Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases

European Journal of Biochemistry

Volumn 243, Issue 1-2, 1997, Pages 10-20

  Exton, John H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Guanine nucleotide binding regulatory protein; Inositol phospholipids; Phosphatidylcholine; Protein kinase C

Indexed keywords

DIACYLGLYCEROL; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; ISOENZYME; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN TYROSINE KINASE;

BRAIN; ENZYME ACTIVATION; HISTOCHEMISTRY; HUMAN; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; REVIEW; SIGNAL TRANSDUCTION; TISSUE;

EID: 0031026288     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.t01-1-00010.x     Document Type: Review

References (112)

1. Berridge, M. J. (1984) Inositol trisphosphate and diacylglycerol as second messengers, Biochem. J. 220, 345-360.
2. Exton, J. H. (1996) Regulation of phosphoinositide phospholipase by hormones, neurotransmitters and other agonists linked to G-proteins, Annu. Rev. Pharmacol. Toxicol. 36, 481-509.
3. 2 hydrolysis and regulation of phospholipase C isozymes. Curr. Opin. Cell Biol. 7, 183-189.
4. Exton, J. H. (1994) Phosphatidylcholine breakdown and signal transduction, Biochim. Biophys. Acta 1212, 26-42.
5. 2, J. Lipid Mediat. & Cell Signal. 12, 83-117.
6. Rhee, S. G. & Choi, K. D. (1992) Regulation of inositol phospholipid-specific phospholipase C isozymes, J. Biol. Chem. 267, 12393-12396.
7. 1. Catalytic and membrane binding properties, J. Biol. Chem. 268, 11586-11593.
8. Essen, L.-O., Perisic, O., Cheung, R., Katan, M. & Williams, R. L. (1996) Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ, Nature 380, 595-602.
9. 1 for enzyme activity, Eur. J. Biochem. 213, 339-347.
10. Nakashima, S., Banno, Y., Watanabe, T., Nakamura, Y., Mizutani, T., Sakai, H., Zhao, Y., Sugimoto, Y. & Nozawa, Y. (1995) Deletion and site-directed mutagenesis of EF-hand domain of phospholipase C-δ1: effects on its activity, Biochem. Biophys. Res. Commun. 211, 364-369.
11. 1, J. Biol. Chem. 269, 20179-20188.
12. Cockcroft, S. & Thomas, G. M. H. (1992) Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors, Biochem. J. 288, 1-14.
13. 2, Cell 83, 1047-1058.
14. Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E. & Sigler, P. B. (1996) The 2.0 Å crystal structure of a heterotrimeric G protein, Nature 379, 311-319.
15. Sondek, J., Bohm, A., Lambright, D. G., Hamm, H. E. & Sigler, P. B. (1996) Crystal structure of a Gα protein βγ dimer at 2.1 Å resolution, Nature 379, 369-374.
16. Noel, J. P., Hamm, H. E. & Sigler, P. B. (1993) The 2.2 Å crystal structure of transducin-α complexed with GTPγS, Nature 366, 654-663.
17. iα1 and the mechanism of GTP hydrolysis, Science 265, 1405-1412.
18. Gudermann, T., Kalkbrenner, F. & Schultz, G. (1996) Diversity and selectivity of receptor-G protein interaction, Annu. Rev. Pharmacol. Toxicol. 36, 429-459.
19. Savarese, T. M. & Fraser, C. M. (1992) In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors, Biochem. J. 283, 1-19.
20. Wess, J. (1993) Mutational analysis of muscarinic acetylcholine receptors: structural basis of ligand/receptor/G protein interactions, Life Sci. 53, 1447-1463.
21. Strader, C. D., Fong, T. M., Graziano, M. P. & Tota, M. R. (1995) The family of G-protein-coupled receptors, FASEB J. 9, 745-754.
22. Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994) Structural determinants for activation of the α-subunit of a heterotrimeric G protein, Nature 369, 621-628.
