Activation of the β-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis

Cancer Letters

Volumn 159, Issue 1, 2000, Pages 73-78

  Murata, Masaru ^a   Iwao, Kyoko ^b   Miyoshi, Yasuo ^b   Nagasawa, Yutaka ^b   Yabu, Michihiro ^c   Himeno, Seiichi ^c   Imanishi, Kiyoshi ^d   Ohsawa, Masahiko ^a   Wada, Hisashi ^a   Tominaga, Shusei ^a   Shimano, Takashi ^a   Kobayashi, Tetsuro ^a   Nakamura, Yusuke ^b,e  

^a IKEDA MUNICIPAL HOSPITAL   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c Ashiya Municipal Hospital   (Japan)

^d KAWACHI GENERAL HOSPITAL   (Japan)

^e THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

Carcinogenesis; Colorectal adenomas; Tumorigenesis; Catenin

Indexed keywords

BETA CATENIN;

ADENOMATOUS POLYP; ARTICLE; COLORECTAL CANCER; EPITHELIUM CELL; EXON; GENE ACTIVATION; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; TRANSCRIPTION REGULATION;

EID: 0034676240     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00533-4     Document Type: Article

References (31)

1. E.R. Fearon B.A. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
2. S. Ichii S. Takeda A. Horii S. Nakatsuru Y. Miyoshi M. Emi Y. Fujiwara K. Koyama J. Furuyama J. Utsunomiya Y. Nakamura Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP) Oncogene 8 1993 2399 2405
3. B. Rubinfeld B. Souza I. Albert O. Müller S.H. Chamberlain F.R. Masiarz S. Munemitsu P. Polakis Association of the APC gene product with β-catenin Science 262 1993 1731 1734
4. L.K. Su B. Vogelstein K.W. Kinzler Association of the APC tumor suppressor protein with catenins Science 262 1993 1734 1737
5. C. Yost M. Torres J.R. Miller E. Huang D. Kimelman R.T. Moon The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3, Genes Dev. 10 1996 1443 1454
6. J. Papkoff B. Rubinfeld B. Schryver P. Polakis Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes Mol. Cell Biol. 16 1996 2128 2134
7. Y. Nakamura The role of the adenomatous polyposis coli (APC) gene in human cancers Adv. Cancer Res. 62 1993 65 87
8. B. Rubinfeld L. Albert E. Porfiri C. Fiol S. Munemitsu P. Polakis Binding of GSK-3β to the APC-β-catenin complex and regulation of complex assembly Science 272 1996 1023 1026
9. J. Hulsken W. Birchmeier J. Behrens E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton J. Cell. Biol. 127 1994 2061 2069
10. T. Takayama H. Shiozaki Y. Doki H. Oka M. Inoeu M. Yamamoto S. Tamura S. Shibamoto F. Ito M. Monden Aberrant expression and phosphorylation of β-catenin in human colorectal cancer Br. J. Cancer 77 1998 605 613
11. B.M. Gumbinner Signal transduction by β-catenin Curr. Opin. Cell. Biol. 7 1995 634 640
12. M. Molenaar M. Wetering M. Oosterwegel J. Peterson-Maduro S. Goldsave V. Korinek J. Roose O. Destree H. Clevers XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos Cell 86 1996 391 399
13. J. Behrens J.P. Kries M. Kühl L. Bruhn D. Wedlich R. Grosschedl W. Birchmeier Functional interaction of β-catenin with the transcription factor LEF-1 Nature 382 1996 638 642
14. P.J. Morin A.B. Sparks V. Korinek N. Barker H. Clevers B. Vogelstein K.W. Kinzler Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC Science 275 1997 1787 1790
15. K. Iwao S. Nakamori M. Kameyama S. Imaoka M. Kinoshita T. Fukui S. Ishiguro Y. Nakamura Y. Miyoshi Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations Cancer Res. 58 1998 1021 1026
16. T. Sato A. Tanigami K. Yamakawa F. Akiyama F. Kasumi G. Sakamoto Y. Nakamura Allelotype of breast cancer: cumulative allele loses promote tumor progression in primary breast cancer Cancer Res. 50 1990 7184 7189
17. S.M. Hsu L. Raine H. Fanger Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody (PAP) procedures J. Histochem. Cytochem. 29 1981 577 580
18. T.C. He A.B. Sparks C. Rago H. Hermeking L. Zawel L.T. da Coata P.J. Morin B. Vogelstein K.W. Kinzler Identification of c-myc as a target of the APC pathway Science 281 1998 1509 1512
19. O. Tetsu F. McCormick β-Catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
20. M. Shtutman J. Zhurinsky I. Simcha C. Albanese M. D'Amico R. Pestell A. Ben-Ze'ev The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway Proc. Natl. Acad. Sci. USA 96 1999 5522 5527
21. B. Rubinfeld P. Robbins M. El-Gamil I. Albert E. Porfiri P. Polakis Stabilization of β-catenin by genetic defects in melanoma cell lines Science 275 1997 1790 1792
22. Y. Miyoshi K. Iwao Y. Nagasawa T. Aihara Y. Sasaki S. Imaoka M. Murata T. Shimano Y. Nakamura Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3 Cancer Res. 58 1998 2524 2527
23. A.D.L. Coste B. Romagnolo P. Billuart C.A. Renard M.A. Buendia O. Soubrane M. Fabre J. Chelly C. Beldjord A. Kahn C. Perret Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas Proc. Natl. Acad. Sci. USA 95 1998 8847 8851
24. T. Fukuchi M. Sakamoto H. Tsuda K. Maruyama S. Nozawa S. Hirohashi β-Catenin mutation in carcinoma of the uterine endometrium Cancer Res. 58 1998 3526 3528
25. R.H. Zurawei S.A. Chiappa C. Allen C. Raffel Sporadic medulloblastomas contain β-catenin mutations Cancer Res. 58 1998 896 899
26. J. Palacios C. Gamallo Mutations in the β-catenin gene ( CTNNB1 ) in endometriod ovarian carcinomas Cancer Res. 58 1998 1344 1347
27. H.J. Voeller C.I. Truica E.P. Gelmann β-Catenin mutations in human prostate cancer Cancer Res. 58 1998 2520 2523
28. Y. Miyoshi K. Iwao G. Nawa H. Yoshikawa T. Ochi Y. Nakamura Frequent mutations in the β-catenin gene in desmoid tumors from patients without familial adenomatous polyposis Oncol. Res. 10 1998 591 594
29. A.B. Sparks P.J. Morin B. Vogelstein K.W. Kinzler Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer Cancer Res. 58 1998 1130 1134
30. S. Ikeda S. Kishida H. Yamamoto H. Murai S. Koyama A. Kikuchi Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin, EMBO J. 17 1998 1371 1384
31. J. Behrens B.A. Jerchow M. Würtele J. Grimm C. Asbrand R. Wirtz M. Kühl D. Wedlich W. Birchmeier Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK-3β, Science 280 1998 596 599