Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension

Chemistry and Biology

Volumn 5, Issue 8, 1998, Pages 407-412

  Böhm, Ines ^a   Holzbaur, Inès E ^a   Hanefeld, Ulf ^a,b   Cortés, Jesús ^a   Staunton, Jim ^a   Leadlay, Peter F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Minimal polyketide synthase; Modular polyketide synthase; Module swap; Saccharopolyspora erythraea; Streptomyces

Indexed keywords

ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME SPECIFICITY; GENETIC ENGINEERING; POLYKETIDE SYNTHASE; SACCHAROPOLYSPORA ERYTHRAEA; TARGETED MUTAGENESIS;

SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES;

EID: 0032146228     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(98)90157-0     Document Type: Article

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