-
2
-
-
0031685620
-
TGF-β signal transaction
-
Massagué, J. (1998) TGF-β signal transaction. Annu. Rev. Biochem. 67, 753-791
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 753-791
-
-
Massagué, J.1
-
3
-
-
0028940853
-
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
-
Sekelsky, J.J., Newfeld, S.J., Raftery, L.A., Chartoff, E.H., and Gelbart, W.M. (1995) Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358
-
(1995)
Genetics
, vol.139
, pp. 1347-1358
-
-
Sekelsky, J.J.1
Newfeld, S.J.2
Raftery, L.A.3
Chartoff, E.H.4
Gelbart, W.M.5
-
4
-
-
0030058914
-
Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components
-
Savage, C., Das, P., Finelli, A.L., Townsend, S.R., Sun, C.Y., Baird, S.E., and Padgett, R.W. (1996) Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl. Acad. Sci. USA 93, 790-794
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 790-794
-
-
Savage, C.1
Das, P.2
Finelli, A.L.3
Townsend, S.R.4
Sun, C.Y.5
Baird, S.E.6
Padgett, R.W.7
-
5
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn, S.A., Schutte, M., Hoque, A.T., Moskaluk, C.A., da Costa, L.T., Rozenblum, E., Weinstein, C.L., Fischer, A., Yeo, C.J., Hruban, R.H., and Kern, S.E. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
Moskaluk, C.A.4
Da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
6
-
-
0031438047
-
TGF-β signalling from cell membrane to nucleus through SMAD proteins
-
Heldin, C.-H., Miyazono, K., and ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.-H.1
Miyazono, K.2
Ten Dijke, P.3
-
7
-
-
0030765945
-
Smad6 inhibits signalling by the TGF-β superfamily
-
Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., and Miyazono, K. (1997) Smad6 inhibits signalling by the TGF-β superfamily. Nature 389, 622-626
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Takase, M.2
Nishihara, A.3
Oeda, E.4
Hanai, J.5
Kawabata, M.6
Miyazono, K.7
-
8
-
-
0031964859
-
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
-
Hata, A., Lagna, G., Massagué, J., and Hemmati-Brivanlou, A. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12, 186-197
-
(1998)
Genes Dev.
, vol.12
, pp. 186-197
-
-
Hata, A.1
Lagna, G.2
Massagué, J.3
Hemmati-Brivanlou, A.4
-
9
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
-
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.-Y., Grinnell, B.W., Richardson, M.A., Topper, J.N., Gimbrone, M.A., Jr., Wrana, J.L., and Falb, D. (1997) The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89, 1165-1173
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.-Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone M.A., Jr.9
Wrana, J.L.10
Falb, D.11
-
10
-
-
0030611757
-
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
-
Nakao, A., Afrakhte, M., Morén, A., Nakayama, T., Christian, J.L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N.-E., Heldin, C.-H., and ten Dijke, P. (1997) Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389, 631-635
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Morén, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.-E.9
Heldin, C.-H.10
Ten Dijke, P.11
-
11
-
-
0032529159
-
Smads and early developmental signaling by the TGFβ superfamily
-
Whitman, M. (1998) Smads and early developmental signaling by the TGFβ superfamily. Genes Dev. 12, 2445-2462
-
(1998)
Genes Dev.
