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Volumn 6, Issue 1, 1999, Pages 17-34

Gene therapy of viral hepatitis and hepatocellular carcinoma

Author keywords

Cancer; Gene therapy; Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma

Indexed keywords

COMPLEMENTARY DNA; COMPLEMENTARY RNA; CYTOKINE; FLUCYTOSINE; FLUOROURACIL; INTERLEUKIN 2; RIBOZYME; VIRUS ANTIGEN; VIRUS VECTOR;

EID: 0033024418     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1999.6120136.x     Document Type: Review
Times cited : (26)

References (204)
  • 1
    • 0026718123 scopus 로고
    • Human gene therapy comes of age
    • Miller AD. Human gene therapy comes of age. Nature 1992; 357: 455-460.
    • (1992) Nature , vol.357 , pp. 455-460
    • Miller, A.D.1
  • 2
    • 0027595949 scopus 로고
    • The basic science of gene therapy
    • Mulligan RC. The basic science of gene therapy. Science 1993; 260: 926-932.
    • (1993) Science , vol.260 , pp. 926-932
    • Mulligan, R.C.1
  • 3
    • 0027494387 scopus 로고
    • Hepatic gene therapy: Present and future
    • Ledley FD. Hepatic gene therapy: present and future. Hepatology 1993; 18: 1263-1273.
    • (1993) Hepatology , vol.18 , pp. 1263-1273
    • Ledley, F.D.1
  • 4
    • 0028350767 scopus 로고
    • Gene therapy. Applications to the treatment of gastrointestinal and liver diseases
    • Chang AGY, Wu GY. Gene therapy. Applications to the treatment of gastrointestinal and liver diseases. Gastroenterology 1994; 106: 1076-1084.
    • (1994) Gastroenterology , vol.106 , pp. 1076-1084
    • Chang, A.G.Y.1    Wu, G.Y.2
  • 6
    • 0025914897 scopus 로고
    • Antisense RNA
    • Eguchi Y. Antisense RNA. Annu Rev Biochem 1991; 60: 631-652.
    • (1991) Annu Rev Biochem , vol.60 , pp. 631-652
    • Eguchi, Y.1
  • 7
    • 0024291288 scopus 로고
    • Simple RNA enzymes with new and highly specific endoribonuclease activities
    • Haseloff J, Gerlach WL. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 1988; 334: 585-591.
    • (1988) Nature , vol.334 , pp. 585-591
    • Haseloff, J.1    Gerlach, W.L.2
  • 9
    • 0025837282 scopus 로고
    • Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation
    • Sullenger BA, Gallardo FH, Ungers GE, Gilboa E. Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation. J Virol 1991; 65: 6811-6816.
    • (1991) J Virol , vol.65 , pp. 6811-6816
    • Sullenger, B.A.1    Gallardo, F.H.2    Ungers, G.E.3    Gilboa, E.4
  • 10
    • 0023239517 scopus 로고
    • Functional inactivation of genes by dominant negative mutations
    • Herskowitz I. Functional inactivation of genes by dominant negative mutations. Nature 1987; 329: 219-222.
    • (1987) Nature , vol.329 , pp. 219-222
    • Herskowitz, I.1
  • 11
    • 0028170354 scopus 로고
    • Intracellular antibodies as a new class of therapeutic molecules for gene therapy
    • Chen SY, Bagley J, Marasco WA. Intracellular antibodies as a new class of therapeutic molecules for gene therapy. Human Gene Ther 1994; 5: 595-601.
    • (1994) Human Gene Ther , vol.5 , pp. 595-601
    • Chen, S.Y.1    Bagley, J.2    Marasco, W.A.3
  • 13
    • 0028306184 scopus 로고
    • The retroviral vector. Replication cycle and safety considerations for retrovirus-mediated gene therapy
    • Boris-Lawrie K, Temin HM. The retroviral vector. Replication cycle and safety considerations for retrovirus-mediated gene therapy. Ann NY Acad Sci 1994; 716: 50-70.
    • (1994) Ann NY Acad Sci , vol.716 , pp. 50-70
    • Boris-Lawrie, K.1    Temin, H.M.2
  • 14
    • 16944364248 scopus 로고    scopus 로고
    • Highly efficient retrovirusmediated gene transfer into rat hepatocytes in vivo
    • Kitten O, Cosset FL, Ferry N. Highly efficient retrovirusmediated gene transfer into rat hepatocytes in vivo. Human Gene Ther 1997; 8: 1491-1494.
    • (1997) Human Gene Ther , vol.8 , pp. 1491-1494
    • Kitten, O.1    Cosset, F.L.2    Ferry, N.3
  • 15
    • 0028962405 scopus 로고
    • Pseudotyped retroviral vectors for studies of human gene therapy
    • Friedman T, Yee JK. Pseudotyped retroviral vectors for studies of human gene therapy. Nature Med 1995; 1: 275-277.
    • (1995) Nature Med , vol.1 , pp. 275-277
    • Friedman, T.1    Yee, J.K.2
  • 16
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentivirus vector
    • Naldini L, Blomer U, Gallay P et al. In vivo gene delivery and stable transduction of nondividing cells by a lentivirus vector. Science 1996; 272: 2683-2687.
    • (1996) Science , vol.272 , pp. 2683-2687
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 17
    • 0030716959 scopus 로고    scopus 로고
    • Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
    • Kafri T, Blomer U, Peterson DA, Gage FH, Verma IM. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nature Genet 1997; 17: 314-317.
    • (1997) Nature Genet , vol.17 , pp. 314-317
    • Kafri, T.1    Blomer, U.2    Peterson, D.A.3    Gage, F.H.4    Verma, I.M.5
  • 20
    • 0028484704 scopus 로고
    • MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with El-deleted recombinant adenoviruses
    • Yang Y, Hildegund CJE, Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with El-deleted recombinant adenoviruses. Immunity 1994; 1: 433-442.
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Hildegund, C.J.E.2    Wilson, J.M.3
  • 21
    • 0030752379 scopus 로고    scopus 로고
    • Advances in adenoviral vectors: From genetic engineering to their biology
    • Yeh P, Perricaudet M. Advances in adenoviral vectors: from genetic engineering to their biology. FASEB J 1997; 11: 615-623.
    • (1997) FASEB J , vol.11 , pp. 615-623
    • Yeh, P.1    Perricaudet, M.2
  • 22
    • 0030774216 scopus 로고    scopus 로고
    • Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination
    • Bramson JL, Hitt M, Gauldie J, Graham FL. Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination. Gene Ther 1997; 4: 1069-1076.
    • (1997) Gene Ther , vol.4 , pp. 1069-1076
    • Bramson, J.L.1    Hitt, M.2    Gauldie, J.3    Graham, F.L.4
  • 23
    • 0008687567 scopus 로고
    • The development of adeno-associated virus as a vector for cancer gene therapy
    • Sobol RE, Scanlon KJ, eds. Stamford: Appleton & Lange
    • Bartlett JS, Quattrocchi KB, Samulski RJ. The development of adeno-associated virus as a vector for cancer gene therapy. In: Sobol RE, Scanlon KJ, eds. The Internet Book of Gene Therapy, Stamford: Appleton & Lange, 1995: 27-39.
    • (1995) The Internet Book of Gene Therapy , pp. 27-39
    • Bartlett, J.S.1    Quattrocchi, K.B.2    Samulski, R.J.3
  • 24
    • 0031011987 scopus 로고    scopus 로고
    • Adeno-associated virus 2-mediated gene transfer in vivo: Organtropism and expression of transduced sequences in mice
    • Ponnazhagan S, Mukherjee P, Yoder MC et al. Adeno-associated virus 2-mediated gene transfer in vivo: organtropism and expression of transduced sequences in mice. Gene 1997; 190: 203-210.
    • (1997) Gene , vol.190 , pp. 203-210
    • Ponnazhagan, S.1    Mukherjee, P.2    Yoder, M.C.3
  • 25
    • 0030997346 scopus 로고    scopus 로고
    • Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
    • Snyder RO, Miao CH, Patijn GA et al. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nature Genet 1997; 16: 270-276.
    • (1997) Nature Genet , vol.16 , pp. 270-276
    • Snyder, R.O.1    Miao, C.H.2    Patijn, G.A.3
  • 26
    • 0029047860 scopus 로고
    • DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors
    • Russell DW, Alexander IE, Miller AD. DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc Natl Acad Sci USA 1995; 92: 5719-5723.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5719-5723
    • Russell, D.W.1    Alexander, I.E.2    Miller, A.D.3
  • 27
    • 0029883821 scopus 로고    scopus 로고
    • Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors
    • Alexander IE, Russell DW, Spence AM, Miller AD. Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors. Human Gene Ther 1996; 7: 841-850.
    • (1996) Human Gene Ther , vol.7 , pp. 841-850
    • Alexander, I.E.1    Russell, D.W.2    Spence, A.M.3    Miller, A.D.4
  • 28
    • 0031019819 scopus 로고    scopus 로고
    • Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors
    • Koeberl DD, Alexander IE, Halbert CL, Russell DW. Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. Proc Natl Acad Sci USA 1997; 94: 1426-1431.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1426-1431
    • Koeberl, D.D.1    Alexander, I.E.2    Halbert, C.L.3    Russell, D.W.4
  • 29
    • 0029147628 scopus 로고
    • Non viral gene therapy: The promise of genes as pharmaceutical products
    • Ledley F. Non viral gene therapy: the promise of genes as pharmaceutical products. Human Gene Ther 1995; 6: 1129-1144.
    • (1995) Human Gene Ther , vol.6 , pp. 1129-1144
    • Ledley, F.1
  • 30
    • 0025231388 scopus 로고
    • Direct gene transfer into mouse muscle in vivo
    • Wolff JA, Malone RW, Williams P et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.
