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Volumn 286, Issue 2, 1999, Pages 465-474

The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase

Author keywords

Antibiotic TA; Myxococcus xanthus; Peptide synthetase; Polyketide; Polyketide synthase (PKS)

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; PEPTIDE SYNTHASE; POLYKETIDE; SYNTHETASE;

EID: 0033582596     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2478     Document Type: Article
Times cited : (80)

References (46)
  • 1
    • 0028951606 scopus 로고
    • Sequence around the 159 ° region of the Bacillus subtilis genome: The pksX locus spans 33.6-kb
    • Albertini A. M., Caramori T., Scoffone F., Scotti C., Galizzi A. Sequence around the 159 ° region of the Bacillus subtilis genome: the pksX locus spans 33.6-kb. Microbiology. 141:1995;299-309.
    • (1995) Microbiology , vol.141 , pp. 299-309
    • Albertini, A.M.1    Caramori, T.2    Scoffone, F.3    Scotti, C.4    Galizzi, A.5
  • 3
    • 0020607566 scopus 로고
    • In situ transposon replacement and isolation of spontaneous tandem duplication
    • Avery L., Kaiser D. In situ transposon replacement and isolation of spontaneous tandem duplication. Mol. Gen. Genet. 191:1983;99-109.
    • (1983) Mol. Gen. Genet. , vol.191 , pp. 99-109
    • Avery, L.1    Kaiser, D.2
  • 4
    • 0026511543 scopus 로고
    • 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea: Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme
    • Bevitt D. J., Cortes J., Haydock S. F., Leadlay P. F. 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea: cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme. Eur. J. Biochem. 204:1992;39-49.
    • (1992) Eur. J. Biochem. , vol.204 , pp. 39-49
    • Bevitt, D.J.1    Cortes, J.2    Haydock, S.F.3    Leadlay, P.F.4
  • 5
    • 0024449599 scopus 로고
    • Analysis of the nucleotide sequence of the Streptomyces glaucescans tcm I genes provides key information about the enzymology of polyketide antibiotic biosynthesis
    • Bibb M. J., Biro S., Motamedi H., Collins J. F., Hutchinson C. R. Analysis of the nucleotide sequence of the Streptomyces glaucescans tcm I genes provides key information about the enzymology of polyketide antibiotic biosynthesis. EMBO J. 8:1989;2727-2736.
    • (1989) EMBO J. , vol.8 , pp. 2727-2736
    • Bibb, M.J.1    Biro, S.2    Motamedi, H.3    Collins, J.F.4    Hutchinson, C.R.5
  • 7
    • 0026559262 scopus 로고
    • Organization of the enzymatic domain in multifunctional polyketide synthase involved in erythromycin formation inSaccharopolyspora erythraea
    • Donadio S., Katz L. Organization of the enzymatic domain in multifunctional polyketide synthase involved in erythromycin formation inSaccharopolyspora erythraea. Gene. 111:1992;51-60.
    • (1992) Gene , vol.111 , pp. 51-60
    • Donadio, S.1    Katz, L.2
  • 8
    • 0026415106 scopus 로고
    • Modular organization of genes required for complex polyketide biosynthesis
    • Donadio S., Staver M. J., McAlpine J. B., Swanson S. J., Katz L. Modular organization of genes required for complex polyketide biosynthesis. Science. 252:1991;675-679.
    • (1991) Science , vol.252 , pp. 675-679
    • Donadio, S.1    Staver, M.J.2    McAlpine, J.B.3    Swanson, S.J.4    Katz, L.5
  • 9
    • 0027299621 scopus 로고
    • Nucleotide sequence of 5′ portion of srfA that containes the region required for competence establishment in Bacillus subtilis
    • Fuma S., Fujishima Y., Corbell N., D'Souza C., Nakano M. M., Zuber P., Yamane K. Nucleotide sequence of 5′ portion of srfA that containes the region required for competence establishment in Bacillus subtilis. Nucl. Acids. Res. 21:1993;93-97.
