The safety and efficacy of cyclosporine A in the prevention of vasospasm in patients with Fisher Grade 3 subarachnoid hemorrhages: A pilot study

Neurosurgery

Volumn 40, Issue 2, 1997, Pages 289-293

  Manno, Edward M ^a   Gress, Daryl R ^a   Ogilvy, Christopher S ^a   Stone, Christine M ^a   Zervas, Nicholas T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cyclosporine A; Intracranial aneurysm; Subarachnoid hemorrhage; Vasospasm

Indexed keywords

CIMETIDINE; CYCLOSPORIN A; DEXAMETHASONE; NIMODIPINE; PAPAVERINE; PHENYTOIN;

ADULT; AGED; ANGIOGRAPHY; ARTICLE; BRAIN ISCHEMIA; CLINICAL ARTICLE; COLOR ULTRASOUND FLOWMETRY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEMODILUTION; HUMAN; HYPERTENSION; HYPERVOLEMIA; INTRACRANIAL ANEURYSM; MALE; MIDDLE CEREBRAL ARTERY; PRIORITY JOURNAL; SUBARACHNOID HEMORRHAGE; VASOSPASM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEURYSM, RUPTURED; BLOOD FLOW VELOCITY; CRITICAL CARE; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACRANIAL ANEURYSM; ISCHEMIC ATTACK, TRANSIENT; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; PILOT PROJECTS; SUBARACHNOID HEMORRHAGE; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 0031021737     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199702000-00010     Document Type: Article

References (28)

1. Aaslid R, Huber P, Nornes H: Evaluation of cerebrovascular spasm with transcranial doppler ultrasound. J Neurosurg 60:37-41, 1984.
2. Abbott package insertion, Abbott Laboratories, Abbott Park, IL 60064.
3. Chyatte D, Fode NC, Nichols DA, Sundt TM Jr: Preliminary report: Effects of high dose methylprednisolone on delayed cerebral ischemia in patients at high risk for vasospasm after subarachnoid hemorrhage. Neurosurgery 21:157-160, 1987.
4. Cohen DJ, Loerscher R, Rubin MF, Tilney NL, Carpenter CB, Strom TB: Cyclosporin: A new immunosuppressive agent for organ transplantation. Ann Intern Med 101:667-682, 1984.
5. Conway LW, McDonald LW: Structural changes of the intradural arteries following subarachnoid hemorrhage. J Neurosurg 37: 715-723, 1972.
6. Douville CM, Newell DW, Trimble BA, Winn HR: Detection of vasospasm following subarachnoid hemorrhage using transcranial doppler. J Vasc Technol 14:111-115, 1990.
7. Drake CG: Report of the World Federation of Neurological Surgeons committee on a universal subarachnoid hemorrhage grading scale. J Neurosurg 68:985-986, 1988.
8. Fisher CM, Kistler JP, Davis JM: Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 6:1-9, 1980.
9. Handa Y, Hayashi M, Takeuchi H, Kobayashi H, Kawano H, Kabuto M: Effect of cyclosporin on the development of cerebral vasospasm in a primate model. Neurosurgery 28:380-386, 1991.
10. Hongo K, Kobayashi S: Calcium antagonists for the treatment of vasospasm following subarachnoid hemorrhage. Neurol Res 15: 218-224, 1993.
11. Hoshi T, Shimizu T, Kito K, Yamasaki N, Takahoshi K, Takahoshi M, Okada T, Kasuya H, Kitamura K: Immunological study of late cerebral vasospasm in subarachnoid hemorrhage: Detection of immunoglobulins, C3, and fibrinogen in cerebral arterial walls by immunofluorescence method [in Japanese, English abstract]. Neurol Med Chir (Tokyo) 24:647-654, 1984.
12. Hunt WE, Hess RM: Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 28:14-20, 1968.
13. Jennett B, Bond M: Assessment of outcome after severe brain damage: A practical scale. Lancet 1:480-484, 1975.
14. Kahan BD: Individualization of cyclosporin therapy using pharmacokinetic and pharmacodynamic parameters. Transplantation 40:457-476, 1985.
15. Kassell NF, Helm G, Simmons N, Phillips CD, Cail WS: Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg 77:848-852, 1992.
16. Kassell NF, Sasaki T, Colohan AR, Nazar G: Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16:562-572, 1982.
17. Nagata K, Sasaki T, Iwama J, Mori T, Iwamoto S, Nirei H, Hamada K, Kirino T: Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. J Neurosurg 79:710-715, 1993.
18. Nishizawa S, Peterson JW, Shimoyama I, Iwasaki K, Yokoyama T, Ryo H, Vemura K: Immunosuppressants and vasospasm - Therapeutic effect of FK-506, in Findley JM (ed): Cerebral Vasospasm. New York, Elsevier Science Publishers BV, 1993, pp 435-438.
19. Ostergaard JR, Kristensen BO, Svehag S-E, Teisner B, Miletic T: Immune complexes and complement activation following rupture of intracranial saccular aneurysms. J Neurosurg 66:891-897, 1987.
20. Pellettieri L, Carlsson C-A, Lindhom L: Is the vasospasm following subarachnoidal hemorrhage an immunoreactive disease? Experientia 37:1170-1171, 1981.
21. Pellettieri L, Nilsson B, Carlsson C-A: Serum immunocomplexes in patients with subarachnoid hemorrhage. Neurosurgery 19: 767-771, 1986.
22. Peterson JW, Kwun B-D, Hackett BS, Zervas NT: The role of inflammation in experimental cerebral vasospasm. J Neurosurg 72:767-774, 1990.
23. Peterson JW, Nishizawa S, Hackett JD, Bun T, Teramura A, Zervas NT: Cyclosporin A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs. Stroke 21:133-137, 1990.
24. Peterson JW, Roussos L, Kwun B-D, Hackett JD, Owen CJ, Zervas NT: Evidence of the role of hemolysis in experimental cerebral vasospasm. J Neurosurg 72:767-774, 1990.
25. Ryba M, Iwanska K, Walski M, Pastusko M: Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid hemorrhage. Acta Neurochir (Wien) 108:81-84, 1991.
26. Ryba M, Pastusko M, Iwanska K, Bidzinski J, Dziewiecki C: Cyclosporin A prevents neurologic deterioration of patients with SAH: A preliminary report. Acta Neurochir (Wien) 112:25-27, 1991.
27. Sloan MA, Haley EC, Kassell NF, Henry RN, Stewart SR, Beskin RR, Sevilla EA, Torner JC: Sensitivity and specificity of transcranial doppler ultrasonography in the diagnosis of vasospasm following subarachnoid hemorrhage. Neurology 39:1514-1518, 1989.
28. Yanamato H, Kikuchi H, Okamato S: Effects of protease inhibitor and immunosuppressant on cerebral vasospasm after subarachnoid hemorrhage in rabbits. Surg Neurol 142:382-387, 1994.