The adenomatous polyposis coli (APS) tumour suppresor - Genetics, function and disease

Molecular Medicine Today

Volumn 6, Issue 12, 2000, Pages 462-469

  Sieber, Oliver M ^a   Tomlinson, Ian P ^a   Lamlum, Hanan ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

APOPTOSIS; CANCER INHIBITION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHROMOSOMAL LOCALIZATION; CLINICAL FEATURE; COLON CARCINOGENESIS; COLORECTAL CANCER; CYTOSKELETON; DISEASE ASSOCIATION; DNA BINDING; FAMILIAL COLON POLYPOSIS; GENE FUNCTION; GENE MUTATION; GERM LINE; HUMAN; NERVE ENDING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; SOMATIC MUTATION; TISSUE DISTRIBUTION; TISSUE INTERACTION;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; GENES, APC; HUMANS; MUTATION;

EID: 0033673154     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(00)01828-1     Document Type: Review

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4. Immunochemical identification of novel high-molecular-weight protein isoforms of the adenomatuus polyposis coli (APC) gene
5. APC gene messenger RNA: Novel isoforms that lack exon 7
6. A novel coding exon of the human adenomatous polyposis coli gene
7. Exon 14-skipping of the adenomatous polyposis coli gene in purified epithelial cells of colonic mucosa and tumors
8. Multiple APC messenger RNA isoforms encoding exon 15 short open reading frames are expressed in the context of a novel exon 10A-derived sequence
9. Dimer formation by an N-terminal coiled coil in the APC protein
10. Asef, a link between the tumor suppressor APC and G-protein signaling
11. Association of the APC tumor suppressor protein with catenins
12. Association of the APC gene product with β-catenin
13. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
14. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
15. The adenomatous polyposis coli (APC) tumor suppressor
16. Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of β-catenin
17. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
18. Wild-type but not mutant APC associates with the microtubule cytoskeleton
19. A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau
20. The APC tumour suppressor has a nuclear export function
21. APC binds to the novel protein EB1
22. The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain
23. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
24. The APC protein binds to A/T rich DNA sequences
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26. Wnt/beta-catenin signaling
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28. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β
29. β-catenin is a target for the ubiquitin-proteasome pathway
30. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3beta-dependent phosphorylation of β-catenin
31. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with axin
32. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma
33. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties
34. Identification of c-MYC as a target of the APC pathway
35. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
36. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
37. Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells
38. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
39. Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: Growth factors protect against c-myc-independent apoptosis
40. Apoptosis and APC in colorectal tumorigenesis
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46. Hypertrophy of the retinal pigment epithelium associated with Gardner's syndrome
47. Association of Gardner syndrome and thyroid carcinoma
48. Occurrence of desmoid tumours in familial adenomatous polyposis and results of treatment
49. Familial adenomatous polyposis: Desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444
50. Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene
51. Molecular analysis of the APC gene in 205 families: Extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition
52. Genotype-phenotype correlations in attenuated adenomatous polyposis coli
53. Two cases of 5q deletions in patients with familial adenomatous polyposis: Possible link with Caroli's disease
54. Deletions of the entire APC gene are associated with sessile colonic adenomas
55. A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9
56. Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis
57. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
58. The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history
59. Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q
60. Prevalence of the APC E1317Q variant in colorectal cancer patients
61. Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adanomatous polyposis
62. Lessons from hereditary colorectal cancer
63. Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatoas polyposis (FAP)
64. Inactivation of both APC alleles in human and mouse tumors
65. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: A new facet to Knudson's 'two-hit' hypothesis
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67. APC mutations are sufficient for the growth of early colorectal adenomas
68. Activation of the beta-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis
69. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations
70. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
71. Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma
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73. Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration
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76. Localization of the gene for familial adenomatous polyposis on chromosome 5
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81. Characteristics of colorectal epithelia and adenomas as revealed by DNA cytofluorometry
82. A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice
83. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse