The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression

Molecular and Cellular Biology

Volumn 17, Issue 9, 1997, Pages 5275-5287

  Liu, Jinqi ^a   Bramblett, Debra ^a,d   Zhu, Quan ^a   Lozano, Mary ^a   Kobayashi, Ryuji ^a,b   Ross, Susan R ^c   Dudley, Jaquelin P ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS MATRIX; GENE EXPRESSION REGULATION; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALIA; MAMMARY TUMOR ONCOVIRUS; MAMMARY TUMOR VIRUS; MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS; ONCOVIRINAE; TUMOR VIRUS;

EID: 0030875133     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.9.5275     Document Type: Article

References (100)

1. Adachi, Y., E. Kas, and U. K. Laemmli. 1989. Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions. EMBO J. 8:3997-4006.
2. Andres, V., B. Nadal-Ginard, and V. Mahdavi. 1992. Clox, a mammalian homeohox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development 116:321-334.
3. Archer, T. K., P. Lefebvre, R. G. Wolford, and G. L. Hager. 1992. Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation. Science 255:1573-1576. (Erratum, 256:5054, 1992.)
4. Ball, J. K., L. O. Arthur, and G. A. Dekaban. 1985. The involvement of a type-B retrovirus in the induction of thymic lymphomas. Virology 140:159-172.
5. Ball, J. K., G. A. Dekaban, J. A. McCarter, and S. M. Loosmore. 1983. Molecular biological characterization of a highly leukaemogenic virus isolated from the mouse. III. Identity with mouse mammary tumour virus. J. Gen. Virol. 64:2177-2190.
6. Ball, J. K., H. Diggelmann, G. A. Dekaban, G. F. Grossi, R. Semmler, P. A. Waight, and R. F. Fletcher. 1988. Alterations in the U3 region of the long terminal repeat of an infectious thymotropic type B retrovirus. J. Virol. 62:2985-2993.
7. Banan, M., I. C. Rojas, W.-H. Lee, H. L. King, J. V. Harris, R. Kobayashi, C. F. Webb, and P. D. Gottlieb. Interaction of the nuclear matrix association region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8α gene. J. Biol. Chem., in press.
8. Barberis, A., G. Superti-Furga, and M. Busslinger. 1987. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell 50:347-359.
9. Belgrader, P., R. Dey, and R. Berezney. 1991. Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain. J. Biol. Chem. 266:9893-9899.
10. Berezney, R., and D. S. Coffey. 1974. Identification of a nuclear protein matrix. Biochem. Biophys. Res. Commun. 60:1410-1417.
11. Berezney, R., and D. S. Coffey. 1975. Nuclear protein matrix: association with newly synthesized DNA. Science 189:291-292.
12. Berrios, M., N. Osheroff, and P. A. Fisher. 1985. In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction. Proc. Natl. Acad. Sci. USA 82:4142-4146.
13. Beutner, U., E. Kraus, D. Kitamura, K. Rajewsky, and B. T. Huber. 1994. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J. Exp. Med. 179:1457-1466.
14. Blochlinger, K., L. Y. Jan, and Y. N. Jan. 1991. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 5: 1124-1135.
15. Bramblett, D., C.-L. L. Hsu, M. Lozano, K. Earnest, C. Fabritius, and J. Dudley. 1995. A redundant nuclear protein binding site contributes to negative regulation of the mouse mammary tumor virus long terminal repeat. J. Virol. 69:7868-7876.
16. Bresnick, E. H., C. Rories, and G. L. Hager. 1992. Evidence that nucleosomes on the mouse mammary tumor virus promoter adopt specific translational positions. Nucleic Acids Res. 20:865-870.
17. Choi, Y. W., D. Henrard, I. Lee, and S. R. Ross. 1987. The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J. Virol. 61:3013-3019.
18. Cockerill, P. N., and W. T. Garrard. 1986. Chromosomal loop anchorage of the κ immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell 44:273-282.
19. Cockerill, P. N., M.-H. Yuen, and W. T. Garrard. 1987. The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements. J. Biol. Chem. 262:5394-5397.
