The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering

Journal of Molecular Biology

Volumn 275, Issue 1, 1998, Pages 123-132

  Schurtenberger, Peter ^a   Egelhaaf, Stefan U ^b   Hindges, Robert ^c   Maga, Giovanni ^c   Jónsson, Zophonías O ^c   May, Roland P ^b   Glatter, Otto ^d   Hübscher, Ulrich ^c  

^a ETH ZURICH   (Switzerland)

^b INSTITUT LAUE LANGEVIN   (France)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF GRAZ   (Austria)

Author keywords

Proliferating cell nuclear antigen; Small angle neutron scattering; Solution structure

Indexed keywords

CYCLINE;

AQUEOUS SOLUTION; ARTICLE; CRYSTAL STRUCTURE; HUMAN; MOLECULAR MODEL; NEUTRON SCATTERING; PRIORITY JOURNAL; PROTEIN STRUCTURE;

EID: 0032498233     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1435     Document Type: Article

References (40)

1. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
2. Bult, C. J., White, O., Olsen, G. J., Zhou, L., Fleischmann, R. D., Sutton, G. G., Blake, J. A., FitzGerald, L. M., Clayton, R. A., Gocayne, J. D., Kerlavage, A. R., Dougherty, B. A., Tomb, J. F., Adams, M. D., Reich, C. I., Overbeek, R., Kirkness, E. F., Weinstock, K. G., Merrick, J. M., Glodek, A., Scott, J. L., Geoghagen, N. S. M., Weidman, J. F., Fuhrmann, J. L. & Venter, J. C. et al. (1996). Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science, 273, 1058-1073.
3. Burgers, P. M. (1991). Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with proliferating cell nuclear antigen and with DNA polymerases δ and ε. J. Biol. Chem. 266, 22698-22706.
4. Burgers, P. M. & Yoder, B. L. (1993). ATP-independent loading of the proliferating cell nuclear antigen requires DNA ends. J. Biol. Chem. 268, 19923-19926.
5. Chen, J., Chen, S., Saha, P. & Dutta, A. (1996). P 12 disrupts the recruitement of human Fen 1 by proliferating cell nuclear antigen into the DNA replication complex. Proc. Natl Acad. Sci. USA, 93, 11597-11602.
6. Cotton, J. P. (1991). Initial data treatment. In Neutron, X-Ray and Light Scattering: Introduction to an Investigative Tool for Colloidal and Polymeric Systems (Lindner, P. & Zemb, T., eds), pp. 19-31, North-Holland, Amsterdam.
7. Flores-Rozas, H., Kelman, Z., Dean, F. B., Pan, Z. Q., Harper, J. W., Elledge, S. J., O'Donnell, M. & Hurwitz, J. (1994). Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc. Natl Acad Sci. USA, 91, 8655-8659.
8. Fotedar, R., Mossi, R., Fitzgerald, P., Rousselle, T., Maga, G., Brickner, H, Messier, H., Kasibhatla, S., Hübscher, U. & Fotedar, A. (1996). A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells. EMBO J. 15, 4423-4433.
9. Glatter, O. (1977). A new method for the evaluation of small-angle scattering data. J. Appl. Crystallog. 10, 415-421.
10. Glatter, O. (1979). Auswertung physikalischer Experimente mit besonderer Berücksichtigung der Streuung an räumlich beschränkten Streumedien. Habilitation, Universität Graz, Austria.
11. Glatter, O. (1992). X-ray techniques. In International Tables for Crystallography (Wilson, A. J. C., ed.), pp. 89-105, Kluwer Academic Publishers, Dordrecht.
12. Guinier, A. (1939). La diffraction des rayons X aux très petits angles: application à l'étude de phénomènes ultramicroscopiques. Ann. Phys. (Paris), 12, 161-237.
13. Gulbis, J. M., Kelman, Z., Hurwitz, J., O'Donnell, M. & Kuriyan, J. (1996). Structure of the C-terminal region of p21 complexed with human PCNA. Cell, 87, 297-306.
14. Hübscher, U. & Kornberg, A. (1979). The delta subunit of Escherichia coli DNA polymerase III holoenzyme is the dnaX gene product. Proc. Natl Acad. Sci. USA, 76, 6284-6288.
15. Hübscher, U., Maga, G. & Podust, V. N. (1996). DNA Replication Accessory Proteins. In DNA Replication in Eukaryotic Cells (De Pamphilis, M. L., ed.), pp. 525-543, Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
16. Jackson, D. A., Hassan, A. B., Errington, R. J. & Cook, P. R. (1994). Sites in human nuclei where damage induced by ultraviolet light is repaired: localization relative to transcription sites and concentrations of proliferating cell nuclear antigen and the tumor suppressor protein, p53. J. Cell Sci. 107, 1753-1760.
