Free radicals and reactive oxygen species in programmed cell death

Medical Hypotheses

Volumn 52, Issue 5, 1999, Pages 451-463

  Anderson, K M ^a   Seed, T ^b   Ou, D ^c   Harris, J E ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CELL SURVIVAL; EUKARYOTIC CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

EUKARYOTA;

EID: 0033026816     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1997.0521     Document Type: Article

References (140)

1. Kerr J. F.R., Wyllie A. H., Currie A. R. Apoptosis: a basic biologic phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:1972;239-257.
2. Wyllie A. H. Apoptosis: cell death in tissue regulation. J Pathol. 153:1987;313-316.
3. Zakeri Z., Bursch W., Tenniswood M., Lockkshin R. A. Cell death: programmed, apoptosis, necrosis or other. Cell Death Diff. 2:1995;87-96.
4. Clark P. G.H. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol. 181:1990;195-213.
5. Anderson K. M., Seed T., Meng J. Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. Anticancer Res. 18:1998;791-800.
6. Boobis A. R., Fawthrop D. J., Davies D. S. Mechanism of cell death. TIPS. 10:1989;275-280.
7. Egachi Y., Shimizu S., Tsujimoto Y. Intracellular ATP levels determine cell death by necrosis or apoptosis. Cancer Res. 57:1997;1835-1840.
8. Morrison R. T., Boyd R. N. Organic Chemistry. 1987;1-37 Allyn and Bacon, Boston.
9. Matthews P. S.C. Quantum, Chemistry of Atoms and Molecules. 1994;Cambridge Press.
10. Pauling L. Oxidation reduction reactions. College Chemistry. 1964;W. H. Freeman. p. 338-360.
11. Halliwell B., Gutteridge J. M. C. Free Radicals in Biology and Medicine. 1989;Oxford University Press, Oxford. p. 1-81.
12. Cutler R. G. Human longevity and aging: possible role of reactive oxygen species. Physiologic Senescence and its Postponement: Theoretical Approaches and Rational Interventions. 1990;. p. 1-28.
13. Lander H. M. An essential role for free radicals and derived species in signal transduction. FASEB J. 11:1990;118-124.
14. Cross C. E., Halliwell B., Borish E. T. Oxygen radicals and human disease. Ann Intern Med. 107:1987;526-545.
15. Sohal, R. S. Neindruch, R. Oxidative stress, caloric restriction and aging, Science, 1996, 273, 59, 63, Jazwinski, S. M. Longevity, genes and aging, Science, 1996, 273, 54, 59, Smith, J. R. Perrira-Smith, O. M. Replicative senescence: implications for in vivo aging and tumor suppression, Science, 1996, 273, 63, 67.
16. Sohal, R. S. Neindruch, R. Oxidative stress, caloric restriction and aging, Science, 1996, 273, 59, 63, Jazwinski, S. M. Longevity, genes and aging, Science, 1996, 273, 54, 59, Smith, J. R. Perrira-Smith, O. M. Replicative senescence: implications for in vivo aging and tumor suppression, Science, 1996, 273, 63, 67.
17. Sohal, R. S. Neindruch, R. Oxidative stress, caloric restriction and aging, Science, 1996, 273, 59, 63, Jazwinski, S. M. Longevity, genes and aging, Science, 1996, 273, 54, 59, Smith, J. R. Perrira-Smith, O. M. Replicative senescence: implications for in vivo aging and tumor suppression, Science, 1996, 273, 63, 67.
18. Walden T. L., Farzaneh N. K. Effects of radiation on macromolecules. Biochemistry of Ionizing Radiation. 1990;Raven Press. p. 36-48.
19. Powis G., Briehl M., Oblong J. Redox signaling and the control of cell growth and death. Pharmacol Ther. 68:1995;149-173.
20. Sen C. K., Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 10:1996;709-720.
21. Droge W., Eck H.-P., Mihm S. HIV-induced cysteine deficiency and T cell dysfunction - a rationale for treatment with N-acetylcysteine. Immunol Today. 13:1992;211-214.
22. Hainaut P., Milner J. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res. 53:1993;4469-4473.
23. McConkey D. J., Orrenius S. The role of calcium in the regulation of apoptosis. Leuk Biol. 59:1996;775-783.
24. Anderson, M. T. Staal, F. J.T. Gitler, C. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway, Proc Natl Acad Sci USA, 1994, 91, 11527, 11531, Schreck, R. Rieber, P. Baeuerle, P. A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1, EMBO J, 1991, 10, 2247, 2258.
25. Anderson, M. T. Staal, F. J.T. Gitler, C. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway, Proc Natl Acad Sci USA, 1994, 91, 11527, 11531, Schreck, R. Rieber, P. Baeuerle, P. A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1, EMBO J, 1991, 10, 2247, 2258.