    • (1990) Science , vol.247 , pp. 1465-1468
    • Wolff, J.A.1    Malone, R.W.2    Williams, P.3
  • 31
    • 0028670903 scopus 로고
    • Gene expression following direct injection of DNA into liver
    • Hickman MA, Malone RW, Lehmann-Bruinsma K et al. Gene expression following direct injection of DNA into liver. Human Gene Ther 1994; 4: 1477-1483.
    • (1994) Human Gene Ther , vol.4 , pp. 1477-1483
    • Hickman, M.A.1    Malone, R.W.2    Lehmann-Bruinsma, K.3
  • 32
    • 0030709447 scopus 로고    scopus 로고
    • Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers
    • Zhang G, Vargo D, Budker V, Armstrong N, Knechtle S, Wolff JA. Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers. Human Gene Ther 1997; 8: 1763-1772.
    • (1997) Human Gene Ther , vol.8 , pp. 1763-1772
    • Zhang, G.1    Vargo, D.2    Budker, V.3    Armstrong, N.4    Knechtle, S.5    Wolff, J.A.6
  • 33
    • 0024978864 scopus 로고
    • Cationic liposome-mediated transfection
    • Felgner PL, Ringold GM. Cationic liposome-mediated transfection. Nature 1989; 337: 387-388.
    • (1989) Nature , vol.337 , pp. 387-388
    • Felgner, P.L.1    Ringold, G.M.2
  • 34
    • 0029898019 scopus 로고    scopus 로고
    • Long-term expression of the al-antitrypsin gene in mice employing anionic and cationic liposome vectors
    • Crespo J, Blaya C, Crespo A, Aliño SF. Long-term expression of the al-antitrypsin gene in mice employing anionic and cationic liposome vectors. Biochem Pharmacol 1996; 51: 1309-1314.
    • (1996) Biochem Pharmacol , vol.51 , pp. 1309-1314
    • Crespo, J.1    Blaya, C.2    Crespo, A.3    Aliño, S.F.4
  • 35
    • 0031581171 scopus 로고    scopus 로고
    • Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): Reciprocal effect of cationic lipid for in vitro and in vivo gene transfer
    • Saeki Y, Matsumoto N, Nakano Y, Mori M, Awai K, Kaneda Y. Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Human Gene Ther 1997; 8: 2133-2141.
    • (1997) Human Gene Ther , vol.8 , pp. 2133-2141
    • Saeki, Y.1    Matsumoto, N.2    Nakano, Y.3    Mori, M.4    Awai, K.5    Kaneda, Y.6
  • 37
    • 0023811723 scopus 로고
    • Receptor mediated gene delivery and expression in vivo
    • Wu GY, Wu CH. Receptor mediated gene delivery and expression in vivo. J Biol Chem 1988; 263: 14621-14624.
    • (1988) J Biol Chem , vol.263 , pp. 14621-14624
    • Wu, G.Y.1    Wu, C.H.2
  • 38
    • 0024343077 scopus 로고
    • Trageting genes: Delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo
    • Wu CH, Wilson JM, Wu GY. Trageting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J Biol Chem 1989; 264: 16985-16987.
    • (1989) J Biol Chem , vol.264 , pp. 16985-16987
    • Wu, C.H.1    Wilson, J.M.2    Wu, G.Y.3
  • 39
    • 0028223310 scopus 로고
    • Gene transfer in vivo: Sustained expression and regulation of genes introduced into liver by the receptor-targeted uptake
    • Perales JC, Ferkol T, Beegen H, Ratnoff OD, Hanson RW. Gene transfer in vivo: sustained expression and regulation of genes introduced into liver by the receptor-targeted uptake. Proc Natl Acad Sci USA 1994; 91: 4086-4090.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4086-4090
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 40
    • 0030896557 scopus 로고    scopus 로고
    • Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asyaloglycoprotein receptor
    • Perales JC, Grossman GA, Molas M et al. Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asyaloglycoprotein receptor. J Biol Chem 1997; 272: 7398-7407.
    • (1997) J Biol Chem , vol.272 , pp. 7398-7407
    • Perales, J.C.1    Grossman, G.A.2    Molas, M.3
  • 41
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang DC, Devit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992; 356: 152-154.
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.C.1    Devit, M.2    Johnston, S.A.3
  • 43
    • 0030757875 scopus 로고    scopus 로고
    • Genetic immunization: A new era in vaccines and immune therapeutics
    • Chattergoon M, Boyer J, Weiner DB. Genetic immunization: a new era in vaccines and immune therapeutics. FASEB J 1997; 11: 753-763.
    • (1997) FASEB J , vol.11 , pp. 753-763
    • Chattergoon, M.1    Boyer, J.2    Weiner, D.B.3
  • 44
    • 0031474947 scopus 로고    scopus 로고
    • Cytotoxic T cells and viral hepatitis
    • Chisari FV. Cytotoxic T cells and viral hepatitis. J Clin Invest 1997; 100: 519-524.
    • (1997) J Clin Invest , vol.100 , pp. 519-524
    • Chisari, F.V.1
  • 45
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer JB, Donnelly J, Parker SE et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745-1749.
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.2    Parker, S.E.3
  • 47
    • 0030698310 scopus 로고    scopus 로고
    • Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope
    • Casares S, Inaba K, Brumeanu TD, Steinman RM, Bona CA. Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope. J Exp Med 1997; 186: 1481-1486.
    • (1997) J Exp Med , vol.186 , pp. 1481-1486
    • Casares, S.1    Inaba, K.2    Brumeanu, T.D.3    Steinman, R.M.4    Bona, C.A.5
  • 48
    • 0031908427 scopus 로고    scopus 로고
    • Gene vaccination: Plasmid DNA is more than just a blueprint
    • Tighe H, Corr M, Roman M, Raz E. Gene vaccination: plasmid DNA is more than just a blueprint. Immunol Today 1998; 19: 89-97.
    • (1998) Immunol Today , vol.19 , pp. 89-97
    • Tighe, H.1    Corr, M.2    Roman, M.3    Raz, E.4
  • 49
    • 0030764558 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences function as Th1 promoting adjuvants
    • Roman M, Martin-Orozco E, Goodman JS et al. Immunostimulatory DNA sequences function as Th1 promoting adjuvants. Nature Med 1997; 3: 849-854.
    • (1997) Nature Med , vol.3 , pp. 849-854
    • Roman, M.1    Martin-Orozco, E.2    Goodman, J.S.3
  • 50
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T, Koch ES, Vabulas RM et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 1998; 28: 2045-2054.
    • (1998) Eur J Immunol , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3
  • 51
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • Kim JJ, Ayyavoo V, Bagarazzi ML et al. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol 1997; 158: 816-826.
    • (1997) J Immunol , vol.158 , pp. 816-826
    • Kim, J.J.1    Ayyavoo, V.2    Bagarazzi, M.L.3
  • 52
    • 0031569459 scopus 로고    scopus 로고
    • Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12
    • Tsuji T, Hamjima K, Fukushima J et al. Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12. J Immunol 1997; 158: 4008-4013.
    • (1997) J Immunol , vol.158 , pp. 4008-4013
    • Tsuji, T.1    Hamjima, K.2    Fukushima, J.3
  • 53
    • 0031569963 scopus 로고    scopus 로고
    • Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
    • Iwasaki A, Stiernholm BJ, Chan AK, Berinstein NL, Barber BH. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol 1997; 158: 4591-4601.
    • (1997) J Immunol , vol.158 , pp. 4591-4601
    • Iwasaki, A.1    Stiernholm, B.J.2    Chan, A.K.3    Berinstein, N.L.4    Barber, B.H.5
  • 54
    • 0030873202 scopus 로고    scopus 로고
    • Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes
    • Kim JJ, Bagarazzi ML, Trivedi N et al. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes. Nature Biotech 1997; 15: 641-646.
    • (1997) Nature Biotech , vol.15 , pp. 641-646
    • Kim, J.J.1    Bagarazzi, M.L.2    Trivedi, N.3
  • 55
    • 0028819916 scopus 로고
    • Gene-gun based nucleic acid immunization: Elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA
    • Pertmer TM, Eismbraun MD, McCabe D, Prayaga SK, Fuller DH, Haynes JR. Gene-gun based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 1995; 13: 1427-1430.
    • (1995) Vaccine , vol.13 , pp. 1427-1430
    • Pertmer, T.M.1    Eismbraun, M.D.2    McCabe, D.3    Prayaga, S.K.4    Fuller, D.H.5    Haynes, J.R.6
  • 57
    • 0031915963 scopus 로고    scopus 로고
    • Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses
    • Hedley ML, Curley J, Urban R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nature Med 1998; 4: 365-368.
    • (1998) Nature Med , vol.4 , pp. 365-368
    • Hedley, M.L.1    Curley, J.2    Urban, R.3
  • 58
    • 0031015971 scopus 로고    scopus 로고
    • Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus
    • Bruña-Romero O, Lasarte JJ, Wilkinson G et al. Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus. Hepatology 1997; 25: 470-477.
    • (1997) Hepatology , vol.25 , pp. 470-477
    • Bruña-Romero, O.1    Lasarte, J.J.2    Wilkinson, G.3
  • 59
    • 1842369628 scopus 로고    scopus 로고
    • Characterization of CD8+ cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens
    • Townsend K, Sallberg M, OíDea J et al. Characterization of CD8+ cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens. J Virol 1997; 71: 3365-3374.
    • (1997) J Virol , vol.71 , pp. 3365-3374
    • Townsend, K.1    Sallberg, M.2    OíDea, J.3
  • 60
    • 0030579120 scopus 로고    scopus 로고
    • Construction of adenoviral and retroviral vectors coexpressing the genes encoding the hepatitis B surface antigen and B7-1 protein
    • He XS, Rivkina M, Robinson WS. Construction of adenoviral and retroviral vectors coexpressing the genes encoding the hepatitis B surface antigen and B7-1 protein. Gene 1996; 175: 121-125.
