Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins

Brain Research

Volumn 809, Issue 1, 1998, Pages 12-17

  Seaton, Tracey A ^a   Cooper, J M ^a   Schapira, A H V ^a,b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Cyclosporin A; Mitochondrial membrane permeability; Mitochondrial permeability transition; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CYCLOSPORIN; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; N METHYL 4 VALINE CYCLOSPORIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; TETRAHYDROISOQUINOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT;

EID: 0032569676     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00790-2     Document Type: Article

References (39)

1. Bossy-Wetzel E., Newmeyer D.D., Green D.R. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17:1998;37-49.
2. Cheeseman A.J., Clark J.B. Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine and its metabolite 1-methyl-4-phenylpyridine on acetylcholine synthesis in synaptosomes from rat forebrain. J. Neurochem. 48:1987;1209-1214.
3. +) cytotoxicity. Biochem. Biophys. Res. Commun. 137:1986;303-309.
4. Dipasquale B., Marini A.M., Youie R.J. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem. Biophys. Res. Commun. 181:1991;1442-1448.
5. Doherty P., Mann D.A., Walsh G.S. Composition of the effects of NGF activators of protein kinase C and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cell cultures. J. Cell. Biol. 107:1988;333-340.
6. Dosert P., Strolin Benedetti M., Bellotti V., Allievi C., Dordain G. Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid in healthy subjects. J. Neural. Transm. (Gen. Sect.). 81:1990;215-223.
7. Hagihara M., Fujishiro K., Takahasi A., Naoi M., Nagatsu T. Cyclosporin A, an immune suppressor, enhanced neurotoxicity of n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice. Neurochem. Int. 15:1989;249-254.
8. Hartley A., Stone J.M., Heron C., Cooper J.M., Schapira A.H.V. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. J. Neurochem. 63:1994;1987-1990.
9. +) in the pathogenesis of Parkinson's disease. Brain Res. 575:1993;285-298.
10. Janetzky B., Hauck S., Youdim M.B.H., Riederer P., Jellinger K., Pantucek F., Zochling R., Boissl K.W., Reichmann H. Unaltered aconitase activity but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease. Neurosci. Lett. 169:1994;126-128.
11. Kösel S., Egensperger R., von Eitzen U., Mehraein P., Graeber M.B. On the question of apoptosis in the parkinsonian substantia nigra. Acta Neuropathol. 93:1997;103-108.
12. Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analogue synthesis. Science. 219:1983;979-980.
13. Langston J.W., Forno L.S., Robert C.S., Irwin I. MPTP causes selective damage to the zona compacta of the substantia nigra in the squirrel monkey. Brain Res. 292:1984;390-394.
14. Liu X., Naekyung C., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147-157.
15. Marchetti P., Susin S.A., Decaudin D., Gamen S., Castedo M., Hirsch T., Zamzami N., Naval J., Senik A., Kroemer G. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA. Cancer Res. 56:1996;2033-2038.
16. McDonald J.W., Goldberg M.P., Gawg B.J., Chi S.I., Choi D.W. Cyclosporine induces neuronal apoptosis and selective oligodendrocyte death in cortical cultures. Ann. Neurol. 40:1996;750-758.
17. McNaught K.St.P., Thull U., Carrupt P.A., Altomare C., Cellamare S., Carotti A., Testa B., Jenner P., Marsden C.D. Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). Biochem. Pharmacol. 50:1995;1903-1911.
18. McNaught K.St.P., Altomare C., Cellamare S., Carotti A., Thull U., Carrupt P.A., Testa B., Jenner P., Marsden C.D. Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). NeuroReport. 6:1995;1105-1108.
19. McNaught K.St.P., Thull U., Carrupt P.A., Altomare C., Cellamare S., Carotti A., Testa B., Jenner P., Marsden C.D. Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine. Neurodegeneration. 5:1996;265-274.
20. Mizuno Y., Sone N., Saitoh T. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain. J. Neurochem. 48:1987;1787-1793.
21. +) in isolated mitochondria from mouse brains. Neurosci. Lett. 81:1987;204-208.
22. Mochizuki H., Goto K., Mori H., Mizuno Y. Histochemical detection of apoptosis in Parkinson's disease. J. Neurol. Sci. 137:1996;120-123.
23. Mosieniak G., Figiel I., Kaminski B. Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor. J. Neurochem. 68:1997;1142-1149.
24. Nagatsu T., Yoshida M. An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions. Neurosci. Lett. 87:1988;178-182.
25. Naoi M., Maruyama W., Dosert P., Hashizume Y., Nakahara D., Takahashi T., Ota M. Dopamine-derived endogenous 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioural studies. Brain Res. 709:1996;285-295.
26. Negoescu A., Lorimier P., Labat-Moleur F., Azoti L., Robert C., Guillermet C., Brambilla C., Brambilla E. TUNEL: improvement and evaluation of the method for in situ apoptotic cell identification. Biochemica. 2:1997;12-17.
27. Nicklas W.J., Vyas L., Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl 1,2,5,6-tetrahydropyridine. Life Sci. 36:1985;2503-2508.
28. + and mitochondrial function. Life Sci. 40:1987;721-729.
29. Niwa T., Takeda N., Sasaoka T., Kaneda N., Hashizume Y., Yoshizumi H., Tatematsu A., Nagatsu T. Detection of tetrahydroisoquinoline in parkinsonism as an endogenous amine by use of gas-chromatography-mass spectrometry. J. Chromatogr. 491:1988;397-403.
30. +. Biochem. Biophys. Res. Commun. 134:1986;743-748.
31. Ramsay R.R., Salach J.L., Dadgar J., Singer T.P. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relationship to experimental and idiopathic parkinsonism. Biochem. Biophys. Res. Commun. 135:1986;269-275.
32. Rossetti Z.L., Sotgiu A., Sharp D.E., Hadjiconstantinou M., Neff N.H. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro. Biochem. Pharmacol. 37:1988;4573-4574.
33. Schapira A.H.V., Cooper J.M., Dexter D., Clark J.B., Jenner P., Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54:1990;823-827.
34. Scorrano L., Petronelli V., Bernardi P. On the voltage dependence of the mitochondrial permeability transition pore. J. Biol. Chem. 272:1997;12295-12299.
35. Seaton T.A., Cooper J.M., Schapira A.H.V. Free radical scavengers protect dopaminergic cell lines from apoptosis induced by mitochondrial complex I inhibitors. Brain Res. 777:1998;110-118.
36. Yazdanbakhsh, Choi J.W., Li Y., Lau L.F., Choi Y. Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc. Natl. Acad. Sci. U.S.A. 92:1995;437-441.
37. Zamzami N., Susin S.A., Marchetti P., Hirsch T., Gomesmonterrey I., Castedo M., Kroemer G. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183:1996;1533-1544.
38. Zamzami N., Marchetti P., Castedo M., Hirsch T., Susin S.A., Masse B., Kroemer G. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett. 384:1996;53-57.
39. Ziv I., Melamed E., Nardi N., Luria D., Achiron A., Offen D., Barzilai A. Dopamine induces apoptosis-like cell death in cultured sympathetic neurons - A possible novel pathogenetic mechanism in Parkinson's disease. Neurosci. Lett. 170:1994;136-140.