26. Staal, F. J.T. Anderson, M. T. Staal, G. E.J. Redox regulation of signal transduction: tyrosine phosphorylation and calcium fluxes, Proc Natl Acad Sci USA, 1994, 91, 3619, 3622, Berg, A. A. Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death, Science, 1996, 274, 782, 784, Wang, C.-Y. Mayo, M. W. Baldwin, A. S. TNF and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB, Science, 1996, 274, 784, 787, Van Antwerpt, D. J. Martin, S. J. Kafri, T. Suppression of TNF-α-induced apoptosis by NF-κB, Science, 1996, 274, 787, 789.
27. Staal, F. J.T. Anderson, M. T. Staal, G. E.J. Redox regulation of signal transduction: tyrosine phosphorylation and calcium fluxes, Proc Natl Acad Sci USA, 1994, 91, 3619, 3622, Berg, A. A. Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death, Science, 1996, 274, 782, 784, Wang, C.-Y. Mayo, M. W. Baldwin, A. S. TNF and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB, Science, 1996, 274, 784, 787, Van Antwerpt, D. J. Martin, S. J. Kafri, T. Suppression of TNF-α-induced apoptosis by NF-κB, Science, 1996, 274, 787, 789.
28. Staal, F. J.T. Anderson, M. T. Staal, G. E.J. Redox regulation of signal transduction: tyrosine phosphorylation and calcium fluxes, Proc Natl Acad Sci USA, 1994, 91, 3619, 3622, Berg, A. A. Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death, Science, 1996, 274, 782, 784, Wang, C.-Y. Mayo, M. W. Baldwin, A. S. TNF and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB, Science, 1996, 274, 784, 787, Van Antwerpt, D. J. Martin, S. J. Kafri, T. Suppression of TNF-α-induced apoptosis by NF-κB, Science, 1996, 274, 787, 789.
29. Staal, F. J.T. Anderson, M. T. Staal, G. E.J. Redox regulation of signal transduction: tyrosine phosphorylation and calcium fluxes, Proc Natl Acad Sci USA, 1994, 91, 3619, 3622, Berg, A. A. Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death, Science, 1996, 274, 782, 784, Wang, C.-Y. Mayo, M. W. Baldwin, A. S. TNF and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB, Science, 1996, 274, 784, 787, Van Antwerpt, D. J. Martin, S. J. Kafri, T. Suppression of TNF-α-induced apoptosis by NF-κB, Science, 1996, 274, 787, 789.
30. Schultze-Osthoff K., Bakker A. C., Vanhaesebroeck B. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. J Biol Chem. 267:1992;5317-5323.
31. Wong G. H.W. Protective roles of cytokines against radiation: induction of mitochondrial MnSOD. Biochim Biophys Acta. 1271:1995;205-209.
32. Meister, A. Mitochondrial changes associated with glutathione deficiency, Biochim Biophys Acta, 1995, 1271, 35, 42, Jones, D. F. Mitochondrial dysfunction during anoxia and acute cell injury, Biochim Biophys Acta, 1995, 1271, 29, 33.
33. Meister, A. Mitochondrial changes associated with glutathione deficiency, Biochim Biophys Acta, 1995, 1271, 35, 42, Jones, D. F. Mitochondrial dysfunction during anoxia and acute cell injury, Biochim Biophys Acta, 1995, 1271, 29, 33.
34. Torres-Roca J. F., Lecoeur H., Amatore C., Gaugeon M.-L. The early intracellullar production of a reactive oxygen intermediate mediates apoptosis in dexamethasone-treated thymocytes. Cell Death Diff. 2:1995;309-319.
35. Halliwell B., Aruoma O. I. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian species. FEBS Lett. 281:1996;9-19.
36. Janssen Y. M.W., Houten B. V., Borm P. J.A., Mossman B. T. Biology of disease: cell tissue response to oxidative damage. Lab Invest. 69:1993;261-274.
37. Stewart, B. W. Mechanism of apoptosis: integration of genetic, biochemical cellular indicators, J Natl Cancer Inst, 1994, 86, 1286, 1296, Bowen, I. D. Apoptosis or programmed cell death, Cell Biol Int, 1993, 17, 365, 380, Earnshaw, W. C. Nuclear changes in apoptosis, Curr Biol, 1995, 7, 337, 343, Cohen, J. J. Apoptosis, Immunol Today, 1993, 14, 126, 130.
38. Stewart, B. W. Mechanism of apoptosis: integration of genetic, biochemical cellular indicators, J Natl Cancer Inst, 1994, 86, 1286, 1296, Bowen, I. D. Apoptosis or programmed cell death, Cell Biol Int, 1993, 17, 365, 380, Earnshaw, W. C. Nuclear changes in apoptosis, Curr Biol, 1995, 7, 337, 343, Cohen, J. J. Apoptosis, Immunol Today, 1993, 14, 126, 130.
