Genetic immunization: A new era in vaccines and immune therapeutics

FASEB Journal

Volumn 11, Issue 10, 1997, Pages 753-763

  Chattergoon, Michael ^a   Boyer, Jean ^a   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cancer; DNA vaccine; Genetic immunization; Human vaccines; Immunotherapy; Infectious diseases

Indexed keywords

BCG VACCINE; CANCER VACCINE; CYTOKINE; DNA VACCINE; LIVE VACCINE; MALARIA VACCINE; NUCLEIC ACID; PLASMID DNA; VIRUS HEMAGGLUTININ; VIRUS NUCLEOPROTEIN; VIRUS VACCINE;

CLINICAL TRIAL; GENE CASSETTE; GENE EXPRESSION; GENE TARGETING; HEPATITIS B VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOTHERAPY; INFLUENZA VIRUS B; INOCULATION; INTRAMUSCULAR DRUG ADMINISTRATION; MALARIA; NONHUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; REVIEW; SIMIAN IMMUNODEFICIENCY VIRUS; TUBERCULOSIS;

HEPATITIS B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA VIRUS; INFLUENZAVIRUS B; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0030757875     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.10.9271360     Document Type: Review

References (42)

1. Stasney, J., Cantarow, A., and Paschkis, K. E. (1950) Production of neoplasms by fractions of mammalian neoplasms. Cancer Res. 10, 775-782
2. Ito, Y. (1961) Heat-resistance of the tumorigenic nucleic acids of Shope papillomatous. Virology 12, 596-601
3. Atanasiu, P. (1962) Production de tureurs chez le Hamster par inoculation d'acide desoxyribonucleique extrait de cultures de tissus infectees par le virus du polyome. Acad. Sci. 254, 4228-4230
4. Orth, G., Atanasiu, P., Borion, M., Rebiere, J. P., and Paoletti, C. (1964) Infectious and oncogenic effect of DNA extracted from cells infected with polyoma virus. Proc. Soc. Exp. Biol Med. 115, 1090-1095
5. Israel, M., Chan, H., Hourihan, S., Rowe, W., and Martin, M. (1979) Biological activity of polyoma viral DNA in mice and hamsters. J. Virol. 29, 990-996
6. Will, H., Catteneo, R., Koch, H., Darai, G., and Schaller, H. (1982) Clone HBV DNA causes hepatitis in chimpanzees. Nature (London) 299, 740-742
7. Debensky, T., Campbell, B., and Villarreal, L. (1984) Direct transfection of viral and plasmic DNA into the liver or spleen of mice. Proc. Natl. Acad. Sci. USA 81, 7529-7533
8. Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., and Feigner, P. L. (1990) Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468
9. Tang, D. C., Devit, M., and Johnston, S. A. (1992) Genetic immunization is a simple method for eliciting an immune response. Nature (London) 356, 152-154
10. Ulmer, J. B., Donnelly, J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. L., et al. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1749
11. Fynan, E. F., Webster, R. G., Fuller, D. H., and Haynes, J. R. (1993) DNA vaccines: protective immunizations by perenteral, mucosal and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90, 11478-11482
12. Wang, B., Ugen, K., Srikantan, V., Agadjanyan, M. G., Dang, K., Rafaeli, J., Sato, A. I., Boyer, J., Williams, W. W., and Weiner, D. B. (1993) Gene inoculation generates immune responses against HIV-I. Prof. Natl. Acad. Sci. USA 90, 4156-4160
13. Davis, H. L., Michel, M. L., Mancini, M., Schleef, M., and Whalen, R. G. (1994) Direct gene transfer in skeletal muscle: plasmid DNA based immunization againse the hepatitis B virus surface antigen. Vaccine 12, 1503-1509
14. Corny, R., LoBuglio, A., Loechel, F., Moore, S., Sumerel, L., Barlow, D., Pike, J., and Curiel, D. (1995) A carcinoembryonic antigen polynucleotide vaccine for human clinical use. Cancer Gene Ther. 2, 33-38
15. Bright, R., Shearer, M., and Kennedy, R. (1995) Nucleic acid vaccination against virally induced tumors. Ann. N.Y. Acad. Sci. 772, 241-251
16. Wang, B., Merva, M., Dang, K., Ugen, K. E., Williams, W. V., and Weiner, D. B. (1995) Immunization by direct DNA inoculation induces rejection of tumor cell challenge. Human Gene Ther. 6, 407-418
17. Raz, E., Carson, D., Perker, S., Parr, T., Abai, A., Aichinger, G., Gromkowsji, S., Singh, D., Lew, D., Yankaukas, M., Bard, S., and Rhodes, G. (1994) Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91, 9519-9523
18. Xiang, Z., Spitalnik, S., Tran, M., Wunner, W., Cheng, J., and Ertl, H. (1994) Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity. Virology 199, 132-140
19. Davis, H. L., Whalen, R. G., and Demeneix, B. A. (1993) Direct gene transfer in skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum. Gene Ther. 4, 151-156
20. Wang, B., Boyer, J. D., Ugen, K. E., Merva, M., Dang, K., Agadjanyan, M. G., Williams, W. V., and Weiner, D. B. (1994) Analysis of antigen-specific immune responses induced through in vivo genetic inoculation. Vaccines 94, 83-90
