The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo

Cell Death and Differentiation

Volumn 7, Issue 9, 2000, Pages 815-824

  Kugler S ^a   Straten, G ^a   Kreppel, F ^a   Isenmann, S ^a   Liston, P ^b   Bahr M ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

Adenovirus; Apoptosis; CNS; Retina; XIAP

Indexed keywords

CASPASE; CASPASE INHIBITOR; INHIBITOR PROTEIN; PROTEIN P35; VIRUS VECTOR;

ADENOVIRUS; ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CELL REGENERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; GENETIC TRANSDUCTION; IN VIVO STUDY; ISCHEMIA; MAMMAL; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE FIBER; NERVE LESION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; RETINA NERVE CELL; SPINAL CORD NERVE CELL; SPINAL MUSCULAR ATROPHY; X CHROMOSOME LINKAGE;

ADENOVIRIDAE; ANIMALIA; MAMMALIA;

EID: 0033832571     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400712     Document Type: Article

References (40)

1. Sealing one's fate: Control of cell death in neurons
2. Programmed cell death in animal development
3. Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy
4. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
5. Inhibition of presenilin 1 expression is promoted by p53 and p21 (WAF-1) and results in apoptosis and tumor suppression
6. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precurser protein and mayloidogenic Aβ peptide formation
7. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
8. The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: The potential role of apoptosis
9. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus
10. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period
11. Caspases: The executioners of apoptosis
12. Caspases: Killer proteases
13. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex
14. Prevention of apoptosis by a baculovirus gene during infection of insect cells
15. Target protease specificity of the viral serpin CrmA. Analysis of five caspases
16. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
17. X-linked IAP is a direct inhibitor of cell death proteases
18. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
19. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
20. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
21. Inhibition of Fas death signals by FLIPs
22. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
23. Apoptosis in adult retinal ganglion cells after axotomy
24. Apoptotic cell death induced by optic nerve lesion in the neonatal rat
25. Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptic cell death after optic nerve lesion in the rat
26. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo
27. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo
28. Adenovirus-mediated gene transfer to retinal ganglion cells
29. Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons
30. Transduction of axotomized retinal ganglion cells by adenoviral vector administration at the optic nerve stump: An in vivo model system for the inhibition of neuronal apoptotic cell death
31. Stroke-damaged neurons may commit cellular suicide
32. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
33. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
34. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expressin protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
35. Adenovirus mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo
36. Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products
37. Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC1 promoter
38. Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo
39. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
40. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3