, vol.12
, pp. 2445-2462
-
-
Whitman, M.1
-
14
-
-
0029892494
-
MADR1, a MAD-related protein that functions in BMP2 signaling pathways
-
Hoodless, P.A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M.B., Attisano, L., and Wrana, J.L. (1996) MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85, 489-500
-
(1996)
Cell
, vol.85
, pp. 489-500
-
-
Hoodless, P.A.1
Haerry, T.2
Abdollah, S.3
Stapleton, M.4
O'Connor, M.B.5
Attisano, L.6
Wrana, J.L.7
-
15
-
-
0029786212
-
Receptor-associated Mad homologues synergize as effectors of the TGF-β response
-
Zhang, Y., Feng, X.-H., Wu, R.-Y., and Derynck, R. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172
-
(1996)
Nature
, vol.383
, pp. 168-172
-
-
Zhang, Y.1
Feng, X.-H.2
Wu, R.-Y.3
Derynck, R.4
-
16
-
-
0030300115
-
MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
-
Macías-Silva, M., Abdollah, S., Hoodless, P.A., Pirone, R., Attisano, L., and Wrana, J.L. ( 1996) MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224
-
(1996)
Cell
, vol.87
, pp. 1215-1224
-
-
Macías-Silva, M.1
Abdollah, S.2
Hoodless, P.A.3
Pirone, R.4
Attisano, L.5
Wrana, J.L.6
-
17
-
-
0032481351
-
The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors
-
Lo, R.S., Chen, Y.-G., Shi, Y., Pavletich, N.P., and Massagué, J. (1998) The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO J. 17, 996-1005
-
(1998)
EMBO J.
, vol.17
, pp. 996-1005
-
-
Lo, R.S.1
Chen, Y.-G.2
Shi, Y.3
Pavletich, N.P.4
Massagué, J.5
-
18
-
-
0030837455
-
A structural basis for mutational inactivation of the tumour suppressor Smad4
-
Shi, Y., Hata, A., Lo, R.S., Massagué, J., and Pavletich, N.P. (1997) A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87-93
-
(1997)
Nature
, vol.388
, pp. 87-93
-
-
Shi, Y.1
Hata, A.2
Lo, R.S.3
Massagué, J.4
Pavletich, N.P.5
-
19
-
-
0030911104
-
The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
-
Kretzschmar, M., Liu, F., Hata, A., Doody, J., and Massagué, J. (1997) The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11, 984-995
-
(1997)
Genes Dev.
, vol.11
, pp. 984-995
-
-
Kretzschmar, M.1
Liu, F.2
Hata, A.3
Doody, J.4
Massagué, J.5
-
20
-
-
0030886204
-
Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
-
Liu, X., Sun, Y., Constantinescu, S.N., Karam, E., Weinberg, R.A., and Lodish, H.F. (1997) Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. USA 94, 10669-10674
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10669-10674
-
-
Liu, X.1
Sun, Y.2
Constantinescu, S.N.3
Karam, E.4
Weinberg, R.A.5
Lodish, H.F.6
-
21
-
-
0032528236
-
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
-
Feng, X.H., Zhang, Y., Wu, R.Y., and Derynck, R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes Dev. 12, 2153-2163
-
(1998)
Genes Dev.
, vol.12
, pp. 2153-2163
-
-
Feng, X.H.1
Zhang, Y.2
Wu, R.Y.3
Derynck, R.4
-
22
-
-
0030825516
-
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
-
Hata, A., Lo, R.S., Wotton, D., Lagna, G., and Massagué, J. (1997) Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388, 82-87
-
(1997)
Nature
, vol.388
, pp. 82-87
-
-
Hata, A.1
Lo, R.S.2
Wotton, D.3
Lagna, G.4
Massagué, J.5
-
23
-
-
0029931509
-
A human Mad protein acting as a BMP-regulated transcriptional activator
-
Liu, F., Hata, A., Baker, J.C., Doody, J., Cárcamo, J., Harland, R.M., and Massagué, J. (1996) A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623
