Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines

Immunology

Volumn 101, Issue 1, 2000, Pages 46-52

  Lipford, G B ^a   Bendigs, S ^a   Heeg, K ^b   Wagner, H ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTIDINE; CYTOKINE; DNA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GUANOSINE; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTING CELL; ARTICLE; ESCHERICHIA COLI; HOST RESISTANCE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMAL; ANTIGEN-PRESENTING CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL CULTURE; CELL DIVISION; CELL LINE; CYTIDINE; CYTOKINES; DNA, BACTERIAL; FEMALE; GUANOSINE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; POLY G; SUPPORT, NON-U.S. GOV'T;

EID: 0033806950     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00077.x     Document Type: Article

References (43)

1. Dendritic cells and the control of immunity
2. Innate immunity: The virtues of a nonclonal system of recognition
3. C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
4. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
5. Phylogenetic perspectives in innate immunity
6. Bacterial modulins: A novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis
7. Innate immunity: Impact on the adaptive immune response
8. Bacterial CpG DNA activates immune cells to signal infectious danger
9. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
10. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
11. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
12. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
13. Immune cell activation by bacterial CpG-DNA through MyD88 and TRAF6
14. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
15. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
16. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
17. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses
18. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
19. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
20. CpG motifs in bacterial DNA trigger direct B-cell activation
21. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
22. CpG-oligodeoxynucleotides costimulate primary T cells in the absence of APC
23. Type I interferon-mediated stimulation oft cells by CpG DNA
24. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
25. Alterations in the amino-terminal third of mouse interleukin 2: Effects on biological activity and immunoreactivity
26. Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite
27. Immunostimulatory DNA sequence-dependent production of potentially harmful or useful cytokines
28. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
29. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
30. + T cells in vivo by IL-15
31. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
32. Polynucleotide binding to macrophage scavenger receptors depends on the formation of basequartet-stabilized four-stranded helices
33. Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN
34. Stimulation of macrophage DNA synthesis by polyanionic substances through binding to the macrophage scavenger receptor
35. Guanosinerich oligonucleotides induce proliferation of macrophage progenitors in cultures of murine bone marrow cells
36. Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein
37. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
38. Antigen-mediated IGE receptor aggregation and signaling: A window on cell surface structure and dynamics
39. The unique domain as the site or Lyn kinase for its constitutive association with the high affinity receptor for IgE
40. Molecular flypaper and atherosclerosis: Structure of the macrophage scavenger receptor
41. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
42. Activation of human B cells by phosphorothioate oligodeoxynucleotides
43. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs