Toll receptors: An expanding role in our understanding of human disease

Journal of Leukocyte Biology

Volumn 67, Issue 6, 2000, Pages 767-773

  Schuster, J M ^a   Nelson, P S ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Bacterial pathogens; Immunity

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN RECEPTOR; RECEPTOR; TOLL RECEPTOR; UNCLASSIFIED DRUG;

DROSOPHILA; HUMAN; IMMUNE RESPONSE; IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; TISSUE DISTRIBUTION;

EID: 0033848949     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.67.6.767     Document Type: Review

References (72)

1. Structural and functional diversity in the leucine-rich repeat family of proteins
2. The leucine rich repeat: A versatile binding motif
3. RP105, a novel B cell surface molecule implicated in B cell activation, is a member of a leucine rich repeat protein family
4. Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum
5. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein. An antigen associated with metastasis contains leucine-rich repeats
6. Human platelet glycoprotein IX: An adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures
7. The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence
8. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
9. A family of human receptors structurally related to Drosophila Toll
10. Slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
11. Cloning and expressions of three mammalian homologues of Drosophila Slit suggest possible roles for Slit in the formation and maintenance of the nervous system
12. Cloning and mapping of ZNF231, a novel brain specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy (MSA)
13. The cerebellar leucine rich acidic nuclear protein interacts with ataxin-1
14. GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas
15. Drosophila chaoptin, a member of the leucine-rich repeat family, is a photoreceptor cell-specific adhesion molecule
16. The Drosophila membrane receptor Toll can function to promote cellular adhesion
17. Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo
18. Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein
19. The Toll-receptor family and control of innate immunity
20. Innate immunity: The virtues of a nonclonal system of recognition
21. Drosophila Toll and IL-1 receptor
22. Signal perception and transduction in plant defense responses
23. Signal transduction pathways activated by the IL-1 receptor family: Ancient signalling machinery in mammals, insects, and plants
24. Towards an understanding of the signal transduction pathways for interleukin 1
25. The interleukin 1 receptor: Ligand interactions and signal transduction
26. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
27. IRAK: A kinase associated with the interleukin-1 receptor
28. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
29. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
30. Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: Importance of transmembrane signaling for dorsal-ventral pattern formation
31. Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo
32. Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity
33. The Drosophila toll gene functions zygotically and is necessary for proper motoneuron and muscle development
34. A conserved signaling pathway: The Drosophila toll-dorsal pathway
35. Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction
36. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
37. Getting knotted: A model for the structure and activation of Spatzle
38. Pinning down positional information: Dorsal-ventral polarity in the Drosophila embryo
39. Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo
40. The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
41. Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
42. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family
43. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
44. TLR6: A novel member of an expanding toll-like receptor family
45. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
46. The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
47. Epidemiology and clinical impact of gram-negative sepsis
48. The clinical significance of positive blood cultures in the 1990s: A prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults
49. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
50. Recognition of gram-negative bacteria and endotoxin by the innate immune system
51. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
52. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
53. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
54. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
55. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
56. Cutting edge: Cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin
57. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
58. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
59. Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
60. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
61. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
62. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
63. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein
64. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
65. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
66. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
67. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
68. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
69. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
70. Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells
71. Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14
72. A single growth cone is capable of integrating simultaneously presented and functionally distinct molecular cues during target recognition