Long-term expression of the human α1-antitrypsin gene in mice employing anionic and cationic liposome vectors

Biochemical Pharmacology

Volumn 51, Issue 10, 1996, Pages 1309-1314

  Crespo, J ^a   Blaya, C ^a   Crespo, A ^a   Alino S F ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

gene therapy; in vivo gene transfer; liposome vector; liver; partial hepatectomy; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANION; CATION; CHOLESTEROL; DNA; LIPOSOME; MONOSIALOGANGLIOSIDE GM1; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PLASMID; PRIORITY JOURNAL;

EID: 0029898019     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00038-X     Document Type: Article

References (23)

1. Fagerhol MK, The Pi-system genetic variants of serum alpha 1-antitrypsin. Ser Haematol 1: 153-161, 1968.
2. Savransky E, Hytiroglou P, Harpaz N, Thung SN and Johnson EM, Correcting the PiZ defect in the α1-antitrypsin gene of human cells by targeted homologous recombination. Lab Invest 70: 676-683, 1984.
3. Travis J and Salvesen GS, Human plasma proteinase inhibitors. Ann Rev Biochem 52: 655-709, 1983.
4. Gadek JE, Fells GS, Zimmerman RL and Crystal RG, Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphisema. J Clin Invest 68: 889-898, 1981.
5. Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, Demayo J, Ledley FD, Chowdhury JR and Woo SLC, Mouse hepatocytes migrated to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Nat Acad Sci USA 88: 1217-1221, 1991.
6. Kay MA, Baley P, Rothenberg S, Leland F, Flaming L, Ponder KP, Liu TJ, Finegold M, Darlington G, Pokorny W and Woo SLC, Expression of α1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Nat Acad Sci USA 89: 89-93, 1992.
7. Alino SF, Bobadilla M, García-Sanz M, Lejarreta M, Unda F and Hilario E, In vivo delivery of human α1-antitrypsin gene to mouse hepatocytes by liposomes. Biochem Biophys Res Commun 192: 174-181, 1993.
8. Aliño SF, Bobadilla M, Crespo J and Lejarreta M, Human α1-antitrypsin gene transfer to in vivo mouse hepatocytes. Hum Gen Ther 7: 531-536, 1996.
9. Yagi K, Noda H, Kurono M and Ohishi N, Efficient gene transfer with less cytotoxicity by means of cationic multilamellar liposomes. Biochem Biophys Res Commun 196: 1042-1048, 1993.
10. Wu GY, Wilson JM, Shalaby F, Grossman M, Shafritz DA and Wu CH, Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in nagase rats. J Biol Chem 266: 14388-14342, 1991.
11. Aliño SF, Crespo J, Bobadilla M, Lejarreta M, Blaya C and Crespo A, Expression of human α1-antitrypsin in mouse after in vivo gene transfer to hepatocytes by small liposomes. Biochem Biophys Res Commun 204: 1023-1030, 1994.
12. Maniatis T, Fritsch EF and Sambrook J, Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, New York, 1982.
13. Aliño SF, García-Sanz M, Iruarrizaga A, Alfaro J and Hernández J, High encapsulation efficiencies in sized liposomes produced by extrusion of dehydration-rehydration vesicles. J Microencapsulation 7: 479-503, 1990.
14. Stewart JCM, Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal Biochem 104: 10-14, 1980.
15. Machy P, Arnold B, Aliño SF and Leserman LD, Interferon sensitive and insensitive MHC variants of a murine thymoma differentially resistant to methotrexate-containing antibody-directed liposomes and immunotoxin. J Immunol 136: 3110-3115, 1986.
16. Aliño SF, Unda FJ, Iruarrizaga A, Alfaro J, Hilario E, Pérez-Yarza G, Bobadilla M and Lejarreta M, Efficacy of liposome-encapsulated indomethacin in response against metastatic 3LL and B16F1 cells. Lab Invest 66: 671-679, 1992.
17. Smith JC, Walzen RL and German JB, Liposomes as agents of DNA transfer. Biochim Biophys Acta 1154: 327-340, 1993.
18. Perales JC, Ferkol T, Beegen H, Ratnoff OD and Hanson RW, Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc Nat Acad Sci USA 91: 4086-4090, 1994.
19. Johansson S and Andersson G, Similar induction of the hepatic EGF receptor in vivo by EGF and partial hepatectomy. Biochem Biophys Res Commun 166: 661-666, 1990.
20. Wilson JM, Grossman M, Cabrera JA, Wu CH and Wu GY, A novel mechanism for achieving transgene persistence in vivo after somatic gene transfer into hepatocytes. J Biol Chem 267: 11483-11489, 1992.
21. Armentano D, Thompson AR, Darlington G and Woo SLC, Expression of human factor IX in rabbit hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of hemophilia B. Proc Nat Acad Sci USA 87: 6141-6145, 1990.
22. Ponder KP, Dunbar RP, Wilson DR, Darlington GJ and Woo SLC, Evaluation of relative promoter strength in primary hepatocytes using optimized lipofection. Hum Gen Ther 2: 41-52, 1991.
23. Sharfmann R, Axelrod JM and Verma IM, Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc Nat Acad Sci USA 88: 4626-4630, 1991.