    • (1993) Nucl. Acids. Res. , vol.21 , pp. 93-97
    • Fuma, S.1    Fujishima, Y.2    Corbell, N.3    D'Souza, C.4    Nakano, M.M.5    Zuber, P.6    Yamane, K.7
  • 10
    • 0022343606 scopus 로고
    • Novel one-step cloning vector with a transposable element: Application to the Myxococcus xanthus genome
    • Furuichi T., Inouye M., Inouye S. Novel one-step cloning vector with a transposable element: application to the Myxococcus xanthus genome. J. Bacteriol. 164:1985;270-275.
    • (1985) J. Bacteriol. , vol.164 , pp. 270-275
    • Furuichi, T.1    Inouye, M.2    Inouye, S.3
  • 11
  • 12
    • 0028226896 scopus 로고
    • Analysis of core sequences in the D -Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis
    • Gocht M., Marahil M. A. Analysis of core sequences in the D -Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis. J. Bacteriol. 176:1994;2654-2662.
    • (1994) J. Bacteriol. , vol.176 , pp. 2654-2662
    • Gocht, M.1    Marahil, M.A.2
  • 13
    • 0025606149 scopus 로고
    • Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
    • Hopwood D. A., Sherman D. H. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 24:1990;37-66.
    • (1990) Annu. Rev. Genet. , vol.24 , pp. 37-66
    • Hopwood, D.A.1    Sherman, D.H.2
  • 14
    • 0025823924 scopus 로고
    • Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin A methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer
    • Kakinuma S., Takada Y., Ikeda H., Tanaka H., Omura S., Hopwood D. A. Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin A methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer. J. Antibiot. 44:1991;995-1005.
    • (1991) J. Antibiot. , vol.44 , pp. 995-1005
    • Kakinuma, S.1    Takada, Y.2    Ikeda, H.3    Tanaka, H.4    Omura, S.5    Hopwood, D.A.6
  • 15
    • 0028901698 scopus 로고
    • Genetic suppression and phenotypic masking of a Myxococcus xanthus frz F-defect
    • Kashefi A., Hartzell P. L. Genetic suppression and phenotypic masking of a Myxococcus xanthus frz F-defect. Mol. Microbiol. 15:1995;483-494.
    • (1995) Mol. Microbiol. , vol.15 , pp. 483-494
    • Kashefi, A.1    Hartzell, P.L.2
  • 16
    • 0027382486 scopus 로고
    • Polyketide synthesis: Prospects for hybrid antibiotics
    • Katz L., Donadio S. Polyketide synthesis: prospects for hybrid antibiotics. Annu. Rev. Micobiol. 47:1993;875-912.
    • (1993) Annu. Rev. Micobiol. , vol.47 , pp. 875-912
    • Katz, L.1    Donadio, S.2
  • 17
    • 0023801637 scopus 로고
    • Organization of the biosynthesis genes for the peptide antibiotic gramicidin S
    • Krause M., Marahiel M. A. Organization of the biosynthesis genes for the peptide antibiotic gramicidin S. J. Bacteriol. 170:1988;4669-4674.
    • (1988) J. Bacteriol. , vol.170 , pp. 4669-4674
    • Krause, M.1    Marahiel, M.A.2
  • 18
    • 0021221420 scopus 로고
    • Construction of Tn5 lac, a transposon that fuses lacZ expression to exogenous promoters and its introduction into Myxococcus xanthus
    • Kroos L., Kaiser D. Construction of Tn5 lac, a transposon that fuses lacZ expression to exogenous promoters and its introduction into Myxococcus xanthus. Proc. Natl Acad. Sci. USA. 81:1984;5816-5820.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 5816-5820
    • Kroos, L.1    Kaiser, D.2
  • 21
    • 0026696975 scopus 로고
    • Multidomain enzymes involved in peptide synthesis
    • Marahiel M. A. Multidomain enzymes involved in peptide synthesis. FEBS Letters. 307:1992;40-43.
    • (1992) FEBS Letters , vol.307 , pp. 40-43
    • Marahiel, M.A.1
  • 22
    • 0024334515 scopus 로고