39. Stewart, B. W. Mechanism of apoptosis: integration of genetic, biochemical cellular indicators, J Natl Cancer Inst, 1994, 86, 1286, 1296, Bowen, I. D. Apoptosis or programmed cell death, Cell Biol Int, 1993, 17, 365, 380, Earnshaw, W. C. Nuclear changes in apoptosis, Curr Biol, 1995, 7, 337, 343, Cohen, J. J. Apoptosis, Immunol Today, 1993, 14, 126, 130.
40. Stewart, B. W. Mechanism of apoptosis: integration of genetic, biochemical cellular indicators, J Natl Cancer Inst, 1994, 86, 1286, 1296, Bowen, I. D. Apoptosis or programmed cell death, Cell Biol Int, 1993, 17, 365, 380, Earnshaw, W. C. Nuclear changes in apoptosis, Curr Biol, 1995, 7, 337, 343, Cohen, J. J. Apoptosis, Immunol Today, 1993, 14, 126, 130.
41. Steller, H. Mechanism and genes of cellular suicide, Science, 1995, 267, 1445, 1449, Nagata, S. Golstein, P. The fas death factor, Science, 1995, 267, 1449, 1456, Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267, 1456, 1462.
42. Steller, H. Mechanism and genes of cellular suicide, Science, 1995, 267, 1445, 1449, Nagata, S. Golstein, P. The fas death factor, Science, 1995, 267, 1449, 1456, Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267, 1456, 1462.
43. Steller, H. Mechanism and genes of cellular suicide, Science, 1995, 267, 1445, 1449, Nagata, S. Golstein, P. The fas death factor, Science, 1995, 267, 1449, 1456, Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267, 1456, 1462.
44. Bellamy, C. O.C. Malcomson, R. D.G. Harrison, D. J. Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis, Semin Cancer Biol, 1995, 6, 3, 16, Canman, C. E. Kastan, M. B. Induction of apoptosis by tumor suppressor genes and oncogenes, Semin Cancer Biol, 1995, 6, 17, 25, 26, 34, Craig, R. W. The bcl-2 gene family, Semin Cancer Biol, 1995, 6, 35, 43, Eastman, A. Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis, Semin Cancer Biol, 1995, 6, 45, 52, McDonnell, T. J. Meyn, R. E. Robertson, L. E. Implications of apoptotic cell death regulation in cancer therapy, Semin Cancer Biol, 1995, 6, 53, 60.
45. Bellamy, C. O.C. Malcomson, R. D.G. Harrison, D. J. Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis, Semin Cancer Biol, 1995, 6, 3, 16, Canman, C. E. Kastan, M. B. Induction of apoptosis by tumor suppressor genes and oncogenes, Semin Cancer Biol, 1995, 6, 17, 25, 26, 34, Craig, R. W. The bcl-2 gene family, Semin Cancer Biol, 1995, 6, 35, 43, Eastman, A. Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis, Semin Cancer Biol, 1995, 6, 45, 52, McDonnell, T. J. Meyn, R. E. Robertson, L. E. Implications of apoptotic cell death regulation in cancer therapy, Semin Cancer Biol, 1995, 6, 53, 60.
46. Bellamy, C. O.C. Malcomson, R. D.G. Harrison, D. J. Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis, Semin Cancer Biol, 1995, 6, 3, 16, Canman, C. E. Kastan, M. B. Induction of apoptosis by tumor suppressor genes and oncogenes, Semin Cancer Biol, 1995, 6, 17, 25, 26, 34, Craig, R. W. The bcl-2 gene family, Semin Cancer Biol, 1995, 6, 35, 43, Eastman, A. Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis, Semin Cancer Biol, 1995, 6, 45, 52, McDonnell, T. J. Meyn, R. E. Robertson, L. E. Implications of apoptotic cell death regulation in cancer therapy, Semin Cancer Biol, 1995, 6, 53, 60.
47. Bellamy, C. O.C. Malcomson, R. D.G. Harrison, D. J. Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis, Semin Cancer Biol, 1995, 6, 3, 16, Canman, C. E. Kastan, M. B. Induction of apoptosis by tumor suppressor genes and oncogenes, Semin Cancer Biol, 1995, 6, 17, 25, 26, 34, Craig, R. W. The bcl-2 gene family, Semin Cancer Biol, 1995, 6, 35, 43, Eastman, A. Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis, Semin Cancer Biol, 1995, 6, 45, 52, McDonnell, T. J. Meyn, R. E. Robertson, L. E. Implications of apoptotic cell death regulation in cancer therapy, Semin Cancer Biol, 1995, 6, 53, 60.
48. Bellamy, C. O.C. Malcomson, R. D.G. Harrison, D. J. Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis, Semin Cancer Biol, 1995, 6, 3, 16, Canman, C. E. Kastan, M. B. Induction of apoptosis by tumor suppressor genes and oncogenes, Semin Cancer Biol, 1995, 6, 17, 25, 26, 34, Craig, R. W. The bcl-2 gene family, Semin Cancer Biol, 1995, 6, 35, 43, Eastman, A. Survival factors, intracellular signal transduction and the activation of endonucleases in apoptosis, Semin Cancer Biol, 1995, 6, 45, 52, McDonnell, T. J. Meyn, R. E. Robertson, L. E. Implications of apoptotic cell death regulation in cancer therapy, Semin Cancer Biol, 1995, 6, 53, 60.