    • (1996) Gene , vol.175 , pp. 121-125
    • He, X.S.1    Rivkina, M.2    Robinson, W.S.3
  • 61
    • 0030852745 scopus 로고    scopus 로고
    • Gene therapy for chronic viral hepatitis: Ribozymes, antisense oligonucleotides, and dominant negative mutants
    • Weizsacker FV, Wieland S, Lock J et al. Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants. Hepatology 1997; 26: 251-255.
    • (1997) Hepatology , vol.26 , pp. 251-255
    • Weizsacker, F.V.1    Wieland, S.2    Lock, J.3
  • 62
    • 0028081659 scopus 로고
    • Direct gene transfer in skeletal muscle: Plasmid DNA-based immunization against the hepatitis B virus surface antigen
    • Davis HL, Michel ML, Mancini M, Schleef M, Whalen RG. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine 1994; 12: 1503-1509.
    • (1994) Vaccine , vol.12 , pp. 1503-1509
    • Davis, H.L.1    Michel, M.L.2    Mancini, M.3    Schleef, M.4    Whalen, R.G.5
  • 63
    • 0028864849 scopus 로고
    • DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to hepatitis B surface antigen
    • Davis HL, Schirmbeck R, Reimann J, Whalen RG. DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to hepatitis B surface antigen. Human Gene Ther 1995; 6: 1447-1456.
    • (1995) Human Gene Ther , vol.6 , pp. 1447-1456
    • Davis, H.L.1    Schirmbeck, R.2    Reimann, J.3    Whalen, R.G.4
  • 64
    • 0029101242 scopus 로고
    • Nucleic acid vaccination primes hepatitis B surface antigen-specific cytotoxic T lymphocytes in non-respondermice
    • Schirmbeck R, Bohm W, Ando K, Chisari FV, Reimann J. Nucleic acid vaccination primes hepatitis B surface antigen-specific cytotoxic T lymphocytes in non-respondermice. J Virol 1995; 69: 5929-5934.
    • (1995) J Virol , vol.69 , pp. 5929-5934
    • Schirmbeck, R.1    Bohm, W.2    Ando, K.3    Chisari, F.V.4    Reimann, J.5
  • 65
    • 0029957795 scopus 로고    scopus 로고
    • Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen
    • He WS, Chen HS, Chu K, Rivkina M, Robinson WS. Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen. Proc Natl Acad Sci USA 1996; 93: 7274-7278.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7274-7278
    • He, W.S.1    Chen, H.S.2    Chu, K.3    Rivkina, M.4    Robinson, W.S.5
  • 66
    • 0029913027 scopus 로고    scopus 로고
    • DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice
    • Kuhober A, Pudoller HP, Reifenberg K et al. DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J Immunol 1996; 156: 3687-3695.
    • (1996) J Immunol , vol.156 , pp. 3687-3695
    • Kuhober, A.1    Pudoller, H.P.2    Reifenberg, K.3
  • 67
    • 0027369829 scopus 로고
    • DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
    • Davis HL, Michel ML, Whalen RG. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Human Mol Genet 1993; 2: 1847-1851.
    • (1993) Human Mol Genet , vol.2 , pp. 1847-1851
    • Davis, H.L.1    Michel, M.L.2    Whalen, R.G.3
  • 68
    • 0029051321 scopus 로고
    • DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans
    • Michel ML, Davis HL, Schleef M, Mancini M, Tiollais P, Whalen RG. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc Natl Acad Sci USA 1995; 92: 5307-5311.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5307-5311
    • Michel, M.L.1    Davis, H.L.2    Schleef, M.3    Mancini, M.4    Tiollais, P.5    Whalen, R.G.6
  • 69
    • 0030174678 scopus 로고    scopus 로고
    • DNA-mediated immunization to hepatitis B surface antigen: Longevity of primary response and effect of boost
    • Davis HL, Mancini M, Michel ML, Whalen RG. DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost. Vaccine 1996; 14: 910-915.
    • (1996) Vaccine , vol.14 , pp. 910-915
    • Davis, H.L.1    Mancini, M.2    Michel, M.L.3    Whalen, R.G.4
  • 70
    • 0030904125 scopus 로고    scopus 로고
    • Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization
    • Geissler M, Tokushige K, Chante CC, Zurawski VR, Wands JR. Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization. Gastroenterology 1997; 112: 1307-1320.
    • (1997) Gastroenterology , vol.112 , pp. 1307-1320
    • Geissler, M.1    Tokushige, K.2    Chante, C.C.3    Zurawski, V.R.4    Wands, J.R.5
  • 71
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Chow YH, Huang WL, Chi WK, Chu YD, Tao MH. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J Virol 1997; 71: 169-178.
    • (1997) J Virol , vol.71 , pp. 169-178
    • Chow, Y.H.1    Huang, W.L.2    Chi, W.K.3    Chu, Y.D.4    Tao, M.H.5
  • 72
    • 0031808286 scopus 로고    scopus 로고
    • Cytokine and hepatitis B virus DNA co-immunizations enhance cellular and humoral immune responses to the middle but not the large hepatitis B virus surface antigen in mice
    • Geissler M, Schirmbeck R, Reinmann J, Blum HE, Wands JR. Cytokine and hepatitis B virus DNA co-immunizations enhance cellular and humoral immune responses to the middle but not the large hepatitis B virus surface antigen in mice. Hepatology 1998; 28: 202-210.
    • (1998) Hepatology , vol.28 , pp. 202-210
    • Geissler, M.1    Schirmbeck, R.2    Reinmann, J.3    Blum, H.E.4    Wands, J.R.5
  • 73
    • 0031953116 scopus 로고    scopus 로고
    • Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokinc genes
    • Chow YH, Chiang BL, Lee YL et al. Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokinc genes. J Immunol 1998; 160: 1320-1329.
    • (1998) J Immunol , vol.160 , pp. 1320-1329
    • Chow, Y.H.1    Chiang, B.L.2    Lee, Y.L.3
  • 74
    • 0029982850 scopus 로고    scopus 로고
    • DNA vaccine for hepatitis B: Evidence for immunogencity in chimpanzees and comparison with other vaccines
    • Davis HL, McCluskie MJ, Gerin JL, Purcell RH. DNA vaccine for hepatitis B: evidence for immunogencity in chimpanzees and comparison with other vaccines. Proc Natl Acad Sci USA 1996; 93: 7213-7218.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7213-7218
    • Davis, H.L.1    McCluskie, M.J.2    Gerin, J.L.3    Purcell, R.H.4
  • 75
    • 7144256527 scopus 로고    scopus 로고
    • Immune response to a hepatitis B DNA vaccine in Aotus monkeys: A comparison of vaccine formulation, route, and method of administration
    • Gramzinski RA, Brazolot CL, Obaldia N, Hoffman SL, Davis HL. Immune response to a hepatitis B DNA vaccine in Aotus monkeys: a comparison of vaccine formulation, route, and method of administration. Mol Med 1998; 4: 109-118.
    • (1998) Mol Med , vol.4 , pp. 109-118
    • Gramzinski, R.A.1    Brazolot, C.L.2    Obaldia, N.3    Hoffman, S.L.4    Davis, H.L.5
  • 76
    • 0029985146 scopus 로고    scopus 로고
    • DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state
    • Mancini M, Hadchouel M, Davis HL, Whalen RG, Tiollais P, Michel ML. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. Proc Natl Acad Sci USA 1996; 93: 12946-12501.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12946-112501
    • Mancini, M.1    Hadchouel, M.2    Davis, H.L.3    Whalen, R.G.4    Tiollais, P.5    Michel, M.L.6
  • 77
    • 0028348561 scopus 로고
    • Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice
    • Guidotti LG, Ando K, Hobbs MV et al. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci USA 1994; 91: 3764-3768.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3764-3768
    • Guidotti, L.G.1    Ando, K.2    Hobbs, M.V.3
  • 78
    • 0029589910 scopus 로고
    • Post-transcriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes
    • Tsui LV, Guidotti LG, Ishikawa T, Chisari FV. Post-transcriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes. Proc Natl Acad Sci USA 1995; 92: 12398-12402.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12398-12402
    • Tsui, L.V.1    Guidotti, L.G.2    Ishikawa, T.3    Chisari, F.V.4
  • 80
    • 0025685446 scopus 로고
    • Antisense oligodeoxyribonucleotides inhibit the expression of the gene for hepatitis B virus surface antigen
    • Goodarzi G, Gross SC, Tewari A, Watabe K. Antisense oligodeoxyribonucleotides inhibit the expression of the gene for hepatitis B virus surface antigen. J Gen Virol 1990; 71: 3021-3025.
    • (1990) J Gen Virol , vol.71 , pp. 3021-3025
    • Goodarzi, G.1    Gross, S.C.2    Tewari, A.3    Watabe, K.4
  • 81
    • 84920215637 scopus 로고
    • Inhibition of hepatitis B virus by antisense oligodeoxynucleotides
    • Blum HE, Galun E, Weizsacker FV, Wands JR. Inhibition of hepatitis B virus by antisense oligodeoxynucleotides. Lancet 1991; 337: 1230.
    • (1991) Lancet , vol.337 , pp. 1230
    • Blum, H.E.1    Galun, E.2    Weizsacker, F.V.3    Wands, J.R.4
  • 82
    • 0026688793 scopus 로고
    • Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides
    • Wu GY, Wu CH. Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J Biol Chem 1992; 267: 12436-12439.
    • (1992) J Biol Chem , vol.267 , pp. 12436-12439
    • Wu, G.Y.1    Wu, C.H.2
  • 83
    • 0029898537 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro
    • Nakazono K, Ito Y, Wu CH, Wu GY. Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro. Hepatology 1996; 23: 1297-1303.
