Exon 14-skipping of the adenomatous polyposis coli gene in purified epithelial cells of colonic mucosa and tumors

Anticancer Research

Volumn 19, Issue 1 A, 1999, Pages 601-604

  Sulekova, Zora ^a   Reymond, Mark ^a   Köckerling, Ferdinand ^a   Hohenberger, Werner ^a   Ballhausen, Wolfgang G ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Adenomatous polyposis coli; Alternative splicing; Colorectal cancer; Expression

Indexed keywords

COMPLEMENTARY DNA; ISOPROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY;

ARTICLE; CLINICAL ARTICLE; COLON MUCOSA; COLON POLYPOSIS; COLON TUMOR; CONTROLLED STUDY; DENSITOMETRY; EPITHELIUM CELL; EXON; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN VARIANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

COLON; COLONIC NEOPLASMS; EXONS; GENES, APC; HUMANS; INTESTINAL MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032923115     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt R, Hughes JP, Warrington J, McPherson J, Wasmuth J, Le Paslier D, Abderrahim H, Cohen D, Leppert M and White R: Identification of FAP locus genes from chromosome 5q21. Cell 66: 589-600, 1991.
2. Kinzler KW, Nilbert MC, Su L-K, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, Finniear R, Markham A, Groffen J, Boguski MS, Altschul SF, Horii A, Ando H, Miyoshi Y, Miki Y, Nishisho I and Nakamura Y: Identification of FAP locus genes from chromosome 5q21. Science 253: 661-665, 1991.
3. Beroud C and Soussi T: APC gene: database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res 24: 121-124, 1996.
4. Kinzler KW and Vogelstein B: Lessons from hereditary colorectal cancer. Cell 87: 159-170, 1996.
5. Peifer M: Beta-catenin as oncogene: the smoking gun. Science 275: 1752-1753, 1997.
6. Browne SJ, Williams AC, Hague A, Butt AJ and Paraskeva C: Loss of APC protein expressed by human colonic epithelial cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro. Int J Cancer 59: 56-64, 1994.
7. Kraus C, Reina-Sanchez J, Sulekova Z and Ballhausen WG: Immunochemical identification of novel high molecular weight protein isoforms of the adenomatous polyposis coli (APC) gene. Int J Cancer 65: 383-388, 1996.
8. Sulekova Z, Reina-Sanchez J and Ballhausen WG: Multiple APC messenger RNA isoforms encoding exon 15 short open reading frames are expressed in the context of a novel exon 10A-derived sequence. Int J Cancer 63: 435-441, 1995.
9. Bala S, Sulekova Z and Ballhausen WG: Constitutive APC exon 14-skipping in early onset familial adenomatous polyposis reveals a dramatic quantitative distortion of APC gene specific isoforms. Hum Mutation 10: 260-265, 1997.
10. Reymond MA, Sanchez JC, Schneider C, Rohwer P, Tortola S, Hohenberger W, Kirchner T, Hochstrasser DF and Köckerling F: Specific sample preparation in colorectal cancer. Electrophoresis 18: 622-624, 1997.
11. Latza U, Niedobitek G, Schwarting R, Nekarda H and Stein H: Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial. J Clin Pathol 43: 213-219, 1990.
12. Bala S, Kraus C, Wijnen J, Meera Khan P and Ballhausen WG: Multiple products in the protein truncation test due to alternative splicing in the adenomatous polyposis coli (APC) gene. Hum Genet 98: 528-533, 1996.
13. Schnitzler M, Dwight T, Marsh DJ, Gaskin EL and Robinson BG: Quantitation of APC mRNA in human tissues. Biochem Biophys Res Commun 217: 385-392, 1995.
14. Reymond MA, Sanchez JC, Hughes GJ, Günther K, Riese J, Tortola S, Peinado MA, Kirchner T, Hohenberger W, Hochstrasser DF, Kockerling F: Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis. Electrophoresis 18: 2842-2848, 1997.
15. Joslyn G, Richardson DS, White R and Alber T: Dimer formation by an N-terminal coiled coil in the APC protein. Proc Natl Acad Sci USA 90: 11109-11113, 1993.
16. Miyashiro I, Senda T, Matsumine A, Baeg GH, Kuroda T, Shimano T, Miura S, Noda T, Kobayashi S, Monden M, Toyoshima K and Akiyama T: Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene 11: 89-96, 1995.