CpG DNA Rescue of Murine B Lymphoma Cells from Anti-IgM-Induced Growth Arrest and Programmed Cell Death Is Associated with Increased Expression of c-myc and bcl-xL

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 4918-4925

  Yi, Ae Kyung ^a   Hornbeck, Peter ^c   Lafrenz, David E ^d,e   Krieg, Arthur M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Harry S Truman Memorial Veteran's Administration Hospital   (United States)

^e Lafrenz Motors   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; DNA; IMMUNOGLOBULIN M; OLIGODEOXYRIBONUCLEOTIDE;

ANIMAL; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CELL CULTURE; CELL CYCLE; CELL DIVISION; CHEMISTRY; CPG ISLAND; DRUG EFFECT; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PATHOLOGY; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; APOPTOSIS; BASE SEQUENCE; CELL CYCLE; CELL DIVISION; CPG ISLANDS; DNA; GENE EXPRESSION; GENES, BCL-2; GENES, MYC; IMMUNOGLOBULIN M; LYMPHOMA, B-CELL; MICE; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0030444050     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. DeFranco, A. L. 1987. Molecular aspects of B-lymphocyte activation. Annu. Rev. Cell Biol. 3:143.
2. Nossal, G. J., B. L. Pike, and F. L. Battye. 1979. Mechanisms of clonal abortion tolerogenesis. II. Clonal behavior of immature B cells following exposure to anti-mu chain antibody. Immunology 37:203.
3. Boyd, A. W., and J. W. Schrader. 1981. The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies. J. Immunol. 126:2466.
4. Ralph, P. 1979. Functional subsets of murine and human B lymphocyte cell lines. Immunol. Rev. 48:107.
5. Hibner, U., L. E. Benhamou, M. Haury, P.-A. Cazenave, and P. Sarthou. 1993. Signaling of programmed cell death induction in WEHI-231 B lymphoma cells. Eur. J. Immunol 23:2821.
6. Scott, D. W., J. Tuttle, D. Livnat, W. Haynes, J. Cogswell, and P. Keng. 1985. Lymphoma models for B-cell activation and tolerance. II. Growth inhibition by anti-mu of WEHI-231 and the selection of properties of resistants. Cell. Immunol. 93:124.
7. DeFranco, A. L., M. R. Gold, and J. P. Jakway. 1987. B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide. Immunol Rev. 95:161.
8. Scott, D. W., J. H. Chace, G. L. Warner, A. O'Garra, G. G. B. Klaus, and H. Quill. 1987. Role of T cell-derived lymphokines in two models of B-cell tolerance. Immunol. Rev. 99:153.
9. Page, D., and A. DeFranco. 1990. Antigen receptor induced cell cycle arrest in WEH1-231 B-lymphoma cells depends on the duration of signaling before the G, phase restriction point. Mol. Cell. Biol. 10:3003.
10. McCormack, J. E., V. H. Pepe, R. B. Kent, M. Dean, A. Marshak-Rothstein, and G. E. Sonenshein. 1984. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma. Proc. Natl. Acad Sci. USA 81:5546.
11. Cuende, E., J. E. Als-Martinez, L. Ding, M. Gonzalez-Garcia, C. Martinez-A., and G. Nunez. 1993. Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells. EMBO J. 12:1555.
12. Fischer, G., S. C. Kent, L. Joseph, D. R. Green, and D. W. Scott. 1994. Lymphoma models for B cell activation and tolerance. X. Anti-μ-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J. Exp. Med. 179:221.
13. L and CD40 in WEHI-231 cells: dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. J. Immunol. 155:3830.
14. Messina, J. P., G. S. Gilkeson, and D. S. Pisetsky. 1991. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147:1759.
15. Yamamoto, S., T. Yamamoto, S. Shimada, E. Kuramoto, O. Yano, T. Kataoka, and T. Tokunaga. 1992. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36:983.
16. Bird, A. P. 1986. CpG-rich islands and the function of DNA methylation. Nature 321:209.
17. Cardon, L. R., C. Burge, D. A. Clayton, and S. Karlin. 1994. Pervasive CpG suppression in animal mitochondrial genomes. Proc. Natl. Acad. Sci. USA 91: 3799.
18. Krieg, A. M., A.-K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Korelzky, and D. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
19. Klinman, D. M., A.-K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc. Natl. Acad. Sci. USA 93: 2879.
20. Yi, A.-K., J. H. Chace, J. S. Cowdery, and A. M. Krieg. 1996. IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol. 156:558.
21. Wang, Z., J. G. Karras, R. G. Howard, and T. L. Rothstein. 1995. Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J. Immunol. 155:3722.