    • (1996) Hepatology , vol.23 , pp. 1297-1303
    • Nakazono, K.1    Ito, Y.2    Wu, C.H.3    Wu, G.Y.4
  • 84
    • 0029362721 scopus 로고
    • Specific inhibition of hepatitis B virus gene expression by an antisense oligonucleotide in vitro
    • Yao ZQ, Zhou YX, Feng XM, Chen ZX. Specific inhibition of hepatitis B virus gene expression by an antisense oligonucleotide in vitro. Acta Virol 1995; 39: 227-230.
    • (1995) Acta Virol , vol.39 , pp. 227-230
    • Yao, Z.Q.1    Zhou, Y.X.2    Feng, X.M.3    Chen, Z.X.4
  • 85
    • 0029792310 scopus 로고    scopus 로고
    • Receptor-mediated delivery of hepatitis B virus DNA and antisense oligodeoxynucleotides to avian cells
    • Madon J, Blum HE. Receptor-mediated delivery of hepatitis B virus DNA and antisense oligodeoxynucleotides to avian cells. Hepatology 1996; 24: 474-481.
    • (1996) Hepatology , vol.24 , pp. 474-481
    • Madon, J.1    Blum, H.E.2
  • 86
    • 0030051561 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus in vitro antisense oligonucleotides
    • Yao ZQ, Zhou YX, Guo J et al. Inhibition of hepatitis B virus in vitro antisense oligonucleotides. Acta Virol 1996; 40: 35-39.
    • (1996) Acta Virol , vol.40 , pp. 35-39
    • Yao, Z.Q.1    Zhou, Y.X.2    Guo, J.3
  • 87
    • 0031131802 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus by retroviral vectors expressing antisense RNA
    • Ji W, St CW. Inhibition of hepatitis B virus by retroviral vectors expressing antisense RNA. J Viral Hep 1997; 4: 167-173.
    • (1997) J Viral Hep , vol.4 , pp. 167-173
    • Ji, W.1    St, C.W.2
  • 88
    • 0031050937 scopus 로고    scopus 로고
    • The inhibitory effect of antisense RNA on hepatitis virus surface antigen synthesis
    • Wu J, Gerber MA. The inhibitory effect of antisense RNA on hepatitis virus surface antigen synthesis. J Gen Virol 1997; 78: 641-647.
    • (1997) J Gen Virol , vol.78 , pp. 641-647
    • Wu, J.1    Gerber, M.A.2
  • 89
    • 0027053871 scopus 로고
    • Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template
    • Weiszacker FV, Blum HE, Wands JR. Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template. Biochem Biophys Res Commun 1992; 189: 743-748.
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 743-748
    • Weiszacker, F.V.1    Blum, H.E.2    Wands, J.R.3
  • 90
    • 0029586990 scopus 로고
    • Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells
    • Beck J, Nassal M. Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells. Nucl Acids Res 1995; 23: 4954-4962.
    • (1995) Nucl Acids Res , vol.23 , pp. 4954-4962
    • Beck, J.1    Nassal, M.2
  • 91
    • 0031043894 scopus 로고    scopus 로고
    • Design and preparation of a multimeric self-cleaving hammerhead ribozyme
    • Ruiz J, Ito Y, Wu CH, Wu GY. Design and preparation of a multimeric self-cleaving hammerhead ribozyme. Biotechniques 1997; 22: 338-345.
    • (1997) Biotechniques , vol.22 , pp. 338-345
    • Ruiz, J.1    Ito, Y.2    Wu, C.H.3    Wu, G.Y.4
  • 92
    • 0030743739 scopus 로고    scopus 로고
    • Intracellular application of hairpin ribozyme genes against hepatitis B virus
    • Welch PJ, Tritz R, Yei S, Barber J, Yu M. Intracellular application of hairpin ribozyme genes against hepatitis B virus. Gene Ther 1997; 4: 736-743.
    • (1997) Gene Ther , vol.4 , pp. 736-743
    • Welch, P.J.1    Tritz, R.2    Yei, S.3    Barber, J.4    Yu, M.5
  • 93
    • 0029760856 scopus 로고    scopus 로고
    • Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein
    • Weiszacker FV, Wieland S, Blum HE. Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein. Hepatology 1996; 24: 294-299.
    • (1996) Hepatology , vol.24 , pp. 294-299
    • Weiszacker, F.V.1    Wieland, S.2    Blum, H.E.3
  • 94
    • 0029953004 scopus 로고    scopus 로고
    • Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents
    • Scaglioni PP, Melegari M, Takahashi M, Chowdhury JR, Wands JR. Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents. Hepatology 1996; 24: 1010-1017.
    • (1996) Hepatology , vol.24 , pp. 1010-1017
    • Scaglioni, P.P.1    Melegari, M.2    Takahashi, M.3    Chowdhury, J.R.4    Wands, J.R.5
  • 95
    • 0023727192 scopus 로고
    • Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions
    • Sells MA, Zelent AZ, Shvartsman M, Acs G. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J Virol 1988; 62: 2836-2844.
    • (1988) J Virol , vol.62 , pp. 2836-2844
    • Sells, M.A.1    Zelent, A.Z.2    Shvartsman, M.3    Acs, G.4
  • 96
    • 0027528518 scopus 로고
    • In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorotioate modified antisense oligodeoxynucleotides
    • Offensperger WB, Offensperger S, Walter E et al. In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorotioate modified antisense oligodeoxynucleotides. EMBO J 1993; 12: 1257-1262.
    • (1993) EMBO J , vol.12 , pp. 1257-1262
    • Offensperger, W.B.1    Offensperger, S.2    Walter, E.3
  • 97
    • 0029686063 scopus 로고    scopus 로고
    • In vivo inhibition of hepatitis B viral gene expression by antisense phosphorotioate oligodeoxynucleotides in athymic nude mice
    • Yao Z, Chou Y, Feng X, Chen C, Guo J. In vivo inhibition of hepatitis B viral gene expression by antisense phosphorotioate oligodeoxynucleotides in athymic nude mice. J Viral Hep 1996; 3: 19-22.
    • (1996) J Viral Hep , vol.3 , pp. 19-22
    • Yao, Z.1    Chou, Y.2    Feng, X.3    Chen, C.4    Guo, J.5
  • 98
    • 0030066249 scopus 로고    scopus 로고
    • In vivo inhibition of hepatitis B virus gene expression by antisense phosphorothioate oligonucleotides
    • Moriya K, Matsukura M, Kurokawa K, Koike K. In vivo inhibition of hepatitis B virus gene expression by antisense phosphorothioate oligonucleotides. Biochem Biophys Res Commun 1996; 218: 217-223.
    • (1996) Biochem Biophys Res Commun , vol.218 , pp. 217-223
    • Moriya, K.1    Matsukura, M.2    Kurokawa, K.3    Koike, K.4
  • 99
    • 0029461123 scopus 로고
    • Targeted delivery of antisense DNA in woodchuck hepatitis virus-infected woodchucks
    • Bartholomew RM, Carmichael EP, Findeis MA, Wu CH, Wu GY. Targeted delivery of antisense DNA in woodchuck hepatitis virus-infected woodchucks. J Viral Hep 1995; 2: 273-278.
    • (1995) J Viral Hep , vol.2 , pp. 273-278
    • Bartholomew, R.M.1    Carmichael, E.P.2    Findeis, M.A.3    Wu, C.H.4    Wu, G.Y.5
  • 100
    • 0029156764 scopus 로고
    • Immune responses to plasmid DNA encoding the hepatitis C virus core protein
    • Lagging LM, Meyer K, Hoft D, Houghton M, Belshe RB, Ray R. Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J Virol 1995; 69: 5859-5863.
    • (1995) J Virol , vol.69 , pp. 5859-5863
    • Lagging, L.M.1    Meyer, K.2    Hoft, D.3    Houghton, M.4    Belshe, R.B.5    Ray, R.6
  • 101
    • 0029084640 scopus 로고
    • DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid
    • Major ME, Vitvitski L, Mink MA et al. DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J Virol 1995; 69: 5798-5805.
    • (1995) J Virol , vol.69 , pp. 5798-5805
    • Major, M.E.1    Vitvitski, L.2    Mink, M.A.3
  • 102
    • 0029971032 scopus 로고    scopus 로고
    • Expression and immune response to hepatitis C virus core DNA-based vaccine constructs
    • Tokushige K, Wakita T, Pachuk C et al. Expression and immune response to hepatitis C virus core DNA-based vaccine constructs. Hepatology 1996; 24: 14-20.
    • (1996) Hepatology , vol.24 , pp. 14-20
    • Tokushige, K.1    Wakita, T.2    Pachuk, C.3
  • 103
    • 0031066827 scopus 로고    scopus 로고
    • Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
    • Geissler M, Gesien A, Tokushige K, Wands JR. Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J Immunol 1997; 158: 1231-1237.
    • (1997) J Immunol , vol.158 , pp. 1231-1237
    • Geissler, M.1    Gesien, A.2    Tokushige, K.3    Wands, J.R.4
  • 104
    • 0031050444 scopus 로고    scopus 로고
    • Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: Comparative studies of antibody and T-helper responses following genetic immunization
    • Inchauspe G, Vitvitski L, Major ME et al. Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: comparative studies of antibody and T-helper responses following genetic immunization. DNA Cell Biol 1997; 16: 185-195.
    • (1997) DNA Cell Biol , vol.16 , pp. 185-195
    • Inchauspe, G.1    Vitvitski, L.2    Major, M.E.3
  • 105
    • 0030741985 scopus 로고    scopus 로고
    • DNA vaccination for the induction of immune responses against hepatitis C virus proteins
    • Inchauspe G, Major ME, Nakano I, Vitvitski L, Trepo C. DNA vaccination for the induction of immune responses against hepatitis C virus proteins. Vaccine 1997; 15: 853-856.
    • (1997) Vaccine , vol.15 , pp. 853-856
    • Inchauspe, G.1    Major, M.E.2    Nakano, I.3    Vitvitski, L.4    Trepo, C.5
  • 106
    • 0030914741 scopus 로고    scopus 로고
    • Plasmid DNA-based immunization for hepatitis C virus structural proteins: Immune responses in mice
    • Saito T, Sherman GJ, Kurokohchi K et al. Plasmid DNA-based immunization for hepatitis C virus structural proteins: immune responses in mice. Gastroenterology 1997; 112: 1321-1330.
    • (1997) Gastroenterology , vol.112 , pp. 1321-1330
    • Saito, T.1    Sherman, G.J.2    Kurokohchi, K.3
  • 107
    • 0030817934 scopus 로고    scopus 로고
    • Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode
    • Nakano I, Maertens G, Major ME et al. Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode. J Virol 1997; 71: 7101-7109.
    • (1997) J Virol , vol.71 , pp. 7101-7109
    • Nakano, I.1    Maertens, G.2    Major, M.E.3
  • 108
    • 0031808288 scopus 로고    scopus 로고
    • Modulation of immune responses to hepatitis C virus envelope E2 protein following injection of plasmid DNA using single or combined delivery routes
    • Fournillier A, Nakano I, Vitvitski L et al. Modulation of immune responses to hepatitis C virus envelope E2 protein following injection of plasmid DNA using single or combined delivery routes. Hepatology 1998; 28: 237-244.
    • (1998) Hepatology , vol.28 , pp. 237-244
    • Fournillier, A.1    Nakano, I.2    Vitvitski, L.3
  • 109
    • 0030062317 scopus 로고    scopus 로고
    • Induction of antibodies against structural proteins of hepatitis C virus in mice using recombinant adenovirus
    • Makimura M, Miyake S, Takamori AN et al. Induction of antibodies against structural proteins of hepatitis C virus in mice using recombinant adenovirus. Vaccine 1996; 14: 28-36.
    • (1996) Vaccine , vol.14 , pp. 28-36
    • Makimura, M.1    Miyake, S.2    Takamori, A.N.3
  • 110
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale G, Bertoni R, Lamonaca V et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest 1996; 98: 706-714.
    • (1996) J Clin Invest , vol.98 , pp. 706-714
    • Missale, G.1    Bertoni, R.2    Lamonaca, V.3
  • 111
    • 0028303251 scopus 로고
    • Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence
    • Wakita T, Wands JR. Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence. J Biol Chem 1994; 269: 14205-14210.
    • (1994) J Biol Chem , vol.269 , pp. 14205-14210
    • Wakita, T.1    Wands, J.R.2
  • 113
    • 0029156656 scopus 로고
    • Specific inhibition of hepatitis C viral gene expression by antisense phosphorotioate oligodeoxynucleotides
    • Alt M, Renz R, Hofschneider PH, Paumgartner G, Caselmann WH. Specific inhibition of hepatitis C viral gene expression by antisense phosphorotioate oligodeoxynucleotides. Hepatology 1995; 22: 707-717.
    • (1995) Hepatology , vol.22 , pp. 707-717
    • Alt, M.1    Renz, R.2    Hofschneider, P.H.3    Paumgartner, G.4    Caselmann, W.H.5
  • 114
    • 0029996016 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibition of hepatitis C gene expression in transformed hepatocytes
    • Hanecak R, Brown-Driver V, Fox MC et al. Antisense oligonucleotide inhibition of hepatitis C gene expression in transformed hepatocytes. J Virol 1996; 70: 5203-5212.
    • (1996) J Virol , vol.70 , pp. 5203-5212
    • Hanecak, R.1    Brown-Driver, V.2    Fox, M.C.3
  • 115
    • 0031032603 scopus 로고    scopus 로고
    • Combinatorial screening and a rational optimization for hybridization to folded hepatitis C virus RNA of oligonucleotides with biological antisense activity
    • Lima WF, Brown-Driver V, Fox M, Hanecak R, Bruice TW. Combinatorial screening and a rational optimization for hybridization to folded hepatitis C virus RNA of oligonucleotides with biological antisense activity. J Biol Chem 1997; 272: 626-638.
    • (1997) J Biol Chem , vol.272 , pp. 626-638
    • Lima, W.F.1    Brown-Driver, V.2    Fox, M.3    Hanecak, R.4    Bruice, T.W.5
  • 116
    • 0030947884 scopus 로고    scopus 로고
    • Core specific antisense phosphorothioate oligodeoxynucleotides as potent and specific inhibitors of hepatitis C viral translation
    • Alt M, Renz R, Hofschneider PH, Caselmann WH. Core specific antisense phosphorothioate oligodeoxynucleotides as potent and specific inhibitors of hepatitis C viral translation. Arch Virol 1997; 142: 589-599.
    • (1997) Arch Virol , vol.142 , pp. 589-599
    • Alt, M.1    Renz, R.2    Hofschneider, P.H.3    Caselmann, W.H.4
  • 117
    • 0031802131 scopus 로고    scopus 로고
    • Targeted inhibition of hepatitis C virus-directed gene expression in human hepatoma cell lines
    • Wu CH, Wu Gy. Targeted inhibition of hepatitis C virus-directed gene expression in human hepatoma cell lines. Gastroenterology 1998; 114: 1304-1312.
    • (1998) Gastroenterology , vol.114 , pp. 1304-1312
    • Wu, C.H.1    Wu, G.Y.2
  • 118
    • 0029970824 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes
    • Lieber A, He CY, Polyak SJ, Gretch DR, Barr D, Kay MA. Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. J Virol 1996; 70: 8782-8791.
    • (1996) J Virol , vol.70 , pp. 8782-8791
    • Lieber, A.1    He, C.Y.2    Polyak, S.J.3    Gretch, D.R.4    Barr, D.5    Kay, M.A.6
  • 119
    • 0030481468 scopus 로고    scopus 로고
    • Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes
    • Sakamoto N, Wu CH, Wu GY. Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes. J Clin Invest 1996; 98: 2720-2728.
    • (1996) J Clin Invest , vol.98 , pp. 2720-2728
    • Sakamoto, N.1    Wu, C.H.2    Wu, G.Y.3
  • 120
    • 0028145721 scopus 로고
    • Gene therapy for cancer
    • Gore ME, Collins MK. Gene therapy for cancer. Eur J Cancer 1994: 30A: 1047-1049.
    • (1994) Eur J Cancer , vol.30 A , pp. 1047-1049
    • Gore, M.E.1    Collins, M.K.2
  • 122
  • 123
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth JA, Cristiano RJ. Gene therapy for cancer: what have we done and where are we going? J Natl Cancer Inst 1997; 89: 21-39.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 21-39
    • Roth, J.A.1    Cristiano, R.J.2
  • 124
    • 0028033489 scopus 로고
    • Retroviral delivery of DNA into the livers of transgenic mice bearing premalignant and malignant hepatocellular carcinomas
    • Kimura O, Yamaguchi Y, Gunning KB, Teeter LD, Husain F, Kuo MT. Retroviral delivery of DNA into the livers of transgenic mice bearing premalignant and malignant hepatocellular carcinomas. Human Gene Ther 1994; 5: 845-852.
    • (1994) Human Gene Ther , vol.5 , pp. 845-852
    • Kimura, O.1    Yamaguchi, Y.2    Gunning, K.B.3    Teeter, L.D.4    Husain, F.5    Kuo, M.T.6
  • 125
    • 0026735844 scopus 로고
    • Hepatocellular carcinoma
    • Colombo M. Hepatocellular carcinoma. J Hepatol 1992; 15: 225-236.
    • (1992) J Hepatol , vol.15 , pp. 225-236
    • Colombo, M.1
  • 126
    • 0027154890 scopus 로고
    • Early recognition of hepatocellular carcinoma based on altered profiles of alphafetoprotein
    • Sato Y, Nakata K, Kato Y et al. Early recognition of hepatocellular carcinoma based on altered profiles of alphafetoprotein. N Engl J Med 1993; 328: 1802-1806.
    • (1993) N Engl J Med , vol.328 , pp. 1802-1806
    • Sato, Y.1    Nakata, K.2    Kato, Y.3
  • 127
    • 0023266138 scopus 로고
    • Cell-specific enhancer activity in a far upstream region of the human α-fetoprotein gene
    • Watanabe K, Saito A, Tamacki T et al. Cell-specific enhancer activity in a far upstream region of the human α-fetoprotein gene. J Biol Chem 1987; 262: 4812-4818.
    • (1987) J Biol Chem , vol.262 , pp. 4812-4818
    • Watanabe, K.1    Saito, A.2    Tamacki, T.3
  • 128
    • 0025997948 scopus 로고
    • A position-dependent silencer plays a major role in repressing α-fetoprotein expression in human hepatoma
    • Nakabayashi H, Hashimoto T, Miyao Y, Tjong KK, Chan J, Tamaoki T. A position-dependent silencer plays a major role in repressing α-fetoprotein expression in human hepatoma. Mol Cell Biol 1991; 11: 5885-5893.
    • (1991) Mol Cell Biol , vol.11 , pp. 5885-5893
    • Nakabayashi, H.1    Hashimoto, T.2    Miyao, Y.3    Tjong, K.K.4    Chan, J.5    Tamaoki, T.6
  • 129
    • 0024992790 scopus 로고
    • Regulation of the rat α-fetoprotein gene expression in liver
    • Poliard A, Bakkali L, Poiret M, Foiret D, Danan JL. Regulation of the rat α-fetoprotein gene expression in liver. J Biol Chem 1990; 265: 22137-22141.