49. Korsmeyer, S. L. Yin, X. -M. Oltvai, Z. N. Reactive oxygen species and regulation of cell death by the bcl-2 gene family, Rev Biochim Biophys Acta, 1995, 1271, 63, 66, Slater, A. F.G. Nobel, C. S.I. Orrenius, S. The role of intracellular oxidants in apoptosis, 1995, 1271, 59, 62, Richter, C. Gogvadze, V. Laffranchi, R. Oxidants in mitochondria: from physiology to disease, 1995, 1271, 67, 74.
50. Korsmeyer, S. L. Yin, X. -M. Oltvai, Z. N. Reactive oxygen species and regulation of cell death by the bcl-2 gene family, Rev Biochim Biophys Acta, 1995, 1271, 63, 66, Slater, A. F.G. Nobel, C. S.I. Orrenius, S. The role of intracellular oxidants in apoptosis, 1995, 1271, 59, 62, Richter, C. Gogvadze, V. Laffranchi, R. Oxidants in mitochondria: from physiology to disease, 1995, 1271, 67, 74.
51. Korsmeyer, S. L. Yin, X. -M. Oltvai, Z. N. Reactive oxygen species and regulation of cell death by the bcl-2 gene family, Rev Biochim Biophys Acta, 1995, 1271, 63, 66, Slater, A. F.G. Nobel, C. S.I. Orrenius, S. The role of intracellular oxidants in apoptosis, 1995, 1271, 59, 62, Richter, C. Gogvadze, V. Laffranchi, R. Oxidants in mitochondria: from physiology to disease, 1995, 1271, 67, 74.
52. Jacobson, M. D. Burne, J. F. King, M. P. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA, Nature, 1993, 361, 365, 369, Jacobson, M. D. Burne, J. F. Raff, M. C. Programmed cell death and bcl-2 protection in the absence of a nucleus, EMBO J, 1994, 13, 1899, 1910, Schultze-Osthoff, K. Walczak, H. Dodge, W. Krammer, P. H. Cell nucleus and DNA fragmentation are not required for apoptosis, J Cell Biol, 1994, 127, 15, 20, Vaux, D. I. Agula, H. L. Weissman, I. L. Bcl-2 prevents death of factor-dependent cells but fails to prevent apoptosis in targets of cell-mediated killing, Int Immunol, 1994, 4, 801, 824.
53. Jacobson, M. D. Burne, J. F. King, M. P. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA, Nature, 1993, 361, 365, 369, Jacobson, M. D. Burne, J. F. Raff, M. C. Programmed cell death and bcl-2 protection in the absence of a nucleus, EMBO J, 1994, 13, 1899, 1910, Schultze-Osthoff, K. Walczak, H. Dodge, W. Krammer, P. H. Cell nucleus and DNA fragmentation are not required for apoptosis, J Cell Biol, 1994, 127, 15, 20, Vaux, D. I. Agula, H. L. Weissman, I. L. Bcl-2 prevents death of factor-dependent cells but fails to prevent apoptosis in targets of cell-mediated killing, Int Immunol, 1994, 4, 801, 824.
54. Jacobson, M. D. Burne, J. F. King, M. P. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA, Nature, 1993, 361, 365, 369, Jacobson, M. D. Burne, J. F. Raff, M. C. Programmed cell death and bcl-2 protection in the absence of a nucleus, EMBO J, 1994, 13, 1899, 1910, Schultze-Osthoff, K. Walczak, H. Dodge, W. Krammer, P. H. Cell nucleus and DNA fragmentation are not required for apoptosis, J Cell Biol, 1994, 127, 15, 20, Vaux, D. I. Agula, H. L. Weissman, I. L. Bcl-2 prevents death of factor-dependent cells but fails to prevent apoptosis in targets of cell-mediated killing, Int Immunol, 1994, 4, 801, 824.
55. Jacobson, M. D. Burne, J. F. King, M. P. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA, Nature, 1993, 361, 365, 369, Jacobson, M. D. Burne, J. F. Raff, M. C. Programmed cell death and bcl-2 protection in the absence of a nucleus, EMBO J, 1994, 13, 1899, 1910, Schultze-Osthoff, K. Walczak, H. Dodge, W. Krammer, P. H. Cell nucleus and DNA fragmentation are not required for apoptosis, J Cell Biol, 1994, 127, 15, 20, Vaux, D. I. Agula, H. L. Weissman, I. L. Bcl-2 prevents death of factor-dependent cells but fails to prevent apoptosis in targets of cell-mediated killing, Int Immunol, 1994, 4, 801, 824.