    • Gene cluster containing the genes for tyrocidine synthetases 1 and 2 from Bacillus brevis: Evidence for an operon
    • Mittenhuber G., Weckermann R., Marahiel M. A. Gene cluster containing the genes for tyrocidine synthetases 1 and 2 from Bacillus brevis: evidence for an operon. J. Bacteriol. 171:1989;4881-4887.
    • (1989) J. Bacteriol. , vol.171 , pp. 4881-4887
    • Mittenhuber, G.1    Weckermann, R.2    Marahiel, M.A.3
  • 23
    • 0021073779 scopus 로고
    • Construction of improved M13 vector
    • Norrander J., Kempe T., Messing J. Construction of improved M13 vector. Gene. 26:1983;101-106.
    • (1983) Gene , vol.26 , pp. 101-106
    • Norrander, J.1    Kempe, T.2    Messing, J.3
  • 24
    • 0031777277 scopus 로고    scopus 로고
    • Molecular analysis of the gyrB gene from Myxococcus xanthus
    • Paitan Y., Boulton N., Ron E. Z., Orr E., Rosenberg E. Molecular analysis of the gyrB gene from Myxococcus xanthus. Microbiology. 144:1998;1641-1647.
    • (1998) Microbiology , vol.144 , pp. 1641-1647
    • Paitan, Y.1    Boulton, N.2    Ron, E.Z.3    Orr, E.4    Rosenberg, E.5
  • 25
    • 0025272240 scopus 로고
    • Rapid and sensitive sequence comparison with FASTP and FASTA
    • Pearson W. R. Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol. 183:1990;63-98.
    • (1990) Methods Enzymol. , vol.183 , pp. 63-98
    • Pearson, W.R.1
  • 26
    • 0029996171 scopus 로고    scopus 로고
    • Two multifunctional peptide synthetases and an O-methyltransferase are involved in biosynthesis of the DNA-binding antibiotic and antitumor agent saframycin Mx1 from Myxococcus xanthus
    • Pospiech A., Bietenhader J., Schupp T. Two multifunctional peptide synthetases and an O-methyltransferase are involved in biosynthesis of the DNA-binding antibiotic and antitumor agent saframycin Mx1 from Myxococcus xanthus. Microbiology. 142:1996;741-746.
    • (1996) Microbiology , vol.142 , pp. 741-746
    • Pospiech, A.1    Bietenhader, J.2    Schupp, T.3
  • 27
    • 0000691578 scopus 로고
    • Production of bio active secondary metabolites
    • M. Dworkin, & D. Kaiser. Washington: American Society for Microbiology
    • Reichenbach H., Hofle G. Production of bio active secondary metabolites. Dworkin M., Kaiser D. Myxobacteria II. 1993;347-398 American Society for Microbiology, Washington.
    • (1993) Myxobacteria II , pp. 347-398
    • Reichenbach, H.1    Hofle, G.2
  • 28
    • 0027318089 scopus 로고
    • Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase
    • Roberts G. A., Staunton J., Leadlay P. F. Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase. Eur. J. Biochem. 214:1993;305-311.
    • (1993) Eur. J. Biochem. , vol.214 , pp. 305-311
    • Roberts, G.A.1    Staunton, J.2    Leadlay, P.F.3
  • 29
    • 0015685378 scopus 로고
    • Bactericidal action of an antibiotic produced by Myxococcus xanthus
    • Rosenberg E., Vaks B., Zuckerberg A. Bactericidal action of an antibiotic produced by Myxococcus xanthus. Antimicrob. Agents Chemother. 4:1973;507-513.
    • (1973) Antimicrob. Agents Chemother. , vol.4 , pp. 507-513
    • Rosenberg, E.1    Vaks, B.2    Zuckerberg, A.3
  • 34
    • 0025048136 scopus 로고
    • The P-loop. A common motif in ATP- And GTP-binding proteins
    • Saraste M., Sibbald P. R., Wittighofer A. The P-loop. A common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15:1990;430-434.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 430-434
    • Saraste, M.1    Sibbald, P.R.2    Wittighofer, A.3
  • 36
    • 0029006483 scopus 로고
    • A Sorangium cellulosum (Myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic Soraphen A: Cloning, characterization, and homology to polyketide synthase genes from Actinomycetes
    • Schupp T., Toupet C., Cluzel B., Neff S., Hill S., Back J. J., Ligon J. M. A Sorangium cellulosum (Myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic Soraphen A: cloning, characterization, and homology to polyketide synthase genes from Actinomycetes. J. Bacteriol. 177:1995;3673-3679.
    • (1995) J. Bacteriol. , vol.177 , pp. 3673-3679
    • Schupp, T.1    Toupet, C.2    Cluzel, B.3    Neff, S.4    Hill, S.5    Back, J.J.6    Ligon, J.M.7
  • 37
    • 0000601709 scopus 로고
    • Locating, DNA sequencing and disrupting yeast genes using tagged Tn 1000
    • Sedgwick S. G., Morgan B. A. Locating, DNA sequencing and disrupting yeast genes using tagged Tn 1000. Methods Mol. Genet. 3:1994;131-140.
    • (1994) Methods Mol. Genet. , vol.3 , pp. 131-140
    • Sedgwick, S.G.1    Morgan, B.A.2
  • 38
    • 0024438917 scopus 로고
    • Structure and deduced function of the granaticin-producing polyketide synthase gene cluster ofStreptomycesviolaceoruber Tü22
    • Sherman D. H., Malpartida F., Bibb M. J., Kieser H. M., Hopwood D. A. Structure and deduced function of the granaticin-producing polyketide synthase gene cluster ofStreptomycesviolaceoruber Tü22. EMBO J. 8:1989;2717-2725.
    • (1989) EMBO J. , vol.8 , pp. 2717-2725
    • Sherman, D.H.1    Malpartida, F.2    Bibb, M.J.3    Kieser, H.M.4    Hopwood, D.A.5
  • 39
    • 0025202901 scopus 로고
    • Social and developmental biology of myxobacteria
    • Shimkets L. J. Social and developmental biology of myxobacteria. Microbiol. Rev. 54:1990;473-501.
    • (1990) Microbiol. Rev. , vol.54 , pp. 473-501
    • Shimkets, L.J.1
  • 40
    • 0026712181 scopus 로고
    • Use of Tn5 lac to study expression of genes required for antibiotic TA production
    • Tolchinsky S., Fuchs N., Varon M., Rosenberg E. Use of Tn5 lac to study expression of genes required for antibiotic TA production. Antimicrob. Agents Chemother. 36:1992;2322-2327.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 2322-2327
    • Tolchinsky, S.1    Fuchs, N.2    Varon, M.3    Rosenberg, E.4
  • 41
    • 0020395387 scopus 로고
    • Structure of Myxovirescin A, a new macrocyclic antibiotic from gliding bacteria
    • Trowitzsch W., Wray V., Gerth K., Hofle G. Structure of Myxovirescin A, a new macrocyclic antibiotic from gliding bacteria. J. Chem. Soc. Commun. 1982:1982;1340-1342.
    • (1982) J. Chem. Soc. Commun. , vol.1982 , pp. 1340-1342
    • Trowitzsch, W.1    Wray, V.2    Gerth, K.3    Hofle, G.4
  • 42
    • 0026926521 scopus 로고
    • Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes
    • Turgay K., Krause M., Marahiel M. A. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes. Mol. Microbiol. 6:1992;529-546.
    • (1992) Mol. Microbiol. , vol.6 , pp. 529-546
    • Turgay, K.1    Krause, M.2    Marahiel, M.A.3
  • 43
    • 0029930216 scopus 로고    scopus 로고
    • Transcriptional regulation of genes required for antibiotic TA synthesis in Myxococcus xanthus
    • Varon M., Rosenberg E. Transcriptional regulation of genes required for antibiotic TA synthesis in Myxococcus xanthus. FEMS Microbiol. Letters. 136:1996;203-208.
    • (1996) FEMS Microbiol. Letters , vol.136 , pp. 203-208
    • Varon, M.1    Rosenberg, E.2
  • 45
    • 0031572409 scopus 로고    scopus 로고
    • Trans-acting regulation of antibiotic TA genes in Myxococcus xanthus
    • Varon M., Paitan Y., Rosenberg E. Trans-acting regulation of antibiotic TA genes in Myxococcus xanthus. FEMS Microbiol. Letters. 155:1997;141-146.
    • (1997) FEMS Microbiol. Letters , vol.155 , pp. 141-146
    • Varon, M.1    Paitan, Y.2    Rosenberg, E.3


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