메뉴 건너뛰기




Volumn 287, Issue 5462, 2000, Pages 2501-2503

T cell-independent rescue of B lymphocytes from peripheral immune tolerance

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; EPITOPE; IMMUNOGLOBULIN;

EID: 0034737645     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5462.2501     Document Type: Article
Times cited : (54)

References (51)
  • 2
    • 0025108875 scopus 로고
    • N. Sarvetnick et al., Nature 346, 844 (1990); D. Gu et al., J. Exp. Med. 181, 547 (1995); W. R. Heath et al., Nature 359, 547 (1992).
    • (1990) Nature , vol.346 , pp. 844
    • Sarvetnick, N.1
  • 3
    • 0028906589 scopus 로고
    • N. Sarvetnick et al., Nature 346, 844 (1990); D. Gu et al., J. Exp. Med. 181, 547 (1995); W. R. Heath et al., Nature 359, 547 (1992).
    • (1995) J. Exp. Med. , vol.181 , pp. 547
    • Gu, D.1
  • 4
    • 0026688158 scopus 로고
    • N. Sarvetnick et al., Nature 346, 844 (1990); D. Gu et al., J. Exp. Med. 181, 547 (1995); W. R. Heath et al., Nature 359, 547 (1992).
    • (1992) Nature , vol.359 , pp. 547
    • Heath, W.R.1
  • 5
    • 0023651203 scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1987) Cell , vol.50 , pp. 819
    • Oldstone, M.B.A.1
  • 6
    • 0028926223 scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1995) Cell , vol.80 , pp. 695
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 7
    • 0030796646 scopus 로고    scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1997) Nature Med. , vol.3 , pp. 1133
    • Miller, S.D.1
  • 8
    • 0026664422 scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1992) Nature , vol.358 , pp. 155
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 9
    • 0029000750 scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1995) J. Exp. Med. , vol.182 , pp. 75
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal, C.M.3    Miller, S.D.4
  • 10
    • 0029665310 scopus 로고    scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1996) Immunol Rev. , vol.150 , pp. 129
    • Tough, D.F.1    Sprent, J.2
  • 11
    • 0029975898 scopus 로고    scopus 로고
    • M. B. A. Oldstone, Cell 50, 819 (1987); K. W. Wucherpfennig and J. L. Strominger, Cell 80, 695 (1995); S. D. Miller et al., Nature Med. 3, 1133 (1997); P. V. Lehmann, T. Forsthuber, A. Miller, E. E. Sercarz, Nature 358, 155 (1992); B. L. McRae, C. L. Vanderlugt, C. M. Dal, S. D. Miller, J. Exp. Med. 182, 75 (1995); D. F. Tough and J. Sprent, Immunol Rev. 150, 129 (1996); M. Yu, J. M. Johnson, V. K. Tuohy, J. Exp. Med. 183, 1777 (1996)
    • (1996) J. Exp. Med. , vol.183 , pp. 1777
    • Yu, M.1    Johnson, J.M.2    Tuohy, V.K.3
  • 12
    • 0025755292 scopus 로고
    • P. S. Ohashi et al., Cell 65, 305 (1991); A. J. Caton, J. R. Swartzentruber, A. L. Kuhl, S. R. Carding, S. E. Stark, J. Exp. Med. 183, 13 (1996).
    • (1991) Cell , vol.65 , pp. 305
    • Ohashi, P.S.1
  • 17
    • 0020639832 scopus 로고
    • L. Hang et al., J. Exp. Med. 157, 874 (1983); M. G. McHeyzer-Williams and G. J. V. Nossal, J. Immunol. 41, 4118 (1988); M. Rocken, J. F. Urban, E. M. Shevach, Nature 359, 79 (1992).
    • (1983) J. Exp. Med. , vol.157 , pp. 874
    • Hang, L.1
  • 18
    • 0024260057 scopus 로고
    • L. Hang et al., J. Exp. Med. 157, 874 (1983); M. G. McHeyzer-Williams and G. J. V. Nossal, J. Immunol. 41, 4118 (1988); M. Rocken, J. F. Urban, E. M. Shevach, Nature 359, 79 (1992).
    • (1988) J. Immunol. , vol.41 , pp. 4118
    • McHeyzer-Williams, M.G.1    Nossal, G.J.V.2
  • 19
    • 0026775464 scopus 로고
    • L. Hang et al., J. Exp. Med. 157, 874 (1983); M. G. McHeyzer-Williams and G. J. V. Nossal, J. Immunol. 41, 4118 (1988); M. Rocken, J. F. Urban, E. M. Shevach, Nature 359, 79 (1992).
    • (1992) Nature , vol.359 , pp. 79
    • Rocken, M.1    Urban, J.F.2    Shevach, E.M.3
  • 21
    • 0030008694 scopus 로고    scopus 로고
    • D. A. Fulcher et al., J. Exp. Med. 183, 2313 (1996); M. P. Cooke et al., J. Exp. Med. 179, 425 (1994).
    • (1996) J. Exp. Med. , vol.183 , pp. 2313
    • Fulcher, D.A.1
  • 22
    • 0028127965 scopus 로고