20. Cordingley, M. G., A. T. Riegel, and G. L. Hager. 1987. Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. Cell 48:261-270.
21. Corley, R. B., F. E. Lund, T. D. Randall, L. B. King, S. Doerre, and D. L. Woodland. 1992. Mouse mammary tumor proviral gene expression in cells of the B lineage. Semin. Immunol. 4:287-296. (Review.)
22. Cunningham, J. M., M. E. Purucker, S. M. Jane, B. Safer, E. F. Vanin, P. A. Ney, C. H. Lowrey, and A. W. Nienhuis. 1994. The regulatory element 3′ to the Aγ-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein. Blood 84:1298-1308.
23. Davie, J. R. 1995. The nuclear matrix and the regulation of chromatin organization and function. Int. Rev. Cytol. 162A:191-250.
24. Diamond, M. I., J. N. Miner, S. K. Yoshinaga, and K. R. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272.
25. Dickinson, L. A., C. D. Dickinson, and T. Kohwi-Shigematsu. 1997. An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region. J. Biol. Chem. 272:11463-11470.
26. Dickinson, L. A., T. Job, Y. Kohwi, and T. Kohwi-Shigematsu. 1992. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell 70:631-645.
27. Dickinson, L. A., and T. Kohwi-Shigematsu. 1995. Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-pairing potential. Mol. Cell. Biol. 15:456-465.
28. Dignam, J. D., P. L. Martin, B. S. Shastry, and R. G. Roeder. 1983. Eukaryotic gene transcription with purified components. Methods Enzymol. 101: 582-598.
29. Dudley, J., and R. Risser. 1984. Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas. J. Virol. 49:92-101.
30. Dufort, D., and A. Nepveu. 1994. The human Cut homeodomain protein represses transcription from the c-myc promoter. Mol. Cell. Biol. 14:4251-4257.
31. Dworetzky, S. I., E. G. Fey, S. Penman, J. B. Lian, J. L. Stein, and G. S. Stein. 1990. Progressive changes in the protein composition of the nuclear matrix during rat osteoblast differentiation. Proc. Natl. Acad. Sci. USA 87:4605-4609.
32. Dworetzky, S. I., K. L. Wright, E. G. Fey, S. Penman, J. B. Lian, J. L. Stein, and G. S. Stein. 1992. Sequence-specific DNA-binding proteins are components of a nuclear matrix-attachment site. Proc. Natl. Acad. Sci. USA 89: 4178-4182.
33. Forrester, W. C., S. Takegawa, T. Papayannopoulou, G. Stamatoyannopoulos, and M. Groudine. 1987. Evidence for a locus activating region: the formation of developmentally stable hypersensitive sites in globin expressing hybrids. Nucleic Acids Res. 15:10159-10177.
34. Forrester, W. C., C. van Genderen, T. Jenuwein, and R. Grosschedl. 1994. Dependence of enhancer-mediated transcription of the immunoglobulm μ gene on nuclear matrix attachment regions. Science 265:1221-1225.
35. Gabrielsen, O. S., E. Hornes, L. Korsnes, A. Ruet, and T. B. Oyen. 1989. Magnetic DNA affinity purification of yeast transcription factor τ - a new purification principle for the ultrarapid isolation of near homogeneous factor Nucleic Acids Res. 17:6253-6267.
36. Gabrielsen, O. S., and J. Huet. 1993. Magnetic DNA affinity purification of yeast transcription factor. Methods Enzymol. 218:508-525.
37. Georgatos, S. D., J. Meier, and G. Simos. 1994. Lamins and lamin-associated proteins. Curr. Opin. Cell Biol. 6:347-353.
38. Gerdes, M. G., K. C. Carter, P. T. J. Moen, and J. B. Lawrence. 1994. Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos. J. Cell Biol. 126:289-304.
39. Getzenberg, R. H. 1994. Nuclear matrix and the regulation of gene expression: tissue specificity. J. Cell. Biochem. 55:22-31.