56. Goldstein, P. Controlling cell death, Science, 1997, 275, 1081, 1082, Chinnaiyan, A. M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death, Science, 1997, 275, 1122, 1126, Wu, D. Wallen, H. D. Nunez, G. Interaction and regulation of subcellular localization of CED-4 by CED-9, Science, 1997, 275, 1126, 1129, Yang, J. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 1997, 275, 1129, 1132, Kluck, R. M. The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis, Science, 1997, 275, 1132, 1136.
57. Goldstein, P. Controlling cell death, Science, 1997, 275, 1081, 1082, Chinnaiyan, A. M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death, Science, 1997, 275, 1122, 1126, Wu, D. Wallen, H. D. Nunez, G. Interaction and regulation of subcellular localization of CED-4 by CED-9, Science, 1997, 275, 1126, 1129, Yang, J. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 1997, 275, 1129, 1132, Kluck, R. M. The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis, Science, 1997, 275, 1132, 1136.
58. Goldstein, P. Controlling cell death, Science, 1997, 275, 1081, 1082, Chinnaiyan, A. M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death, Science, 1997, 275, 1122, 1126, Wu, D. Wallen, H. D. Nunez, G. Interaction and regulation of subcellular localization of CED-4 by CED-9, Science, 1997, 275, 1126, 1129, Yang, J. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 1997, 275, 1129, 1132, Kluck, R. M. The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis, Science, 1997, 275, 1132, 1136.
59. Goldstein, P. Controlling cell death, Science, 1997, 275, 1081, 1082, Chinnaiyan, A. M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death, Science, 1997, 275, 1122, 1126, Wu, D. Wallen, H. D. Nunez, G. Interaction and regulation of subcellular localization of CED-4 by CED-9, Science, 1997, 275, 1126, 1129, Yang, J. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 1997, 275, 1129, 1132, Kluck, R. M. The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis, Science, 1997, 275, 1132, 1136.
60. Goldstein, P. Controlling cell death, Science, 1997, 275, 1081, 1082, Chinnaiyan, A. M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death, Science, 1997, 275, 1122, 1126, Wu, D. Wallen, H. D. Nunez, G. Interaction and regulation of subcellular localization of CED-4 by CED-9, Science, 1997, 275, 1126, 1129, Yang, J. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 1997, 275, 1129, 1132, Kluck, R. M. The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis, Science, 1997, 275, 1132, 1136.
61. Jacobson, M. D. Weil, M. Raff, M. C. Programmed cell death in animal development, Cell, 1997, 88, 347, 354, Nagata, S. Apoptosis by death factor, Cell, 1997, 88, 355, 365, Levine, A. J. p53 the cellular gatekeeper for growth and division, Cell, 1997, 88, 323, 331, Hunter, T. Oncoprotein networks, Cell, 1997, 88, 333, 346.
62. Jacobson, M. D. Weil, M. Raff, M. C. Programmed cell death in animal development, Cell, 1997, 88, 347, 354, Nagata, S. Apoptosis by death factor, Cell, 1997, 88, 355, 365, Levine, A. J. p53 the cellular gatekeeper for growth and division, Cell, 1997, 88, 323, 331, Hunter, T. Oncoprotein networks, Cell, 1997, 88, 333, 346.
63. Jacobson, M. D. Weil, M. Raff, M. C. Programmed cell death in animal development, Cell, 1997, 88, 347, 354, Nagata, S. Apoptosis by death factor, Cell, 1997, 88, 355, 365, Levine, A. J. p53 the cellular gatekeeper for growth and division, Cell, 1997, 88, 323, 331, Hunter, T. Oncoprotein networks, Cell, 1997, 88, 333, 346.
64. Jacobson, M. D. Weil, M. Raff, M. C. Programmed cell death in animal development, Cell, 1997, 88, 347, 354, Nagata, S. Apoptosis by death factor, Cell, 1997, 88, 355, 365, Levine, A. J. p53 the cellular gatekeeper for growth and division, Cell, 1997, 88, 323, 331, Hunter, T. Oncoprotein networks, Cell, 1997, 88, 333, 346.
65. Ashkenazi, A. Dixit, V. M. Death receptors: Signaling and modulation, Science, 1998, 281, 1305, 1308, Green, D. R. Reed, J. C. Mitochondria and apoptosis, Cell, 1997, 88, 1309, 1312, Thronberry, N. A. Lazebnik, Y. Caspases: enemies within, Cell, 1997, 88, 1312, 1316, Evan, G. Littlewood, T. A matter of life and cell death, Cell, 1997, 88, 1317, 1321, Adams, J. M. Cory, S. The Bcl-2 protein family: arbiters of cell survival, Cell, 1997, 88, 1322, 1325.