23. Rens-Domiano, S. & Hamm, H. E. (1995) Structural and functional relationships of heterotrimeric G-proteins, FASEB J. 9, 1059-1066.
24. Strathmann, M. & Simon, M. I. (1990) G protein diversity: a distinct class of a subunits is present in vertebrates and invertebrates. Proc. Natl Acad. Sci. USA 87, 9113-9117.
25. Simon, M. I., Strathmann, M. P. & Gautam, N. (1991) Diversity of G proteins in signal transduction, Science 252, 802-808.
26. q, Science 251, 9667-9674.
27. q class of G proteins, Nature 350, 516-518.
28. 2+ release in Xenopus oocytes, J. Biol. Chem. 270, 30068-30074.
29. q, J. Biol. Chem. 268, 3704-3709.
30. Park, D., Jhon, D.-Y., Lee, C.-W., Ryu, S.-H. & Rhee, S. G. (1993) Removal of the carboxyl-terminal region of phospholipase C-β1 by calpain abolishes activation by Gαq, J. Biol. Chem. 268, 3710-3714.
31. q required for phospholipase C activation, J. Biol Chem. 271, 5066-5072.
32. αq interacting with PLCβ1 using multiple overlapping synthetic peptides, FEBS Lett. 364, 45-50.
33. Camps, M., Hou, C., Sidiropoulos, D., Stock, J. B., Jakobs, K. H. & Gierschik, P. (1992) Stimulation of phospholipase C by guanine-nucleotide-binding protein βγ subunits. Eur. J. Biochem. 206, 821-831.
34. q, J. Biol. Chem. 269, 25335-25338.
35. Jiang, H., Wu, D. & Simon, M. I. (1994) Activation of phospholipase C β4 by helerotrimeric GTP-binding proteins, J. Biol. Chem. 269, 7593-7596.
36. 2 region that intercts with Gβγ, Proc. Natl Acad. Sci. USA 93, 2964-2968.
37. Ueda, N., Iniguez-Lluhi, J. A., Lee, E., Smrcka, A. V., Robishaw, J. D. & Gilman, A. G. (1994) G protein βγ subunits. Simplified purification and properties of novel isoforms, J. Biol. Chem. 269, 4388-4395.
38. Clapham, D. E. & Neer, E. J. (1993) New roles for G-protein βγ-dimers in transmembrane signalling, Nature 365, 403-406.
39. Sternweis, P. C. (1994) The active role of βγ in signal transduction, Curr. Opin. Cell Biol. 6, 198-203.
40. Sternweis, P. C. & Robishaw, J. D. (1984) Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain, J. Biol. Chem. 259, 13806-13813.
41. Hepler, J. R. & Gilman, A. G. (1992) G proteins, Trends Biochem. Sci. 17, 383-387.
42. α, Proc. Natl Acad. Sci. USA 87, 6477-6481.
43. Neubig, R. R. (1994) Membrane organization in G-protein mechanisms, FASEB J. 8, 939-946.
44. Rhee, S. G., Kim, H., Suy, P.-G. & Choi, W. C. (1991) Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation, Biochem. Soc. Trans. 19, 337-341.
45. q-dependent activation of phospholipase C-β3, J. Biol. Chem. 268, 6654-6661.
46. q-independent activation of phospholipase C-β2, J. Biol. Chem. 267, 16048-16055.
47. Lee, C.-W., Park, D. J., Lee, K.-H., Kim, C. G. & Rhee, S. G. (1993) Purification, molecular cloning, and sequencing of phospholipase C-β4, J. Biol. Chem. 268, 21318-21327.
48. Wang, H. Y., Berrios, M. & Malbon, C. C. (1989) Indirect immunoflourescence localization of β-adrenergic receptors and G-proteins in human A431 cells. Biochem. J. 263, 519-532.
49. 2A adrenergic receptors achieve basolateral localization, J. Biol. Chem. 271, 995-1002.
50. 2-adrenergic receptor subtypes achieve basolateral localization in Madin-Darby canine kidney II cells via different targeting mechanisms, J. Biol. Chem. 271, 5017-5024.
51. Denker, S. P., McCaffery, J. M., Palade, G. E., Insel, P. A. & Farquhar, M. G. (1996) Differential distribution of α subunits and βγ subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas, J. Cell Biol. 133, 1027-1040.
52. Kleuss, C., Hescheler, J., Ewel, J., Rosenthal, W., Schultz, G. & Wittig, B. (1991) Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents, Nature 353, 43-48.
53. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G. & Wittig, B. (1992) Different β-subunits determine G-protein interaction with transmembrane receptors. Nature 358, 424-426.
54. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G. & Wittig, B. (1993) Selectivity of signal transduction determined by 7 subunits of heterotrimeric G proteins, Science 259, 832-834.
55. α proteins functionally coupling galanin receptors to voltage-gated calcium channels, EMBO J. 14, 4728-4737.
56. Dippel, E., Kalkbrenner, F., Wittig, B. & Schultz, G. (1996) A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholpase C-β, Proc. Natl Acad. Sci. USA 93, 1391-1396.
57. Exton, J. H. (1997) Phospholipase D, Physiol. Rev., in the press.
58. Hammond, S. M., Altshuller, Y. M., Sung, T.-C., Rudge, S. A., Rose, K., Engebrecht, J. A., Morris, A. J. & Frohman, M. A. (1995) Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family, J. Biol. Chem. 270, 29640-29643.
59. Provost, J. J., Fudge. J., Israelit, S., Siddiqi, A. R. & Exton, J. H. (1996) Tissue specific distribution and subcellular distribution of phospholipase D in rat. Evidence for distinct RhoA- and ARF-regulated isozymes, Biochem. J., in the press.
60. Balboa, M. A., Balsinde, J., Dennis, H. A. & Insel, P. A. (1995) A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells, J. Biol. Chem. 270, 11738-11749.
61. Vinggaard, A. M., Provost, J. J., Exton, J. H. & Hansen, H. S. (1997) Arf and RhoA regulate both the cytosolic and the membrane-bound phospholpase D from human placenta, Cell. Signalling, in the press.
62. Ktistakis, N. T., Brown, H. A., Sternweis, P. C. & Roth, M. G. (1995) Phospholipase D is present on Golgi-enriched membranes and its activation by ADP-ribosylation factor is sensitive to brefeldin A, Proc. Natl Acad. Sci. USA 92, 4952-4956.
63. Taki, T. & Kanter, J. N. (1979) Partial purification and properties of a rat brain phospholipase D, J. Biol Chem. 254, 9761-9765.
64. Okamura, S.-L. & Yamashita, S. (1994) Purification and characterization of phosphatidylcholine phospholipase D from pig lung, J. Biol. Chem. 269, 31207-31213.
65. Malcolm, K. C., Ross, A. H., Qiu, R.-G., Symons, M. & Exton, J. H. (1994) Activation of rat liver phospholipase D by the small GTP binding protein rhoA, J. Biol. Chem. 269, 25951-25954.
66. Siddiqi, A. R., Smith, J. L., Ross, A. H., Qiu, R.-G., Symons, M. & Exton, J. H. (1995) Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D, J. Biol. Chem. 270, 8466-8473.
67. Brown, H. A., Gutowski, S., Kahn, R. A. & Sternweis, P. C. (1995) Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain, J. Biol. Chem. 270, 14935-14943.
68. Massenburg, D., Han, J.-S., Liyanage, M., Patton, W. A., Rhee, S. G., Moss, J. & Vaughan, M. (1994) Activation of rat brain phospholipase D by ADP-ribosylation factors 1, 5, and 6; separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes, Proc. Natl Acad. Sci. USA 91, 11718-11722.
69. Nakamura, S.-I., Kiyohara, Y., Jinnai, H., Hitomi, T., Ogino, C., Yoshida, K. & Nishizuka, Y. (1996) Mammalian phospholipase D: phosphatidylethanolamine as an essential component, Proc. Natl Acad. Sci. USA 93, 4300-4304.
70. Kanter, J. N., McCartney, D. G., Singh, I. N. & Freysz, L. (1996) Acidic phospholipids inhibit the phospholipase D activity of rat brain neuronal nuclei, FEBS Lett. 383, 6-8.
71. Exton, J. H. (1990) Signaling through phosphatidylcholine breakdown, J. Biol. Chem. 265, 1-4.
