Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 3042-3049

  Jakob, Thilo ^a   Walker, Patricia S ^a   Krieg, Arthur M ^b   Udey, Mark C ^a   Vogel, Jonathan C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIUM LIPOPOLYSACCHARIDE; DNA VACCINE; INTERLEUKIN 12; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OLIGODEOXYNUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA;

ACCESSORY CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; GENE THERAPY; IMMUNOSTIMULATION; LANGERHANS CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN-PRESENTING CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DINUCLEOSIDE PHOSPHATES; DNA; EPIDERMIS; FEMALE; INTERLEUKIN-12; LANGERHANS CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; SKIN; TH1 CELLS;

EID: 0032531036     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Wolff, J. A., and R. W. Malone. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465.
2. Hengge, U. R., E. F. Chan, R. A. Foster, P. S. Walker, and J. C. Vogel. 1995. Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat. Genet. 10:161.
3. Hengge, U. R., P. S. Walker, and J. C. Vogel. 1996. Expression of naked DNA in human, pig, and mouse skin. J. Clin. Invest. 97:2911.
4. Condon, C., S. C. Watkins, C. M. Celluzzi, K. Thompson, and L. D. Falo, Jr. 1996. DNA-based immunization by in vivo transfection of dendritic cells. Nat. Med. 2:1122.
5. Con, M., D. J. Lee, D. A. Carson, and H. Tighe. 1996. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J. Exp. Med. 184:1555.
6. Casares, S., K. Inaba, T.-D. Brumeanu, R. M. Steinman, and C. A. Bona. 1997. Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope. J. Exp. Med. 186:1481.
7. Shimada, S., O. Yano, and T. Tokunaga. 1986. In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG. Jpn. J. Cancer Res. 77:808.
8. Yamamoto, S., T. Yamamoto, S. Shimada, E. Kuramoto, O. Yano, T. Kataoka, and T. Tokunaga. 1992. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36:983.
9. Krieg, A. M., A.-K. Yi, S. Maison, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
10. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M.-D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352.
11. Yi, A.-K., D. M. Klinman, T. L. Martin, S. Matson, and A. M. Krieg. 1996. Rapid immune activation by CpG motifs in bacterial DNA. J. Immunol. 157:5394.
12. Pisetsky, D. S. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5:303.
13. Walker, P. S., T. Scharton-Kersten, E. D. Rowton, U. R. Hengge, A. Bouloc, M. C. Udey, and J. C. Vogel. Genetic immunization with gp63 cDNA results in a Th1 type immune response and protection in a murine model of leishmaniasis. Hum. Gene Ther. In press.
14. Gurunathan, S., D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder. 1997. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186:1137.
15. Lipford, G. B., T. Sparwasser, M. Bauer, S. Zimmerman, E. S. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:3420.
16. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
17. Moll, H., H. Fuchs, C. Blank, and M. Rollinghoff. 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol 23:1595.
18. Reis e Sousa, C., P. D. Stahl, and J. M. Austyn. 1993. Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178:509.
19. Jakob, T., A. Saitoh, and M. C. Udey. 1997. E-cadherin-mediated adhesion involving Langerhans cell-like dendritic cells expanded from murine fetal skin. J. Immunol. 159:2693.
20. Jakob, T., and M. C. Udey. 1998. Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo. J. Immunol 160:4067.
21. Weiner, G. J., H.-M. Liu, J. E. Wooldridge, C. E. Dahle, and A. M. Krieg. 1997. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA 94:10833.
22. Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623.
23. Davis, H. L., R. Weeranta, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870.
24. Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840.
25. Yuspa, S. H. 1985. Methods for the use of epidermal cell culture to study chemical carcinogenesis. In Methods in Skin Research. D. Skerrow and C. J. Skerrow, eds. John Wiley and Sons, Sussex, U.K., p. 213.
26. Jung, T., U. Schauer, C. Heusser, C. Neumann, and C. Rieger. 1993. Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods 159:197.
27. Cowdery, J. S., J. H. Chace, A.-K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570.
28. Tang, A., and M. C. Udey. 1991. Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation: ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells. J. Immunol. 146: 3347.
29. Tang, A., M. Amagai, L. G. Granger, J. R. Stanley, and M. C. Udey. 1993. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361:82.
30. Enk, A. H., V. L. Angeloni, M. C. Udey, and S. I. Katz. 1993. An essential role for Langerhans cell-derived IL-1β in the initiation of primary immune responses in skin. J. Immunology 150:3698.
31. Macatonia, S. E., S. C. Knight, A. J. Edwards, S. Griffiths, and P. Fryer. 1987. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate: functional and morphologic studies. J. Exp. Med. 166:1654.
32. Roake, J. A., A. S. Rao, P. J. Morris, C. P. Larsen, D. F. Hankins, and J. M. Austyn. 1995. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor and interleukin-1. J. Exp. Med. 181:2237.
33. Cumberbatch, M., I. Fielding, and I. Kimber. 1994. Modulation of epidermal Langerhans cell frequency by tumor necrosis factor-α. Immunology 81:395.
34. Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116.
35. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell. Immunol. 167:72.
36. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-mediated shock. Eur. J. Immunol. 27:1671.
37. Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185.
38. Roman, M., E. Martin-Orozco, J. S. Goodman, M.-D. Nguyen, Y. Sato. A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849.
39. Agrawal, S., J. Temsamani, W. Galbraith, and J. Tang. 1996. Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28:7.
40. Zhao, Q., J. Temsamani, P. L. Ladarola, Z. Jiang, and S. Agrawal. 1996. Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem. Pharmacol. 51:173.
41. Krieg, A. M., S. Matson, and E. Fisher. 1996. Oligodeoxynucleotide modifications determine the magnitude of B cell stimulation by CpG motifs. Antisense Nucleic Drug Dev. 6:133.
42. Boggs, R. T., K. Mcgraw, T. Condon, S. Floumoy, P. Villiet, C.-F. Bennett, and B. P. Monia. 1997. Characterization and modulation of immune stimulation by modified oligonucleotides. Antisense Nucleic Acid Drug Dev. 7:461.
43. 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate. Mol. Pharmacol. 45:932.
44. Minchin, S. A., D. Leitenberg, L. L. Stunz, and T. L. Feldbush. 1990. Polyclonal activation of rat B cells. II. Dextran sulfate as a cofactor in mitogen-induced and antigen-induced differentiation of rat B lymphocytes. J. Immunol. 145:2427.
45. Wrenshall, L. E., F. B. Cerra, A. Carlson, F. H. Bach, and J. L. Platt. 1991. Regulation of murine splenocyte responses by heparan sulfate. J. Immunol. 147: 455.
46. Reis e Sousa, C., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R. N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin-12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819.
47. Schwarzenberger, K., and M. C. Udey. 1996. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J. Invest. Dermatol. 106:553.
48. L. J. Immunol. 157:4918.