    • D. A. Fulcher et al., J. Exp. Med. 183, 2313 (1996); M. P. Cooke et al., J. Exp. Med. 179, 425 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 425
    • Cooke, M.P.1
  • 27
    • 0026041119 scopus 로고
    • D. M. Russell et al., Nature 354, 308 (1991).
    • (1991) Nature , vol.354 , pp. 308
    • Russell, D.M.1
  • 29
    • 0342334934 scopus 로고    scopus 로고
    • note
    • To generate nondeleting mice (3-83 ND mice), we backcrossed 3-83 transgenic mice (13), which express IgM and IgD forms of the 3-83 antibody, a minimum of 10 times onto a B10,D2nSn/J background.
  • 32
    • 0342334932 scopus 로고    scopus 로고
    • note
    • b double Tg mice presented a peripheral deletion phonotype similar to those described using 3-83 mice crossed to mice expressing Kb in the liver under the control of the sheep metallothionein promoter (13).
  • 33
    • 0032547805 scopus 로고    scopus 로고
    • V. Kouskoff et al., J. Exp. Med. 188, 1453 (1998); V. Kouskoff et al., unpublished data.
    • (1998) J. Exp. Med. , vol.188 , pp. 1453
    • Kouskoff, V.1
  • 34
    • 0032547805 scopus 로고    scopus 로고
    • unpublished data
    • V. Kouskoff et al., J. Exp. Med. 188, 1453 (1998); V. Kouskoff et al., unpublished data.
    • Kouskoff, V.1
  • 35
    • 0343640099 scopus 로고    scopus 로고
    • note
    • Phage was purified as described (19), and mice were immunized with 300 μg of phage intraperitoneally (ip) at day 0. Anti-IL-7 (IM25) was prepared and used as described (30). Anti-CD4 (GK1.5) was obtained from ascites and injected at a dose of 0.5 mg per mouse per day. Analysis of 3-83 in the sera was performed using plates coated with rat 3-83 idiotypic antibody (54.1) at 5 μg/ml, as described (19).
  • 36
    • 0028931102 scopus 로고    scopus 로고
    • A. M. Krieg et al., Nature 374, 546 (1995); V. Kouskoff, A. Krieg, D. Nemazee, unpublished data.
    • (1995) Nature , vol.374 , pp. 546
    • Krieg, A.M.1
  • 38
    • 0343204522 scopus 로고    scopus 로고
    • note
    • 3. The following antibody reagents were used: mouse anti-IgM conjugated with fluorescein isothiocyanate (FITC) (Zymed), mouse anti-B220 conjugated with phycoerythrin (PE) (Caltag), mouse anti-CD8 conjugated with FITC, and mouse anti-CD4 conjugated with PE (Pharmingen). Flow cytometric analysis was done with a FacScan (Becton Dickinson) and the data were analyzed by Cell Quest software.
  • 39
    • 0343204523 scopus 로고    scopus 로고
    • note
    • Spleens were flash-frozen in O.C.T. embedding medium (Miles), and 6-μm sections were cut and fixed in acetone. Serial sections were blocked for 10 min with PBS and 10% fetal calf serum, incubated with 2.4G2 culture supernatant for 30 min, then stained for 30 min with PE-labeled anti-B220 and FITC-labeled IgM, idiotype, or isotype control monoclonal antibodies.
  • 40
    • 0342769836 scopus 로고    scopus 로고
    • unpublished data
    • Plasma transaminase levels were analyzed at days 0, 4, and 8 after immunization and were not altered in a comparison of three PBS-injected, five Pwt-injected, and four P31-immunized PD mice (V. Kouskoff, unpublished data).
    • Kouskoff, V.1
  • 44
    • 0025674112 scopus 로고
    • C. Leclerc, A. Charbit, P. Martineau, E. Deriaud, M. Hofnung, J. Immunol. 147, 3545 (1991); S. X. Qin et al., Eur. J. Immunol. 20, 2737 (1990); F. S. Jin et al., J. Immunol. 146, 1806 (1991).
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2737
    • Qin, S.X.1
  • 45
    • 0025852415 scopus 로고
    • C. Leclerc, A. Charbit, P. Martineau, E. Deriaud, M. Hofnung, J. Immunol. 147, 3545 (1991); S. X. Qin et al., Eur. J. Immunol. 20, 2737 (1990); F. S. Jin et al., J. Immunol. 146, 1806 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 1806
    • Jin, F.S.1
  • 48
    • 0033605250 scopus 로고    scopus 로고
    • K. Bachmaier et al., Science 283, 1335 (1999); Z.-S. Zhao, F. Granucci, L. Yeh, P. A. Schaffer, H. Cantor, Science 279, 1344 (1998).
    • (1999) Science , vol.283 , pp. 1335
    • Bachmaier, K.1
  • 51
    • 0342769834 scopus 로고    scopus 로고
    • note
    • b mice.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.