    • (1990) J Biol Chem , vol.265 , pp. 22137-22141
    • Poliard, A.1    Bakkali, L.2    Poiret, M.3    Foiret, D.4    Danan, J.L.5
  • 130
    • 0023007174 scopus 로고
    • Liver-specific expression of the mouse α-fetoprotein gene is mediated by cis-acting DNA elements
    • Widen SG, Papaconstantinou J. Liver-specific expression of the mouse α-fetoprotein gene is mediated by cis-acting DNA elements. Proc Natl Acad Sci USA 1986; 83: 8196-8200.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8196-8200
    • Widen, S.G.1    Papaconstantinou, J.2
  • 131
    • 0028880994 scopus 로고
    • Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by α-feto-protein but not insulin-like growth factor II regulatory sequences
    • Arbuthnot P, Bralet M-P, Thomassin H, Danan J-L, Brechet C, Ferry N. Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by α-feto-protein but not insulin-like growth factor II regulatory sequences. Hepatology 1995; 22: 1788-1796.
    • (1995) Hepatology , vol.22 , pp. 1788-1796
    • Arbuthnot, P.1    Bralet, M.-P.2    Thomassin, H.3    Danan, J.-L.4    Brechet, C.5    Ferry, N.6
  • 132
    • 0029759957 scopus 로고    scopus 로고
    • In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector
    • Arbuthnot P, Bralet MP, Le Jossic C et al. In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector. Human Gene Ther 1996; 7: 1503-1514.
    • (1996) Human Gene Ther , vol.7 , pp. 1503-1514
    • Arbuthnot, P.1    Bralet, M.P.2    Le Jossic, C.3
  • 133
    • 15844416306 scopus 로고    scopus 로고
    • Gene therapy for α-fetoprotein-producing human hepatoma cell lines by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene
    • Kanai F, Shiratori Y, Yoshida T et al. Gene therapy for α-fetoprotein-producing human hepatoma cell lines by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Hepatology 1996; 23: 1359-1367.
    • (1996) Hepatology , vol.23 , pp. 1359-1367
    • Kanai, F.1    Shiratori, Y.2    Yoshida, T.3
  • 134
    • 0029921190 scopus 로고    scopus 로고
    • Selective killing of AFP-positive hepatocellular carcinoma cells by adenoassociated virus transfer of the herpes simplex virus thymidine kinase
    • Su H, Chang JC, Xu SM, Kan YW. Selective killing of AFP-positive hepatocellular carcinoma cells by adenoassociated virus transfer of the herpes simplex virus thymidine kinase. Human Gene Ther 1996; 7: 463-470.
    • (1996) Human Gene Ther , vol.7 , pp. 463-470
    • Su, H.1    Chang, J.C.2    Xu, S.M.3    Kan, Y.W.4
  • 135
    • 0024496498 scopus 로고
    • Transcriptional regulation of α-fetoprotein expression by dexamethasone in human hepatoma cells
    • Nakabayashi H, Watanabe K, Saito A, Otsuru A, Sawadaishi K, Tamaoki T. Transcriptional regulation of α-fetoprotein expression by dexamethasone in human hepatoma cells. J Biol Chem 1989; 264: 266-271.
    • (1989) J Biol Chem , vol.264 , pp. 266-271
    • Nakabayashi, H.1    Watanabe, K.2    Saito, A.3    Otsuru, A.4    Sawadaishi, K.5    Tamaoki, T.6
  • 136
    • 0029018605 scopus 로고
    • Gene therapy for hepatoma cells using a retroviral vector carrying herpes simplex virus thymidine kinase gene under control of human alpha-fetoprotein gene promoter
    • Ido A, Nakata K, Kato Y et al. Gene therapy for hepatoma cells using a retroviral vector carrying herpes simplex virus thymidine kinase gene under control of human alpha-fetoprotein gene promoter. Cancer Res 1995; 55: 3105-3109.
    • (1995) Cancer Res , vol.55 , pp. 3105-3109
    • Ido, A.1    Nakata, K.2    Kato, Y.3
  • 137
    • 0031564326 scopus 로고    scopus 로고
    • In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin 2
    • Bui LA, Butterfield LH, Kim JY et al. In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin 2. Human Gene Ther 1997; 8: 2173-2182.
    • (1997) Human Gene Ther , vol.8 , pp. 2173-2182
    • Bui, L.A.1    Butterfield, L.H.2    Kim, J.Y.3
  • 138
    • 0028353711 scopus 로고
    • Multifactorial analysis of p53 alteration in human cancer: A review
    • Soussi T, Legros Y, Lubin R, Ory K, Schlichtholz B. Multifactorial analysis of p53 alteration in human cancer: a review. Int J Cancer 1994; 57: 1-9.
    • (1994) Int J Cancer , vol.57 , pp. 1-9
    • Soussi, T.1    Legros, Y.2    Lubin, R.3    Ory, K.4    Schlichtholz, B.5
  • 139
    • 0026726059 scopus 로고
    • Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas
    • Huetow KH, Sheffield VC, Zhu M et al. Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas. Proc Natl Acad Sci USA 1992; 89: 9622-9626.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9622-9626
    • Huetow, K.H.1    Sheffield, V.C.2    Zhu, M.3
  • 140
    • 0027952779 scopus 로고
    • Genetic heterogeneity of hepatocellular carcinoma
    • Unsal H, Yakicier C, Marçais C et al. Genetic heterogeneity of hepatocellular carcinoma. Proc Natl Acad Sci USA 1994; 91: 822-826.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 822-826
    • Unsal, H.1    Yakicier, C.2    Marçais, C.3
  • 141
    • 0028855276 scopus 로고
    • Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
    • Truant R, Antunovic J, Greenblatt J, Prives C, Cromlish JA. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. J Virol 1995; 69: 1851-1859.
    • (1995) J Virol , vol.69 , pp. 1851-1859
    • Truant, R.1    Antunovic, J.2    Greenblatt, J.3    Prives, C.4    Cromlish, J.A.5
  • 142
    • 0028843480 scopus 로고
    • Functional inactivation but not structural mutation of p53 causes liver cancer
    • Ueda H, Ullrich SJ, Gangemi JD et al. Functional inactivation but not structural mutation of p53 causes liver cancer. Nature Genet 1995; 9: 41-47.
    • (1995) Nature Genet , vol.9 , pp. 41-47
    • Ueda, H.1    Ullrich, S.J.2    Gangemi, J.D.3
  • 143
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HR, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74: 957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.R.2    Jacks, T.3    Housman, D.E.4
  • 145
    • 0027398585 scopus 로고
    • Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells
    • Wang NP, To H, Lee W-H, Lee EY-HP. Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells. Oncogene 1993; 8: 279-288.
    • (1993) Oncogene , vol.8 , pp. 279-288
    • Wang, N.P.1    To, H.2    Lee, W.-H.3    Lee, E.Y-H.P.4
  • 146
    • 0028069906 scopus 로고
    • Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus
    • Liu T, Zhang W, Taylor DL. Roth JA, Goepfert H, Clayman GL. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res 1994; 54: 3662-3667.
    • (1994) Cancer Res , vol.54 , pp. 3662-3667
    • Liu, T.1    Zhang, W.2    Taylor, D.L.3    Roth, J.A.4    Goepfert, H.5    Clayman, G.L.6
  • 147
    • 0028963221 scopus 로고
    • In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma
    • Glaymann GL, El-Naggar AK, Roth JA et al. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res 1995; 55: 1-6.
    • (1995) Cancer Res , vol.55 , pp. 1-6
    • Glaymann, G.L.1    El-Naggar, A.K.2    Roth, J.A.3
  • 148
    • 0028560460 scopus 로고
    • Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer
    • Wills KN, Maneval DC, Menzel P et al. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Human Gene Ther 1994; 5: 1079-1088.
    • (1994) Human Gene Ther , vol.5 , pp. 1079-1088
    • Wills, K.N.1    Maneval, D.C.2    Menzel, P.3
  • 149
    • 0028143201 scopus 로고
    • Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
    • Fujiwara T, Cai DW, Georges RN, Mukhopahyay T, Grimm EA, Roth JA. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J Natl Cancer Inst 1994; 86: 1458-1462.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1458-1462
    • Fujiwara, T.1    Cai, D.W.2    Georges, R.N.3    Mukhopahyay, T.4    Grimm, E.A.5    Roth, J.A.6
  • 150
    • 0006525298 scopus 로고
    • Growth Suppression of Human hepato-cellular carcinoma (HCC) cells by the introduction of wild-type p53 (WT-p53)
    • Qian C, Prieto J. Growth Suppression of Human hepato-cellular carcinoma (HCC) cells by the introduction of wild-type p53 (WT-p53). J Hepatol 1994; 21: S9.
    • (1994) J Hepatol , vol.21
    • Qian, C.1    Prieto, J.2
  • 151
    • 0001642806 scopus 로고    scopus 로고
    • Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene
    • Xu GW, Sun ZT, Forrester K, Wang XW, Coursen J, Harris CC. Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene. Hepatology 1996; 24: 1264-1268.
    • (1996) Hepatology , vol.24 , pp. 1264-1268
    • Xu, G.W.1    Sun, Z.T.2    Forrester, K.3    Wang, X.W.4    Coursen, J.5    Harris, C.C.6
  • 152
    • 0029922952 scopus 로고    scopus 로고
    • p53 gene therapy in vivo of hepatocellular and liver metastatic colorectal cancer
    • Bookstein R, Demers W, Gregory R, Maneval D, Park J, Willis K. p53 gene therapy in vivo of hepatocellular and liver metastatic colorectal cancer. Semin Oncol 1996; 23: 66-77.
    • (1996) Semin Oncol , vol.23 , pp. 66-77
    • Bookstein, R.1    Demers, W.2    Gregory, R.3    Maneval, D.4    Park, J.5    Willis, K.6
  • 154
    • 0000521641 scopus 로고
    • Construction and packaging of pseudotype retrovirus containing human N-ras cDNA antisense sequence and its biological effects on human hepatoma cells
    • Jia L, Wang X, Xu X et al. Construction and packaging of pseudotype retrovirus containing human N-ras cDNA antisense sequence and its biological effects on human hepatoma cells. Cell Res 1990; 2: 132-141.
    • (1990) Cell Res , vol.2 , pp. 132-141
    • Jia, L.1    Wang, X.2    Xu, X.3
  • 155
    • 0028029832 scopus 로고
    • Reversal of malignant phenotype of human hepatoma cells by antisense c-ets-2, c-myc and N-ras
    • Huang XM, Wei SG, Wang LF. Reversal of malignant phenotype of human hepatoma cells by antisense c-ets-2, c-myc and N-ras. Chung Hua Chung Liu Tsa Chin 1994; 16: 243-246.
    • (1994) Chung Hua Chung Liu Tsa Chin , vol.16 , pp. 243-246
    • Huang, X.M.1    Wei, S.G.2    Wang, L.F.3
  • 156
    • 0028889597 scopus 로고
    • Inhibition of fibroblast growth factor 2 expression by antisense RNA induced a loss of the transformed phenotype in a human hepatoma cell line
    • Maret A, Galy B, Arnaud E, Bayard F, Prats H. Inhibition of fibroblast growth factor 2 expression by antisense RNA induced a loss of the transformed phenotype in a human hepatoma cell line. Cancer Res 1995; 55: 075-5079.
    • (1995) Cancer Res , vol.55 , pp. 075-5079
    • Maret, A.1    Galy, B.2    Arnaud, E.3    Bayard, F.4    Prats, H.5
  • 157
    • 0028702018 scopus 로고
    • Drug sensitivity ('suicide') genes for selective cancer chemotherapy
    • Moolten FL. Drug sensitivity ('suicide') genes for selective cancer chemotherapy. Cancer Gene Ther 1994; 1: 279-287.
    • (1994) Cancer Gene Ther , vol.1 , pp. 279-287
    • Moolten, F.L.1
  • 158
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldfield, E.H.5    Blaese, R.M.6
  • 159
    • 0027291236 scopus 로고
    • Regression of established macroscopic liver metastases after in situ transduction of a suicide gene
    • Caruso M, Panis Y, Gagandeep S, Houssin D, Salzmann J, Klatzmann D. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 1993; 90: 7024-7028.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7024-7028
    • Caruso, M.1    Panis, Y.2    Gagandeep, S.3    Houssin, D.4    Salzmann, J.5    Klatzmann, D.6
  • 160
    • 0028202066 scopus 로고
    • Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo
    • Chen S, Shine HD, Goodman JC, Grossman RG, Woo SLC. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994; 91: 3054-3057.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3054-3057
    • Chen, S.1    Shine, H.D.2    Goodman, J.C.3    Grossman, R.G.4    Woo, S.L.C.5
  • 161
    • 0029340302 scopus 로고
    • Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models for human malignant mesothelioma and lung cancer
    • Hwang HC, Smythe WR, Elshami AA et al. Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models for human malignant mesothelioma and lung cancer. Am J Respir Cell Biol 1995; 13: 7-16.
    • (1995) Am J Respir Cell Biol , vol.13 , pp. 7-16
    • Hwang, H.C.1    Smythe, W.R.2    Elshami, A.A.3
  • 162
    • 0029131940 scopus 로고
    • Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase
    • Qian C, Bilbao R, Bruña O, Prieto J. Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase. Hepatology 1995; 22: 118-123.
    • (1995) Hepatology , vol.22 , pp. 118-123
    • Qian, C.1    Bilbao, R.2    Bruña, O.3    Prieto, J.4
  • 163
    • 0027483695 scopus 로고
    • The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
    • Freeman SM, Abboud CN, Whartenby KA et al. The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
    • (1993) Cancer Res , vol.53 , pp. 5274-5283
    • Freeman, S.M.1    Abboud, C.N.2    Whartenby, K.A.3
  • 164
    • 0028856844 scopus 로고
    • Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the 'bystander effect'
    • Chen CY, Chang YN, Ryan P, Linscott M, McGarrity G, Chiang YL. Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the 'bystander effect'. Human Gene Ther 1995; 6: 1467-1476.
    • (1995) Human Gene Ther , vol.6 , pp. 1467-1476
    • Chen, C.Y.1    Chang, Y.N.2    Ryan, P.3    Linscott, M.4    McGarrity, G.5    Chiang, Y.L.6
  • 165
    • 0027787053 scopus 로고
    • In vivo evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
    • Bi WL, Parysek LM, Warnick R, Stambrook PJ. In vivo evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Human Gene Ther 1993; 4: 725-731.
    • (1993) Human Gene Ther , vol.4 , pp. 725-731
    • Bi, W.L.1    Parysek, L.M.2    Warnick, R.3    Stambrook, P.J.4
  • 166
    • 0028864786 scopus 로고
    • The extent of heterocellular communication mediated by gap junctions is preditive of bystander tumor cytotoxicity in vitro
    • Fick J, Barker II FG, Dazin P, Westphale EM, Beyer EC, Israel MA. The extent of heterocellular communication mediated by gap junctions is preditive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci USA 1995; 92: 11071-11075.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11071-11075
    • Fick, J.1    Barker II, F.G.2    Dazin, P.3    Westphale, E.M.4    Beyer, E.C.5    Israel, M.A.6
  • 167
    • 0028075655 scopus 로고
    • Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
    • Vile RG, Nelson JA, Castleden S, Chong H, Hart IR. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res 1994; 54: 6228-6234.
    • (1994) Cancer Res , vol.54 , pp. 6228-6234
    • Vile, R.G.1    Nelson, J.A.2    Castleden, S.3    Chong, H.4    Hart, I.R.5
  • 168
    • 0030668915 scopus 로고    scopus 로고
    • A 'distant' bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distanr transduced tumor
    • Kianmanesh AR, Perrin H, Panis Y et al. A 'distant' bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distanr transduced tumor. Human Gene Ther 1997; 8: 1807-1814.
    • (1997) Human Gene Ther , vol.8 , pp. 1807-1814
    • Kianmanesh, A.R.1    Perrin, H.2    Panis, Y.3
  • 169
    • 0029364610 scopus 로고
    • Gene therapy for hepatocellular carcinoma: Chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene
    • Will KN, Huang WM, Harris MP, Machemer T, Maneval DC, Gregory RJ. Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene. Cancer Gene Ther 1995; 2: 191-197.
    • (1995) Cancer Gene Ther , vol.2 , pp. 191-197
    • Will, K.N.1    Huang, W.M.2    Harris, M.P.3    Machemer, T.4    Maneval, D.C.5    Gregory, R.J.6
  • 170
    • 0029908175 scopus 로고    scopus 로고
    • Evaluation of prodrugs' ability to induce effective ablation of cells transduced with viral thymidine kinase gene
    • Kuriyama S, Nakatani T, Masui K et al. Evaluation of prodrugs' ability to induce effective ablation of cells transduced with viral thymidine kinase gene. Anticancer Res 1996; 16: 2623-2628.
    • (1996) Anticancer Res , vol.16 , pp. 2623-2628
    • Kuriyama, S.1    Nakatani, T.2    Masui, K.3
  • 171
    • 0030798508 scopus 로고    scopus 로고
    • Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma
    • Qian C, Iodate M, Bilbao R et al. Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. Human Gene Ther 1997; 8: 349-358.
    • (1997) Human Gene Ther , vol.8 , pp. 349-358
    • Qian, C.1    Iodate, M.2    Bilbao, R.3
  • 172
    • 0031919447 scopus 로고    scopus 로고
    • Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration
    • van der Eb MM, Cramer SJ, Vergouwe Y et al. Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration. Gene Ther 1998; 5: 451-458.
    • (1998) Gene Ther , vol.5 , pp. 451-458
    • Van Der Eb, M.M.1    Cramer, S.J.2    Vergouwe, Y.3
  • 173
    • 0030636585 scopus 로고    scopus 로고
    • Liver-associated toxicity of the HSV-tk/GCV approach and adenoviral vectors
    • Brand K, Arnold W, Bartels T et al. Liver-associated toxicity of the HSV-tk/GCV approach and adenoviral vectors. Cancer Gene Ther 1997; 4: 9-16.
    • (1997) Cancer Gene Ther , vol.4 , pp. 9-16
    • Brand, K.1    Arnold, W.2    Bartels, T.3
  • 174
    • 0028808656 scopus 로고
    • Adenovirusmediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression
    • Kaneko S, Hallenbeck P, Kotani T et al. Adenovirusmediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res 1995; 55: 5283-5287.
    • (1995) Cancer Res , vol.55 , pp. 5283-5287
    • Kaneko, S.1    Hallenbeck, P.2    Kotani, T.3
  • 175
    • 0031941292 scopus 로고    scopus 로고
    • Regional 'pro-drug' gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma
    • Topf N, Worgall S, Hacknett NR, Crystal RG. Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene Ther 1998; 5: 507-513.
    • (1998) Gene Ther , vol.5 , pp. 507-513
    • Topf, N.1    Worgall, S.2    Hacknett, N.R.3    Crystal, R.G.4
  • 176
    • 0031043426 scopus 로고    scopus 로고
    • In vivo gene therapy for α-fetoprotein-producing hepatocelluar carcinoma by adenovirus-mediated transfer of the cytosine deaminase gene
    • Kanai F, Lan K-H, Shiratori Y et al. In vivo gene therapy for α-fetoprotein-producing hepatocelluar carcinoma by adenovirus-mediated transfer of the cytosine deaminase gene. Cancer Res 1997; 57: 461-465.