21. Wang, B., Merva, M., Dang, K., Ugen, K. E., Boyer, J. D., Williams, W. V., and Weiner, D. B. (1994) DNA inoculation induces protective in vivo immune responses against cellular challenge with HIV-1 antigen-expressing cells. AIDS Res. Human Retrovir. 10, S35-S41
22. Raz, E., Tighe, H., Sato, Y., Corr, M., Dudler, J., Roman, M., Swain, S., Spiegelberg, H., and Carson, D. (1996) Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc. Natl. Acad. Sci. USA 93, 5141-5145
23. Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M., Silverman, G., Lotz, M., Carson, D., and Raz, E. (1996) Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352-354
24. Kim, J., Ayyavoo, V., Bagarazzi, M., Chattergoon, M., Dang, K., Wang, B., and Weiner, D. (1997) In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158, 816-826
25. Xiang, Z. Q., and Ertl, H. C. J. (1995) Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2, 129-137
26. Ulmer, J., Deck, R., DeWitt, C., Friedman, A., Donnelly, J., and Liu, M. (1994) Protective immunity by intramuscular injection of low doses of influenza. Vaccine 12, 1541-1544
27. Davis, H. L., Michel, M. L., and Whalen, R. G. (1993) DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Human Mol Genet. 2, 1847-1851
28. Mancini, M., Davis, H., and Tiollais, P. (1996) DNA-based immunization against the envelope proteins of the hepatitis B virus, J. Biotechnol. 44, 47-57
29. Davis, H., McCluskie, M., Gerin, J., and Purcell, R. (1996) DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc. Natl. Acad. Sci. USA 93, 7213-7218
30. Doolan, D., Sedegah, M., Hedstrom. R., Hobart, P., Charoenvit, Y., and Hoffman, S. (1996) Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-; interferon gamma-, and nitric oxide-dependent immunity. J. Exp. Med. 183, 1739-1746
31. Huygen, K., Content, J., Denis, O., Montgomery, D., Yawman, A., Deck, R., DeWitt, C., Orme, I., Baldwin, S., D'Souza, C., Drowart, A., Lozes, E., Vandenbussche, P., Van Vooren, J., Liu, M., and Ulmer, J. (1996) Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nature Med. 2, 983-988
32. Tascon, R. E., Colston, M. J., Ragno, S., Stavropoulos, E., Gregory, D., and Lowie, D. B. (1996.) Vaccination against tuberculosis by DNA injection. Nature Med. 2, 888-892
33. Yasutomi, Y., Robinson, H., Lu, S., Mustafa, F., Lekutis. C., Arthos, J., Mullins, J., Voss, G., Manson, K., Wyand, M., and Letvin N. L. (1996) Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys. J. Virol. 70, 678-681
34. Wang, B., Boyer, J., Srikantan, V., Ugen, K., Gilbert, L., Phan, C., Dang, K., Merva, M., Agadjanyan, M., Newman, M., Carrano, R., McCallus, D., Coney, L., Williams, W. V., and Weiner, D. B. (1995) Induction of humoral and cellular immune responses to the human immunodeficiency vims type 1 in non-human primates. Virology 221, 102-112
35. Campo, M., and Jarrett, W. (1994) Vaccination against cutaneous and mucosal papillomavirus in cattle. In Ciba Foundation Symposium, Vol. 187, pp. 61-73
36. Khanna, R., Burrows, S., Steigerwald-Mullen, P., Thomson, S., Kurilla, M., and Moss, D. (1995) Isolation of cytotoxic T lymphocytes from healthy seropositive individuals specific for peptide epitopes from Epstein-Barr virus nuclear antigen 1: implications for viral persistence and tumor surveillance. Virology 214, 633-637
37. Gaukroger, J., Chandrachud, L., O'Neil, B., Grindlay, G., Knowles, G., and Campo, M. (1996) Vaccination of cattle with bovine papillomavirus type 4 L2 elicits the production of virus-neutralizing antibodies. J. Gen. Virol. 77, 1577-1583
38. Kirnbauer, R., Chandrachud, L., O'Neil, B., Wagner, E., Grindlay, G., Armstrong, A., McGarvie, G., Schiller, J., Lowy, D., and Campo, M. (1996) Virus-like particles of bovine papillomavirus type 4 in prophylactic and therapeutic immunization. Virology 219, 37-44
39. Donnelly, J. J., Martinez, D., Jansen, K. U., Ellis, R. W., Montgomery, D. L., and Liu, M. A. (1996) Protection against papillomavirus with a polynucleotide vaccine. J. Inject. Dis. 173, 314-320
40. Roth, J., Dittmer, D., Rea, D., Tartaglia, J., Paoletti, E., and Levine, A. (1996) p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc. Natl. Acad. Sci. USA 93, 4781-4790
41. Tsang, K., Zaremba, S., Nieroda, C., Zhu, M., Hamilton, J., and Schlom, J. (1995) Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J. Natl. Cancer Inst. 87, 982-990
42. Regimbald, L., Pilarski, L., Longenecker, B., Reddish, M., Zimmermann, G., and Hugh, J. (1996) The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res. 56, 4244-4249