-
(1996)
Nature
, vol.381
, pp. 620-623
-
-
Liu, F.1
Hata, A.2
Baker, J.C.3
Doody, J.4
Cárcamo, J.5
Harland, R.M.6
Massagué, J.7
-
24
-
-
0030872367
-
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
-
Kim, J., Johnson, K., Chen, H.J., Carroll, S., and Laughon, A. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308
-
(1997)
Nature
, vol.388
, pp. 304-308
-
-
Kim, J.1
Johnson, K.2
Chen, H.J.3
Carroll, S.4
Laughon, A.5
-
25
-
-
0029834067
-
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
-
Lagna, G., Hata, A., Hemmati-Brivanlou, A., and Massagué, J. (1996) Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383, 832-836
-
(1996)
Nature
, vol.383
, pp. 832-836
-
-
Lagna, G.1
Hata, A.2
Hemmati-Brivanlou, A.3
Massagué, J.4
-
26
-
-
0030963943
-
DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells
-
de Winter, J.P., Roelen, B. A., ten Dijke, P., van der Burg, B., and van den Eijnden-van Raaij, A. J. (1997) DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells. Oncogene 14, 1891-1899
-
(1997)
Oncogene
, vol.14
, pp. 1891-1899
-
-
De Winter, J.P.1
Roelen, B.A.2
Ten Dijke, P.3
Van Der Burg, B.4
Van Den Eijnden-Van Raaij, A.J.5
-
27
-
-
0030768644
-
TGF-β receptor mediated signaling through Smad2, Smad3, and Smad4
-
Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C.-H., Miyazono, K., and ten Dijke, P. (1997) TGF-β receptor mediated signaling through Smad2, Smad3, and Smad4. EMBO J. 16, 5353-5362
-
(1997)
EMBO J.
, vol.16
, pp. 5353-5362
-
-
Nakao, A.1
Imamura, T.2
Souchelnytskyi, S.3
Kawabata, M.4
Ishisaki, A.5
Oeda, E.6
Tamaki, K.7
Hanai, J.8
Heldin, C.-H.9
Miyazono, K.10
Ten Dijke, P.11
-
28
-
-
0032528041
-
Smad proteins exist as monomers in vivo and undergo homo- and heterooligomerization upon activation by serine/threonine kinase receptors
-
Kawabata, K., Inoue, H., Hanyu, A., Imamura, T., and Miyazono, K. (1998) Smad proteins exist as monomers in vivo and undergo homo- and heterooligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17, 4056-4065
-
(1998)
EMBO J.
, vol.17
, pp. 4056-4065
-
-
Kawabata, K.1
Inoue, H.2
Hanyu, A.3
Imamura, T.4
Miyazono, K.5
-
29
-
-
0030690337
-
Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
-
Liu, F., Pouponnot, C., and Massagué, J. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11, 3157-3167
-
(1997)
Genes Dev.
, vol.11
, pp. 3157-3167
-
-
Liu, F.1
Pouponnot, C.2
Massagué, J.3
-
30
-
-
0031812037
-
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
-
Wisotzkey, R., Mehra, A., Sutherland, D., Dobens, L., Liu, X., Dohrmann, C., Attisano, L., and Raftery, L. (1998) Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125, 1433-1445
-
(1998)
Development
, vol.125
, pp. 1433-1445
-
-
Wisotzkey, R.1
Mehra, A.2
Sutherland, D.3
Dobens, L.4
Liu, X.5
Dohrmann, C.6
Attisano, L.7
Raftery, L.8
-
31
-
-
0032483544
-
Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
-
Shi, Y., Wang, Y.F., Jayaraman, L., Yang, H., Massagué, J., and Pavletich, N.P. (1998) Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell 94, 585-594
-
(1998)
Cell
, vol.94
, pp. 585-594
-
-
Shi, Y.1
Wang, Y.F.2
Jayaraman, L.3
Yang, H.4
Massagué, J.5
Pavletich, N.P.6
-
32
-
-
0029829230
-
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
-
Baker, J.C. and Harland, R.M. (1996) A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880-1889
-
(1996)
Genes Dev.
