Details and concerns regarding the G2/M DNA damage checkpoint in budding yeast

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 65, Issue , 2000, Pages 433-441

  Weinert, T ^a   Little, E ^a   Shanks, L ^a   Admire, A ^a   Gardner, R ^a   Putnam, C ^a   Michelson, R ^a   Nyberg, K ^a   Sundareshan, P ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE G2 PHASE; CONFERENCE PAPER; DNA DAMAGE; DNA METABOLISM; GENETIC STABILITY; NONHUMAN; PRIORITY JOURNAL; YEAST; ANIMAL; CELL CYCLE; CYTOLOGY; GENETICS; REVIEW; SACCHAROMYCES; ARTICLE; BUDDING YEAST; DNA DAMAGE CHECKPOINT; DNA DEGRADATION; FUNGUS MUTANT; G2 PHASE CELL CYCLE CHECKPOINT; GENOMIC INSTABILITY; IN VIVO STUDY; M PHASE CELL CYCLE CHECKPOINT; MALIGNANT NEOPLASM; MEDICAL LITERATURE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EUKARYOTA; FUNGI; SACCHAROMYCETALES;

SCHIZOSACCHAROMYCES POMBE PROTEIN; CHECKPOINT KINASE 2; CYCLINE; FUNGAL DNA; PEPTIDES AND PROTEINS; PROTEIN RAD9; RAD17 PROTEIN; RAD24 PROTEIN; REPLICATION FACTOR C; UNCLASSIFIED DRUG;

ANIMALS; CELL CYCLE; DNA DAMAGE; G2 PHASE; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 0034437667     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2000.65.433     Document Type: Conference Paper

References (90)

1. A novel role for the budding yeast RAD9 checkpoint gene in DNA damage- dependent transcription
2. DNA repair protein rad55 is a terminal substrate of the DNA damage checkpoints
3. Damage recognition in nucleotide excision repair of DNA
4. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
5. Human DNA damage checkpoint protein hRAD9 is a 3′ to 5′ exonuclease
6. DMC1: A meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
7. Trimeric structure of human proliferating cell nuclear antigen. Implications for enzymatic function and autoantibody recognition
8. The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
9. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae
10. Structure-function correlations in the XerD site-specific recombinase revealed by pentapeptide scanning mutagenesis
11. Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway
12. Characterization of Schizosaccharomyces pombe Hus1: A PCNA-related protein that associates with Rad1 and Rad9
13. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions
14. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
15. Recovery from DNA replication stress is the essential function of the S-phase checkpoint pathway
16. A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells
17. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
18. Cell cycle checkpoints: Preventing an identity crisis
19. The Saccharomyces cerevisiae RAD9 checkpoint reduces the DNA Damage-associated stimulation of directed translocations
20. RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
21. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
22. Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
23. The DNA-dependent protein kinase:Requirement for DNA ends and association with Ku antigen
24. A novel Rad24 checkpoint protein complex closely related to replication factor C
25. A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints
26. Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
27. Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice
28. Response of Xenopus cds1 in cell-free extracts to DNA templates with double-stranded ends
29. Trinucleotide instability: A repeating theme in human inherited disorders
30. Checkpoints: Controls that ensure the order of cell cycle events
31. Telomere dynamics and telomerase activation in tumor progression: Prospects for prognosis and therapy
32. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
33. An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
34. Meiosis-specific DNA double-strand breaks are catalyzed by Spoll, a member of a widely conserved protein family
35. Protein-PCNA interactions: A DNA-scanning mechanism?
36. Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis
37. Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway
38. Hus 1p, a conserved fission yeast checkpoint protein, interacts with Rad 1p and is phosphorylated in response to DNA damage
39. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA
40. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
41. Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase
42. The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast
43. Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
44. G2/M checkpoint genes of Saccharomyces cerevisiae: Further evidence for roles in DNA replication and/or repair
45. A meiotic recombination checkpoint controlled by mitotic checkpoint genes
46. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
47. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
48. High spontaneous intrachromosomal recombination rates in ataxia- telangiectasia
49. Sensor-less checkpoint activation?
50. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
51. Regulation of the APC and the exit from mitosis
52. DNA hydrolytic activity associated with the Ustilago maydis REC1 gene product analyzed on hairpin oligonucleotide substrates
53. Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
54. Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene
55. + checkpoint gene encodes an exonuclease
56. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA
57. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage
58. RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage
59. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
60. Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?
61. Checkpoint controls in Schizosaccharomyces pombe: Rad1
62. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
63. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
64. The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering
65. Identification of functional connections between calmodulin and the yeast actin cytoskeleton
66. Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
67. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
68. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways
69. The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition
70. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
71. The DNA-dependent protein kinase
72. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1
73. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
74. Fragile sites still breaking
75. The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease
76. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins
77. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
78. Replication factors required for SV40 DNA replication in vitro. I. DNA structure-specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory proteins
79. A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis
80. Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities
81. Mutations in RAD27 define a potential link between G1 cyclins and DNA replication
82. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
83. DNA damage and checkpoint pathways: Molecular anatomy and interactions with repair
84. DNA damage checkpoints update: Getting molecular
85. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
86. Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage
87. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint
88. Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: A gene required for the DNA damage checkpoint but not the replication checkpoint
89. Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme
90. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools