메뉴 건너뛰기




Volumn 13, Issue 1, 2000, Pages 1-13

Calcineurin inhibitors as neuroprotectants: Focus of tacrolimus and cyclosporin

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CYCLOSPORIN; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 0033956809     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200013010-00001     Document Type: Review
Times cited : (16)

References (207)
  • 2
    • 0027274978 scopus 로고
    • Cyclosporin A, FK506 and rapamycin: More than just immunosuppressants
    • 2. Kunz J, Hall MN. Cyclosporin A, FK506 and rapamycin: more than just immunosuppressants. Trends Biochem Sci 1993; 18 (9): 334-8
    • (1993) Trends Biochem Sci , vol.18 , Issue.9 , pp. 334-338
    • Kunz, J.1    Hall, M.N.2
  • 3
    • 0027157178 scopus 로고
    • FK506 and cyclosporin: Molecular probes for studying intracellular signal transduction
    • 3. Liu J. FK506 and cyclosporin: molecular probes for studying intracellular signal transduction. Trends Pharmacol Sci 1993; 14 (5): 182-8
    • (1993) Trends Pharmacol Sci , vol.14 , Issue.5 , pp. 182-188
    • Liu, J.1
  • 4
    • 0008927673 scopus 로고
    • Discovery and development of FK506 (Tacrolimus), a potent immunosuppressant of microbial origin
    • Merluzzi VJ, Adams J, editors. Boston (MA): Birkhauser
    • 4. Nishiyama M, Izumi S, Okuhara M. Discovery and development of FK506 (Tacrolimus), a potent immunosuppressant of microbial origin. In: Merluzzi VJ, Adams J, editors. The search for anti-inflammatory drugs. Boston (MA): Birkhauser, 1995: 65-104
    • (1995) The Search for Anti-inflammatory Drugs , pp. 65-104
    • Nishiyama, M.1    Izumi, S.2    Okuhara, M.3
  • 5
    • 0026643141 scopus 로고
    • Identification of calcincurin as a key signalling enzyme in T-lymphocyte activation
    • 5. Clipstone NA, Crabtree GR. Identification of calcincurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992; 357 (6380): 695-7
    • (1992) Nature , vol.357 , Issue.6380 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 6
    • 0024472603 scopus 로고
    • A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
    • 6. Harding MW, Galat A, Uehling DE, et al. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 1989; 341 (6244): 758-60
    • (1989) Nature , vol.341 , Issue.6244 , pp. 758-760
    • Harding, M.W.1    Galat, A.2    Uehling, D.E.3
  • 7
    • 0024442393 scopus 로고
    • A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
    • 7. Siekierka JJ, Hung SHY, Poe M, et al. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341 (6244): 755-7
    • (1989) Nature , vol.341 , Issue.6244 , pp. 755-757
    • Siekierka, J.J.1    Hung, S.H.Y.2    Poe, M.3
  • 8
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
    • 8. Fruman DA, Klee CB, Bierer BE, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc Natl Acad Sci U S A 1992; 89 (9): 3686-90
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.9 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3
  • 9
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • 9. Liu J, Farmer JD, Lane WS, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66 (4): 807-15
    • (1991) Cell , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3
  • 10
    • 0027937489 scopus 로고
    • Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
    • 10. Sharkey J, Butcher SP. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature 1994; 371 (6495): 336-9
    • (1994) Nature , vol.371 , Issue.6495 , pp. 336-339
    • Sharkey, J.1    Butcher, S.P.2
  • 11
    • 0030850505 scopus 로고    scopus 로고
    • Neuroprotective actions of FK506 in experimental stroke: In vivo evidence against an antiexcitotoxic mechanism
    • 11. Butcher SP, Henshall DC, Teramura Y, et al. Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. J Neurosci 1997; 17: 6939-46
    • (1997) J Neurosci , vol.17 , pp. 6939-6946
    • Butcher, S.P.1    Henshall, D.C.2    Teramura, Y.3
  • 12
    • 4243242973 scopus 로고
    • Calcineurin: A target for anti-ischaemic drug therapy
    • 12. Sharkey J, Butcher SP. Calcineurin: a target for anti-ischaemic drug therapy [abstract]. J Cereb Blood Flow Metab 1995; 15: S387
    • (1995) J Cereb Blood Flow Metab , vol.15
    • Sharkey, J.1    Butcher, S.P.2
  • 13
    • 0030464736 scopus 로고    scopus 로고
    • Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats
    • 13. Sharkey J, Crawford JH, Butcher SP, et al. Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. Stroke 1996; 27: 2282-6
    • (1996) Stroke , vol.27 , pp. 2282-2286
    • Sharkey, J.1    Crawford, J.H.2    Butcher, S.P.3
  • 14
    • 0030730804 scopus 로고    scopus 로고
    • The effect of FK 506, an immunosuppressant, on cerebral infarction volume in focal cerebral ischemia in rats
    • 14. Aoyama S, Katayama Y, Terashi A. The effect of FK 506, an immunosuppressant, on cerebral infarction volume in focal cerebral ischemia in rats. J Nippon Med Sch 1997; 64 (5): 416-21
    • (1997) J Nippon Med Sch , vol.64 , Issue.5 , pp. 416-421
    • Aoyama, S.1    Katayama, Y.2    Terashi, A.3
  • 15
    • 0026446691 scopus 로고
    • Cyclosporin-A protects against ischemia-reperfusion injury in the brain
    • 15. Shiga Y, Onodera H, Matsuo Y, et al. Cyclosporin-A protects against ischemia-reperfusion injury in the brain. Brain Res 1992; 595 (1): 145-8
    • (1992) Brain Res , vol.595 , Issue.1 , pp. 145-148
    • Shiga, Y.1    Onodera, H.2    Matsuo, Y.3
  • 16
    • 0033019790 scopus 로고    scopus 로고
    • Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury
    • 16. Bochelen D, Rudin M, Sauter A. Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury. J Pharmacol Exp Ther 1999; 288: 653-9
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 653-659
    • Bochelen, D.1    Rudin, M.2    Sauter, A.3
  • 17
    • 4243799564 scopus 로고    scopus 로고
    • Neuroprotective effects of immunosuppressant FK506 in focal cerebral ischemia in the rat-the effect on cerebral infarction, brain edema, immediate early gene and heat shock protein hsp72
    • 17. Kamiya T, Katayama Y, Aoyama S, et al. Neuroprotective effects of immunosuppressant FK506 in focal cerebral ischemia in the rat-the effect on cerebral infarction, brain edema, immediate early gene and heat shock protein hsp72 [abstract]. J Cereb Blood Flow Metab 1997; 17: S372
    • (1997) J Cereb Blood Flow Metab , vol.17
    • Kamiya, T.1    Katayama, Y.2    Aoyama, S.3
  • 18
    • 0029843536 scopus 로고    scopus 로고
    • Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia
    • 18. Kuroda S, Siesjo BK. Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia. Neurosci Res Com 1996; 19: 83-90
    • (1996) Neurosci Res Com , vol.19 , pp. 83-90
    • Kuroda, S.1    Siesjo, B.K.2
  • 19
    • 4243242971 scopus 로고    scopus 로고
    • Protective effect of FK506 on secondary mitochondrial dysfunction due to transient focal cerebral ischemia in the rat
    • 19. Nakai A, Kuroda S, Siesjo BK. Protective effect of FK506 on secondary mitochondrial dysfunction due to transient focal cerebral ischemia in the rat [abstract]. J Cereb Blood Flow Metab 1997; 17: S665
    • (1997) J Cereb Blood Flow Metab , vol.17
    • Nakai, A.1    Kuroda, S.2    Siesjo, B.K.3
  • 20
    • 4243693873 scopus 로고    scopus 로고
    • Immunosuppressive agent FK506 reduces experimental stroke injury
    • 20. Toung TJK, Hurn PD, Bhardwaj A, et al. Immunosuppressive agent FK506 reduces experimental stroke injury [abstract]. J Cereb Blood Flow Metab 1997; 17: S617
    • (1997) J Cereb Blood Flow Metab , vol.17
    • Toung, T.J.K.1    Hurn, P.D.2    Bhardwaj, A.3
  • 21
    • 0029846173 scopus 로고    scopus 로고
    • The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain
    • 21. Drake M, Friberg H, Boris-Moller F, et al. The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. Acta Physiol Scand 1996; 158 (2): 155-9
    • (1996) Acta Physiol Scand , vol.158 , Issue.2 , pp. 155-159
    • Drake, M.1    Friberg, H.2    Boris-Moller, F.3
  • 22
    • 0030959940 scopus 로고    scopus 로고
    • Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects
    • 22. Folbergrova J, Li PA, Uchino H, et al. Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects. Exp Brain Res 1997; 114: 44-50
    • (1997) Exp Brain Res , vol.114 , pp. 44-50
    • Folbergrova, J.1    Li, P.A.2    Uchino, H.3
  • 23
    • 0030951890 scopus 로고    scopus 로고
    • Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia
    • 23. Li PA, Uchino H, Elmer E, et al. Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia. Brain Res 1997; 753: 133-40
    • (1997) Brain Res , vol.753 , pp. 133-140
    • Li, P.A.1    Uchino, H.2    Elmer, E.3
  • 24
    • 0029590050 scopus 로고
    • Cyclosporin A dramatically ameliorates CAI hippocampal damage following transient forebrain ischaemia in the rat
    • 24. Uchino H, Elmer E, Uchino K, et al. Cyclosporin A dramatically ameliorates CAI hippocampal damage following transient forebrain ischaemia in the rat. Acta Physiol Scand 1995; 155: 469-71
    • (1995) Acta Physiol Scand , vol.155 , pp. 469-471
    • Uchino, H.1    Elmer, E.2    Uchino, K.3
  • 25
    • 0032482134 scopus 로고    scopus 로고
    • Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia
    • 25. Wakita H, Tomimoto H, Akiguchi I, et al. Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia. Brain Res 1998; 792: 105-13
    • (1998) Brain Res , vol.792 , pp. 105-113
    • Wakita, H.1    Tomimoto, H.2    Akiguchi, I.3
  • 26
    • 0029112805 scopus 로고
    • Protective effect of cyclosporin A on white matter changes in the rat brain after chronic cerebral hypoperfusion
    • 26. Wakita H, Tomimoto H, Akiguchi I, et al. Protective effect of cyclosporin A on white matter changes in the rat brain after chronic cerebral hypoperfusion. Stroke 1995; 26 (8): 1415-22
    • (1995) Stroke , vol.26 , Issue.8 , pp. 1415-1422
    • Wakita, H.1    Tomimoto, H.2    Akiguchi, I.3
  • 27
    • 0030019624 scopus 로고    scopus 로고
    • An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil
    • 27. Ide T, Morikawa E, Kirino T. An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil. Neurosci Lett 1996; 204: 157-60
    • (1996) Neurosci Lett , vol.204 , pp. 157-160
    • Ide, T.1    Morikawa, E.2    Kirino, T.3
  • 28
    • 0031894355 scopus 로고    scopus 로고
    • Involvement of calcincurin A alpha and A beta in neuronal death in a gerbil model of cerebral ischemia
    • 28. Hashimoto T, Kawamata T, Tanaka C. Involvement of calcincurin A alpha and A beta in neuronal death in a gerbil model of cerebral ischemia. Nippon Yakurigaku Zasshi 1998; 111: 21-8
    • (1998) Nippon Yakurigaku Zasshi , vol.111 , pp. 21-28
    • Hashimoto, T.1    Kawamata, T.2    Tanaka, C.3
  • 29
    • 4244138800 scopus 로고    scopus 로고
    • Immunosuppressant FK506 enhances immediate early gene expression and prevents delayed neuronal death in the gerbil hippocampus
    • 29. Katayama Y, Kamiya T, Muramatsu H, et al. Immunosuppressant FK506 enhances immediate early gene expression and prevents delayed neuronal death in the gerbil hippocampus [abstract]. J Cereb Blood Flow Metab 1997; 17: S492
    • (1997) J Cereb Blood Flow Metab , vol.17
    • Katayama, Y.1    Kamiya, T.2    Muramatsu, H.3
  • 30
    • 0028915760 scopus 로고
    • Cyclosporin A prevents ischemia-induced reduction of muscarinic acetylcholine receptors with suppression of microglial activation in gerbil hippocampus
    • 30. Kondo Y, Ogawa N, Asanuma M, et al. Cyclosporin A prevents ischemia-induced reduction of muscarinic acetylcholine receptors with suppression of microglial activation in gerbil hippocampus. Neurosci Res 1995; 22 (1): 123-7
    • (1995) Neurosci Res , vol.22 , Issue.1 , pp. 123-127
    • Kondo, Y.1    Ogawa, N.2    Asanuma, M.3
  • 31
    • 0029918506 scopus 로고    scopus 로고
    • Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil
    • 31. Tokime T, Nozaki K, Kikuchi H. Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. Neurosci Lett 1996; 206: 81-4
    • (1996) Neurosci Lett , vol.206 , pp. 81-84
    • Tokime, T.1    Nozaki, K.2    Kikuchi, H.3
  • 32
    • 0030569031 scopus 로고    scopus 로고
    • Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils
    • 32. Yagita Y, Kitagawa K, Matsushita K, et al. Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. Life Sci 1996; 59: 1643-50
    • (1996) Life Sci , vol.59 , pp. 1643-1650
    • Yagita, Y.1    Kitagawa, K.2    Matsushita, K.3
  • 33
    • 0028080370 scopus 로고
    • Involvement of immune mechanism in the progressive brain damage
    • 33. Ogawa N, Asanuma M, Kondo Y. Involvement of immune mechanism in the progressive brain damage. Jap J Psychopharmacol 1994; 14: 377-81
    • (1994) Jap J Psychopharmacol , vol.14 , pp. 377-381
    • Ogawa, N.1    Asanuma, M.2    Kondo, Y.3
  • 34
    • 0027158431 scopus 로고
    • The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia
    • 34. Ogawa N, Tanaka K, Kondo Y, et al. The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia. Neurosci Lett 1993; 152 (1-2): 173-6
    • (1993) Neurosci Lett , vol.152 , Issue.1-2 , pp. 173-176
    • Ogawa, N.1    Tanaka, K.2    Kondo, Y.3
  • 35
    • 0029010910 scopus 로고
    • Protective effects of cyclosporine and allopurinol on transient global cerebral ischemia in gerbils
    • 35. Xu X, Ogata H, Luo XX. Protective effects of cyclosporine and allopurinol on transient global cerebral ischemia in gerbils. J Anesth 1995; 9: 170-5
    • (1995) J Anesth , vol.9 , pp. 170-175
    • Xu, X.1    Ogata, H.2    Luo, X.X.3
  • 36
    • 0030961442 scopus 로고    scopus 로고
    • Calcineurin inhibitor, FK506, prevents reduction in the binding capacity of cyclic AMP-dependent protein kinase in ischemic gerbil brain
    • 36. Tanaka K, Fukuuchi Y, Nozaki H, et al. Calcineurin inhibitor, FK506, prevents reduction in the binding capacity of cyclic AMP-dependent protein kinase in ischemic gerbil brain. J Cereb Blood Flow Metab 1997; 17: 412-20
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 412-420
    • Tanaka, K.1    Fukuuchi, Y.2    Nozaki, H.3
  • 37
    • 0028152885 scopus 로고
    • The effect of FK506 on warm ischemia and reperfusion injury in the rat liver
    • 37. Wakabayshi H, Karasawa Y, Tanaka S, et al. The effect of FK506 on warm ischemia and reperfusion injury in the rat liver. Surg Today 1994; 24: 994-1002
    • (1994) Surg Today , vol.24 , pp. 994-1002
    • Wakabayshi, H.1    Karasawa, Y.2    Tanaka, S.3
  • 38
    • 0030038818 scopus 로고    scopus 로고
    • FK506 maintains cellular calcium homeostasis in ischemia. Reperfusion injury of the canine liver
    • 38. Dhar DK, Takemoto Y, Nagasue N, et al. FK506 maintains cellular calcium homeostasis in ischemia. Reperfusion injury of the canine liver. J Surg Res 1996; 60: 142-6
    • (1996) J Surg Res , vol.60 , pp. 142-146
    • Dhar, D.K.1    Takemoto, Y.2    Nagasue, N.3
  • 39
    • 0027724261 scopus 로고
    • Effective prevention of ischemic injury of the dearterialized canine liver by FK506 pretreatment
    • 39. Dhar DK, Nagasue N, Uchida M, et al. Effective prevention of ischemic injury of the dearterialized canine liver by FK506 pretreatment. Transplantation 1993; 56: 1555-8
    • (1993) Transplantation , vol.56 , pp. 1555-1558
    • Dhar, D.K.1    Nagasue, N.2    Uchida, M.3
  • 40
    • 0026657804 scopus 로고
    • The salutary effect of FK506 in ischemia-reperfusion injury of the canine liver
    • 40. Dhar DK, Nagasue N, Kimoto T, et al. The salutary effect of FK506 in ischemia-reperfusion injury of the canine liver. Transplantation 1992; 54: 583-8
    • (1992) Transplantation , vol.54 , pp. 583-588
    • Dhar, D.K.1    Nagasue, N.2    Kimoto, T.3
  • 41
    • 0028593986 scopus 로고
    • Prevention of ischemic injury in hepatocellular transplantation in the rat
    • 41. Echevarria MI, GarciaAlonso I, Portugal V, et al. Prevention of ischemic injury in hepatocellular transplantation in the rat [in Spanish]. Rev Esp Enferm Dig 1994; 86 (6): 894-7
    • (1994) Rev Esp Enferm Dig , vol.86 , Issue.6 , pp. 894-897
    • Echevarria, M.I.1    Garciaalonso, I.2    Portugal, V.3
  • 42
    • 0030961001 scopus 로고    scopus 로고
    • Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia
    • 42. Garcia-Criado FJ, Palma-Vargas JM, Valdunciel-Garcia JJ, et al. Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia. Transplantation 1997; 64: 594-8
    • (1997) Transplantation , vol.64 , pp. 594-598
    • Garcia-Criado, F.J.1    Palma-Vargas, J.M.2    Valdunciel-Garcia, J.J.3
  • 43
    • 0025106029 scopus 로고
    • Modifications induced by cyclosporin A on ischemic liver regeneration
    • 43. Garcia-Alonso I, Portugal V, Iturburu I, et al. Modifications induced by cyclosporin A on ischemic liver regeneration. Surg Res Com 1990; 9: 227-33
    • (1990) Surg Res Com , vol.9 , pp. 227-233
    • Garcia-Alonso, I.1    Portugal, V.2    Iturburu, I.3
  • 44
    • 0029942711 scopus 로고    scopus 로고
    • Protective effect of FK 506 on hepatic energy metabolism in warm ischemic canine livers induced by total hepatic vascular exclusion
    • 44. Jin MB, Yamagishi H, Ochiai T, et al. Protective effect of FK 506 on hepatic energy metabolism in warm ischemic canine livers induced by total hepatic vascular exclusion. Transplant Proc 1996; 28: 1108-10
    • (1996) Transplant Proc , vol.28 , pp. 1108-1110
    • Jin, M.B.1    Yamagishi, H.2    Ochiai, T.3
  • 45
    • 0029794347 scopus 로고    scopus 로고
    • Premedication with cyclosporine and perindopril modifies the ischaemia-reperfusion injury during liver resection in rats
    • 45. Hardy KJ, Tancheroen S, Shulkes A. Premedication with cyclosporine and perindopril modifies the ischaemia-reperfusion injury during liver resection in rats. J Gastro Hepatol 1996; 11: 652-7
    • (1996) J Gastro Hepatol , vol.11 , pp. 652-657
    • Hardy, K.J.1    Tancheroen, S.2    Shulkes, A.3
  • 46
    • 0029946860 scopus 로고    scopus 로고
    • FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation
    • 46. Kawano K, Bowers JL, Kim YI, et al. FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. Transplant Proc 1996; 28: 1902-3
    • (1996) Transplant Proc , vol.28 , pp. 1902-1903
    • Kawano, K.1    Bowers, J.L.2    Kim, Y.I.3
  • 47
    • 0028798612 scopus 로고
    • Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: Influence on hepatic microcirculation
    • 47. Kawano K, Bowers JL, Clouse ME. Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. Transplant Proc 1995; 27: 362-3
    • (1995) Transplant Proc , vol.27 , pp. 362-363
    • Kawano, K.1    Bowers, J.L.2    Clouse, M.E.3
  • 48
    • 0028208741 scopus 로고
    • Evidence that FK506 alleviates ischemia/reperfusion injury to the rat liver: In vivo demonstration for suppression of TNF-alpha production in response to endotoxemia
    • 48. Kawano K, Kim YI, Kai T, et al. Evidence that FK506 alleviates ischemia/reperfusion injury to the rat liver: in vivo demonstration for suppression of TNF-alpha production in response to endotoxemia. Eur Surg Res 1994; 26: 108-15
    • (1994) Eur Surg Res , vol.26 , pp. 108-115
    • Kawano, K.1    Kim, Y.I.2    Kai, T.3
  • 49
    • 0025813037 scopus 로고
    • A protective effect of FK506 in ischemically injured rat livers
    • 49. Kawano K, Kim YI, Goto S, et al. A protective effect of FK506 in ischemically injured rat livers. Transplantaion 1991; 52: 143-5
    • (1991) Transplantaion , vol.52 , pp. 143-145
    • Kawano, K.1    Kim, Y.I.2    Goto, S.3
  • 50
    • 0025768692 scopus 로고
    • Beneficial effect of cyclosporine pretreatment in canine liver ischemia. Enzymalic and electronmicroscopic studies
    • 50. Hayashi T, Nagasue N, Kohno H, et al. Beneficial effect of cyclosporine pretreatment in canine liver ischemia. Enzymalic and electronmicroscopic studies. Transplantation 1991; 52: 116-21
    • (1991) Transplantation , vol.52 , pp. 116-121
    • Hayashi, T.1    Nagasue, N.2    Kohno, H.3
  • 51
    • 0024246542 scopus 로고
    • Beneficial effect of cyclosporine pretreatrnent in preventing ischemic damage to the liver in dogs
    • 51. Hayashi T, Nagasue N, Kohno H, et al. Beneficial effect of cyclosporine pretreatrnent in preventing ischemic damage to the liver in dogs. Transplantation 1988; 46: 923-4
    • (1988) Transplantation , vol.46 , pp. 923-924
    • Hayashi, T.1    Nagasue, N.2    Kohno, H.3
  • 52
    • 0028064253 scopus 로고
    • FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation
    • 52. Kim YI, Akizuki S, Kawano K, et al. FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. Transplant Proc 1994; 26: 2384-7
    • (1994) Transplant Proc , vol.26 , pp. 2384-2387
    • Kim, Y.I.1    Akizuki, S.2    Kawano, K.3
  • 53
    • 0027977839 scopus 로고
    • Attenuation of cold ischemic liver injury by cyclosporine in association with endotoxemia and chemokine release
    • 53. Kai T, Kim YI, Kitamura H, et al. Attenuation of cold ischemic liver injury by cyclosporine in association with endotoxemia and chemokine release. Transplant Proc 1994; 26: 2370-4
    • (1994) Transplant Proc , vol.26 , pp. 2370-2374
    • Kai, T.1    Kim, Y.I.2    Kitamura, H.3
  • 54
    • 0028107754 scopus 로고
    • Ameliorative effect of FK506 on cold ischemia reperfusion injury of the rat liver
    • 54. Okano K, Hamamoto I, Izuishi K, et al. Ameliorative effect of FK506 on cold ischemia reperfusion injury of the rat liver. Transplant Proc 1994; 26: 2367-9
    • (1994) Transplant Proc , vol.26 , pp. 2367-2369
    • Okano, K.1    Hamamoto, I.2    Izuishi, K.3
  • 55
    • 0027484176 scopus 로고
    • Evidence that both cyclosporin and azathioprine prevent warm ischemia reperfusion injury to the rat liver
    • 55. Kawano K, Kim YI, Ono M, et al. Evidence that both cyclosporin and azathioprine prevent warm ischemia reperfusion injury to the rat liver. Transplant Int 1993; 6: 330-6
    • (1993) Transplant Int , vol.6 , pp. 330-336
    • Kawano, K.1    Kim, Y.I.2    Ono, M.3
  • 56
    • 0024363591 scopus 로고
    • The beneficial effect of cyclosporine on liver ischemia in rats
    • 56. Kawano K, Kim YI, Kaketani K, et al. The beneficial effect of cyclosporine on liver ischemia in rats. Transplantation 1989; 48; 759-64
    • (1989) Transplantation , vol.48 , pp. 759-764
    • Kawano, K.1    Kim, Y.I.2    Kaketani, K.3
  • 57
    • 0027212047 scopus 로고
    • FK506 pre-treatment is associated with reduced levels of tumour necrosis factor and interleukin-6 following hepatic ischemia/reperfusion
    • 57. Sakr MF, McClain CJ, Gavaler JS, et al. FK506 pre-treatment is associated with reduced levels of tumour necrosis factor and interleukin-6 following hepatic ischemia/reperfusion. J Hepatol 1993; 17 (3): 301-7
    • (1993) J Hepatol , vol.17 , Issue.3 , pp. 301-307
    • Sakr, M.F.1    McClain, C.J.2    Gavaler, J.S.3
  • 58
    • 0026734787 scopus 로고
    • The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats
    • 58. Sakr M, Zetti G, McClain C, et al. The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats. Transplantation 1992; 53: 987-91
    • (1992) Transplantation , vol.53 , pp. 987-991
    • Sakr, M.1    Zetti, G.2    McClain, C.3
  • 59
    • 0026099934 scopus 로고
    • Protective effect of FK506 against hepatic ischemia in rats
    • 59. Sakr MF, Zetti GM, Farghali H, et al. Protective effect of FK506 against hepatic ischemia in rats. Transplant Proc 1991; 23: 340-1
    • (1991) Transplant Proc , vol.23 , pp. 340-341
    • Sakr, M.F.1    Zetti, G.M.2    Farghali, H.3
  • 60
    • 0026695538 scopus 로고
    • Protection of pig liver against normothermic ischemia by immunosuppressants cyclosporine and azathioprine
    • 60. Kim YI, Kawano K, Goto S, et al. Protection of pig liver against normothermic ischemia by immunosuppressants cyclosporine and azathioprine. Transplantation 1992; 54: 182-4
    • (1992) Transplantation , vol.54 , pp. 182-184
    • Kim, Y.I.1    Kawano, K.2    Goto, S.3
  • 61
    • 0026031570 scopus 로고
    • Amelioration of 3.5-hour warm ischemia time for pig livers by cyclosporine pretherapy, compared with azathioprine
    • 61. Kim YI, Kawano K, Goto S, et al. Amelioration of 3.5-hour warm ischemia time for pig livers by cyclosporine pretherapy, compared with azathioprine. Transplant Proc 1991; 23: 655-6
    • (1991) Transplant Proc , vol.23 , pp. 655-656
    • Kim, Y.I.1    Kawano, K.2    Goto, S.3
  • 62
    • 4243629138 scopus 로고
    • Prophylactic effect of FK506 on porcine hepatic injury by ischemia
    • 62. Sawada T, Inoue K, Tanabe T, et al. Prophylactic effect of FK506 on porcine hepatic injury by ischemia [abstract]. Jap J Transplant 1992; 26: S259
    • (1992) Jap J Transplant , vol.26
    • Sawada, T.1    Inoue, K.2    Tanabe, T.3
  • 63
    • 0032490544 scopus 로고
    • Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat
    • 63. Konukoglu D, Tasci I, Cetinkale O. Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat. Clin Chim Acta 1988; 275: 1-8
    • (1988) Clin Chim Acta , vol.275 , pp. 1-8
    • Konukoglu, D.1    Tasci, I.2    Cetinkale, O.3
  • 64
    • 0027319824 scopus 로고
    • Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury: Modulating effects of FK506 and cyclosporine
    • 64. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, et al. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury: modulating effects of FK506 and cyclosporine. Transplantation 1993; 55: 1265-72
    • (1993) Transplantation , vol.55 , pp. 1265-1272
    • Suzuki, S.1    Toledo-Pereyra, L.H.2    Rodriguez, F.J.3
  • 65
    • 0026520240 scopus 로고
    • Beneficial effects of cyclosporine on postischemic liver injury in rats
    • 65. Kurokawa T, Kobayashi H, Nonami T, et al. Beneficial effects of cyclosporine on postischemic liver injury in rats. Transplantation 1992; 53: 308-11
    • (1992) Transplantation , vol.53 , pp. 308-311
    • Kurokawa, T.1    Kobayashi, H.2    Nonami, T.3
  • 66
    • 0026664618 scopus 로고
    • Effect of FK 506 and cyclosporine A on hepatic energy status in the rat after warm ischemia, as monitored by 31P nuclear magnetic resonance spectroscopy in vivo
    • 66. Wakabayashi H, Karasawa Y, Maeba T, et al. Effect of FK 506 and cyclosporine A on hepatic energy status in the rat after warm ischemia, as monitored by 31P nuclear magnetic resonance spectroscopy in vivo. Transplant Proc 1992; 24: 1993-5
    • (1992) Transplant Proc , vol.24 , pp. 1993-1995
    • Wakabayashi, H.1    Karasawa, Y.2    Maeba, T.3
  • 67
    • 0028970196 scopus 로고
    • Effect of allopurinol, folinic acid, SOD and cyclosporine A on ischemic liver regeneration
    • 67. Portugal V, Garcia-Alonso I, Barcelo P, et al. Effect of allopurinol, folinic acid, SOD and cyclosporine A on ischemic liver regeneration. Eur Surg Res 1995; 27 (2): 69-76
    • (1995) Eur Surg Res , vol.27 , Issue.2 , pp. 69-76
    • Portugal, V.1    Garcia-Alonso, I.2    Barcelo, P.3
  • 68
    • 0029859721 scopus 로고    scopus 로고
    • Protective effect of cyclosporine A (CyA) against the hepatic injury associated with ischemia and reperfusion
    • 68. Sakr MF, Abdel-Aal AN. Protective effect of cyclosporine A (CyA) against the hepatic injury associated with ischemia and reperfusion. Int Surg 1996; 81: 180-3
    • (1996) Int Surg , vol.81 , pp. 180-183
    • Sakr, M.F.1    Abdel-Aal, A.N.2
  • 69
    • 0029756403 scopus 로고    scopus 로고
    • Mechanisms of the protective effect of cyclosporine against hepatic is chemiareperfusion injury in canine model
    • 69. Takemoto Y, Dhar DK, Nagasue N, et al. Mechanisms of the protective effect of cyclosporine against hepatic is chemiareperfusion injury in canine model. Surg Res Com 1996; 18: 155-66
    • (1996) Surg Res Com , vol.18 , pp. 155-166
    • Takemoto, Y.1    Dhar, D.K.2    Nagasue, N.3
  • 70
    • 0028120285 scopus 로고
    • Suppression of superoxide production from polymorphonuclear leukocytes by cyclosporine in ischemia-reperfusion of the liver
    • 70. Tatsuma I, Kim YI, Ono M, et al. Suppression of superoxide production from polymorphonuclear leukocytes by cyclosporine in ischemia-reperfusion of the liver. Transplant Proc 1994; 26: 2413-6
    • (1994) Transplant Proc , vol.26 , pp. 2413-2416
    • Tatsuma, I.1    Kim, Y.I.2    Ono, M.3
  • 71
    • 0028227002 scopus 로고
    • Beneficial effect of donor pretreatment with cyclosporin A in porcine liver transplantation
    • 71. Yamanoi A, Nagasue N, Kohno H, et al. Beneficial effect of donor pretreatment with cyclosporin A in porcine liver transplantation. Surg Res Com 1994; 15: 229-36
    • (1994) Surg Res Com , vol.15 , pp. 229-236
    • Yamanoi, A.1    Nagasue, N.2    Kohno, H.3
  • 72
    • 0025861746 scopus 로고
    • Attenuation of ischemia-reperfusion injury of the liver in dogs by cyclosporine. A comparative study with allopurinol and methylprednisolone
    • 72. Yamanoi A, Nagasue N, Kohno H, et al. Attenuation of ischemia-reperfusion injury of the liver in dogs by cyclosporine. A comparative study with allopurinol and methylprednisolone. Transplantation 1991; 52: 27-30
    • (1991) Transplantation , vol.52 , pp. 27-30
    • Yamanoi, A.1    Nagasue, N.2    Kohno, H.3
  • 73
    • 0029842162 scopus 로고    scopus 로고
    • Protective effect of FK506 on myocardial reperfusion injury following normothermic global ischemia in rat hearts
    • 73. Morishita K. Protective effect of FK506 on myocardial reperfusion injury following normothermic global ischemia in rat hearts. Sapporo Med J 1996; 65: 113-9
    • (1996) Sapporo Med J , vol.65 , pp. 113-119
    • Morishita, K.1
  • 74
    • 0031899148 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha is expressed by monocytes/macrophages following cardiac microembolization and is antagonized by cyclosporine
    • 74. Arras M, Strasser R, Mohri M, et al. Tumor necrosis factor-alpha is expressed by monocytes/macrophages following cardiac microembolization and is antagonized by cyclosporine. Basic Res Cardiol 1998; 93: 97-107
    • (1998) Basic Res Cardiol , vol.93 , pp. 97-107
    • Arras, M.1    Strasser, R.2    Mohri, M.3
  • 75
    • 0027462048 scopus 로고
    • Protective effect of FK506 on ischemia-reperfusion-induced myocardial damage in canine heart