40. Gilead, Z., Y.-H. Jeng, W. S. M. Wold, K. Sugawara, H. M. Rho, M. L. Harter, and M. Green. 1976. Immunological identification of two adenovirus 2-induced early proteins possibly involved in cell transformation. Nature 264:263-266.
41. Golovkina, T. V., A. Chervonsky, J. P. Dudley, and S. R. Ross. 1992. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69:637-645.
42. Guo, B., P. R. Odgren, A. J. van Wijnen, T. J. Last, J. Nickerson, S. Penman, J. B. Lian, J. L. Stein, and G. S. Stein. 1995. The nuclear matrix protein NMP-1 is the transcription factor YY1. Proc. Natl. Acad. Sci. USA 92: 10526-10530.
43. Hager, D. A., and R. R. Burgess. 1980. Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity; results with sigma subunit of Escherichia coli RNA polymerase, wheat germ topoisomerase, and other enzymes. Anal. Biochem. 109:75-86.
44. Held, W., G. A. Waanders, A. N. Shakhov, L. Scarpellino, H. Acha-Orbea, and H. R. MacDonald. 1993. Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell 74:529-540.
45. Held, W. H., H. Acha-Orbea, H. R. MacDonald, and G. A. Waanders. 1994. Superantigens and retroviral infection: insights from mouse mammary tumor virus. Immunol. Today 15:184-190.
46. Herrscher, R. F., M. H. Kaplan, D. L. Lelsz, C. Das, R. Scheuermann, and P. W. Tucker. 1995. The immunoglobulin heavy-chain matrix-associating regions are hound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family. Genes Dev. 9:3067-3082.
47. Hsu, C. L., C. Fabritius, and J. Dudley. 1988. Mouse mammary tumor virus proviruses in T-cell lymphomas lack a negative regulatory element in the long terminal repeat. J. Virol. 62:4644-4652.
48. Huang, M., J. W. Lee, and D. O. Peterson. 1993. Functional redundancy of octamer elements in the mouse mammary tumor virus promoter. Nucleic Acids Res. 21:5235-5241.
49. Jarman, A. P., and D. R. Higgs. 1988. Nuclear scaffold attachment sites in the human globin gene complexes. EMBO J. 7:3337-3344.
50. Karapetian, O., A. N. Shakhov, J.-P. Kraehenbuhl, and H. Acha-Orbea. 1994. Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model. J. Exp. Med. 180:1511-1516.
51. Kas, E., E. Isaurralde, and U. K. Laemmli. 1989. Specific inhibition of binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA) · oligo(dT) tracts. J. Mol. Biol. 210:587-599.
52. Kohwi-Shigematsu, T., and Y. Kohwi. 1990. Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer. Biochemistry 29:9551-9560.
53. Kusk, P., K. E. Carlson, B. S. Warren, and G. L. Hager. 1995. Role of the TATA box in transcription of the mouse mammary tumor virus long terminal repeat. Mol. Endocrinol. 9:1180-1192.
54. Lee, W. T., O. Prakash, D. Klein, and N. H. Sarkar. 1987. Structural alterations in the long terminal repeat of an acquired mouse mammary tumor virus provirus in a T-cell leukemia of DBA/2 mice. Virology 159: 39-48.
55. Lowenthal, J. W., D. W. Ballard, H. Bogerd, E. Bohnlein, and W. C. Greene. 1989. Tumor necrosis factor-α activation of the IL-2 receptor-α gene involves the induction of κB-specific DNA binding proteins. J. Biol. Chem. 142:3121-3128.
56. Lydersen, B. K., and D. E. Pettijohn. 1980. Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell. Cell 22:489-499.
57. Mailly, F., G. Berube, R. Harada, P.-L. Mao, S. Phillips, and A. Nepveu. 1996. The human Cut homeodomain protein can repress gene expression by two distinct mechanisms: active repression and competition for binding site occupancy. Mol. Cell. Biol. 16:5346-5357.
58. Maxam, A. M., and W. Gilbert. 1977. A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74:560-564.
59. Michalides, R., and E. Wagenaar. 1986. Site-specific rearrangements in the long terminal repeat of extra mouse mammary tumor proviruses in murine T-cell leukemias. Virology 154:76-84.
