A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis

Molecular and Cellular Biology

Volumn 17, Issue 6, 1997, Pages 3103-3115

  Uchiyama, Masashi ^a   Galli, Ivo ^a   Griffiths, Dominic J F ^a   Wang, Teresa S F ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; GENE PRODUCT; HYDROXYUREA;

ARTICLE; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPLICATION; GENE MUTATION; GENETIC ANALYSIS; MITOSIS INHIBITION; PRIORITY JOURNAL; RADIATION INJURY; SCHIZOSACCHAROMYCES POMBE;

EID: 0030924348     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.6.3103     Document Type: Article

References (54)

1. Al-Khodairy, F., and A. M. Carr. 1992. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO. J. 11:1343-1350.
2. Al-Khodairy, F., T. Enoch, I. M. Hagan, and A. M. Carr. 1995. Schizosaccharomyces pombe hus5 gene encodes a ubiquitin-conjugating enzyme required for normal mitosis. J. Cell Sci. 108:475-486.
3. Al-Khodairy, F., E. Fotou, K. S. Sheldrick, D. J. Griffiths, A. R. Lehmann, and A. M. Carr. 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5:147-160.
4. Allen, J. B., Z. Zhou, W. Siede, E. C. Friedberg, and S. J. Elledge. 1994. The SAD/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8:2416-2428.
5. Barbet, N., W. J. Muriel, and A. M. Carr. 1992. Versatile shuttle vectors and genomic libraries for use with Schizosaccharomyces pombe. Gene 114:59-66.
6. 5a. Bhaumik, D., and T. S. Wang. Unpublished data.
7. Carr, A. M. 1996. Checkpoints take the next step. Science 271:314-315.
8. Carr, A. M., and M. F. Hoekstra. 1995. The cellular responses to DNA damage. Trends Cell Biol. 5:32-40.
9. Carr, A. M., M. Moudjou, N. J. Bentley, and I. M. Hagan. 1995. The chk1 pathway is required to prevent mitosis following cell-cycle arrest at "start." Curr. Biol. 5:1179-1190.
10. D'Urso, G., B. Grallert, and P. Nurse. 1995. DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J. Cell Sci. 108:3109-3118.
11. Elledge, S. J. 1996. Cell cycle checkpoints: preventing an identity crisis. Science 274:1664-1672.
12. Enoch, T., A. Carr, and P. Nurse. 1993. Checkpoint check. Nature 361:26.
13. Enoch, T., A. M. Carr, and P. Nurse. 1992. Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev. 6:2035-2046.
14. Enoch, T., K. L. Gould, and P. Nurse. 1991. Mitotic checkpoint control in fission yeast. Cold Spring Harbor Symp. Quant. Biol. 56:409-416.
15. Enoch, T., and P. Nurse. 1990. Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60:665-673.
16. Fernandez-Sarabia, M. J., C. McInerny, P. Harris, C. Gordon, and P. Fantes. 1993. The cell cycle genes cdc22 and suc22 of fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet. 238:241-251.
17. Francesconi, S., H. Park, and T. S. Wang. 1993. Fission yeast with DNA polymerase 5 temperature-sensitive alleles exhibits cell division cycle phenotype. Nucleic Acids Res. 21:3821-3828.
18. Griffiths, D. J. F., N. C. Barbet, S. McCready, A. R. Lehmann, and A. M. Carr. 1995. Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 14:5812-5823.
19. 17a. Griffiths, D. J. F., et al. Unpublished data.
20. Gutz, H., H. Heslot, U. Leupold, and N. Loprieno. 1974. Schizosaccharomyces pombe, p. 395-446. In R. C. King (ed.), Handbook of genetics 1, vol. I. Plenum Press, New York, N.Y.
21. Harrwell, L. H., and T. A. Weinert. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science 246:629-634.
22. cdc2 tyrosine phosphorylation. EMBO J. 14:2760-2771.
23. Hirano, T., S. Funahashi, T. Uemura, and M. Yanagida. 1986. Isolation and characterization of Schizosaccharomyces pombe cut mutants that block nuclear division but not cytokinesis. EMBO J. 5:2973-2979.
24. Hoffman, C. S., and F. Winston. 1987. A ten minutes DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57:267-272.
25. Hofmann, J. X., and D. Beach. 1994. cdt1 is an essential target of the cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J. 13:425-434.
26. Humphrey, T., and T. Enoch. 1995. Keeping mitosis in check. Curr. Biol. 5:376-378.
27. Jimenez, G., J. Yucel, R. Rowley, and S. Subramani. 1992. The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl. Acad. Sci. USA 89:4952-4956.
28. +. Mol. Biol. Cell 6:1793-1805.
29. + gene product couples S phase to START and mitosis. Cell 74:371-382.
30. Li, J. J., and R. J. Deshaies. 1993. Exercising self-restraint: discouraging illicit acts of S and M in eukaryotes. Cell 74:223-226.
31. Lydall, D., and T. A. Weinert. 1995. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270:1488-1491.
32. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
33. Moreno, S., A. Klar, and P. Nurse. 1991. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194:795-823.
34. Murakami, H., and H. Okayama. 1995. A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374:817-819.
35. Murray, A. W. 1992. Creative blocks: cell cycle checkpoints and feedback controls. Nature 359:599-604.
36. Nurse, P. 1975. Genetic control of cell size at cell division in yeast. Nature 256:547-551.
37. Nurse, P. 1994. Ordering S phase and M phase in the cell cycle. Cell 79:547-550.
38. Nurse, P., P. Thuriaux, and K. Nasmyth. 1976. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 146:167-178.
39. Paulovich, A. G., and L. H. Hartwell. 1995. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82:841-847.
40. Paulovich, A. G., D. P. Toxzyski, and L. H. Hartwell. 1997. When checkpoints fail. Cell 88:315-321.
41. Rowley, R. 1992. Radiation-induced mitotic delay: a genetic characterization in the fission yeast. Radiat. Res. 132:144-152.
42. Rowley, R., S. Subramani, and P. G. Young. 1992. Checkpoint controls in Schizosaccharomyces pombe: rad1. EMBO J. 11:1335-1342.
43. +, a gene encoding a protein kinase homolog. Cell 49:559-567.
44. +, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Cell 74:383-393.
45. Sazer, S., and S. W. Sherwood. 1990. Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast. J. Cell Sci. 97:509-516.
46. 2 checkpoints: fission yeast as a model system. Bioessays 15:775-782.
47. 44a. Uchiyama, M. Unpublished data.
48. Walworth, N., S. Daveyk, and D. Beach. 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363:368-371.
49. Walworth, N. C., and R. Bernards. 1996. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271: 353-356.
50. Wang, T. S.-F. 1996. Cellular DNA polymerases, p. 461-493. In M. L. DePamphilis (ed.), DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
51. Weinert, T. A., and L. H. Hartwell. 1993. Cell cycle arrest of cdc mutants and specificity of the Rad9 checkpoint. Genetics 134:63-80.
52. Weinert, T. A., and L. H. Hartwell. 1988. The Rad9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.
53. Weinert, T. A., G. L. Kiser, and L. H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8:652-665.
54. Zheng, P., D. S. Fay, J. Burton, H. Xiao, J. L. Pinkham, and D. F. Stern. 1993. SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. Mol. Cell. Biol. 13:5829-5842.