66. Ashkenazi, A. Dixit, V. M. Death receptors: Signaling and modulation, Science, 1998, 281, 1305, 1308, Green, D. R. Reed, J. C. Mitochondria and apoptosis, Cell, 1997, 88, 1309, 1312, Thronberry, N. A. Lazebnik, Y. Caspases: enemies within, Cell, 1997, 88, 1312, 1316, Evan, G. Littlewood, T. A matter of life and cell death, Cell, 1997, 88, 1317, 1321, Adams, J. M. Cory, S. The Bcl-2 protein family: arbiters of cell survival, Cell, 1997, 88, 1322, 1325.
67. Ashkenazi, A. Dixit, V. M. Death receptors: Signaling and modulation, Science, 1998, 281, 1305, 1308, Green, D. R. Reed, J. C. Mitochondria and apoptosis, Cell, 1997, 88, 1309, 1312, Thronberry, N. A. Lazebnik, Y. Caspases: enemies within, Cell, 1997, 88, 1312, 1316, Evan, G. Littlewood, T. A matter of life and cell death, Cell, 1997, 88, 1317, 1321, Adams, J. M. Cory, S. The Bcl-2 protein family: arbiters of cell survival, Cell, 1997, 88, 1322, 1325.
68. Ashkenazi, A. Dixit, V. M. Death receptors: Signaling and modulation, Science, 1998, 281, 1305, 1308, Green, D. R. Reed, J. C. Mitochondria and apoptosis, Cell, 1997, 88, 1309, 1312, Thronberry, N. A. Lazebnik, Y. Caspases: enemies within, Cell, 1997, 88, 1312, 1316, Evan, G. Littlewood, T. A matter of life and cell death, Cell, 1997, 88, 1317, 1321, Adams, J. M. Cory, S. The Bcl-2 protein family: arbiters of cell survival, Cell, 1997, 88, 1322, 1325.
69. Ashkenazi, A. Dixit, V. M. Death receptors: Signaling and modulation, Science, 1998, 281, 1305, 1308, Green, D. R. Reed, J. C. Mitochondria and apoptosis, Cell, 1997, 88, 1309, 1312, Thronberry, N. A. Lazebnik, Y. Caspases: enemies within, Cell, 1997, 88, 1312, 1316, Evan, G. Littlewood, T. A matter of life and cell death, Cell, 1997, 88, 1317, 1321, Adams, J. M. Cory, S. The Bcl-2 protein family: arbiters of cell survival, Cell, 1997, 88, 1322, 1325.
70. Buttke T. M., Sandstrom P. A. Oxidative stress as a mediator of apoptosis. Immunol Today. 15:1994;7-10.
71. Sarafian T. A., Bredesen D. E. Invited commentary - Is apoptosis mediated by reactive oxygen species. Free Radic Res. 21:1994;1-8.
72. Lazebnik Y. A., Kaufmann S. H., Desnoyers S. Cleavage of poly (ADP ribose) polymerase by a proteinase with properties like ICE. Nature. 371:1994;346-347.
73. Miura M., Zhu H., Rotello R. Induction of apoptosis in fibroblasts by IL-1β converting enzyme, a mammalian homolog of the C. elegans death gene CED-3. Cell. 75:1993;653-660.
74. Cohen G. M., Sun X.-M., Snowden R. T. Key morphological features of apoptosis may occur in the absence of inter-nucleosomal and DNA fragmentation. Bio J. 286:1992;331-334.
75. Collins R. J., Harmon B. V., Gobe G., Kerr J. F.R. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radiat Biol. 61:1992;451-453.
76. Murgia M., Pizzo P., Sandona D. Mitochondrial DNA is not fragmented during apoptosis. J Biol Chem. 267:1992;10939-10941.
77. Henkart, P. A. ICE family proteases: mediators of all apoptotic cell death, Immunity, 1996, 4, 195, 201, Holzman, Apoptosis provides new tagets for chemotherapy, J Natl Cancer Inst, 1996, 88, 1098, 1100.
78. Henkart, P. A. ICE family proteases: mediators of all apoptotic cell death, Immunity, 1996, 4, 195, 201, Holzman, Apoptosis provides new tagets for chemotherapy, J Natl Cancer Inst, 1996, 88, 1098, 1100.
79. Wolfe J. T., Ross D., Cohen G. M. A role for metals and free radicals in the induction of apoptosis in thymocytes. FEBS Lett. 352:1994;58-62.
80. Slater A. F.G., Nobel C. S.I., Maellaro E. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Bio J. 306:1995;771-778.
81. Clopton D. A., Saltman P. Low-level oxidative stress causes cell-cycle specific arrest in cultured cells. Biochim Biophys Res Commun. 210:1995;189-196.
82. Tsujimoto, Y. Gorham, J. Cossman, The t(14:18) chromosomal translocation involved in B-cell neoplasms results from mistakes in VDJ joining, Science, 1985, 229, 1390, 1393, Yin, X. -M. Oltvai, Z. N. Korsmayer, S. J. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with BAX, Nature, 1994, 369, 321, 323.
83. Tsujimoto, Y. Gorham, J. Cossman, The t(14:18) chromosomal translocation involved in B-cell neoplasms results from mistakes in VDJ joining, Science, 1985, 229, 1390, 1393, Yin, X. -M. Oltvai, Z. N. Korsmayer, S. J. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with BAX, Nature, 1994, 369, 321, 323.
84. Hockenbery D. M., Oltavi Z. N., Yin X.-M. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 75:1993;241-251.
85. Kane D. J., Sarafian T. A., Anton R. Bcl-2 inhibition of neural death. Decreased generation of reactive oxygen species. Science. 262:1993;1274-1277.
86. Ratan R. R., Murphy T. H., Baraban J. M. Oxidative stress induces apoptosis in embryonic cortical neurones. J Neurochem. 62:1994;376-379.
87. Zhong L. -T., Sarafian T., Kane D. J. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA. 90:1993;4533-4537.
88. Trump B. F., Berezesky I. K. Calcium-mediated cell injury and cell death. FASEB J. 9:1995;219-228.
89. Wang J.-F., Jerrells T. R., Spitzer J. J. Decreased production of reactive oxygen intermediates is an early event during in vitro apoptosis of rat thymocytes. Free Radic Biol Med. 20:1996;533-542.
90. 2+fluxes. Proc Natl Acad Sci USA. 91:1994;6569-6573.
91. Baffy G., Niyashita T., Williamson J. R., Reed J. C. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartition of intracellular calcium and is blocked by enforced bcl-2 oncoprotein production. J Biol Chem. 268:1993;6511-6519.
92. Ryan J. J., Prochownik E., Gottlieb C. A. C-myc and bcl-2 modulate P53 function by altering P53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA. 91:1994;5878-5882.
93. Wang H.-G., Miyashita T., Takayama S. Apoptosis regulation by interaction of bcl- 2 protein and raf-1 kinase. Oncogene. 9:1994;2751-2756.
94. Chen, Q. Fischer, A. Reagan, J. D. Oxidative DNA damage and senescence of human diploid fibroblast cells, Proc Natl Acad Sci USA, 1995, 92, 4337, 4341, Chen, Q. Ames, B. N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells, Proc Natl Acad Sci USA, 1994, 91, 4130, 4134.
95. Chen, Q. Fischer, A. Reagan, J. D. Oxidative DNA damage and senescence of human diploid fibroblast cells, Proc Natl Acad Sci USA, 1995, 92, 4337, 4341, Chen, Q. Ames, B. N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells, Proc Natl Acad Sci USA, 1994, 91, 4130, 4134.
96. Weise A. G., Pacifici R. E., Davies K. J. Transient adaptation of oxidative stress in mammalian cells. Arch Biochem Biophys. 312:1995;231-240.
97. 2for platelet-derived growth factor signal transduction. Science. 270:1995;296-299.
98. Janssen Y. M.W., van Houten B., Born P. J.A., Mossman B. T. Biology of disease: cell and tissue response to oxidative damage. Lab Invest. 69:1993;261-274.
99. Rothstein J. D., Bristol L. A., Hosler B. Chronic inhibition of superoxide dismutase produced apoptotic death of spinal neurones. Proc Natl Acad Sci USA. 91:1994;4155-4159.
100. Troy C. M., Shelanski M. L. Down regulation of copper-zinc superoxide dismutase causes apoptotic death in PC 12 neuronal cells. Proc Natl Acad Sci USA. 91:1994;6384-6387.
101. Wiedav-Pazos N., Gotto J. J., Rabizadeh S. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science. 271:1996;515-518.
102. Williams N. Thyroid disease: a case of cell suicide. Science. 275:1997;926.
103. Busciglio J., Yankner B. A. Apoptosis and increased generation of reactive oxygen species in Down'syndrome neurones in vitro. Nature. 378:1995;776-779.
104. Pizzo P. A. The compromised host. Bennet J. C., Plum F. Cecil's Textbook of Medicine. 1996;1540-1541 WB Saunders, New York.
105. Traystman R. J., Kirsch J. R., Koehler R. C. Oxygen radical mechanism of brain injury following ischemia and reperfusion. J Appl Physiol. 71:1991;1185-1195.
106. Pissarek M., Janichen F., Blasig I. E. Cardioprotection potency of the radical scavanger S-2-(3-amino propylamino)-ethylphosphorothioate in the post-ischemic rat heart. Mol Cell Biochem. 145:1995;121-129.
107. Anderson K. M., Jajeh A., Meng J. Paradoxical induction of type 1 PCD in U937 cells by an antioxidant and the free radical spin trap, NTBN. Blood. 90:1997;#3468.
108. Choi H. -S., Moore D. D. Induction of c-fos and c-jun gene expression by phenolic antioxidants. Mol Endocrinol. 7:1993;1596-1602.
109. Kroemer G., Petit P., Zamzami N. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
110. Payne C. M., Bernstein C., Bernstein H. Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal transduction pathways. Leuk Lymphoma. 995:1995;43-93.