    • 75. Nishinaka Y, Sugiyama S, Yokota M, et al. Protective effect of FK506 on ischemia-reperfusion-induced myocardial damage in canine heart. J Cardiovasc Pharmacol 1993; 21 (3): 448-54
    • (1993) J Cardiovasc Pharmacol , vol.21 , Issue.3 , pp. 448-454
    • Nishinaka, Y.1    Sugiyama, S.2    Yokota, M.3
  • 76
    • 0026669291 scopus 로고
    • Impairment by cyclosporin A of reperfusion-induced arrhythmias
    • 76. Arteaga D, Odor A, Lopez RM, et al. Impairment by cyclosporin A of reperfusion-induced arrhythmias. Life Sci 1992; 51: 1127-34
    • (1992) Life Sci , vol.51 , pp. 1127-1134
    • Arteaga, D.1    Odor, A.2    Lopez, R.M.3
  • 77
    • 0029745769 scopus 로고    scopus 로고
    • A novel mechanism for cyclosporine: Inhibition of myocardial ischemia and reperfusion injury in a heterotopic rabbit heart transplant model
    • 77. Gatewood LB, Larson DF, Bowers MC, et al. A novel mechanism for cyclosporine: inhibition of myocardial ischemia and reperfusion injury in a heterotopic rabbit heart transplant model. J Heart Lung Transplant 1996; 15: 936-47
    • (1996) J Heart Lung Transplant , vol.15 , pp. 936-947
    • Gatewood, L.B.1    Larson, D.F.2    Bowers, M.C.3
  • 78
    • 0027761474 scopus 로고
    • Protection by cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts
    • 78. Griffiths EJ, Halestrap AP. Protection by cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. J Mol Cell Cardiol 1993; 25: 1461-9
    • (1993) J Mol Cell Cardiol , vol.25 , pp. 1461-1469
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 79
    • 0031080128 scopus 로고    scopus 로고
    • Cardioprotection by cyclosporine A in experimental ischemia and reperfusion - evidence for a nitric oxide - dependent mechanism mediated by endothelin
    • 79. Massoudy P, Zahler S, Kupatt C, et al. Cardioprotection by cyclosporine A in experimental ischemia and reperfusion - evidence for a nitric oxide - dependent mechanism mediated by endothelin. J Mol Cell Cardiol 1997; 29: 535-44
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 535-544
    • Massoudy, P.1    Zahler, S.2    Kupatt, C.3
  • 80
    • 0030729252 scopus 로고    scopus 로고
    • Cyclosporine A prevents ischemia-reperfusion myocardial dysfunction in the isolated rat heart
    • 80. Mathieu P, Bendavid Y, Buluran J, et al. Cyclosporine A prevents ischemia-reperfusion myocardial dysfunction in the isolated rat heart. Ann Chir 1997; 51: 912-8
    • (1997) Ann Chir , vol.51 , pp. 912-918
    • Mathieu, P.1    Bendavid, Y.2    Buluran, J.3
  • 81
    • 0343580456 scopus 로고    scopus 로고
    • Effects of increased ICAM-1 on reperfusion injury and chronic graft vascular disease
    • 81. Poston Jr RS, Billingham ME, Pollard J, et al. Effects of increased ICAM-1 on reperfusion injury and chronic graft vascular disease. Ann Thorac Surg 1997; 64: 1004-12
    • (1997) Ann Thorac Surg , vol.64 , pp. 1004-1012
    • Poston R.S., Jr.1    Billingham, M.E.2    Pollard, J.3
  • 82
    • 0026528183 scopus 로고
    • Effect of renal ischemia on plasma levels of FK 506 in rats
    • 82. Sakr M, Zetti G, Gavaler J, et al. Effect of renal ischemia on plasma levels of FK 506 in rats. Transplant Proc 1992; 24: 425-8
    • (1992) Transplant Proc , vol.24 , pp. 425-428
    • Sakr, M.1    Zetti, G.2    Gavaler, J.3
  • 83
    • 0025267576 scopus 로고
    • The effect of FK 506 on CyA on the lewis rat renal ischemia model
    • 83. Nalesnik MA, Lai HS, Murase N, et al. The effect of FK 506 on CyA on the Lewis rat renal ischemia model. Transplant Proc 1990; 22: 87-9
    • (1990) Transplant Proc , vol.22 , pp. 87-89
    • Nalesnik, M.A.1    Lai, H.S.2    Murase, N.3
  • 84
    • 0028519257 scopus 로고
    • Influence of the timing of FK506 (tacrolimus) administration on recovery of renal function from warm ischemic injury in rats
    • 84. Cacciarelli TV, Sumrani NB, Hong JH, et al. Influence of the timing of FK506 (tacrolimus) administration on recovery of renal function from warm ischemic injury in rats. ASAIO J 1994; 40: 964-7
    • (1994) ASAIO J , vol.40 , pp. 964-967
    • Cacciarelli, T.V.1    Sumrani, N.B.2    Hong, J.H.3
  • 85
    • 0029847286 scopus 로고    scopus 로고
    • Effect of FK506 on the mucosal perfusion of the rat intestinal allograft
    • 85. Cicalese L, Weber K, Lee RG. et al. Effect of FK506 on the mucosal perfusion of the rat intestinal allograft. Transplant Proc 1996; 28 (5): 2575
    • (1996) Transplant Proc , vol.28 , Issue.5 , pp. 2575
    • Cicalese, L.1    Weber, K.2    Lee, R.G.3
  • 86
    • 0025995316 scopus 로고
    • Effects of cyclosporin A and FK506 on ischemia/reperfusion-induced neutrophil infiltration in the cat
    • 86. Kubes P, Hunter J, Granger DN. Effects of cyclosporin A and FK506 on ischemia/reperfusion-induced neutrophil infiltration in the cat. Dig Dis Sci 1991; 36: 1469-72
    • (1991) Dig Dis Sci , vol.36 , pp. 1469-1472
    • Kubes, P.1    Hunter, J.2    Granger, D.N.3
  • 87
    • 0030049767 scopus 로고    scopus 로고
    • The effect of cyclosporine in gut ischemic injury: A computerised morphometric and enzymatic analysis
    • 87. Puglisi RN, Strande L, Santos M, et al. The effect of cyclosporine in gut ischemic injury: a computerised morphometric and enzymatic analysis. J Pediatr Surg 1996; 31: 319-22
    • (1996) J Pediatr Surg , vol.31 , pp. 319-322
    • Puglisi, R.N.1    Strande, L.2    Santos, M.3
  • 88
    • 0030273698 scopus 로고    scopus 로고
    • Beneficial effects of cyclosporine and rapamycin in small bowel ischemic injury
    • 88. Puglisi RN, Strande L, Santos M, et al. Beneficial effects of cyclosporine and rapamycin in small bowel ischemic injury. J Surg Res 1996; 65: 115-8
    • (1996) J Surg Res , vol.65 , pp. 115-118
    • Puglisi, R.N.1    Strande, L.2    Santos, M.3
  • 89
    • 0026772369 scopus 로고
    • Cytomegalovirus infection of the upper gastrointestinal tract following liver transplantation - incidence, location, and severity in cyclosporine-and FK506-treated patients
    • 89. Sakr M, Hassanein T, Gavaler J, et al. Cytomegalovirus infection of the upper gastrointestinal tract following liver transplantation - incidence, location, and severity in cyclosporine-and FK506-treated patients. Transplantation 1992; 53: 786-91
    • (1992) Transplantation , vol.53 , pp. 786-791
    • Sakr, M.1    Hassanein, T.2    Gavaler, J.3
  • 90
    • 0030728707 scopus 로고    scopus 로고
    • Involvement of neutrophils in ischemic injury. I. Biochemical and histopathological investigation of the effect of FK506 on dorsal skin flaps in rats
    • 90. Cetinkale O, Sengul R, Bilgic L, et al. Involvement of neutrophils in ischemic injury. I. Biochemical and histopathological investigation of the effect of FK506 on dorsal skin flaps in rats. Ann Plastic Surg 1997; 39: 505-15
    • (1997) Ann Plastic Surg , vol.39 , pp. 505-515
    • Cetinkale, O.1    Sengul, R.2    Bilgic, L.3
  • 91
    • 0029957329 scopus 로고    scopus 로고
    • Neutrophil-mediated injury in ischemic skin flaps: Amelioration of ischemic injury by cyclosporine in the rat
    • 91. Cetinkale O, Bilgic L, Ayan F, et al. Neutrophil-mediated injury in ischemic skin flaps: amelioration of ischemic injury by cyclosporine in the rat. Ann Plastic Surg 1996; 37: 66-74
    • (1996) Ann Plastic Surg , vol.37 , pp. 66-74
    • Cetinkale, O.1    Bilgic, L.2    Ayan, F.3
  • 92
    • 0026743057 scopus 로고
    • The beneficial effect of cyclosporin-A on the no-reflow phenomenon in rat skin island flaps
    • 92. Kucukcelebi A, Ozcan M. The beneficial effect of cyclosporin-A on the no-reflow phenomenon in rat skin island flaps. Br J Plastic Surg 1992; 45: 512-4
    • (1992) Br J Plastic Surg , vol.45 , pp. 512-514
    • Kucukcelebi, A.1    Ozcan, M.2
  • 93
    • 0024947768 scopus 로고
    • Pharmacology of cyclosporin (Sandimmune) VII. Pathophysiology and toxicology of cyclosporin in humans and animals
    • 93. Mason J. Pharmacology of cyclosporin (Sandimmune) VII. Pathophysiology and toxicology of cyclosporin in humans and animals. Pharmacol Rev 1989; 42 (3): 423-34
    • (1989) Pharmacol Rev , vol.42 , Issue.3 , pp. 423-434
    • Mason, J.1
  • 94
    • 0025078137 scopus 로고
    • The spectrum of cyclosporin nephrotoxicity
    • 94. Puschett JB, Greenberg A, Holley J, et al. The spectrum of cyclosporin nephrotoxicity. Am J Nephrol 1990; 10(4): 296-309
    • (1990) Am J Nephrol , vol.10 , Issue.4 , pp. 296-309
    • Puschett, J.B.1    Greenberg, A.2    Holley, J.3
  • 95
    • 0028043348 scopus 로고
    • Morphopathological findings of renal allografts under FK506 therapy: Japanese FK506 study group
    • 95. Sonada T. Morphopathological findings of renal allografts under FK506 therapy: Japanese FK506 study group. Transplant Proc 1994; 26: 1933-6
    • (1994) Transplant Proc , vol.26 , pp. 1933-1936
    • Sonada, T.1
  • 96
    • 0030023484 scopus 로고    scopus 로고
    • Ischemic stroke: Treatment on the horizon
    • 96. Giroux C, Scattom B. Ischemic stroke: treatment on the horizon. Eur Neurol 1996; 36 (2): 61-4
    • (1996) Eur Neurol , vol.36 , Issue.2 , pp. 61-64
    • Giroux, C.1    Scattom, B.2
  • 97
    • 0029973646 scopus 로고    scopus 로고
    • Emerging treatments for stroke in humans
    • 97. Koroshetz WJ, Moskowitz MA. Emerging treatments for stroke in humans. Trends Pharmacol Sci 1996; 17 (6): 227-33
    • (1996) Trends Pharmacol Sci , vol.17 , Issue.6 , pp. 227-233
    • Koroshetz, W.J.1    Moskowitz, M.A.2
  • 98
    • 0031759682 scopus 로고    scopus 로고
    • Reperfusion injury after focal cerebral ischemia: The role of inflammation and the therapeutic horizon
    • 98. Jean WC, Spellman SR, Nussbaum ES, et al. Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery 1998; 43: 1382-97
    • (1998) Neurosurgery , vol.43 , pp. 1382-1397
    • Jean, W.C.1    Spellman, S.R.2    Nussbaum, E.S.3
  • 99
    • 0031718663 scopus 로고    scopus 로고
    • Inflammation and glial responses in ischemic brain lesions
    • 99. Stoll G, Jander S, Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 1998; 56: 149-71
    • (1998) Prog Neurobiol , vol.56 , pp. 149-171
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 100
    • 0029121104 scopus 로고
    • Microglia as a unique cellular target in the treatment of stroke: Potential neurotoxic mediators produced by activated microglia
    • 100. Wood PL. Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol Res 1995; 17: 242-48
    • (1995) Neurol Res , vol.17 , pp. 242-248
    • Wood, P.L.1
  • 101
    • 0029809417 scopus 로고    scopus 로고
    • The role of inflammation and cytokines in brain injury
    • 101. Arvin B, Neville LF, Barone FC, et al. The role of inflammation and cytokines in brain injury. Neurosci Biobehav Rev 1996; 20: 445-52
    • (1996) Neurosci Biobehav Rev , vol.20 , pp. 445-452
    • Arvin, B.1    Neville, L.F.2    Barone, F.C.3
  • 102
    • 0030013371 scopus 로고    scopus 로고
    • Cytokines and adhesion molecules in stroke and related diseases
    • 102. Kim JS. Cytokines and adhesion molecules in stroke and related diseases. J Neurol Sci 1996; 137: 69-78
    • (1996) J Neurol Sci , vol.137 , pp. 69-78
    • Kim, J.S.1
  • 103
    • 0031899340 scopus 로고    scopus 로고
    • Role of proinflammatory cytokines in cerebral ischemia: A review
    • 103. Sharma BK, Kumar K. Role of proinflammatory cytokines in cerebral ischemia: a review. Metab Brain Dis 1998; 13: 1-8
    • (1998) Metab Brain Dis , vol.13 , pp. 1-8
    • Sharma, B.K.1    Kumar, K.2
  • 104
    • 0026667919 scopus 로고
    • Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
    • 104. Kochanek PM, Hallenbeck JM. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 1992; 23 (9): 1367-79
    • (1992) Stroke , vol.23 , Issue.9 , pp. 1367-1379
    • Kochanek, P.M.1    Hallenbeck, J.M.2
  • 105
    • 0030769136 scopus 로고    scopus 로고
    • Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion
    • 105. Lehrmann E, Christensen T, Zimmer J, et al. Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion. J Comp Neurol 1997; 386: 461-76
    • (1997) J Comp Neurol , vol.386 , pp. 461-476
    • Lehrmann, E.1    Christensen, T.2    Zimmer, J.3
  • 106
    • 0031831559 scopus 로고    scopus 로고
    • Cellular surface molecular and cytokine gene expression in rat heart allografts under optimal doses of cyclosporine and FK 506
    • 106. Fujimura T, Yang X, Soriano R, et al. Cellular surface molecular and cytokine gene expression in rat heart allografts under optimal doses of cyclosporine and FK 506. Transplant Proc 1998; 30: 1023-6
    • (1998) Transplant Proc , vol.30 , pp. 1023-1026
    • Fujimura, T.1    Yang, X.2    Soriano, R.3
  • 107
    • 0032532195 scopus 로고    scopus 로고
    • Do immunosuppressants directly affect neutrophils, resulting in protection of the liver against ischemia-reperfusion injury?
    • 107. Ohmori M, Kobayashi E, Harada K, et al. Do immunosuppressants directly affect neutrophils, resulting in protection of the liver against ischemia-reperfusion injury? Transplantation 1998; 66: 940-1
    • (1998) Transplantation , vol.66 , pp. 940-941
    • Ohmori, M.1    Kobayashi, E.2    Harada, K.3
  • 108
    • 0027240533 scopus 로고
    • Macrolide antibiotics protect neurons in culture against N-methyl-D-aspartate (NMDA) receptor mediated toxicity of glutamate
    • 108. Manev H, Favaron M, Fadda E, et al. Macrolide antibiotics protect neurons in culture against N-methyl-D-aspartate (NMDA) receptor mediated toxicity of glutamate. Brain Res 1993; 624 (1-2): 331-5
    • (1993) Brain Res , vol.624 , Issue.1-2 , pp. 331-335
    • Manev, H.1    Favaron, M.2    Fadda, E.3
  • 109
    • 0031840626 scopus 로고    scopus 로고
    • Effect of cyclosporin A on inflammatory cytokine production by human alveolar macrophages
    • 109. Losa Garcia JE, Mateos Rodriguez F, Jimenez Lopez A, et al. Effect of cyclosporin A on inflammatory cytokine production by human alveolar macrophages. Respir Med 1998; 92 (5): 722-8
    • (1998) Respir Med , vol.92 , Issue.5 , pp. 722-728
    • Losa Garcia, J.E.1    Mateos Rodriguez, F.2    Jimenez Lopez, A.3
  • 110
    • 0031951375 scopus 로고    scopus 로고
    • Suppression of nitric oxide formation by tyrosine kinase inhibitors in murine N9 microglia
    • 110. Lockhart BP, Cressey KC, Lepagnol JM. Suppression of nitric oxide formation by tyrosine kinase inhibitors in murine N9 microglia. Br J Pharmacol 1998; 123: 879-89
    • (1998) Br J Pharmacol , vol.123 , pp. 879-889
    • Lockhart, B.P.1    Cressey, K.C.2    Lepagnol, J.M.3
  • 112
    • 0344766073 scopus 로고    scopus 로고
    • Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages
    • 112. Hortelano S, Lopez-Collazo E, Bosca L. Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. Br J Pharmacol 1999; 126: 1139-46
    • (1999) Br J Pharmacol , vol.126 , pp. 1139-1146
    • Hortelano, S.1    Lopez-Collazo, E.2    Bosca, L.3
  • 113
    • 0031874792 scopus 로고    scopus 로고
    • Inflammation in the CNS: Balance between immunological privilege and immune responses
    • 113. Matyszak MK. Inflammation in the CNS: balance between immunological privilege and immune responses. Prog Neurobiol 1998; 56: 19-35
    • (1998) Prog Neurobiol , vol.56 , pp. 19-35
    • Matyszak, M.K.1
  • 114
    • 0030070721 scopus 로고    scopus 로고
    • Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat
    • 114. Buttini M, Appel K, Sauter A, et al. Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat. Neurosci 1996; 71: 1-16
    • (1996) Neurosci , vol.71 , pp. 1-16
    • Buttini, M.1    Appel, K.2    Sauter, A.3
  • 115
    • 0028675999 scopus 로고
    • Cytokines, inflammation and brain injury; role of tumour necrosis factor-α
    • 115. Feuerstein GZ, Liu T, Barone FC. Cytokines, inflammation and brain injury; role of tumour necrosis factor-α. Cerebrovasc Brain Metab Rev 1994; 6 (4): 341-60
    • (1994) Cerebrovasc Brain Metab Rev , vol.6 , Issue.4 , pp. 341-360
    • Feuerstein, G.Z.1    Liu, T.2    Barone, F.C.3
  • 116
    • 0031718374 scopus 로고    scopus 로고
    • Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation
    • 116. Fink K, Zhu J, Namura S, et al. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation. J Cereb Blood Flow Metab 1998; 18: 1071-6
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 1071-1076
    • Fink, K.1    Zhu, J.2    Namura, S.3
  • 117
    • 0030236313 scopus 로고    scopus 로고
    • Involvement of cytokine production in the pathogenesis of transient cerebral ischaemic damage
    • 117. Yamasaki Y, Itoyama Y, Kogure K. Involvement of cytokine production in the pathogenesis of transient cerebral ischaemic damage. Keio J Med 1996; 45: 225-9
    • (1996) Keio J Med , vol.45 , pp. 225-229
    • Yamasaki, Y.1    Itoyama, Y.2    Kogure, K.3
  • 118
    • 0028958354 scopus 로고
    • Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats
    • 118. Yamasaki Y, Matsuura N, Shozuhara H, et al. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 1995; 26: 676-81
    • (1995) Stroke , vol.26 , pp. 676-681
    • Yamasaki, Y.1    Matsuura, N.2    Shozuhara, H.3
  • 119
    • 0031892704 scopus 로고    scopus 로고
    • Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
    • 119. Endres M, Namura S, Shimizu-Sasamata M, et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 1998; 18: 238-47
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 238-247
    • Endres, M.1    Namura, S.2    Shimizu-Sasamata, M.3
  • 120
    • 0026782517 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia. Pt II. Mechanisms of damage and treatment
    • 120. Sicsjo BK. Pathophysiology and treatment of focal cerebral ischemia. Pt II. Mechanisms of damage and treatment. J Neurosurg 1992; 77: 337-54
    • (1992) J Neurosurg , vol.77 , pp. 337-354
    • Sicsjo, B.K.1
  • 121
    • 0029257347 scopus 로고
    • Extracellular neurotransmitter changes in cerebral ischaemia
    • 121. Obrenovitch TP, Richards DA. Extracellular neurotransmitter changes in cerebral ischaemia. Cerebrovasc Brain Metab Rev 1995; 7: 1-54
    • (1995) Cerebrovasc Brain Metab Rev , vol.7 , pp. 1-54
    • Obrenovitch, T.P.1    Richards, D.A.2
  • 122
    • 0031817860 scopus 로고    scopus 로고
    • Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice
    • 122. Rupalla K, Allegrini PR, Sauer D, et al. Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice. Acta Neuropathol 1998; 96: 172-8
    • (1998) Acta Neuropathol , vol.96 , pp. 172-178
    • Rupalla, K.1    Allegrini, P.R.2    Sauer, D.3
  • 123
    • 0027386940 scopus 로고
    • Characterization of microglial reaction after middle cerebral artery occlusion in rat brain
    • 123. Morioka T, Kalehua AN, Streit WJ. Characterization of microglial reaction after middle cerebral artery occlusion in rat brain. J Comp Neurol 1993; 327: 123-32
    • (1993) J Comp Neurol , vol.327 , pp. 123-132
    • Morioka, T.1    Kalehua, A.N.2    Streit, W.J.3
  • 124
    • 0029847804 scopus 로고    scopus 로고
    • Molecular mechanisms of microglial activation. A. Implications for regeneration and neurodegenerative diseases
    • 124. Gebicke-Haerter PJ, Van Calker D, Norenberg W, et al. Molecular mechanisms of microglial activation. A. Implications for regeneration and neurodegenerative diseases. Neurochem Int 1996; 29: 1-12
    • (1996) Neurochem Int , vol.29 , pp. 1-12
    • Gebicke-Haerter, P.J.1    Van Calker, D.2    Norenberg, W.3
  • 125
    • 0027463358 scopus 로고
    • Brain glia release factors with opposing actions upon neuronal survival
    • 125. Giulian D, Vaca K, Corpuz M. Brain glia release factors with opposing actions upon neuronal survival. J Neurosci 1993; 13: 29-37
    • (1993) J Neurosci , vol.13 , pp. 29-37
    • Giulian, D.1    Vaca, K.2    Corpuz, M.3
  • 126
    • 0031835483 scopus 로고    scopus 로고
    • Ischemic neuronal injury is ameliorated by astrocyte activation
    • 126. Louw DF, Masada T, Sutherland GR. Ischemic neuronal injury is ameliorated by astrocyte activation. Can J Neurol Sci 1998; 25: S102-7
    • (1998) Can J Neurol Sci , vol.25
    • Louw, D.F.1    Masada, T.2    Sutherland, G.R.3
  • 127
    • 0031897688 scopus 로고    scopus 로고
    • Neuronal death: Is there a role for astrocytes?
    • 127. Tacconi MT. Neuronal death: is there a role for astrocytes? Neurochem Res 1998; 23: 759-65
    • (1998) Neurochem Res , vol.23 , pp. 759-765
    • Tacconi, M.T.1
  • 128
    • 0031891307 scopus 로고    scopus 로고
    • 2+ antiporter to ischemia and glial/neuronal death
    • 2+ antiporter to ischemia and glial/neuronal death. Folia Pharmacol Jap 1998; 111 (1): 13-9
    • (1998) Folia Pharmacol Jap , vol.111 , Issue.1 , pp. 13-19
    • Matsuda, T.1    Baba, A.2
  • 129
    • 0031807664 scopus 로고    scopus 로고
    • Tacrolimus (FK506) attenuates leukocyte accumulation after transient retinal ischemia
    • 129. Tsujikawa A, Ogura Y, Hiroshiba N, et al. Tacrolimus (FK506) attenuates leukocyte accumulation after transient retinal ischemia. Stroke 1998; 29: 1431-8
    • (1998) Stroke , vol.29 , pp. 1431-1438
    • Tsujikawa, A.1    Ogura, Y.2    Hiroshiba, N.3
  • 131
    • 0343052748 scopus 로고    scopus 로고
    • FK506 suppresses the mitogen-induced increase in lymphocyte adhesiveness to endothelial cells, but does not affect endothelial cell activation in response to inflammatory stimuli
    • 131. Karlsson H, Nassberger L. FK506 suppresses the mitogen-induced increase in lymphocyte adhesiveness to endothelial cells, but does not affect endothelial cell activation in response to inflammatory stimuli. Transplantation 1997; 64: 1217-20
    • (1997) Transplantation , vol.64 , pp. 1217-1220
    • Karlsson, H.1    Nassberger, L.2
  • 132
    • 0029097801 scopus 로고
    • Asymmetric retraction of growth cone filopodia following focal inactivation of calcincurin
    • 132. Chang HY, Takei K, Sydor AM, et al. Asymmetric retraction of growth cone filopodia following focal inactivation of calcincurin. Nature 1995; 376 (6542): 686-90
    • (1995) Nature , vol.376 , Issue.6542 , pp. 686-690
    • Chang, H.Y.1    Takei, K.2    Sydor, A.M.3
  • 133
    • 0028213268 scopus 로고
    • Effects of the inhibitor for calcium/calmodulin-dependent protein phosphatase, calcincurin, on induction of long-term potentiation in rat visual cortex
    • 133. Funauchi M, Haruta H, Tsumoto T. Effects of the inhibitor for calcium/calmodulin-dependent protein phosphatase, calcincurin, on induction of long-term potentiation in rat visual cortex. Neurosci Res 1994; 19 (3): 269-78
    • (1994) Neurosci Res , vol.19 , Issue.3 , pp. 269-278
    • Funauchi, M.1    Haruta, H.2    Tsumoto, T.3
  • 134
    • 0028202076 scopus 로고
    • Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia
    • 134. Lyons WE, George EB, Dawson TM, et al. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc Natl Acad Sci U S A 1994; 91 (8): 3191-5
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.8 , pp. 3191-3195
    • Lyons, W.E.1    George, E.B.2    Dawson, T.M.3
  • 135
    • 0028200736 scopus 로고
    • Immunosuppressant and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit eleptogenesis in amygdaloid kindled rat
    • 135. Moia LJMP, Matsui H, de Barros GAM, et al. Immunosuppressant and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit eleptogenesis in amygdaloid kindled rat. Brain Res 1994; 648 (2): 337-41
    • (1994) Brain Res , vol.648 , Issue.2 , pp. 337-341
    • Moia, L.J.M.P.1    Matsui, H.2    De Barros, G.A.M.3
  • 136
    • 0008883548 scopus 로고
    • An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex
    • 136. Torii N, Kamishita T, Otsu Y, et al. An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. Science 1994; 265: 674-6
    • (1994) Science , vol.265 , pp. 674-676
    • Torii, N.1    Kamishita, T.2    Otsu, Y.3
  • 137
    • 0027453536 scopus 로고
    • Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
    • 137. Dawson T, Steiner JP, Dawson VL, et al. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci U S A 1993; 90 (21): 9808-12
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.21 , pp. 9808-9812
    • Dawson, T.1    Steiner, J.P.2    Dawson, V.L.3
  • 138
    • 0028236667 scopus 로고
    • 2+ -dependent phosphatase
    • 2+ -dependent phosphatase. Nature 1994; 369 (6477): 235-9
    • (1994) Nature , vol.369 , Issue.6477 , pp. 235-239
    • Lieberman DN Mody, I.1
  • 140
    • 0024503519 scopus 로고
    • 2+-activated phosphatase in the mammalian brain
    • 2+-activated phosphatase in the mammalian brain. Trends Neurosci 1989; 12 (3): 117-22
    • (1989) Trends Neurosci , vol.12 , Issue.3 , pp. 117-122
    • Armstrong, D.A.1
  • 141
    • 0028358901 scopus 로고
    • Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
    • 141. Brillantes AB, Ondrias K, Scott A, et al. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 1994; 77 (4): 513-23
    • (1994) Cell , vol.77 , Issue.4 , pp. 513-523
    • Brillantes, A.B.1    Ondrias, K.2    Scott, A.3
  • 142
    • 0028918776 scopus 로고
    • Immunophilin FK506 binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium influx
    • 142. Cameron AM, Steiner JP, Sabalini DM, et al. Immunophilin FK506 binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium influx. Proc Natl Acad Sci U S A 1995; 92 (5): 1784-8
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.5 , pp. 1784-1788
    • Cameron, A.M.1    Steiner, J.P.2    Sabalini, D.M.3
  • 143
    • 0030025286 scopus 로고    scopus 로고
    • Calcineurin regulates M-channel modal gating in sympathetic neurons
    • 143. Marriott J. Calcineurin regulates M-channel modal gating in sympathetic neurons. Neuron 1996; 16: 163-73
    • (1996) Neuron , vol.16 , pp. 163-173
    • Marriott, J.1
  • 144
    • 0027500789 scopus 로고
    • The calcium release channel of the sarcoplasmic reticulum is modulated by FK506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum
    • 144. Timerman AP, Ogunbumni E, Freund E, et al. The calcium release channel of the sarcoplasmic reticulum is modulated by FK506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. J Biol Chem 1993; 268 (31): 22992-9
    • (1993) J Biol Chem , vol.268 , Issue.31 , pp. 22992-22999
    • Timerman, A.P.1    Ogunbumni, E.2    Freund, E.3
  • 145
    • 0027490697 scopus 로고
    • Nitric oxide: Foe or friend to the injured brain?