60. Michalides, R., E. Wagenaar, J. Hilkens, J. Hilgers, B. Groner, and N. E. Hynes. 1982. Acquisition of proviral DNA of mouse mammary tumor virus in thymic leukemia cells from GR mice. J. Virol. 43:819-829.
61. Michalides, R., E. Wagenaar, and P. Weijers. 1985. Rearrangements in the long terminal repeat of extra mouse mammary tumor proviruses in T-cell leukemias of mouse strain GR result in a novel enhancer-like structure. Mol. Cell. Biol. 5:823-830.
62. Nakagomi, K., Y. Kohwi, L. A. Dickinson, and T. Kohwi-Shigematsu. 1994. A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. Mol. Cell. Biol. 14:1852-1860.
63. Neufeld, E. J., D. G. Skalnik, P. M.-J. Lievens, and S. H. Orkin. 1992. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat. Genet. 1:50-55.
64. Nickerson, J. A., B. J. Blencowe, and S. Penman. 1995. The architectural organization of nuclear metabolism. Int. Rev. Cytol. 162A:67-123.
65. Nicolas, J.-F., D. Wegmann, P. Lebrun, D. Kaiserlian, J. Tovey, and A. L. Glasebrook. 1987. Relationship of B cell Fc receptors to T cell recognition of MIs antigen. Eur. J. Immunol. 17:1561-1565.
66. Noller, H. F., V. Hoffarth, and L. Zimniak. 1992. Unusual resistance of peptidyl transferase to protein extraction procedures. Science 256:1416-1419.
67. Olnes, M. J., and R. N. Kurl. 1994. Isolation of nuclear extracts from fragile cells: a simplified procedure applied to thymocytes. BioTechniques 17:828-829.
68. Phi-Van, L., J. P. von Kries, W. Ostertag, and W. H. Stratling. 1990. The chicken lysozyme 5′ matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol. Cell. Biol. 10:2302-2307.
69. Pina, B., U. Bruggemeier, and M. Beato. 1990. Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell 60:719-731.
70. Richard-Foy, H., and G. L. Hager. 1987. Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. EMBO J. 6:2321-2328.
71. Ringold, G. M., K. R. Yamamoto, J. M. Bishop, and H. E. Varmus. 1977. Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. Proc. Natl. Acad. Sci. USA 74:2879-2883.
72. Roberts, M. S., G. Fragoso, and G. L. Hager. 1995. Nucleosomes reconstituted in vitro on mouse mammary tumor virus B region DNA occupy multiple translational and rotational frames. Biochemistry 34:12470-12480.
73. Ross, S. R., L. Choy, R. A. Graves, N. Fox, V. Solovjeva, S. Klaus, D. Ricquier, and B. M. Spiegelman. 1992. Hihernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein. Proc. Natl. Acad. Sci. USA 89:7561-7565.
74. Ross, S. R., R. A. Graves, A. Greenstein, K. A. Platt, H.-L. Shyu, B. Mellovitz, and B. M. Spiegelman. 1990. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc. Natl. Acad. Sci. USA 87:9590-9594.
75. Ross, S. R., C. L. Hsu, Y. Choi, E. Mok, and J. P. Dudley. 1990. Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice. Mol. Cell. Biol. 10:5822-5829.
76. Saitoh, N., I. G. Goldberg, E. R. Wood, and W. C. Earnshaw. 1994. SCII: an abundant chromosome scaffold protein is a member of a family of putative ATPases with unusual predicted tertiary structure. J. Cell Biol. 127: 303-318.
77. Scheuermann, R. H., and U. Chen. 1989. A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer. Genes Dev. 3:1255-1266.
78. Sharma, S., L. B. King, and R. B. Corley. 1988. Molecular events during B lymphocyte differentiation. Induction of endogenous mouse mammary tumor proviral envelope transcripts after B cell stimulation. J. Immunol. 141: 2510-2518.
79. Skalnik, D. G., E. C. Strauss, and S. H. Orkin. 1991. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J. Biol. Chem. 266:16736-16744.
