Inhibition of phosphoinositide hydrolysis and cell growth of Swiss 3T3 cells by myristoylated phospholipase C inhibitor peptides

Journal of Biochemistry

Volumn 122, Issue 4, 1997, Pages 738-742

  Komma, Miwako K ^a   Yamasaki, Motoo ^b   Ohmi, Shinobu ^c   Homma, Yoshimi ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cell growth; Inhibitor; Receptor; Second messenger; Synthetic peptide

Indexed keywords

BOMBESIN; EPIDERMAL GROWTH FACTOR; PHENYLALANINE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PLATELET DERIVED GROWTH FACTOR; SYNTHETIC PEPTIDE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL STRAIN 3T3; HYDROLYSIS; MITOSIS INHIBITION; MOUSE; MYRISTYLATION; NONHUMAN; SERUM;

ANIMALIA;

EID: 0030666620     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021817     Document Type: Article

References (17)

1. Berridge, M.J. and Irvine, R.F. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315-321
2. Nishizuka, Y. (1984) Turnover of inositol phospholipids and signal transduction. Science 225, 1365-1370
3. Berridge, M.J. (1993) Inositol phosphate and calcium signalling. Nature 361, 315-325
4. Rhee, S.G. and Choi, K.D. (1992) Multiple forms of phospholipase C isozymes and their activation mechanisms. Adv. Second Messenger Phosphoprotein Res. 26, 35-61
5. Emori, Y., Homma, Y., Sorimachi, H., Kawasaki, H., Nakanishi, O., Suzuki, K., and Takenawa, T. (1989) A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. J. Biol. Chem. 264, 21885-21890
6. Homma, Y., Emori, Y., and Takenawa, T. (1992) Isolation and characterization of rat 3Y1 fibroblast clones overexpressing the src homology region of phospholipase C-γ2. J. Biol. Chem. 267, 3778-3782
7. Sieh, M., Batzer, A., Schlessinger, J., and Weiss, A. (1994) Grb2 and phospholipase C-γ associate with a 36-to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol. Cell. Biol. 14, 4435-4442
8. Maa, M.-C., Leu, T.-H., Trandel, B.J., Chang, J.-H., and Persons, S.H. (1994) A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase Cγ. Mol. Cell. Biol. 14, 5466-5473
9. Seedorf, K., Kostka, G., Lammers, R., Baskin, P., Daly, R., Burgess, W.H., van der Bliek, A., Schlessinger, J., and Ullrich, A. (1994) Dynamin binds to SH3 domains of phospholipase Cγ. J. Biol. Chem. 269, 16009-16014
10. Homma, Y. and Takenawa, T. (1992) Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-γ on the catalytic activity of phospholipase C isoforms. J. Biol. Chem. 267, 21844-21849
11. Homma, Y. (1993) Suppression of membrane phospholipase C activity by synthetic autoinhibitor peptides. Methods: Companion Methods Enzymol. 5, 229-232
12. Eichholtz, T., deBont, D.B.A., de Widt, J., Liskamp, R.M.J., and Ploegh, H.L. (1993) A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J. Biol. Chem. 268, 1982-1986
13. O'Brian, C.A., Ward, N.E., Liskamp, R.M.J., de Bont, K.B., and van Boom, J.H. (1990) N-Myristyl-Lys-Arg-The-Leu-Arg: a novel protein kinase C inhibitor. Biochem. Pharmacol. 39, 49-57
14. Ioannides, C.G., Freedman, R.S., Liskamp, R.M., Ward, N.E., and O'Brian, C. A. (1990) Inhibition of IL-2 receptor induction in the human leukemic cell line Jarkat by a novel peptide inhibitor of protein kinase C. Cell. Immunol. 131, 242-252
15. O'Brian, C.A., Ward, N.E., Liskamp, R.M., de Bont, D.B., Earnest, L.E., van Boom, J.H., and Fan, D. (1991) A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin. Invest. New Drugs 9, 169-179
16. Bleasdale, J.E., Thakur, N.R., Gremban, R.S., Bundy, G.L., Fitzpatrick, F.A., Smith, R.J., and Bunting, S. (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J. Pharmacol. Exp. Ther. 255, 756-768
17. Thompson, A.K., Mostafapour, S.P., Denlinger, C.L., Bleasdale, J.E., and Fisher, S.K. (1991) The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. J. Biol. Chem. 266, 23856-23862