Neuroprotective actions of FK506 in experimental stroke: In vivo evidence against an antiexcitotoxic mechanism

Journal of Neuroscience

Volumn 17, Issue 18, 1997, Pages 6939-6946

  Butcher, Steven P ^a   Henshall, David C ^a   Teramura, Yoshinori ^b   Iwasaki, Kazuhide ^b   Sharkey, John ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

cyclosporin A; Dizocli pine; Excitotoxicity; FK506; Ischemia; MK801; Neuroprotection; Stroke; Tacrolimus

Indexed keywords

ACYLTRANSFERASE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CALCINEURIN; CYCLOSPORIN A; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; QUINOLINIC ACID; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; MIDDLE CEREBRAL ARTERY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

EID: 0030850505     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-18-06939.1997     Document Type: Article

References (17)

1. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CCW, Revest PA, Greenwood J (1990) Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem 55:1222-1230.
2. Bierer BE, Mattila PS, Standaert RF, Herzenberg LA, Burakoff SJ, Crabtree G, Schreiber SL (1990) Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci USA 87:9231-9235.
3. Bonfoco E, Krainc D, Ankarcrona M, Nocitera P, Lipton SA (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/Superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
4. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of dye-protein binding. Anal Biochem 72:248-254.
5. Brillantes AB, Ondrias K, Scott A, Kobrinsky E, Ondriasova E, Moschella MC, Jayaraman T, Landers M, Ehrlich BE, Marks AR (1994) Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 77:513-523.
6. Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane SW, Schreiber SL (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756-758.
7. 2+ flux. Cell 83:463-472.
8. Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH (1995b) Immunophilin FK506 binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium flux. Proc Natl Acad Sci USA 92:1784-1788.
9. Chang HY, Takei K, Sydor AM, Born T, Rusnak F, Jay DG (1995) Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature 376:686-690.
10. Charters AR, Kobayashi M, Butcher SP (1995) Developmental expression of FK506 binding protein and calcineurin in rat brain. Biochem Soc Trans 23:422S.
11. 2+ release channel (ryanodine receptor) by 12 kDa FK506 binding protein. Proc Natl Acad Sci USA 91:11953-11957.
12. Chiu MI, Katz H, Berlin V (1994) RAPT1, a mammalian homolog of yeast TOR, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci USA 91:12574-12578.
13. Choi DW (1995) Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18:58-60.
14. Clipstone NA, Crabtree GR (1992) Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation. Nature 357:695-698.
15. Dawson TM, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH (1993) Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci USA 90:9808-9812.
16. Dawson TM, Steiner JP, Lyons WE, Fotuhi M, Blue M, Snyder SH (1994) The immunophilins, FK506 binding protein and cyclophilin, are discreetly localised in the brain: relationship to calcineurin. Neuroscience 62:569-580.
17. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371.