메뉴 건너뛰기




Volumn 17, Issue 4, 1997, Pages 453-456

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN BAX; PROTEIN P21; PROTEIN P53;

EID: 0030667522     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1297-453     Document Type: Article
Times cited : (193)

References (31)
  • 1
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • Kastan, M.B. et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597 (1992).
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1
  • 2
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu, X. & Lane, D.P. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75, 765-778 (1993).
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 3
    • 0027486024 scopus 로고
    • Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells
    • Khanna, K.K. & Lavin, M.F. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8, 3307-3312 (1993).
    • (1993) Oncogene , vol.8 , pp. 3307-3312
    • Khanna, K.K.1    Lavin, M.F.2
  • 4
    • 0029821651 scopus 로고    scopus 로고
    • Dual responses of ATM in the cellular response to irradiation and in cell growth
    • Xu, Y. & Baltimore, D. Dual responses of ATM in the cellular response to irradiation and in cell growth. Genes Dev. 10, 2401-2410 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 5
    • 0030925565 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
    • Baskaran, R. et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387, 516-519 (1997).
    • (1997) Nature , vol.387 , pp. 516-519
    • Baskaran, R.1
  • 6
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L.J. & Prives, C. p53: puzzle and paradigm. Genes Dev. 10, 1054-1072 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 7
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. p53, the cellular gatekeeper for growth and division. Cell 88, 323-331 (1997).
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 8
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7 (1994).
    • (1994) Curr. Biol. , vol.4 , pp. 1-7
    • Jacks, T.1
  • 9
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684 (1995).
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 10
    • 0029002103 scopus 로고
    • Ataxia-telangiectasia: Closer to unraveling the mystery
    • Shiloh, Y. Ataxia-telangiectasia: closer to unraveling the mystery. Eur. J. Hum. Genet. 3, 116-38 (1995).
    • (1995) Eur. J. Hum. Genet. , vol.3 , pp. 116-138
    • Shiloh, Y.1
  • 11
    • 0028880649 scopus 로고
    • Ataxia-telangiectasia and cellular responses to DNA damage
    • Meyn, M.S. Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res. 55, 5991-6001 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 5991-6001
    • Meyn, M.S.1
  • 12
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow, C. et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159-171 (1996).
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1
  • 13
    • 0028566172 scopus 로고
    • Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia
    • Meyn, M.S., Strasfeld, L. & Allen, C. Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. Int. J. Radiat. Biol. 66, S141-S149 (1994).
    • (1994) Int. J. Radiat. Biol. , vol.66
    • Meyn, M.S.1    Strasfeld, L.2    Allen, C.3
  • 14
    • 0030879563 scopus 로고    scopus 로고
    • atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
    • Westphal, C.H. et al. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nature Genet. 16, 397-401 (1997).
    • (1997) Nature Genet. , vol.16 , pp. 397-401
    • Westphal, C.H.1
  • 16
    • 0029097759 scopus 로고
    • Radiation-induced cell cycle arrest compromised by p21 deficiency
    • Brugarolas, J. et al. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552-557 (1995).
    • (1995) Nature , vol.377 , pp. 552-557
    • Brugarolas, J.1
  • 17
    • 0027319521 scopus 로고
    • pS3 is required for radidtion-indiced apaptosis in mouse thymocytes
    • Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. & Jacks, T. pS3 is required for radidtion-indiced apaptosis in mouse thymocytes. Nature 362, 847-849 (1993).
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 18
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke, A.R. et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852 (1993).
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1
  • 19
    • 16044364385 scopus 로고    scopus 로고
    • Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
    • Santana, P. et al. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86, 189-199 (1996).
    • (1996) Cell , vol.86 , pp. 189-199
    • Santana, P.1
  • 20
    • 0030476720 scopus 로고    scopus 로고
    • The product of the ATM gene is a 370-kDa nuclear phosphoprotein
    • Chen, G. & Lee, E.Y.H.-P. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. J. Biol. Chem. 271, 33693-33697 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 33693-33697
    • Chen, G.1    Lee, E.Y.H.-P.2
  • 21
    • 0030472725 scopus 로고    scopus 로고
    • Analysis of the ATM protein in wild-type and ataxia telangiectasia cells
    • Lakin, N.D. et al. Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene 13, 2707-2716 (1996).
    • (1996) Oncogene , vol.13 , pp. 2707-2716
    • Lakin, N.D.1
  • 22
    • 0031047915 scopus 로고    scopus 로고
    • The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not upregulated following genome damage
    • Brown, K.D. et al. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not upregulated following genome damage. Proc. Natl. Acad. Sci. USA 94, 1840-1845 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1840-1845
    • Brown, K.D.1
  • 23
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • El-Deiry, W.S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1
  • 24
    • 0027496935 scopus 로고
    • The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1-cyclin-dependent kinases
    • Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. & Elledge, S.J. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1-cyclin-dependent kinases. Cell 75, 805-816 (1993).
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 25
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T. & Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299 (1995).
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 26
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes and cannot induce apoptosis
    • Friedlander, P., Haupt, Y., Prives, C. & Oren, M. A mutant p53 that discriminates between p53-responsive genes and cannot induce apoptosis. Mol. Cell. Biol. 16, 4961-4971 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 27
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen, X., Ko, L.J., Jayaraman, L. & Prives, C. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10, 2438-2451 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 28
    • 0028209857 scopus 로고
    • Sequence-specific transcriptional activation is essential for growth suppression by p53
    • Pietenpol, J.A. et al. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc. Natl. Acad. Sci. USA 91, 1998-2002 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1998-2002
    • Pietenpol, J.A.1
  • 29
    • 0025219216 scopus 로고
    • Improved method for computing potential doubling time from flow cytometric data
    • White, R.A., Terry, N.H., Meistrich, M.L. & Calkins, D.P. Improved method for computing potential doubling time from flow cytometric data. Cytometry 11, 314-317 (1990).
    • (1990) Cytometry , vol.11 , pp. 314-317
    • White, R.A.1    Terry, N.H.2    Meistrich, M.L.3    Calkins, D.P.4
  • 31
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
    • Harlow, E. & Lane, D. Antibodies: A Laboratory Manual (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1988).
    • (1988) Antibodies: A Laboratory Manual
    • Harlow, E.1    Lane, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.