Beneficial effects of cyclosporine and rapamycin in small bowel ischemic injury

Journal of Surgical Research

Volumn 65, Issue 2, 1996, Pages 115-118

  Puglisi, R N ^a   Strande, L ^a   Santos, M ^a   Schulte, G ^a   Hewitt, C W ^a   Whalen, T V ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; RAPAMYCIN;

ANIMAL MODEL; ARTICLE; DRUG EFFECT; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE BLOOD FLOW; INTESTINE ISCHEMIA; MALE; NECROTIZING ENTEROCOLITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0030273698     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0352     Document Type: Article

References (20)

1. 1. Nowicki, P. Intestinal ischemia and necrotizing enterocolitis. J. Pediatr. 117: S14, 1990.
2. 2. Kurokawa, T., Kobayashi, H., and Nonami, T. The beneficial effects of cyclosporine on postischemic liver injury in rats. Transplantation 53(2): 308, 1992.
3. 3. Shiga, Y., Onodera, H., Matsuo, Y., et al. Cyclosporine A protects against ischemia-reperfusion injury in the brain. Brain. Res. 595(1): 145, 1992.
4. 4. Kucukcelebi, A., and Ozcan, M. The beneficial effect of cyclosporine A on the no-reflow phenomenon in rat island skin flaps. Br. J. Plast. Surg. 45(7): 512, 1992.
5. 5. Puglisi, R. N., Strande, L., Santos, M., Doolin, E. J., Hewitt, C. W., Whalen, T. V. The effect of cyclosporine in gut ischemic injury: A computerized morphometric and enzymatic analysis. J. Pediatr. Surg. 31(2): 319-322, 1996.
6. 6. Sandborn, W., and Tremaine, W. Cyclosporine treatment of inflammatory bowel disease. Mayo. Clin. Proc. 67: 981, 1992.
7. 7. Matsumoto, T., Mitsudo, L, Nakamura, S., et al. Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. Dig. Dis. Sci. 39(4): 787, 1994.
8. 8. Stepkowski, S. M., Chen, H. F., Wang, M. E., Daloze, P., and Kahan, B. D. Inhibition of host-versus-graft and graft-versushost responses after small bowel transplantation in rats by rapamycin. Transplantation 53(2): 258, 1992.
9. 9. Puglisi, R. N., Doolin, E. J., and Whalen, T. V. Computer analyzed histology of ischemic injury to the gut. J. Pediatr. Surg. 30(6): 1, 1995.
10. 10. Musemeche, C. A., Pizzini, R. P., and Andrassy, R. J. Intestinal ischemia in the newborn: The role of intestinal maturation. J. Surg. Res. 55: 595, 1993.
11. 11. Dahlqvist, A. Method for assay of intestinal dissaccharidases. Anal. Biochem. 7: 18, 1964.
12. 12. Granger, D. N., McCord, J. M., Parks, D. A., et al. Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat small intestine. Gastroenterology 90: 80, 1986.
13. 13. Granger, D. N., Rutili, G., and McCord, J. M. Superoxide radicals in feline intestinal ischemia. Gastroenterology 81: 22, 1981.
14. 14. Suzuki, S., Toledo-Pereyra, L. H., Rodriguez, F. J., et al. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury: Modulating effects of FK506 and cyclosporine. Transplantation 55(6): 1265, 1993.
15. 15. Remick, D. G., Kunkel, R. G., Larrick, J. W., et al. Acute in vivo effects of human recombinant tumor necrosis factor. Lab. Invest. 56: 583, 1987.
16. 16. Braun, W., Kallen, J., Mikol, V., et al. Three-dimensional structure and actions of immunosuppressants and their immunophilins. FASEB J. 9: 63, 1995.
17. 17. Schreiber, S. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251: 283, 1991.
18. 18. Abraham, R. T., Karnitz, L. M., Burns, L. A., and Brunn, G. J. Proximal signals and the control of S-phase entry in interleukin-2-stimulated T-lymphocytes. In S. Gupta et al. (Eds.), Mechanisms of Lymphocyte Activation and Immune Regulation V. New York: Plenum, 1994. Pp. 197-210.
19. 19.Siekierka, J. J. Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. Immunol. Res. 13: 110, 1994.
20. 20. Chen, H., Wu, J., Xu, D., Aboujaoude, M., Stepkowski, S., and Kahan, B. The effect of rapamycin on orthotopic small bowel transplantation in the rat. Transplant. Proc. 24(3): 1157, 1992.