    • (1997) Cancer Res , vol.57 , pp. 461-465
    • Kanai, F.1    Lan, K.-H.2    Shiratori, Y.3
  • 177
    • 0025858452 scopus 로고
    • Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: An innovative approach for cancer therapy
    • Huber BE, Richards CA, Krenitsky TA. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc Natl Acad Sci USA 1991; 88: 8039-8043.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8039-8043
    • Huber, B.E.1    Richards, C.A.2    Krenitsky, T.A.3
  • 178
    • 0027363194 scopus 로고
    • Immunological responses against an autologous human hepatocellular carcinoma cell line
    • Usuda S, Yoshizawa K, Yabu K, Kiyosawa K. Immunological responses against an autologous human hepatocellular carcinoma cell line. J Gastroenterol Hepatol 1993; 8: 517-523.
    • (1993) J Gastroenterol Hepatol , vol.8 , pp. 517-523
    • Usuda, S.1    Yoshizawa, K.2    Yabu, K.3    Kiyosawa, K.4
  • 179
    • 0026907926 scopus 로고
    • Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma
    • Kawata A, Une Y, Hosokawa M, Uchino J, Kobayashi H. Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma. Jpn J Clin Oncol 1992; 22: 256-263.
    • (1992) Jpn J Clin Oncol , vol.22 , pp. 256-263
    • Kawata, A.1    Une, Y.2    Hosokawa, M.3    Uchino, J.4    Kobayashi, H.5
  • 182
    • 0029842830 scopus 로고    scopus 로고
    • Production of vascular endothelial growth factor by human tumors inhbits the functional maturation of dendritic cells
    • Gabrilovich DI, Chen HL, Girgis KR et al. Production of vascular endothelial growth factor by human tumors inhbits the functional maturation of dendritic cells. Nature Med 1996; 2: 1096-1103.
    • (1996) Nature Med , vol.2 , pp. 1096-1103
    • Gabrilovich, D.I.1    Chen, H.L.2    Girgis, K.R.3
  • 183
    • 0030026798 scopus 로고    scopus 로고
    • Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy
    • Zier K, Gansbacher B, Salvadori S. Preventing abnormalities in signal transduction of T cells in cancer: the promise of cytokine gene therapy. Immunol Today 1996; 17: 39-45.
    • (1996) Immunol Today , vol.17 , pp. 39-45
    • Zier, K.1    Gansbacher, B.2    Salvadori, S.3
  • 184
    • 0031024948 scopus 로고    scopus 로고
    • Cytokine, tumor-cell death and immunogenicity: A question of choice
    • Musiani P, Modesti A, Giovarella M et al. Cytokine, tumor-cell death and immunogenicity: a question of choice. Immunol Today 1997; 18: 32-36.
    • (1997) Immunol Today , vol.18 , pp. 32-36
    • Musiani, P.1    Modesti, A.2    Giovarella, M.3
  • 186
    • 0028052808 scopus 로고
    • Cytokine gene transfer in tumor inhibition and tumor therapy: Where are we now?
    • Colombo M, Forni G. Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? Immunol Today 1994; 15: 48-51.
    • (1994) Immunol Today , vol.15 , pp. 48-51
    • Colombo, M.1    Forni, G.2
  • 187
    • 0031052118 scopus 로고    scopus 로고
    • Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor α gene transfer
    • Cao G, Kuriyama S, Du P et al. Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor α gene transfer. Gastroenterology 1997; 112: 501-510.
    • (1997) Gastroenterology , vol.112 , pp. 501-510
    • Cao, G.1    Kuriyama, S.2    Du, P.3
  • 188
    • 0002774685 scopus 로고    scopus 로고
    • Immunotherapy of hepatocellular carcinoma (HCC) by engineering tumor cells to express B7-1 and/or IL-12
    • Sun Y, Qian C, Peng D, Prieto J. Immunotherapy of hepatocellular carcinoma (HCC) by engineering tumor cells to express B7-1 and/or IL-12. J Hepatol 1998; 28: S59.
    • (1998) J Hepatol , vol.28
    • Sun, Y.1    Qian, C.2    Peng, D.3    Prieto, J.4
  • 189
    • 0029972263 scopus 로고    scopus 로고
    • Gene therapy for hepatocellular carcinoma: Long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo
    • Huang H, Chen SH, Kosai K, Finegold MJ, Woo SLC. Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. Gene Ther 1996; 3: 980-987.
    • (1996) Gene Ther , vol.3 , pp. 980-987
    • Huang, H.1    Chen, S.H.2    Kosai, K.3    Finegold, M.J.4    Woo, S.L.C.5
  • 190
    • 0027087331 scopus 로고
    • Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
    • Schwartz R. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71: 1065-1068.
    • (1992) Cell , vol.71 , pp. 1065-1068
    • Schwartz, R.1
  • 192
    • 0027078670 scopus 로고
    • Costimulation of anti-tumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
    • Chen L, Ashe S, Brady WA et al. Costimulation of anti-tumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 1992; 71: 1093-1102.
    • (1992) Cell , vol.71 , pp. 1093-1102
    • Chen, L.1    Ashe, S.2    Brady, W.A.3
  • 193
    • 0030904284 scopus 로고    scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on human hepatocellular carcinoma
    • Tatsumi T, Takehara T, Katayama K, Mochizuki K, Yamamoto M, Kanto T. Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on human hepatocellular carcinoma. Hepatology 1997; 25: 1108-1114.
    • (1997) Hepatology , vol.25 , pp. 1108-1114
    • Tatsumi, T.1    Takehara, T.2    Katayama, K.3    Mochizuki, K.4    Yamamoto, M.5    Kanto, T.6
  • 194
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 195
    • 0028967430 scopus 로고
    • Dendritic cells as initiators of tumor immune responses: A possible strategy for tumor immunotherapy
    • Grabbe S, Beissert S, Schwarz T, Granstein RD. Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy. Immunol Today 1995; 16: 117-121.
    • (1995) Immunol Today , vol.16 , pp. 117-121
    • Grabbe, S.1    Beissert, S.2    Schwarz, T.3    Granstein, R.D.4
  • 196
    • 0031106588 scopus 로고    scopus 로고
    • Dendritic cells hold promise for immunotherapy
    • Girolomoni G, Ricciardi-Castagnoli P. Dendritic cells hold promise for immunotherapy. Immunol Today 1997; 18: 102-104.
    • (1997) Immunol Today , vol.18 , pp. 102-104
    • Girolomoni, G.1    Ricciardi-Castagnoli, P.2
  • 197
    • 0030820002 scopus 로고    scopus 로고
    • Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination
    • Wan Y, Bramson J, Carter R, Graham F, Gauldie J. Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination. Human Gene There 1997; 8: 1355-1363.
    • (1997) Human Gene There , vol.8 , pp. 1355-1363
    • Wan, Y.1    Bramson, J.2    Carter, R.3    Graham, F.4    Gauldie, J.5
  • 198
    • 0030026776 scopus 로고    scopus 로고
    • Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
    • Hsu FJ, Benike C, Fagnoni F et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med 1996; 2: 52-58.
    • (1996) Nature Med , vol.2 , pp. 52-58
    • Hsu, F.J.1    Benike, C.2    Fagnoni, F.3
  • 199
    • 0030781054 scopus 로고    scopus 로고
    • Dendritic cells retrovirally transduced with a model tumor antigen gene are therapeutic effective against established pulmonary metastasis
    • Specht JM, Wang G, Do MT et al. Dendritic cells retrovirally transduced with a model tumor antigen gene are therapeutic effective against established pulmonary metastasis. J Exp Med 1997; 186: 1213-1221.
    • (1997) J Exp Med , vol.186 , pp. 1213-1221
    • Specht, J.M.1    Wang, G.2    Do, M.T.3
  • 200
    • 0032499913 scopus 로고    scopus 로고
    • A one-year trial of lamivudine for chronic hepatitis B
    • Lai C, Chien R, Leung NWY et al. A one-year trial of lamivudine for chronic hepatitis B. N Engl J Med 1998; 339: 61-68.
    • (1998) N Engl J Med , vol.339 , pp. 61-68
    • Lai, C.1    Chien, R.2    Leung, N.W.Y.3
  • 201
    • 0031720702 scopus 로고    scopus 로고
    • Cell immunity to HCV core protein and the response to interferon in patients with chronic hepatitis C
    • Lasarte JJ, Garcia-Granero M, Lopez A et al. Cell immunity to HCV core protein and the response to interferon in patients with chronic hepatitis C. Hepatology 1998; 28: 815-822.
    • (1998) Hepatology , vol.28 , pp. 815-822
    • Lasarte, J.J.1    Garcia-Granero, M.2    Lopez, A.3
  • 202
    • 0031042534 scopus 로고    scopus 로고
    • Tumor vascular endothelium: Barrier or target in tumor directed drug delivery and immunotherapy
    • Molema G, de Leij LF, Meijer DK. Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy. Pharmacol Res 1997; 14: 2-10.
    • (1997) Pharmacol Res , vol.14 , pp. 2-10
    • Molema, G.1    De Leij, L.F.2    Meijer, D.K.3
  • 203
    • 0031747280 scopus 로고    scopus 로고
    • The next frontier of molecular medicine: Delivery of therapeutics
    • Jain RK. The next frontier of molecular medicine: delivery of therapeutics. Nature Med 1998; 4: 655-657.
    • (1998) Nature Med , vol.4 , pp. 655-657
    • Jain, R.K.1
  • 204
    • 0342306812 scopus 로고    scopus 로고
    • Vasoactive compounds increase the efficiency of adenoviral gene transfer to primary liver tumors
    • Bilbao R, Qian C, Drozdzik M, Pajares MJ, Prieto J. Vasoactive compounds increase the efficiency of adenoviral gene transfer to primary liver tumors. J Hepatol 1998; 28: S143.
    • (1998) J Hepatol , vol.28
    • Bilbao, R.1    Qian, C.2    Drozdzik, M.3    Pajares, M.J.4    Prieto, J.5


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