Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats

Stroke

Volumn 27, Issue 12, 1996, Pages 2282-2286

  Sharkey, John ^a   Crawford, Jane H ^a   Butcher, Steven P ^a   Marston, Hugh M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

behavior, animal; cerebral ischemia, focal; middle cerebral artery occlusion; neuroprotection; rats

Indexed keywords

ENDOTHELIN 1; TACROLIMUS;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; GRAFT REJECTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

EID: 0030464736     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.27.12.2282     Document Type: Article

References (32)

1. Fung J, Abu-Elmagd K, Jain A, Tzakis A, Martin M, Selby R, Bronsther O, Doyle H, Gayowski T, Ramos H, Kishida A, Starzl T. Randomized trial of primary liver transplantation under immunosuppression with FK506 versus cyclosporin. Transplant Proc. 1991;23: 2977-2983.
2. Klintmalm GB. FK506: an update. Clin Transplant. 1994;8:207-210.
3. Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramanan R, Jain A. FK506 for human liver, kidney, and pancreas transplantation. Lancet. 1989;2:1000-1004.
4. Sharkey J, Butcher SP. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature. 1994;371: 336-339.
5. Sharkey J, Butcher SP. Calcineurin: a target for anti-ischaemic drug therapy. J Cereb Blood Flow Metab. 1995;15:S387. Abstract.
6. Snyder SH, Sabatini DM. Immunophilins and the nervous system. Nat Med. 1995;1:32-37.
7. Dawson TM, Steiner JP, Dinerman JL, Uhl GR, Snyder SH. Immunosuppressant, FK506, enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci U S A. 1993;90:9808-9812.
8. McCulloch J, Bulloch R, Teasdale GM. Excitatory amino acids antagonists: opportunities for the treatment of ischaemic brain damage in man. In: Meldrum BS, ed. Excitatory Amino Acid Antagonists. Oxford, UK: Blackwell Scientific Publications; 1992;287-326.
9. Ginsberg MD, Busto R. Rodent models of cerebral ischemia. Stroke, 1989;20:1627-1642.
10. Grabowski M, Brudin P, Johansson BB. Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats. Stroke. 1993; 24:889-895.
11. Yamamoto M, Tamura A, Kirino T, Shimizu M, Sano K. Behavioral changes after focal cerebral ischemia by left middle cerebral artery occlusion in rats. Brain Res. 1988;452:323-328.
12. Persson L, Hardemark HG, Bolander HG, Hillered L, Olsson Y. Neurological and neuropathological outcome after middle cerebral artery occlusion in rats. Stroke. 1989;20:641-645.
13. Markgraf CG, Green EJ, Hurwitz BE, Morikawa E, Deitrich D, McCabe PM, Ginsberg MD, Schneiderman N. Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res. 1992;575:238-246.
14. Markgraf CG, Green EJ, Watson B, McCabe PM, Schneiderman N, Deitrich D, Ginsberg MD. Recovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats. Stroke. 1994;25:153-159.
15. Montoya CP, Campbeli-Hope LJ, Pemberton KD, Dunnett SB. The 'staircase test': a measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods. 1991;36:219-228.
16. Marston HM, Faber ESL, Crawford JH, Butcher SP, Sharkey J. Behavioural assessment of endothelin-1 induced middle cerebral artery occlusion in the rat. Neuroreport. 1995;6:1067-1071.
17. Aggleton JP. The ability of different strains of rats to acquire a visual nonmatching-to-sample task. Psychobiol. 1996;24:44-48.
18. Sharkey J, Butcher SP, Kelly JS. Endothelin-1 induced middle cerebral artery occlusion: pathological consequences and neuroprotective effects of MK801. J Auton Trans. 1994;49:177-185.
19. Sharkey J, Ritchie IM, Kelly PAT. Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab. 1993;13:865-871.
20. Duverger D, MacKenzie ET. The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration and age. J Cereb Blood Flow Metab. 1988;8:449-461.
21. Yamori Y, Horie R, Handa H, Sato M, Fukase M. Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans. Stroke. 1976;7:46-53.
22. Scremin OU. Cerebral vascular system. In: Paxinos G, ed. The Rat Nervous System. Sydney, Australia: Academic Press; 1995.
23. Dirnagl U, Tanabe J, Pulsinelli W. Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat. Brain Res. 1990;527:62-68.
24. Newman M. The process of recovery after hemplegia. Stroke. 1972; 3:702-710.
25. Tracey DJ. Ascending and descending pathways in the spinal cord. In: Paxinos G, ed. The Rat Nervous System. Sydney, Australia: Academic Press; 1995.
26. Price AW, Fowler SC. Deficits in contralateral and ipsilateral forepaw motor control following unilateral motor cortical ablations. Brain Res. 1981;205:81-90.
27. Whishaw IQ, Castaneda E, Gorny BP. Dopamine and skilled limb use in the rat: more severe bilateral impairments following substantia nigra than sensorimotor cortex 6-hydroxydopamine injection. Behav Brain Res. 1992;47:89-92.
28. Shiga Y, Onodera H, Matsuo Y, Kogure K. Cyclosporin A protects against ischemia-reperfusion injury in the brain. Brain Res. 1992; 595:145-148.
29. Nishinaka Y, Sugiyama S, Yokota M, Saito H, Ozawa T. Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart. J Cardiovasc Pharmacol. 1993;21:448-454.
30. Dawson T, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH. Immnuosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci U S A. 1993;90:9808-9812.
31. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke. 1993;24:2002-2009.
32. Fruman DA, Mather PE, Burakoff SJ, Bierer BE. Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. Eur J Immunol. 1992;22:2513-2517.