. H. Bel, A. H. Zwinderman, and J. H. Dijkman. 1992. Auranofin in the treatment of steroid dependent asthma: a double blind study. Thorax 47:349-354.
4. Hodges, N. G.,R. A. L. Brewis, and J. B. L. Howell. 1971. An evaluation of azathioprine in severe chronic asthma. Thorax 26:734-739.
5. Corrigan, C. J., A. Hartnell, and A. B. Kay. 1988. T lymphocyte activation in acute severe asthma. Lancet 1:1129-1132.
6. Corrigan, C. J., and A. B. Kay. 1990. CD4 T-lymphocyte activation in acute severe asthma: relationship to disease severity and atopic status. Am. Rev. Respir. Dis. 141:970-977.
7. Azzawi, M., B. Bradley, P. K. Jeffery, A. J. Frew, A. J. Wardlaw, G. Knowles, B. Assoufi, J. V. Collins, S. Durham, and A. B. Kay. 1990. Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am. Rev. Respir. Dis. 142:1407-1413.
8. Walker, C., J. C. Virchow, P. L. B. Bruijnzeel, and K. Blaser. 1991. T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma. J. Immunol. 146:1829-1835.
9. Robinson, D. S., S. Ying, A. M. Bentley, Q. Meng, J. North, S. R. Durham, A. B. Kay, and Q. Hamid. 1993. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J. Allergy Clin. Immunol. 92:397-403.
10. Corrigan, C. J., A. Haczku, V. Gemou-Engesaeth, S. Doi, Y. Kikuchi, K. Takatsu, S. R. Durham, and A. B. Kay. 1993. CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Am. Rev. Respir. Dis. 147:540-547.
11. Granelli-Piperno, A., K. Inaba, and R. M. Steinman. 1984. Stimulation of lymphokine release from T lymphoblasts: requirement for mRNA synthesis and inhibition by cyclosporin A. J. Exp. Med. 160: 1792-1802.
12. Granelli-Piperno, A., L. Andrus, and R. M. Steinman. 1986. Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. J. Exp. Med. 163:922-937.
13. Schreiber, S. L., and G. R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13:136-141.
14. Alexander, A. G., N. C. Barnes, and A. B. Kay. 1992. Trial of cyclosporin in corticosteroid-dependent chronic severe asthma. Lancet 339:324-328.
15. Armatidge, P., and G. Berry. 1994. Statistical Methods in Medical Research. 1994. Blackwell Scientific Publications, Oxford.
16. Cotes, J. E. 1979. Lung Function: Assessment and Application in Medicine, 4th ed., Ch. 14. Blackwell Scientific Publications, Oxford.
17. Szczeklik, A., E. Nizankowska, R. Dworski, B. Domagala, and G. Pinis. 1991. Cyclosporin for steroid-dependent asthma. Allergy 46:312-315.
18. Frey, F. J., A. Schnetzer, F. F. Horber, and B. M. Frey. 1987. Evidence that cyclosporine does not affect the metabolism of prednisolone after renal transplantation. Transplantation 43:494-498.
19. Rocci, M. L., K. J. Tietze, J. Lee, H. Harris, J. Danzeisen, and J. F. Burke. 1987. The effect of cyclosporine on the pharmacokinetics of prednisolone in renal transplant patients. Transplantation 45:656-660.
20. Lacronique, J., D. Renon, D. Georges, M. Henry-Amar, and J. Marsac. 1991. High-dose beclomethasone: oral steroid-sparing effect in severe asthmatic patients. Eur. Respir. J. 4:807-812.
21. von Graffenried, B., and P. Krupp. 1986. Side effects of cyclosporine (Sandimmun) in renal transplant recipients and in patients with autoimmune diseases. Transplantation Proc. 18:876-883.
22. Mihatsch, M. J., G. Thiel, and B. Ryffel. 1988. Hazards of cyclosporin A therapy and recommendations for its use. J. Autoimmunity 1:533-543.
23. Feutren, G., and M. J. Mihatsch. 1992. Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. N. Engl. J. Med. 326:1654-1660.
24. Iacono, A. T., R. J. Keenan, S. R. Duncan, W. F. Grgurich, G. C. Smaldone, G. J. Burckart, N. P. Ohori, E. Delgado, M. M. Zendarsky, A. Zeevi, I. L. Paradis, and B. P. Griffith. 1994. Aerosolized cyclosporine as additional therapy for the treatment of refractory chronic rejection in lung transplant recipients (abstract). Am. Rev. Respir. Dis. 149:A730.
25. Thomson, A. W., and T. E. Starzl. 1993. New immunosuppressive drugs: mechanistic insights and potential therapeutic advances. Immunol. Rev. 136:71-98.