17. Jacrot, B. & Zaccai, G. (1981). Determination of molecular weight by neutron scattering. Biopolymers, 20, 2413-2426.
18. Jónsson, Z. O., Podust, V. N., Podust, L. M. & Hubscher, U. (1995). Tyrosine 114 Is essential for the trimeric structure and the functional activities of human proliferating cell nuclear antigen. EMBO J. 14, 5745-5751.
19. Krishna, T. S. R., Kong, X.-P., Gary, S., Burgers, P. M. & Kuriyan, J. (1994). Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell, 79, 1233-1243.
20. Kuriyan, J. & O'Donnell, M. (1993). Sliding clamps of DNA polymerase. J. Mol. Biol. 234, 915-925.
21. Lee, S.-H. & Hurwitz, J. (1990). Mechanism of elongation of primed DNA by DNA polymerase δ, proliferating cell nuclear antigen, and activator 1. Proc. Natl Acad. Sci. USA, 87, 5672-5676.
22. Li, R., Waga, S., Hannon, G. J., Beach, D. & Stillman, B. (1994). Differential effects by the p21 CDL inhibitor on PCNA-dependent DNA replication and repair. Nature, 371, 534-537.
23. Matsuoka, S., Yamaguchi, M. & Matsukage, A. (1994). D-type cyclin-binding regions of proliferating cell nuclear antigen. J. Biol. Chem. 269, 11030-11036.
24. Mossi, R., Jónsson, Z. O., Allen, B. L., Hardin, S. H. & Hübscher, U. (1997). Replication factor C interacts with the C-terminal site of proliferating cell nuclear antigen. J. Biol. Chem. 272, 1769-1776.
25. Pedersen, J. S., Hansen, S. & Bauer, R. (1994). The aggregation behavior of Zinc-free insulin studied by small-angle neutron scattering. Eur. Biophys. J. 23, 379-389.
26. Podust, V. N., Georgaki, A., Strack, B. & Hübscher, U. (1992a). Calf thymus RF-C as an essential component for DNA polymerase δ and ε holoenzymes funtion. Nucl. Acids Res. 20, 4159-4165.
27. Podust, V. N., Mikhailov, V., Georgaki, A. & Hübscher, U. (1992b). DNA polymerases delta and epsilon holoenzymes from calf thymus. Chromosoma, 102, 133-141.
28. Podust, L. M., Podust, V. N., Sogo, J. M. & Hübscher, U. (1995). Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA. Mol. Cell. Biol. 15, 3072-3081.
29. Smith, M. L., Chen, I.-T., Zhan, Q., Bae, I., Chen, C.-Y., Gilmer, T. M., Kastan, M. B., O'Connor, P. M. & Fornace, A. J., Jr (1994). Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science, 266, 1376-1380.
30. Stillman, B. (1994). Smart machines at the DNA replication fork. Cell, 78, 725-728.
31. Svergun, D. I. & Pedersen, J. S. (1994). On the estimation of error propagation in small-angle treatment. J. Appl. Crystallog. 27, 241-248.
32. Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A. B., Liskay, R. M. & Kunkel, T. A. (1996). Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis. Cell, 87, 65-73.
33. Vairapandi, M., Balliet, A. G., Fornace, A. J., Jr, Hoffman, B. & Liebermann, D. A. (1996). The differentiation primary response gne MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21 WAF1/CIP1. Oncogene, 12, 2579-94.
34. Waga, S., Hannon, G. J., Beach, D. & Stillman, B. (1994). The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature, 369, 574-578.
35. Weiser, T., Gassmann, M., Thömmes, P., Ferrari, E., Hafkemeyer, P. & Hübscher, U. (1991). Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. J. Biol. Chem. 266, 10420-10428.
36. Wu, X. T., Li, J., Li, X. Y., Hsieh, C. L., Burgers, P. M. J. & Lieber, M. R. (1996). Processing of branched DNA intermediates by a complex of human Fen-1 and PCNA. Nucl. Acids Res. 24, 2036-2043.
37. Xiong, Y., Zhang, H. & Beach, D. (1992). D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell, 71, 505-514.
38. Yamaguchi, M., Hayashi, Y., Matsuoka, S., Takahashi, T. & Matsukage, A. (1994). Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating cell nuclear antigen gene. Eur. J. Biochem. 221, 227-237.
39. Yao, N., Turner, J., Kelman, Z., Stukenberg, P. T., Dean, F., Schechter, D., Zhen-Qiang, P., Hurwitz, J. & O'Donnell, M. (1996). Clamp loading, unloading and intrinsic stability of the PCNA, β and gp45 sliding clamps of Human, E. coli and T4 replicases. Genes Cells, 1, 101-113.
40. Zhang, H., Xiong, Y. & Beach, D. (1993). Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell, 4, 897-906.