Interferon-γ inhibits insulin release and induces cell death in the pancreatic β-cell line INS-1 independently of nitric oxide production

Experimental Cell Research

Volumn 237, Issue 1, 1997, Pages 217-222

  Laffranchi, R ^a   Spinas, G A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; 4 AMINOBENZAMIDE; ACETYLCYSTEINE; ANTIOXIDANT; BENZAMIDE DERIVATIVE; INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; OXYGEN RADICAL; POLY(ADP RIBOSE)POLYMERASE INHIBITOR; RECOMBINANT GAMMA INTERFERON; SCAVENGER; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; IMMUNOPATHOLOGY; INHIBITION KINETICS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0031586615     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1997.3791     Document Type: Article

References (36)

1. 1. Bach, J. F. (1994). Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15, 516-542.
2. 2. Nerup, J., Mandrup Poulsen, T., Helqvist, S., Andersen, H. U., Pociot, F., Reimers, J. I., Cuartero, B. G., Karlsen, A. E., Bjerre, U., and Lorenzen, T. (1994). On the pathogenesis of IDDM. Diabetologia 37, S82-9.
3. 3. Bendtzen, K., Mandrup Poulsen, T., Nerup, J., Nielsen, J. H., Dinarello, C. A., and Svenson, M. (1986). Cytotoxicity of human pl 7 interleukin-1 for pancreatic islets of Langerhans. Science 232, 1545-1547.
4. 4. Sandler, S., Andersson, A., and Hellerstrom, C. (1987). Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology 121, 1424-1431.
5. 5. Corbett, J. A., Wang, J. L., Sweetland, M. A., Lancaster, J. R., Jr., and McDaniel, M. L. (1992). Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. J. Clin. Invest. 90, 2384-2391.
6. 6. Welsh, N., Eizirik, D. L., Bendtzen, K., and Sandler, S. (1991). Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129, 3167-3173.
7. 7. Cetkovic Cvrlje, M., and Eizirik, D. L. (1994). TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6, 399-406.
8. 8. Rabinovitch, A., Suarez Pinzon, W. L., Shi, Y., Morgan, A. R., and Bleackley, R. C. (1994). DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction. Diabetologia 37, 733-738.
9. 9. Eizirik, D. L., Sandler, S., Welsh, N., Cetkovic Cvrlje, M., Nieman, A., Geller, D. A., Pipeleers, D. G., Bendtzen, K., and Hellerstrom, C. (1994). Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J. Clin. Invest. 93, 1968-1974.
10. 10. Corbett, J. A., Sweetland, M. A., Wang, J. L., Lancaster, J. R., Jr., and McDaniel, M. L. (1993). Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. USA 90, 1731-1735.
11. 11. Von Herrath, M. G., and Oldstone, M. B. A. (1997). Interferon-gamma is essential for destruction of b cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185, 531-539.
12. 12. Kawahara, D. J., and Kenney, J. S. (1991). Species differences in human and rat islet sensitivity to human cytokines. Monoclonal anti-interleukin-1 (IL-1) influences on direct and indirect IL-1-mediated islet effects. Cytokine 3, 117-124.
13. 13. Janjic, D., and Asfari, M. (1992). Effects of cytokines on rat insulinoma INS-1 cells. J. Endocrinol. 132, 67-76.
14. 14. Celada, A. (1988). The interferon gamma receptor. Lymphokine Res. 7, 61-73.
15. 15. Aguet, M., Dembic, Z., and Merlin, G. (1988). Molecular cloning and expression of the human interferon-gamma receptor. Cell 55, 273-280.
16. 16. Kumar, C. S., Muthukumaran, G., Frost, L. J., Noe, M., Ahn, Y. H., Mariano, T. M., and Pestka, S. (1989). Molecular characterization of the murine interferon gamma receptor cDNA. J. Biol. Chem. 264, 17939-17946.
