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Volumn 121, Issue 39, 1999, Pages 9023-9033

Chemistry of the bleomycin-induced alkali-labile DNA lesion

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; BUTYLAMINE; DINUCLEOTIDE; DNA FRAGMENT; LACTAM;

EID: 0032878569     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja991574a     Document Type: Article
Times cited : (39)

References (65)
  • 7
    • 0002228491 scopus 로고
    • Foye, W. O., Ed.; American Chemical Society: Washington, DC
    • (g) Hecht, S. M. In Cancer Chemotherapeutic Agents; Foye, W. O., Ed.; American Chemical Society: Washington, DC, 1995; p 369ff.
    • (1995) Cancer Chemotherapeutic Agents
    • Hecht, S.M.1
  • 8
    • 0003701639 scopus 로고
    • Carter, S. K., Crooke, S. T., Umezawa, H., Eds.; Academic Press: New York
    • (a) Umezawa, H. In Bleomycin: Current Status and New Developments; Carter, S. K., Crooke, S. T., Umezawa, H., Eds.; Academic Press: New York, 1978.
    • (1978) Bleomycin: Current Status and New Developments
    • Umezawa, H.1
  • 22
    • 0002713581 scopus 로고    scopus 로고
    • Eggleston, D. S., Prescott, C. D., Pearson, N. D., Eds.; Academic Press Ltd.: London
    • (f) Hecht, S. M. In The Many Faces of RNA; Eggleston, D. S., Prescott, C. D., Pearson, N. D., Eds.; Academic Press Ltd.: London, 1998; p 3ff.
    • (1998) The Many Faces of RNA
    • Hecht, S.M.1
  • 53
    • 0344817572 scopus 로고    scopus 로고
    • note
    • The low yield of lactam observed under basic conditions was found to be due to its instability under the reaction conditions. Amine treatment of authentic 15 resulted in considerable decomposition and 15 was recovered only in 14% yield. This indicated that lactam formation under basic conditions may also proceed via the mechanism shown in Scheme 7 although the yield of 15 was low.


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