    • 145. Choi DW. Nitric oxide: foe or friend to the injured brain? Proc Natl Acad Sci U S A 1993; 90 (21): 9741-3
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.21 , pp. 9741-9743
    • Choi, D.W.1
  • 146
    • 0028674890 scopus 로고
    • Nitric oxide and focal cerebral ischaemia: Multiplicity of actions: Multiplicity of actions and diverse outcome
    • 146. Dawson DA. Nitric oxide and focal cerebral ischaemia: multiplicity of actions: multiplicity of actions and diverse outcome. Cerebrovasc Brain Metab Rev 1994; 6: 299-324
    • (1994) Cerebrovasc Brain Metab Rev , vol.6 , pp. 299-324
    • Dawson, D.A.1
  • 147
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • 147. Lipton SA, Choi YB, Pan ZH, et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993; 364 (6438): 626-31
    • (1993) Nature , vol.364 , Issue.6438 , pp. 626-631
    • Lipton, S.A.1    Choi, Y.B.2    Pan, Z.H.3
  • 148
    • 0029814793 scopus 로고    scopus 로고
    • Immunophilin regulation of neurotransmitter release
    • 148. Steiner JP, Dawson TM, Fotuhi M, et al. Immunophilin regulation of neurotransmitter release. Mol Med 1996; 2: 325-33
    • (1996) Mol Med , vol.2 , pp. 325-333
    • Steiner, J.P.1    Dawson, T.M.2    Fotuhi, M.3
  • 149
    • 0028793257 scopus 로고
    • Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
    • 149. Ankarcrona M, Dypbukt JM, Bonfoco E, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995; 15 (4): 961-73
    • (1995) Neuron , vol.15 , Issue.4 , pp. 961-973
    • Ankarcrona, M.1    Dypbukt, J.M.2    Bonfoco, E.3
  • 150
    • 0028877170 scopus 로고
    • Potential role of cyclosporin A-sensitive mitochondrial channels in ischemia-reperfusion injury
    • 150. Nicolli A, Costantini P, Basso E, et al. Potential role of cyclosporin A-sensitive mitochondrial channels in ischemia-reperfusion injury. Transplant Proc 1995; 27: 2825-6
    • (1995) Transplant Proc , vol.27 , pp. 2825-2826
    • Nicolli, A.1    Costantini, P.2    Basso, E.3
  • 151
    • 0030298459 scopus 로고    scopus 로고
    • Cyclosporin a delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: Evidence of the mitochondrial permeability transition
    • 151. Nieminen AL, Petrie TG, Lemasters JJ, et al. Cyclosporin a delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition. Neurosci 1996; 75: 993-7
    • (1996) Neurosci , vol.75 , pp. 993-997
    • Nieminen, A.L.1    Petrie, T.G.2    Lemasters, J.J.3
  • 152
    • 0029810095 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
    • 152. Schinder AF, Olson EC, Spitzer NC, et al. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 1996; 16: 6125-33
    • (1996) J Neurosci , vol.16 , pp. 6125-6133
    • Schinder, A.F.1    Olson, E.C.2    Spitzer, N.C.3
  • 153
    • 0029788243 scopus 로고    scopus 로고
    • Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxic exposure
    • 153. White RJ, Reynolds IJ. Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxic exposure. J Neurosci 1996; 16 (18): 568-97
    • (1996) J Neurosci , vol.16 , Issue.18 , pp. 568-597
    • White, R.J.1    Reynolds, I.J.2
  • 154
    • 0027381281 scopus 로고
    • On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury
    • 154. Duchen MR, McGuinness O, Brown LA, et al. On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc Res 1993; 27: 1790-4
    • (1993) Cardiovasc Res , vol.27 , pp. 1790-1794
    • Duchen, M.R.1    McGuinness, O.2    Brown, L.A.3
  • 155
    • 0030725897 scopus 로고    scopus 로고
    • The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat
    • 155. Nakai A, Kuroda S, Kristian T, et al. The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat. Neurobiol Dis 1997; 4: 288-300
    • (1997) Neurobiol Dis , vol.4 , pp. 288-300
    • Nakai, A.1    Kuroda, S.2    Kristian, T.3
  • 156
    • 0026132165 scopus 로고
    • Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase
    • 156. Griffiths EJ, Halestrap AP. Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Biochem J 1991; 274: 611-4
    • (1991) Biochem J , vol.274 , pp. 611-614
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 157
    • 0030051609 scopus 로고    scopus 로고
    • Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin-A-sensitive channel
    • 157. Nicolli A, Basso E, Petronilli V, et al. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin-A-sensitive channel. J Biol Chem 1996; 271: 2185-92
    • (1996) J Biol Chem , vol.271 , pp. 2185-2192
    • Nicolli, A.1    Basso, E.2    Petronilli, V.3
  • 158
    • 0033386202 scopus 로고    scopus 로고
    • Mitochondria in neurodegeneration: Bioenergetic function in cell life and death
    • 158. Murphy AN, Fiskum G, Beal MF. Mitochondria in neurodegeneration: bioenergetic function in cell life and death. J Cereb Blood Flow Metab 1999; 19 (3): 231-45
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.3 , pp. 231-245
    • Murphy, A.N.1    Fiskum, G.2    Beal, M.F.3
  • 159
    • 0032559799 scopus 로고    scopus 로고
    • The caspase-3 precursor has a cystolic and mitochondrial distribution: Implications for apoptotic signalling
    • 159. Mancini M, Nicholson DW, Roy S, et al. The caspase-3 precursor has a cystolic and mitochondrial distribution: implications for apoptotic signalling. J Cell Biol 1998; 140: 1485-95
    • (1998) J Cell Biol , vol.140 , pp. 1485-1495
    • Mancini, M.1    Nicholson, D.W.2    Roy, S.3
  • 160
    • 0033579810 scopus 로고    scopus 로고
    • Mitochondrial release of caspase-2 and -9 during the apoptotic process
    • 160. Susin SA, Lorenzo HK, Zamzami N, et al. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med 1999; 2: 381-94
    • (1999) J Exp Med , vol.2 , pp. 381-394
    • Susin, S.A.1    Lorenzo, H.K.2    Zamzami, N.3
  • 161
    • 0031788661 scopus 로고    scopus 로고
    • Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition
    • 161. Andreyev AY, Fahy B, Fiskum G. Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition. FEBS Lett 1998; 20: 373-6
    • (1998) FEBS Lett , vol.20 , pp. 373-376
    • Andreyev, A.Y.1    Fahy, B.2    Fiskum, G.3
  • 163
    • 0032472329 scopus 로고    scopus 로고
    • Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
    • 163. Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 1998; 17: 37-49
    • (1998) EMBO J , vol.17 , pp. 37-49
    • Bossy-Wetzel, E.1    Newmeyer, D.D.2    Green, D.R.3
  • 164
    • 0033607865 scopus 로고    scopus 로고
    • 2+-sensitive cyclical mitochondrial depolarizations in cell culture
    • 2+-sensitive cyclical mitochondrial depolarizations in cell culture. Biochem Biophys Acta 1999; 1410: 77-84
    • (1999) Biochem Biophys Acta , vol.1410 , pp. 77-84
    • Fall, C.P.1    Bennett J.P., Jr.2
  • 165
    • 0033021780 scopus 로고    scopus 로고
    • Transient and long lasting-openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence
    • 165. Petronlilli V, Miotto G, Brini M, et al. Transient and long lasting-openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 1999; 76: 725-34
    • (1999) Biophys J , vol.76 , pp. 725-734
    • Petronlilli, V.1    Miotto, G.2    Brini, M.3
  • 166
    • 0008892042 scopus 로고    scopus 로고
    • Differing effects of the neuroprotective immunosuppressants FK506 and cyclosporin-A on local cerebral glucose utilisation in the rat
    • 166. Jones PA, Henshall DC, Pollock JM, et al. Differing effects of the neuroprotective immunosuppressants FK506 and cyclosporin-A on local cerebral glucose utilisation in the rat [abstract]. Br Neurosci Assoc Abstr 1999; 15: 120
    • (1999) Br Neurosci Assoc Abstr , vol.15 , pp. 120
    • Jones, P.A.1    Henshall, D.C.2    Pollock, J.M.3
  • 167
    • 0032102414 scopus 로고    scopus 로고
    • Tacrolimus decreases in vitro oxidative phosphorylation of mitochondria from rat forebrain
    • 167. Zini R, Simon N, Morin C, et al. Tacrolimus decreases in vitro oxidative phosphorylation of mitochondria from rat forebrain. Life Sci 1998; 63: 357-68
    • (1998) Life Sci , vol.63 , pp. 357-368
    • Zini, R.1    Simon, N.2    Morin, C.3
  • 168
    • 0029051550 scopus 로고
    • FK506 increases permeability in rat intestine by inhibiting mitochondrial function
    • 168. Madsen KL, Yanchar NL, Sigalet DL, et al. FK506 increases permeability in rat intestine by inhibiting mitochondrial function. Gastroenterology 1995; 109: 107-14
    • (1995) Gastroenterology , vol.109 , pp. 107-114
    • Madsen, K.L.1    Yanchar, N.L.2    Sigalet, D.L.3
  • 169
    • 0029970017 scopus 로고    scopus 로고
    • 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression
    • 169. Nishino H, Fujimoto I, Shimano Y, et al. 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression. J Chem Neuroanal 1996; 10: 209-12
    • (1996) J Chem Neuroanal , vol.10 , pp. 209-212
    • Nishino, H.1    Fujimoto, I.2    Shimano, Y.3
  • 170
    • 0028262480 scopus 로고
    • Suppressive effect of FK506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice
    • 170. Kitamura Y, Itano Y, Kubo T, et al. Suppressive effect of FK506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. J Neuroimmunol 1994; 50: 221-4
    • (1994) J Neuroimmunol , vol.50 , pp. 221-224
    • Kitamura, Y.1    Itano, Y.2    Kubo, T.3
  • 171
    • 0032569676 scopus 로고    scopus 로고
    • Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins
    • 171. Seaton TA, Cooper JM, Schapira AH. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Brain Res 1998; 809: 12-7
    • (1998) Brain Res , vol.809 , pp. 12-17
    • Seaton, T.A.1    Cooper, J.M.2    Schapira, A.H.3
  • 173
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide ranging implications
    • 173. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications. Br J Cancer 1972; 26 (4): 239-57
    • (1972) Br J Cancer , vol.26 , Issue.4 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 174
    • 0029153913 scopus 로고
    • Apoptosis and necrosis; two distinct events induced, respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • 174. Bonfoco E, Kraine D, Ankarcrona M, et al. Apoptosis and necrosis; two distinct events induced, respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A 1995; 92 (16): 7162-6
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.16 , pp. 7162-7166
    • Bonfoco, E.1    Kraine, D.2    Ankarcrona, M.3
  • 175
    • 0029050456 scopus 로고
    • Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo
    • 175. Columhano A. Cell death: current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J Cell Biochem 1995; 58 (2): 181-90
    • (1995) J Cell Biochem , vol.58 , Issue.2 , pp. 181-190
    • Columhano, A.1
  • 176
    • 0028361211 scopus 로고
    • Inhibition of apoptosis as a mechanism of tumour promotion
    • 176. Wright SC, Zhong J, Larrick JW. Inhibition of apoptosis as a mechanism of tumour promotion. FASEB J 1994; 8 (9): 654-60
    • (1994) FASEB J , vol.8 , Issue.9 , pp. 654-660
    • Wright, S.C.1    Zhong, J.2    Larrick, J.W.3
  • 177
    • 0027369909 scopus 로고
    • Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain
    • 177. Heron A, Pollard H, Dessi F, et al. Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain. J Neurochem 1993; 61 (5): 1973-6
    • (1993) J Neurochem , vol.61 , Issue.5 , pp. 1973-1976
    • Heron, A.1    Pollard, H.2    Dessi, F.3
  • 178
    • 0028873415 scopus 로고
    • Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia
    • 178. Iwai T, Hara A, Niwa M, et al. Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia. Brain Res 1995; 671 (2): 305-8
    • (1995) Brain Res , vol.671 , Issue.2 , pp. 305-308
    • Iwai, T.1    Hara, A.2    Niwa, M.3
  • 179
    • 0028905230 scopus 로고
    • Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat
    • 179. Li Y, Chopp M, Jiang N, et al. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1995; 15 (3): 389-97
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.3 , pp. 389-397
    • Li, Y.1    Chopp, M.2    Jiang, N.3
  • 180
    • 0029001888 scopus 로고
    • Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats
    • 180. Li Y, Chopp M, Jiang N, et al. Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats. Stroke 1995; 26 (7): 1252-8
    • (1995) Stroke , vol.26 , Issue.7 , pp. 1252-1258
    • Li, Y.1    Chopp, M.2    Jiang, N.3
  • 181
    • 0029038416 scopus 로고
    • Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat
    • 181. Li Y, Sharov VG, Jiang N, et al. Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat. Am J Pathol 1995; 146: 1045-51
    • (1995) Am J Pathol , vol.146 , pp. 1045-1051
    • Li, Y.1    Sharov, V.G.2    Jiang, N.3
  • 182
    • 0027501851 scopus 로고
    • Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
    • discussion 2008-9
    • 182. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993; 24 (12): 2002-8; discussion 2008-9
    • (1993) Stroke , vol.24 , Issue.12 , pp. 2002-2008
    • Linnik, M.D.1    Zobrist, R.H.2    Hatfield, M.D.3
  • 183
    • 0027371673 scopus 로고
    • Internucleosomal DNA cleavage involved in ischemia-induced neuronal death
    • 183. Okamoto M, Matsumoto M, Ohtsuki T, et al. Internucleosomal DNA cleavage involved in ischemia-induced neuronal death. Biochem Biophys Res Comm 1993; 196: 1356-62
    • (1993) Biochem Biophys Res Comm , vol.196 , pp. 1356-1362
    • Okamoto, M.1    Matsumoto, M.2    Ohtsuki, T.3
  • 184
    • 0008938188 scopus 로고
    • Endonuclease activation following focal ischemic injury in the rat brain
    • 184. Tominaga T, Kure S, Narisawa K, et al. Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 1993; 60 (1): 821-6
    • (1993) Brain Res , vol.60 , Issue.1 , pp. 821-826
    • Tominaga, T.1    Kure, S.2    Narisawa, K.3
  • 185
    • 0028894725 scopus 로고
    • In situ detection of DNA fragmentation after focal cerebral ischemia in mice
    • 185. Li Y, Chopp M, Jiang N, et al. In situ detection of DNA fragmentation after focal cerebral ischemia in mice. Mol Brain Res 1995; 28 (1): 164-8
    • (1995) Mol Brain Res , vol.28 , Issue.1 , pp. 164-168
    • Li, Y.1    Chopp, M.2    Jiang, N.3
  • 186
    • 0029079440 scopus 로고
    • Apoptotic fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion
    • 186. Linnik MD, Miller JA, Sprinle-Cavallo J, et al. Apoptotic fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion. Mol Brain Res 1995; 32 (1): 116-24
    • (1995) Mol Brain Res , vol.32 , Issue.1 , pp. 116-124
    • Linnik, M.D.1    Miller, J.A.2    Sprinle-Cavallo, J.3
  • 187
    • 0007309605 scopus 로고    scopus 로고
    • Inflammatory responses to cerebral ischemia
    • Ter Horst GJ, Korf J, editors. Totowa (NJ): Humana Press, Inc.