72. Eldar, H., Ben-Av, P., Schmidt, U.-S., Livneh, E. & Liscovitch, M. (1993) Upregulation of phospholipase D activity induced by overexpression of protein kinase C-α. Studies in intact Swiss/ 3T3 cells and in detergent-solubilized membranes in vitro. J. Biol. Chem. 268, 12560-12564.
73. Pachter, J. A., Pai, J.-K., Mayer-Ezell, R., Petrin, J. M., Dobek, E. & Bishop, W. R. (1992) Differential regulation of phosphoinositide and phosphatildylcholine hydrolysis by protein kinase C-β1 overexpression. Effects on stimulation by α-thrombin, guanosine 5′-O-(thiotriphosphate). and calcium, J. Biol. Chem. 267, 9826-9830.
74. β1. Cell Regul. 2, 897-903.
75. 2. J. Biol. Chem. 269, 10511-10516.
76. Yeo, E.-J. & Exton, J. H. (1995) Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells, J. Biol. Chem. 270, 3980-3988.
77. 76a. Lee, Y. H., Kim, H. S., Pai, J.-K., Ryu, S. H. & Suh, P.-G. (1994) Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-γ1, J. Biol. Chem. 269, 26842-26847.
78. Conricode, K. M., Brewer, K. A. & Exton, J. H. (1992) Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism, J. Biol. Chem. 267, 7199-7202.
79. Conricode, K. M., Smith, J. L., Burns, D. J. & Exton, J. H. (1994) Phospholipase D activation in fibroblast membranes by the α and β isoforms of protein kinase C, FEBS Lett. 342, 149-153.
80. Singer, W. D., Brown, H. A., Jiang, X. & Sternweis, P. C. (1996) Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity, J. Biol. Chem. 271, 4504-4510.
81. Ohguchi, K., Banno, Y., Nakashima, S. & Nozawa, Y. (1996) Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA, J. Biol. Chem. 271, 4366-4372.
82. Moss, J. & Vaughan, M. (1995) Structure and function of ARF proteins: activators of cholera toxin and critical components of intracellular vesicular transport processes. J. Biol. Chem. 270, 12327-12330.
83. Brown, H. A., Gutowski, S., Moomaw, C. R., Slaughter, C. & Sternweis, P. C. (1993) ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity, Cell 75, 1137-1144.
84. Cockcroft, S., Thomas, G. M. H., Fensome, A., Geny, B., Cunningham, E., Gout, I., Hiles, I., Totty, N. F., Truong, O. & Hsuan, J. J. (1994) Phospholipase D: a downstream effector of ARF in granulocytes, Science 263, 523-526.
85. Bourgoin, S., Harbour, D., Desmarais, Y., Takai, Y. & Beaulieu, A. (1995) Low molecular mass GTP-binding proteins in HL-60 granulocytes. Assessment of the role of ARF and of a 50-kDa cytosolic protein in phospholipase D activation, J. Biol. Chem. 270, 3172-3178.
86. Lambeth, J. D., Kwak, J.-Y., Bowman, E. P., Perry, D., Uhlinger, D. J. & Lopez, I. (1995) ADP-ribosylation factor functions synergistically with a 50 kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D, J. Biol. Chem. 270, 2431-2434.
87. Houle, M. G., Kahn, R. A., Naccache, P. H. & Bourgoin, S. (1995) ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells, J. Biol. Chem. 270, 22795-22800.
88. Rümenapp, U., Geiszt, M., Wahn, F., Schmidt, M. & Jakobs, K. H. (1995) Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor, Eur. J. Biochem. 234, 240-244.
89. Donaldson, J. G., Dinazzi, D. & Klausner, R. D. (1992) Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein, Nature 360, 350-352.
90. Helms, J. B. & Rothman, J. E. (1992) Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF, Nature 360, 352-354.
91. Symons, M. (1996) Rho family GTPases: the cytoskeleton and beyond. Trends Biochem. Sci. 21, 178-181.
92. Nobes, C. D. & Hall, A. (1995) Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell 81, 53-62.
93. Ridley, A. J. & Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
94. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diegmann, D. & Hall, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell 70, 401-410.