80. Smith, D. B., and L. M. Corcoran. 1995. Expression and purification of glutathione-S-transferase fusion proteins, p. 16.7.1-16.7.7. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. John Wiley & Sons, Inc., Brooklyn, N.Y.
81. Staudt, L. M., and M. J. Lenardo. 1991. Immunoglobulin gene transcription. Annu. Rev. Immunol. 9:373-398.
82. Stein, G. S., A. J. van Wijnen, J. L. Stein, J. B. Lian, J. P. Bidwell, and M. Montecino. 1994. Nuclear architecture supports integration of physiological regulatory signals for transcription of cell growth and tissue-specific genes during osteoblast differentiation. J. Cell. Biochem. 55:4-15.
83. Stief, A., D. M. Winter, W. H. Stratling, and A. E. Sippel. 1989. A nuclear DNA attachment element mediates elevated and position-independent gene activity. Nature 341:343-345.
84. Tang, Y., and D. B. DeFranco. 1996. ATP-dependent release of glucocorticoid receptors from the nuclear matrix. Mol. Cell. Biol. 16:1989-2001.
85. Tremethick, D. J., and P. L. Molloy. 1986. High mobility group proteins 1 and 2 stimulate transcription in vitro by RNA polymerases II and III. J. Biol. Chem. 261:6986-6992.
86. Truss, M., G. Chalepakis, B. Pina, D. Barettino, U. Breggemeier, M. Kalff, E. P. Slater, and M. Beato. 1992. Transcriptional control by steroid hormones. J. Steroid Biochem. Mol. Biol. 41:241-248. (Review.)
87. Valarche, I., J.-P. Tissier-Seta, M.-R. Hirsch, S. Martinez, C. Goridis, and J.-F. Brunet. 1993. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development 119:881-896.
88. van Wijnen, A. J., J. P. Bidwell, E. G. Fey, S. Penman, J. B. Lian, J. L. Stein, and G. S. Stein. 1993. Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP-1. Biochemistry 32:8397-8402.
89. Vieira, J., and J. Messing. 1982. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19:259-268.
90. von Kries, J. P., H. Buhrmester, and W. H. Stratling. 1991. A matrix/scaffold attachment region binding protein: identification, purification, and mode of binding. Cell 64:123-135.
91. Wang, R., R. Kobayashi, and J. M. Bishop. 1996. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc. Natl. Acad. Sci. USA 93:8425-8430.
92. Wang, Z., E. J. Neufeld, R. H. Scheuermann, and P. W. Tucker. Repression of immunoglobulin heavy chain intronic enhancer through nuclear matrix attachment sites: Cux/CDP homeoprotein is a component of NF-μNR repressor. Immunity, in press.
93. Webb, C. F., C. Das, S. Eaton, K. Calame, and P. W. Tucker. 1991. Novel protein-DNA interactions associated with increased immunoglobulin transcription in response to antigen plus interleukin-5. Mol. Cell. Biol. 11:5197-5205.
94. Webb, C. F., C. Das, K. L. Eneff, and P. W. Tucker. 1991. Identification of a matrix-associated region 5′ of an immunoglobulin heavy chain variable region gene. Mol. Cell. Biol. 11:5206-5211.
95. Wilson, C. J., D. M. Chao, A. N. Imbalzano, G. R. Schnitzler, R. E. Kingston, and R. A. Young. 1996. RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell 84:235-244.
96. Yamamoto, K. R. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:209-252.
97. Yanagawa, S.-I., K. Kakimi, H. Tanaka, A. Murakami, Y. Nakagawa, Y. Kubo, Y. Yamada, H. Hiai, K. Kuribayashi, T. Masuda, and A. Ishimoto. 1993. Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas. J. Virol. 67:112-118.
98. Yang, J. N., and J. Dudley. 1992. Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream Vκ9 gene. J. Immunol. 149:1242-1251.
99. Zaret, K. S., and K. R. Yamamoto. 1984. Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element. Cell 38:29-38.
100. Zong, R.-T., and R. H. Scheuermann. 1995. Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-μNR enhancer repressor. J. Biol. Chem. 270:24010-24018.