    • 187. Sharkey J, Kelly JS, Butcher SP. Inflammatory responses to cerebral ischemia. In: Ter Horst GJ, Korf J, editors. Clinical pharmacology of cerebral ischaemia. Totowa (NJ): Humana Press, Inc., 1997: 235-63
    • (1997) Clinical Pharmacology of Cerebral Ischaemia , pp. 235-263
    • Sharkey, J.1    Kelly, J.S.2    Butcher, S.P.3
  • 188
    • 0030813422 scopus 로고    scopus 로고
    • Gene expression induced by cerebral ischemia: An apoptotic perspective
    • 188. MacManus JP, Linnik MD. Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 1997; 17: 815-32
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 815-832
    • MacManus, J.P.1    Linnik, M.D.2
  • 189
    • 0031929439 scopus 로고    scopus 로고
    • Alterations of Bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centres following focal cerebral ischemia in mice
    • 189. Matsushita K, Matsuyama T, Kitagawa K, et al. Alterations of Bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centres following focal cerebral ischemia in mice. Neuroscience 1998; 83 (2): 439-48
    • (1998) Neuroscience , vol.83 , Issue.2 , pp. 439-448
    • Matsushita, K.1    Matsuyama, T.2    Kitagawa, K.3
  • 190
    • 0030901628 scopus 로고    scopus 로고
    • Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2
    • 190. Shibasaki F, Kondo E, Akagi T, et al. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature 1997; 386: 728-31
    • (1997) Nature , vol.386 , pp. 728-731
    • Shibasaki, F.1    Kondo, E.2    Akagi, T.3
  • 191
    • 0032528118 scopus 로고    scopus 로고
    • Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
    • 191. Gross A, Jockel J, Wei MC, et al. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J 1998; 17: 3878-85
    • (1998) EMBO J , vol.17 , pp. 3878-3885
    • Gross, A.1    Jockel, J.2    Wei, M.C.3
  • 192
    • 0033537768 scopus 로고    scopus 로고
    • 2+-induced apoptosis through calcineurin dephosphorylation of BAD
    • 2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999; 284: 339-43
    • (1999) Science , vol.284 , pp. 339-343
    • Wang, H.-G.1    Pathan, N.2    Ethell, I.M.3
  • 193
    • 0033135379 scopus 로고    scopus 로고
    • FK506 prevents stroke-induced generation of ceramide and apoptosis signalling
    • 193. Herr I, Martin-Villalba A, Kurz E, et al FK506 prevents stroke-induced generation of ceramide and apoptosis signalling. Brain Res 1999; 826: 210-9
    • (1999) Brain Res , vol.826 , pp. 210-219
    • Herr, I.1    Martin-Villalba, A.2    Kurz, E.3
  • 194
    • 0032557888 scopus 로고    scopus 로고
    • FK506 antagonises apoptosis and C-jun protein expression in neuronal cultures
    • 194. Yardin C, Terro F, Lesort M, et al. FK506 antagonises apoptosis and C-jun protein expression in neuronal cultures. Neuro-report 1998; 22: 2077-80
    • (1998) Neuro-report , vol.22 , pp. 2077-2080
    • Yardin, C.1    Terro, F.2    Lesort, M.3
  • 195
    • 0030972976 scopus 로고    scopus 로고
    • Native recombinant cyclophilins A, B and C degrade DNA independently of polypeptide cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis
    • 195. Montague JW, Hughes Jr FM, Cidlowski JA. Native recombinant cyclophilins A, B and C degrade DNA independently of polypeptide cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis. J Biol Chem 1997; 272: 6677-84
    • (1997) J Biol Chem , vol.272 , pp. 6677-6684
    • Montague, J.W.1    Hughes F.M., Jr.2    Cidlowski, J.A.3
  • 196
    • 0027382025 scopus 로고
    • Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model
    • 196. Nagata K, Sasaki T, Iwama J, et al. Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. J Neurosurg 1993; 79: 710-5
    • (1993) J Neurosurg , vol.79 , pp. 710-715
    • Nagata, K.1    Sasaki, T.2    Iwama, J.3
  • 197
    • 0027173088 scopus 로고
    • Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage
    • 197. Nishizawa S, Peterson JW, Shimoyama I, et al. Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage. Neurosurg 1993; 32: 986-92
    • (1993) Neurosurg , vol.32 , pp. 986-992
    • Nishizawa, S.1    Peterson, J.W.2    Shimoyama, I.3
  • 198
    • 0025191287 scopus 로고
    • Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs
    • 198. Peterson JW, Nishizawa S, Hackett JD, et al. Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs. Stroke 1990; 21: 133-7
    • (1990) Stroke , vol.21 , pp. 133-137
    • Peterson, J.W.1    Nishizawa, S.2    Hackett, J.D.3
  • 199
    • 0026069209 scopus 로고
    • Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits
    • 199. Ryba M, Iwanska K, Walski M, et al. Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits. Acta Neurochir 1991; 108: 81-4
    • (1991) Acta Neurochir , vol.108 , pp. 81-84
    • Ryba, M.1    Iwanska, K.2    Walski, M.3
  • 200
    • 0025982079 scopus 로고
    • Effect of cyclosporine on the development of cerebral vasospasm in a primate model
    • 200. Handa Y, Hayashi M, Takeuchi H, et al. Effect of cyclosporine on the development of cerebral vasospasm in a primate model. Neurosurg 1991; 28: 380-6
    • (1991) Neurosurg , vol.28 , pp. 380-386
    • Handa, Y.1    Hayashi, M.2    Takeuchi, H.3
  • 201
    • 0027960451 scopus 로고
    • Effects of protease inhibitor and immunosuppressant on cerebral vasospasm after subarachnoid hemorrhage in rabbits
    • 201. Yanamoto H, Kikuchi H, Okamoto S. Effects of protease inhibitor and immunosuppressant on cerebral vasospasm after subarachnoid hemorrhage in rabbits. Surg Neurol 1994; 42: 382-7
    • (1994) Surg Neurol , vol.42 , pp. 382-387
    • Yanamoto, H.1    Kikuchi, H.2    Okamoto, S.3
  • 202
    • 0031021737 scopus 로고    scopus 로고
    • The safety and efficacy of cyclosporine A in the prevention of vasospasm in patients with Fisher Grade 3 subarachnoid hemorrhages: A pilot study
    • 202. Manno EM, Gress DR, Ogilvy CS, et al. The safety and efficacy of cyclosporine A in the prevention of vasospasm in patients with Fisher Grade 3 subarachnoid hemorrhages: a pilot study. Neurosurg 1997; 40: 289-93
    • (1997) Neurosurg , vol.40 , pp. 289-293
    • Manno, E.M.1    Gress, D.R.2    Ogilvy, C.S.3
  • 203
    • 0027172052 scopus 로고
    • A strategy for analyzing multiple parameters with application to aneurysmal SAH patients all of them clipped but treated with and without cyclosporine
    • 203. Ryba M, Pastuszko M, Dziewiecki C, et al. A strategy for analyzing multiple parameters with application to aneurysmal SAH patients all of them clipped but treated with and without cyclosporine. Acta Neurochir 1993; 122: 194-9
    • (1993) Acta Neurochir , vol.122 , pp. 194-199
    • Ryba, M.1    Pastuszko, M.2    Dziewiecki, C.3
  • 204
    • 0027477946 scopus 로고
    • Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
    • 204. Beal MF, Hyman BT, Koroshetz WJ. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 1993; 16 (4): 125-31
    • (1993) Trends Neurosci , vol.16 , Issue.4 , pp. 125-131
    • Beal, M.F.1    Hyman, B.T.2    Koroshetz, W.J.3
  • 205
    • 0029902166 scopus 로고    scopus 로고
    • Evidence fov neuronal oxidative damage in Alzheimer's disease
    • 205. Good PF, Werner P, Hsu A, et al. Evidence fov neuronal oxidative damage in Alzheimer's disease. Am J Pathol 1996; 149: 21-8
    • (1996) Am J Pathol , vol.149 , pp. 21-28
    • Good, P.F.1    Werner, P.2    Hsu, A.3
  • 206
    • 0027496238 scopus 로고
    • A radical hypothesis for neurodegeneration
    • 206. Olanow CW. A radical hypothesis for neurodegeneration. Trends Neurosci 1993; 16: 439-44
    • (1993) Trends Neurosci , vol.16 , pp. 439-444
    • Olanow, C.W.1
  • 207
    • 0029866972 scopus 로고    scopus 로고
    • Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging
    • 207. Jenkins BG, Brouillet E, Chen YCI, et al. Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. J Cereb Blood Flow Metab 1996; 16: 450-61
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 450-461
    • Jenkins, B.G.1    Brouillet, E.2    Chen, Y.C.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.