The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

Nature

Volumn 389, Issue 6654, 1997, Pages 974-978

  Matilla, Antoni ^a   Koshy, Beena T ^a   Cummings, Christopher J ^a   Isobe, Toshiaki ^c   Orr, Harry T ^d   Zoghbi, Huda Y ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c TOKYO METROPOLITAN UNIVERSITY   (Japan)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; GENE PRODUCT; LEUCINE; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBELLUM DISEASE; DEGENERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PURKINJE CELL; SPINOCEREBELLAR DEGENERATION;

ANIMALS; BINDING SITES; CELL NUCLEUS; CEREBELLUM; CLONING, MOLECULAR; COS CELLS; GLUTAMINE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICROSCOPY, CONFOCAL; MUTATION; NERVE TISSUE PROTEINS; NEUROPEPTIDES; NUCLEAR MATRIX; NUCLEAR PROTEINS; PURKINJE CELLS; RATS; SACCHAROMYCES CEREVISIAE; SPINOCEREBELLAR DEGENERATIONS;

EID: 0030716768     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/40159     Document Type: Article

References (22)

1. Zoghbi, H. & Orr, H. Spinocerebellar ataxia type 1. Semin. Cell Biol. 6, 29-35 (1995).
2. Orr, H. et al. Expansion of an unstable trinucleotide (CAG) repeat in spinocerebellar ataxia type 1. Nature Genet. 4, 221-226 (1993).
3. Matsuoka, K. et al. A nuclear factor containing the leucine-rich repeats expressed in murine cerebeliar neurons. Proc. Natl Acad. Sci. USA 91, 9670-9674 (1994).
4. Servadio, A. et al Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals. Nature Genet 10, 94-98 (1995).
5. Fields, S. & Song, O.-K. A novel genetic system to detect protein-protein interactions. Nature 340, 245-246 (1989).
6. Kordeli, E., Lambert, S. & Bennet, V. AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J. Biol. Chem. 270, 2352-2359 (1995).
7. Wong, Y. H., Kalmbach, S. J., Hartman, B. K. & Sherman, W. R. Immunohistochemical staining and enzyme activity measurements show myo-inositol-1-phosphate synthase to be localized in the vasculature of brain. J. Neurochem. 48, 1434-1442 (1987).
8. Smith, K. E. et al. Molecular cloning of an orphan transporter. A new member of the neurotransmitter transporter family. FEBS Lett. 357, 86-92 (1995).
9. Koshy, B. et al. Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase. Hum. Mol. Genet. 5, 1311-1318 (1996).
10. Kobe, B. & Deisenhofer, J. The leucine-rich repeat: a versatile binding motif. Trends Biochem. Sci. 19, 415-421 (1994).
11. Banfi, S. et al. Cloning and developmental expression analysis of the murine homolog of the spinocerebellar ataxia type 1 gene (Sca1). Hum. Mol. Genet. 5, 33-40 (1996).
12. Skinner, P. et al. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature 389, 971-974 (1997).
13. Fey, E. G. & Penman, S. Nuclear matrix proteins reflect cell type of origin in cultured human cells. Proc.l Natl Acad. Sci. USA 85, 121-125 (1988).
14. Berezney, R. & Coffey, D. S. Nuclear matrix isolation and characterization of a framework structure from rat liver nuclei. J. Cell Biol. 73, 616-632 (1977).
15. Burright, E. et al. SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat. Cell 82, 937-948 (1995).
16. Matilla, A. et al. Ataxin-1, the SCA1 gene product, is required for learning tasks mediated by both the hippocampus and cerebellum. Proc. Natl Acad. Sci. USA (submitted).
17. Kobe, B. & Deisenhofer, J. Proteins with leucine-rich repeats. Curr. Opin. Struct. Biol. 5, 409-416 (1995).
18. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816 (1993).
19. Feilotter, H. E., Hannon, G. J., Ruddell, C. J. & Beach, D. Construction of an improved host strain for two hybrid screening. Nucleic Acids Res. 22, 1502-1503 (1994).
20. Durfee, X et al. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569 (1993).
21. Breeden, L. & Nasmyth, K. Regulation of the yeast HO gene. Cold Spring Hark Symp. Quant. Biol. 50, 643-650 (1985).
22. Rose, M. & Botstein, D. Construction and use of gene fusions to lacZ (β-galactosidase) that are expressed in yeast. Methods Enzymol. 101, 167-180 (1983).