, vol.10
, pp. 1880-1889
-
-
Baker, J.C.1
Harland, R.M.2
-
33
-
-
0030885190
-
Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade
-
Newfeld, S., Mehra, A., Singer, M., Wrana, J., Attisano, L., and Gelbart, W. (1997) Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade. Development 124, 3167-3176
-
(1997)
Development
, vol.124
, pp. 3167-3176
-
-
Newfeld, S.1
Mehra, A.2
Singer, M.3
Wrana, J.4
Attisano, L.5
Gelbart, W.6
-
34
-
-
0030863365
-
Daughters against dpp modulates dpp organizing activity in Drosophila wing development
-
Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T.B., Christian, J.L., and Tabata, T. (1997) Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389, 627-631
-
(1997)
Nature
, vol.389
, pp. 627-631
-
-
Tsuneizumi, K.1
Nakayama, T.2
Kamoshida, Y.3
Kornberg, T.B.4
Christian, J.L.5
Tabata, T.6
-
35
-
-
0031876205
-
Interplay of signal meditors of decapentaplegic (Dpp): Molecular characterization of Mothers against dpp, Medea, and Daughters against dpp
-
Inoue, H., Imamura, T., Ishidou, Y., Takase, M., Udagawa, Y., Oka, Y., Tsuneizumi, K., Tabata, T., Miyazono, K., and Kawabata, M. (1998) Interplay of signal meditors of decapentaplegic (Dpp): Molecular characterization of Mothers against dpp, Medea, and Daughters against dpp. Mol. Biol. Cell 9, 2145-2156
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 2145-2156
-
-
Inoue, H.1
Imamura, T.2
Ishidou, Y.3
Takase, M.4
Udagawa, Y.5
Oka, Y.6
Tsuneizumi, K.7
Tabata, T.8
Miyazono, K.9
Kawabata, M.10
-
36
-
-
0032489280
-
Induction of Smad6 mRNA by bone morphogenetic proteins
-
Takase, M., Imamura, T., Sampath, T.K., Takeda, K., Ichijo, H., Miyazono, K., and Kawabata, M. (1998) Induction of Smad6 mRNA by bone morphogenetic proteins. Biochem. Biophys. Res. Commun. 244, 26-29
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.244
, pp. 26-29
-
-
Takase, M.1
Imamura, T.2
Sampath, T.K.3
Takeda, K.4
Ichijo, H.5
Miyazono, K.6
Kawabata, M.7
-
37
-
-
0032547272
-
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members
-
Afrakhte, M., Morén, A., Jossan, S., Itoh, S., Sampath, T., Westermark, B., Heldin, C.-H., Heldin, N.-E., and ten Dijke, P. (1998) Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members. Biochem. Biophys. Res. Commun. 249, 505-511
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.249
, pp. 505-511
-
-
Afrakhte, M.1
Morén, A.2
Jossan, S.3
Itoh, S.4
Sampath, T.5
Westermark, B.6
Heldin, C.-H.7
Heldin, N.-E.8
Ten Dijke, P.9
-
38
-
-
16044369574
-
Madr2 maps to 18q21 and encodes a TGFβ-regulated Mad-related protein that is functionally mutated in colorectal carcinoma
-
Eppert, K., Scherer, S.W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L.C., Bapat, B., Gallinger, S., Andrulis, I.L., Thomsen, G.H., Wrana, J.L., and Attisano, L. (1996) Madr2 maps to 18q21 and encodes a TGFβ-regulated Mad-related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543-552
-
(1996)
Cell
, vol.86
, pp. 543-552
-
-
Eppert, K.1
Scherer, S.W.2
Ozcelik, H.3
Pirone, R.4
Hoodless, P.5
Kim, H.6
Tsui, L.C.7
Bapat, B.8
Gallinger, S.9
Andrulis, I.L.10
Thomsen, G.H.11
Wrana, J.L.12
Attisano, L.13
-
39
-
-
0032479464
-
A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-β signals
-
Goto, D., Yagi, K., Inoue, H., Iwamoto, I., Kawabata, M., Miyazono, K., and Kato, M. (1998) A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-β signals. FEBS Lett. 430, 201-204
-
(1998)
FEBS Lett.