22. Jakway, J. P., W. R. Usinger, M. R. Gold, R. I. Mishell, and A. L. DeFranco. 1986. Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products. J. Immunol. 137:2225.
23. Kamesaki, H., J. A. Zwiebel, J. C. Reed, and J. Cossman. 1994. Role of bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines: a cooperative regulation model for B cell deletion. J. Immunol. 152:3294.
24. McCormack, J.-E., V. H. Pepe, R. B. Kent, M. Dean, A. Marshak-Rothstein, and G. E. Sonenshein. 1984. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma. Pro. Natl. Acad. Sci. USA 81:5546.
25. Gottschalk, A. R., L. H. Boise, C. B. Thompson, and J. Quintans. 1994. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc. Natl. Acad. Sci. USA 91:7350.
26. Bissonnette, R. P., A. McGahon, A. Mahboubi, and D. R. Green. 1994. Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas. J. Exp. Med. 180:2413.
27. + T cells from young and old mice. J. Immunol. 150:3602.
28. Rajchel, A., Y. L. Chan, and I. G. Wool. 1987. The primary structure of rat ribosomal protein L32. Nucleic Acids Res. 16:2347.
29. Seyfert, V. L., S. B. McMahon, W. D. Glenn, A. J. Yellen, V. P. Sukhatme, X. Cao, and J. G. Moeroe. 1990. Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction. Science 250:797.
30. Chleq-Deschamps, C. M., D. P. LeBrun, P. Huie, D. P. Besnier, R. A. Warnke, R. K. Sibley, and M. L. Cleary. 1993. Topographical dissociation of BCL-2 messenger RNA and protein expression in human lymphoid tissues. Blood 81: 213.
31. Friedman, S. M., D. N. Posnett, J. R. Tumang, B. C. Cole, and M. K. Crow. 1991. A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease. Arthritis Rheum. 34:468.
32. Murakami, M., T. Tsubata, R. Shinkura, S. Nisitani, M. Okamoto, H. Yoshioka, T. Usui, S. Miyawaki, and T. Honjo. 1994. Oral administration of lipopolysaccharides activates B-a cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med. 180:111.
33. Evan, G. J., A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-Myc protein. Cell 69:119.
34. Kimura, S., T. Maekawa, K. Hirakawa, A. Murakami, and T. Abe. Alterations of c-myc expression by antisense oligodeoxynucleotides enhance the induction of apoptosis in HL-60 cells. Cancer Res. 55:1379.
35. Kohlhuber, F., H. Hermeking, A, Graessmann, and D. Eick. 1995. Induction of apoptosis by the c-Myc helix-loop-helix/leucine zipper domain in mouse 3T3-L1 fibroblasts. J. Biol. Chem. 270:28797.
36. Amati, B., S. Dalton, M. W. Brooks, T. D. Littlewood, G. I. Evan, and H. Land. 1992. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature 359:423.
37. Kretzner, L., E. M. Blackwood, and R. N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature 359:426.
38. Classon, M., M. Henriksson, J. Sumegi, G. Klein, and M.-L. Hammaskjold. 1987. Elevated c-myc expression facilitates the replication of SV40 DNA in human lymphoma cells. Nature 330:272.
39. Iguchi-Ariga, S. M. M., T. Itani, Y. Kiji, and H. Ariga. 1987. Possible function of the c-myc product: promotion of cellular DNA replication. EMBO J. 6:2365.
40. Rustgi, A. K., N. Dyson, and R. Bernards. 1991. Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product. Nature 352:541.
41. Blackwell, T. K., L. Kretzner, E. M. Blackwood, R. N. Eisenman, and H. Weintraub. 1990. Sequence-specific DNA binding by the c-Myc protein. Science 250:1149.
42. Bissonnette, R. P., F. Echeverri, A. Mahboubi, and D. R. Green. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552.
43. Fanidi, A., E. A. Harrington, and G. I. Evan. 1992. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359:554.
44. Wagner, A. J., M. B. Small, and N. Hay. 1993. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol. Cell. Biol. 13:2432.
45. Nunez, G., M. Seto, S. Seremetis, D. Ferrero, F. Grignani, S. J. Korsmeyer, and R. Dalla-Favera. 1989. Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 86:4589.
46. Reed, J. C., M. Cuddy, S. Haldar, C. Croce, P. Nowell, D. Makover, and K. Bradley. 1990. BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition of BCL2 antisense. Proc. Natl. Acad. Sci. USA 87:3660.
47. Strasser, A., A. W. Harris, M. L. Bath, and S. Cory. 1990. Novel primitive lymphoid tumorous induced in transgenic mice by cooperation between myc and bcl-2. Nature 348:331.
48. L rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J. Immunol. 155:66.
49. L in CD40-mediated rescue from anti-mu-induced apoptosis in WEHI-231 B lymphoma cells. Eur. J. Immunol 25:1352.