111. Kroemer G., Zamzami N., Sisin S. A. Mitochondrial control of apoptosis. Immunol Today. 18:1997;44-51.
112. Shimizu, S. Eguchi, Y. Kosaka, H. Prevention of hypoxia-related cell death by Bcl-2 and Bcl-xl, Nature, 1995, 374, 811, 813, Shimizu, S. Eguchi, Y. Kamiike, W. Reduction of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible evolution of common mediators in apoptotic and necrotic signal transduction, Oncogene, 1996, 12, 2045, 2050.
113. Shimizu, S. Eguchi, Y. Kosaka, H. Prevention of hypoxia-related cell death by Bcl-2 and Bcl-xl, Nature, 1995, 374, 811, 813, Shimizu, S. Eguchi, Y. Kamiike, W. Reduction of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible evolution of common mediators in apoptotic and necrotic signal transduction, Oncogene, 1996, 12, 2045, 2050.
114. Jacobson M. D., Raff M. C. Programmed cell death and Bcl-2 protection in very low oxygen. Nature. 374:1995;814-816.
115. Muschel R. J., Bernhard E. J., Garza L. Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling. Cancer Res. 55:1995;995-998.
116. Graeber T. G., Osmanian C., Jacks T. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid cancers. Nature. 379:1996;88-92.
117. Strasser A., Harris A. W., Jacks T., Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via P53-independent mechanisms inhibitable by bcl-2. Cell. 79:1994;329-339.
118. Lotem J., Sachs L. Control of sensitivity to induction of apoptosis in myeloid leukemia cells by differentiation and bcl-2 dependent and independent pathways. Cell Growth Diff. 5:1994;321-327.
119. Wolvetang E. J., Johnson K. L., Krauer K. Mitochondrial respiratory inhibitors induce apoptosis. FEBS Lett. 339:1994;42-44.
120. Carmeliet P., Dor Y., Herbert J.-M. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:1998;485-490.
121. Polyak K., Xia Y., Zweier J. L. A model for P-53 induced apoptosis. Nature. 389:1997;300-306.
122. Yarmolinsky M. B. Programmed cell death in bacterial populations. Science. 267:1995;836-837.
123. Vaux D. L., Haecker G., Strasser A. An evolutionary perspective on apoptosis. Cell. 76:1994;777-779.
124. Ameisan J. C. The origin of programmed cell death. Science. 272:1996;1278-1279.
125. Hedlev D. W., McCulloch E. A., Minden M. D., Chow S., Curtis J. Antileukemic action of buthionine sulfoximine: evidence for an intrinsic death mechanism based on oxidative stress. Leukemia. 12:1998;1545-1552.
126. Marchetti P., Susin S. A., Decaudin D. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA. Cancer Res. 56:1996;2033-2038.
127. Esposti M. D., McLennan H. Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis. FEBS Lett. 430:1998;338-342.
128. Zhang J., Liu X., Scherer D. C., van Kaer L., Wang X., Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor. Proc Natl Acad Sci USA. 95:1998;12480-12485.
129. Cory S. Cell death throes. Proc Natl Acad Sci USA. 95:1998;12077-12079.
130. Lennon S. V., Martin S. J., Cotter T. G. Induction of apoptosis (programmed cell death) in tumor cell lines by widely diverging stimuli. Biochem Soc Trans. 18:1990;343-345.
131. Bowen, I. D. Apoptosis or programmed cell death, Cell Biol Int, 1993, 17, 365, 380, Evans, V. G. Multiple pathways to apoptosis, Cell Biol Int, 1993, 17, 461, 476.
132. Bowen, I. D. Apoptosis or programmed cell death, Cell Biol Int, 1993, 17, 365, 380, Evans, V. G. Multiple pathways to apoptosis, Cell Biol Int, 1993, 17, 461, 476.
133. Gjertsen B. T., Cressey L. I., Rachlaud S. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in an IPC leukemia cell line. J Cell Sci. 107:1994;3363-3377.
134. Xiang J., Chao D. T., Korsmeyer S. J. BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci USA. 93:1996;14559-14563.
135. McCarthy N. J., Whyte M. K.B., Gilbert C. S., Evan G. I. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage or the Bcl-2 homologue Bak. J Cell Biol. 136:1997;215-227.
136. Amarante-Mendes G. P., Finucane D. M., Martin S. J. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death Diff. 5:1998;298-306.
137. Anderson K. M., Seed T., Vos M. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death. Prostate. 37:1998;161-173.
138. Anderson K. M., Seed T., Alrefrai W., Harris J. E. NTBN, a free radical spin trap induces programmed cell death in human pancreatic cancer PANC-1 cells. Anticancer Res. 18:1998;3213-3222.
139. King D., Pringle J. H., Hutchinson M., Cohen G. M. Processing/activation of caspases-3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells. Leukemia. 12:1998;1553-1560.
140. Janicke R. U., Sprengart M. L., Wati M. R., Porter A. G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Bio Chem. 273:1998;9357-9360.