, vol.430
, pp. 201-204
-
-
Goto, D.1
Yagi, K.2
Inoue, H.3
Iwamoto, I.4
Kawabata, M.5
Miyazono, K.6
Kato, M.7
-
40
-
-
0029802485
-
A transcriptional partner for MAD proteins in TGF-β signalling
-
Chen, X., Rubock, M.J., and Whitman, M. (1996) A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383, 691-696
-
(1996)
Nature
, vol.383
, pp. 691-696
-
-
Chen, X.1
Rubock, M.J.2
Whitman, M.3
-
41
-
-
0030961168
-
Smad4 and FAST-1 in the assembly of activin-responsive factor
-
Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-89
-
(1997)
Nature
, vol.389
, pp. 85-89
-
-
Chen, X.1
Weisberg, E.2
Fridmacher, V.3
Watanabe, M.4
Naco, G.5
Whitman, M.6
-
42
-
-
0032528055
-
Determinants of specificity in TGF-β signal transduction
-
Chen, Y.-G., Hata, A., Lo, R.S., Wotton, D., Shi, Y., Pavletich, N., and Massagué, J. (1998) Determinants of specificity in TGF-β signal transduction. Genes Dev. 12, 2144-2152
-
(1998)
Genes Dev.
, vol.12
, pp. 2144-2152
-
-
Chen, Y.-G.1
Hata, A.2
Lo, R.S.3
Wotton, D.4
Shi, Y.5
Pavletich, N.6
Massagué, J.7
-
43
-
-
0032145411
-
Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
-
Xu, X., Yin, Z., Hudson, J.B., Ferguson, E.L., and Frasch, M. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12, 2354-2370
-
(1998)
Genes Dev.
, vol.12
, pp. 2354-2370
-
-
Xu, X.1
Yin, Z.2
Hudson, J.B.3
Ferguson, E.L.4
Frasch, M.5
-
44
-
-
0032110707
-
Characterization of human FAST-1, a TGFβ and activin signal transducer
-
Zhou, S., Zawel, L., Lengauer, C., Kinzler, K.W., and Vogelstein, B. (1998) Characterization of human FAST-1, a TGFβ and activin signal transducer. Mol. Cell 2, 121-127
-
(1998)
Mol. Cell
, vol.2
, pp. 121-127
-
-
Zhou, S.1
Zawel, L.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
-
45
-
-
0030697971
-
Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein
-
Yingling, J.M., Datto, M.B., Wong, C., Frederick, J.P., Liberati, N.T., and Wang, X.-F. (1997) Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol. 17, 7019-7028
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 7019-7028
-
-
Yingling, J.M.1
Datto, M.B.2
Wong, C.3
Frederick, J.P.4
Liberati, N.T.5
Wang, X.-F.6
-
46
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel, L., Dai, J.L., Buckhaults, P., Zhou, S., Kinzler, K.W., Vogelstein, B., and Kern, S.E. (1998) Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1, 611-617
-
(1998)
Mol. Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
47
-
-
0032101178
-
Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
-
Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J.M. (1998) Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100
-
(1998)
EMBO J.