17. 17. Yamada, K., Takane, N., Otabe, S., Inada, C., Inoue, M., and Nonaka, K. (1993). Pancreatic beta-cell-selective production of tumor necrosis factor-alpha induced by interleukin-1. Diabetes 42, 1026-1031.
18. 18. Rabinovitch, A., Sumoski, W., Rajotte, R. V., and Warnock, G. L. (1990) Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. J. Clin. Endocrinol. Metab. 71, 152-156.
19. 19. Dunger, A., Cunningham, J. M., Delaney, C. A., Lowe, J. E., Green, M. H., Bone, A. J., and Green, I. C. (1996). Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement. Diabetes 45, 183-189.
20. 20. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., and Wollheim, C. B. (1992). Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130, 167-178.
21. 21. Kekow, J., Ulrichs, K., Muller Ruchholtz, W., and Gross, W. L. (1988). Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay. Diabetes 37, 321-326.
22. 22. Webster, H. V., Bone, A. J., Webster, K. A., and Wilkin, T. J. (1990). Comparison of an enzyme-linked immunosorbent assay (ELISA) with a radioimmunoassay (RIA) for the measurement of rat insulin. J. Immunol. Methods 134, 95-100.
23. 23. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
24. 24. Janjic, D., and Wollheim, C. B. (1992). Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35, 482-485.
25. 25. Corbett, J. A., Lancaster, J. R., Jr., Sweetland, M. A., and McDaniel, M. L. (1991). Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. J. Biol. Chem. 266, 21351-21354.
26. 26. Flodstrom, M., Niemann, A., Bedoya, F. J., Morris, S. M., Jr., and Eizirik, D. L. (1995). Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: Induction of argininosuccinate synthetase by cytokines. Endocrinology 136, 3200-3206.
27. 27. Niemann, A., Bjorklund, A., and Eizirik, D. L. (1994). Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Mol. Cell. Endocrinol. 106, 151-155.
28. 28. Yamada, K., Otabe, S., Inada, C., Takane, N., and Nonaka, K. (1993). Nitric oxide and nitric oxide synthase mRNA induction in mouse islet cells by interferon-gamma plus tumor necrosis factor-alpha. Biochem. Biophys. Res. Commun. 197, 22-27.
29. 29. Corbett, J. A., and McDaniel, M. L. (1995). Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J. Exp. Med. 181, 559-568.
30. 30. Steiner, L., Kroncke, K. D., Fehsel, K., and Kolb-Bachofen, V. (1997). Endothelial cells as cytotoxic effector cells: Cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide. Diabetologia 40, 150-155.
31. 31. Zhang, J., Dawson, V. L., Dawson, T. M., and Snyder, S. H. (1994). Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263, 687-689.
32. 32. Heller, B., Wang, Z. Q., Wagner, E. F., Radons, J., Burkle, A., Fehsel, K., Burkart, V., and Kolb, H. (1995). Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem. 270, 11176-11180.
33. 33. Castle, L., and Perkins, M. J. (1986). Inhibition kinetics of chain-breaking phenolic antioxidants in SDS micelles. Evidence that intermicellar diffusion may be rate-limiting for hydrophobic inhibitors such as alpha-tocopherol. J. Am. Chem. Soc. 108, 6381-6382.
34. 34. Salgo, M. G., and Pryor, W. A. (1996). Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes. Arch. Biochem. Biophys. 333, 482-488.
35. 35. McClain, D. E., Kalinich, J. F., and Ramakrishnan, N. (1995). Trolox inhibits apoptosis in irradiated MOLT-4 lymphocytes. FASEB J. 9, 1345-1354.
36. 36. Cossarizza, A., Franceschi, C., Monti, D., Salvioli, S., Bellesia, E., Rivabene, R., Biondo, L., Rainaldi, G., Tinari, A., and Malorni, W. (1995). Protective effect of N-acetylcysteine in tumor necrosis factor-α-induced apoptosis in U937 cells: The role of mitochondria. Exp. Cell Res. 220, 232-240.