The origin of programmed cell death

Science

Volumn 272, Issue 5266, 1996, Pages 1278-1279

  Ameisen, Jean Claude ^a  

^a BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL CYCLE; CELL DAMAGE; CELL DIFFERENTIATION; CELL SURVIVAL; EVOLUTION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL SURVIVAL; DICTYOSTELIUM; EVOLUTION; GENES; TETRAHYMENA THERMOPHILA; TRYPANOSOMA; VARIATION (GENETICS);

EID: 0029893702     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5266.1278     Document Type: Short Survey

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17. The conserved Ced-3/ICE/CPP32 cysteine protease gene families that are considered as downstream executioners of apoptosis in multicellular animals may in fact be upstream regulators of cell suicide or may act in conjunction with regulators of the cell cycle (or both). This is consistent with findings indicating that (i) the Bcl-2 survival gene product prevents apoptosis downstream of ICE activation [M, Enari, A. Hase, S Nagata, EMBO J. 14, 5201 (1995)]; and (ii) granzyme B, which directly activates CPP32 [A. J. Darmon, D. W. Nicholson, R. C. Bleakley, Nature 377, 446 (1995)], also requires cdc2 cyclin-dependent kinase activation in order to induce apoptosis (8).
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