95. Kozma, R., Ahmed, S., Best, A. & Lim, L. (1995) The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts, Mol. Cell. Biol. 15, 1942-1952.
96. Qiu, R.-G., Chen, J., Korn, D., McCormick, F. & Symons, M. (1995) An essential role for Rac in Ras transformation, Nature 374, 457-459.
97. Qiu, R.-G., Chen, J., McCormick, F. & Symons, M. (1995) A role for Rho in Ras transformation, Proc. Natl Acad. Sci. USA 92, 11781-11785.
98. Prendergast, G. C., Khosravi-Far, R., Solski, P. A., Kurzawa, H., Lebowitz, P. F. & Der, C. J. (1995) Critical role of Rho in cell transformation by oncogenic Rac, Oncogene 10, 2289-2296.
99. Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S. & Der, C. J. (1995) Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation, Mol. Cell. Biol. 15, 6443-6453.
100. 1, Science 269, 1270-1272.
101. Bowman, E. P., Uhlinger, D. J. & Lambeth, J. D. (1993) Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular mass GTP-binding protein, J. Biol. Chem. 268, 21509-21512.
102. Kwak, J.-Y., Lopez, I., Uhlinger, D. J., Ryu, S. Y. & Lambeth, J. D. (1995) RhoA and a cytosolic 50-kDa factor reconstitute GTPγS-dependent phospholipase D activity in human neutrophil subcellular fractions, J. Biol. Chem. 270, 27093-27098.
103. Ohguchi, K., Banno, Y. Nakashima, S. & Nozawa, Y. (1995) Activation of membrane-hound phospholipase D by protein kinase C in HL60 cells: synergistic action of a small GTP-binding protein RhoA. Biochem. Biophys. Res. Commun. 211, 306-311.
104. Balboa, M. A. & Insel, P. A. (1995) Nuclear phospholipase D in Madin-Darby canine kidney cells. Guanosine 5′-O-(thiolriphosphate)-stimulated activation is mediated by RhoA and is downstream of protein kinase C, J. Biol. Chem. 270, 29843-29847.
105. Kuribara, H., Tago, K., Yokozeki, T., Sasaki, T., Takai, Y., Morii, N., Narumiya, S., Katada, T. & Kanaho, Y. (1995) Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by Clostridium botulinum C3 exoenzyme, J. Biol. Chem. 270, 25667-25671.
106. Martin, A., Brown, F. D., Hodgkin, M. N., Brudwell, A. J., Cook, S. J., Hart, M. & Wakelam, M. J. O. (1996) Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho, J. Biol. Chem. 271, 17397-17403.
107. Fleming, I. N. & Exton, J. H. (1996) Differential translocation of Rho-family GTPases by lysophosphatidic acid, ebdothelin-1 and platelet-derived growth factor, J. Biol. Chem., in the press.
108. Shimooku, K., Akisue, T., Jinnai, H., Hitomi, T., Ogino, C., Yoshida, K., Nakamura, S.-I. & Nishizuka, Y. (1996) Reconstitution of GTP-γ-S-dependent phospholipase D activity with ARF, RhoA, and a soluble 36-kDa protein, FEBS Lett. 387, 141-144.
109. Schmidt, M., Rümenapp, U., Bienek, C., Keller, J., von Eichel-Streiber, C. & Jakobs, K. H. (1996) Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins, J. Biol. Chem. 271, 2422-2426.
110. Martin, T. W., Feldman, D. R., Goldstein, K. E. & Wagner, J. R. (1989) Long-term phorbol ester treatment dissociates phospholipase D activation from phosphoinositide hydrolysis and prostacyclin synthesis in endothelial cells stimulated with bradykinin, Biochem. Biophys. Res. Commun. 165, 319-326.
111. 109a. Malcolm, K. C., Elliott, C. M. & Exton, J. H. (1996) Evidence for Rho-mediated agonist stimulation of phospholipase D in Rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme, J. Biol. Chem. 271, 13135-13139.
112. Hess, J. A., Ross, A. H., Qiu, R.-G., Symons, M. & Exton, J. H. (1997) Role of Rho family proteins in phospholipase D activation by growth factors, J. Biol. Chem., in the press.