, vol.17
, pp. 3091-3100
-
-
Dennler, S.1
Itoh, S.2
Vivien, D.3
Ten Dijke, P.4
Huet, S.5
Gauthier, J.M.6
-
48
-
-
0032516862
-
Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer
-
Jonk, L.J.C., Itoh, S., Heldin, C.-H., ten Dijke, P., and Kruijer, W. (1998) Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer. J. Biol. Chem. 273, 21145-21152
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21145-21152
-
-
Jonk, L.J.C.1
Itoh, S.2
Heldin, C.-H.3
Ten Dijke, P.4
Kruijer, W.5
-
49
-
-
0033534573
-
Alternatively-spliced variant of Smad2 lacking exon 3: Comparison with wild-type Smad2 and Smad3
-
Yagi, K., Goto, D., Hamamoto, T., Takenoshita, S., Kato, M., and Miyazono, K. (1999) Alternatively-spliced variant of Smad2 lacking exon 3: comparison with wild-type Smad2 and Smad3. J. Biol. Chem. 274, 728-734
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 728-734
-
-
Yagi, K.1
Goto, D.2
Hamamoto, T.3
Takenoshita, S.4
Kato, M.5
Miyazono, K.6
-
50
-
-
0032110463
-
Smad2 and Smad3 positively and negatively regulate TGF β-dependent transcription through the forkhead DNA-binding protein FAST2
-
Labbé, E., Silvestri, C., Hoodless, P.A., Wrana, J.L., and Attisano, L. (1998) Smad2 and Smad3 positively and negatively regulate TGF β-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2, 109-120
-
(1998)
Mol. Cell
, vol.2
, pp. 109-120
-
-
Labbé, E.1
Silvestri, C.2
Hoodless, P.A.3
Wrana, J.L.4
Attisano, L.5
-
51
-
-
0032572723
-
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
-
Zhang, Y., Feng, X.H., and Derynck, R. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394, 909-913
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Derynck, R.3
-
52
-
-
0032527756
-
TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300
-
Janknecht, R., Wells, N.J., and Hunter, T. (1998) TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev. 12, 2144-2152
-
(1998)
Genes Dev.
, vol.12
, pp. 2144-2152
-
-
Janknecht, R.1
Wells, N.J.2
Hunter, T.3
-
53
-
-
0032482946
-
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells
-
Topper, J.N., DiChiara, M.R., Brown, J.D., Williams, A.J., Falb, D., Collins, T., and Gimbrone, M.A. Jr. (1998) CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. USA 95, 9506-9511
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9506-9511
-
-
Topper, J.N.1
DiChiara, M.R.2
Brown, J.D.3
Williams, A.J.4
Falb, D.5
Collins, T.6
Gimbrone M.A., Jr.7
-
54
-
-
0032483493
-
Physical and functional interaction of SMADs and p300/CBP
-
Pouponnot, C., Jayaraman, L., and Massagué, J. (1998) Physical and functional interaction of SMADs and p300/CBP. J. Biol. Chem. 273, 22865-22868
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22865-22868
-
-
Pouponnot, C.1
Jayaraman, L.2
Massagué, J.3
-
55
-
-
0031741487
-
Role of p300, a transcriptional coactivator, in signaling of TGF-β
-
Nishihara, A., Hanai, J., Okamoto, N., Yanagisawa, J., Kato, S., Miyazono, K., and Kawabata, M. (1998) Role of p300, a transcriptional coactivator, in signaling of TGF-β. Genes Cells 3, 613-623
-
(1998)
Genes Cells
, vol.3
, pp. 613-623
-
-
Nishihara, A.1
Hanai, J.2
Okamoto, N.3
Yanagisawa, J.4
Kato, S.5
Miyazono, K.6
Kawabata, M.7
-
56
-
-
0031984518
-
Smad proteins physically interact with calmodulin
-
Zimmerman, C., Kariapper, M., and Mathews, L. (1998) Smad proteins physically interact with calmodulin. J. Biol. Chem. 273, 677-680
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 677-680
-
-
Zimmerman, C.1
Kariapper, M.2
Mathews, L.3
-
57
-
-
0030773834
-
Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
-
Kretzschmar, M., Doody, J., and Massagué, J. (1997) Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature 389, 618-622
-
(1997)
Nature
, vol.389
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massagué, J.3
-
58
-
-
2642605344
-
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases
-
de Caestecker, M., Parks, W., Frank, C., Castagnino, P., Bottaro, D., Roberts, A., and Lechleider, R. (1998) Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev. 12, 1587-1592
-
(1998)
Genes Dev.
, vol.12
, pp. 1587-1592
-
-
Caestecker, M.1
Parks, W.2
Frank, C.3
Castagnino, P.4
Bottaro, D.5
Roberts, A.6
Lechleider, R.7
-
59
-
-
15444348295
-
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
-
Sirard, C., de la Pompa, J.L., Elia, A., Itie, A., Mirtsos, C., Cheung, A., Hahn, S., Wakeham, A., Schwartz, L., Kern, S., Rossant, J., and Mak, T. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12, 107-119
-
(1998)
Genes Dev.
, vol.12
, pp. 107-119
-
-
Sirard, C.1
De La Pompa, J.L.2
Elia, A.3
Itie, A.4
Mirtsos, C.5
Cheung, A.6
Hahn, S.7
Wakeham, A.8
Schwartz, L.9
Kern, S.10
Rossant, J.11
Mak, T.12
-
60
-
-
0032584068
-
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
-
Yang, X., Li, C., Xu, X., and Deng, C. (1998) The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl. Acad. Sci. USA 95, 3667-3672
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3667-3672
-
-
Yang, X.1
Li, C.2
Xu, X.3
Deng, C.4
-
61
-
-
0032549806
-
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
-
Waldrip, W., Bikoff, E., Hoodless, P., Wrana, J., and Robertson, E. (1998) Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797-808
-
(1998)
Cell
, vol.92
, pp. 797-808
-
-
Waldrip, W.1
Bikoff, E.2
Hoodless, P.3
Wrana, J.4
Robertson, E.5
-
62
-
-
0032565859
-
Roles for Smad2 in mesoderm formation, left right patterning, and craniofacial development in mice
-
Nomura, M. and Li, E. (1998) Roles for Smad2 in mesoderm formation, left right patterning, and craniofacial development in mice. Nature 393, 786-789
-
(1998)
Nature
, vol.393
, pp. 786-789
-
-
Nomura, M.1
Li, E.2
-
63
-
-
0032482751
-
Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
-
Weinstein, M., Yang, X., Li, C., Xu, X., Gotay, J., and Deng, C.X. (1998) Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc. Natl. Acad. Sci. USA 95, 9378-9383
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9378-9383
-
-
Weinstein, M.1
Yang, X.2
Li, C.3
Xu, X.4
Gotay, J.5
Deng, C.X.6
-
64
-
-
0032544448
-
Smad3 mutant mice develop metastatic colorectal cancer
-
Zhu, Y., Richardson, J.A., Parada, L.F., and Graff, J.M. (1998) Smad3 mutant mice develop metastatic colorectal cancer. Cell 94, 703-714
-
(1998)
Cell
, vol.94
, pp. 703-714
-
-
Zhu, Y.1
Richardson, J.A.2
Parada, L.F.3
Graff, J.M.4
-
65
-
-
0032489508
-
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
-
Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M.F., and Taketo, M.M. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92, 645-656
-
(1998)
Cell
, vol.92
, pp. 645-656
-
-
Takaku, K.1
Oshima, M.2
Miyoshi, H.3
Matsui, M.4
Seldin, M.F.5
Taketo, M.M.6
-
66
-
-
0032524069
-
Mutations in the SMAD4/DPC4 gene in juvenile polyposis
-
Howe, J.R., Roth, S., Ringold, J.C., Summers, B.W., Jarvinen, H.J., Sistonen, P., Tomlinson, I.P., Houlston, R.S., Bevan, S., Mitros, F.A., Stone, E.M., and Aaltonen, L.A. (1998) Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 280, 1086-1088
-
(1998)
Science
, vol.280
, pp. 1086-1088
-
-
Howe, J.R.1
Roth, S.2
Ringold, J.C.3
Summers, B.W.4
Jarvinen, H.J.5
Sistonen, P.6
Tomlinson, I.P.7
Houlston, R.S.8
Bevan, S.9
Mitros, F.A.10
Stone, E.M.11
Aaltonen, L.A.12
-
67
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
-
Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., and Matsumoto, K. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270, 2008-2011
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
|