-
1
-
-
0026386753
-
Dementia: The neurochemical basis of putative transmitter orientated therapy
-
Court JA, Periv EK. Dementia: the neurochemical basis of putative transmitter orientated therapy. Pharmac Ther 1991; 52: 423-43
-
(1991)
Pharmac Ther
, vol.52
, pp. 423-443
-
-
Court, J.A.1
Periv, E.K.2
-
2
-
-
0027943964
-
Progress and perspectives in new muscarinic agonists
-
Fisher A. Barak D. Progress and perspectives in new muscarinic agonists. Drug News Perspectives 1994; 7: 453-64
-
(1994)
Drug News Perspectives
, vol.7
, pp. 453-464
-
-
Fisher, A.1
Barak, D.2
-
3
-
-
0032211787
-
Promising agents for treating Alzheimer's disease
-
Simonson W. Promising agents for treating Alzheimer's disease. Am J Health Cvst Pharm 1998; 55: S11-S16
-
(1998)
Am J Health Cvst Pharm
, vol.55
-
-
Simonson, W.1
-
4
-
-
0031755416
-
Rivastigmine: A review of its use in Alzheimer's disease
-
Spencer CM, Noble S. Rivastigmine: a review of its use in Alzheimer's disease. Drugs Aging 1998; 13: 391-411
-
(1998)
Drugs Aging
, vol.13
, pp. 391-411
-
-
Spencer, C.M.1
Noble, S.2
-
5
-
-
0031902295
-
Etiologies, pathophysiology, cognitive reserve, and treatment opportunities
-
Cummings JL, Vinters HV, Cole GM, et al. Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 1998; 51: S2-S17
-
(1998)
Neurology
, vol.51
-
-
Cummings, J.L.1
Vinters, H.V.2
Cole, G.M.3
-
6
-
-
0030763602
-
From molecular structure to Alzheimer therapy
-
Giacobini E. From molecular structure to Alzheimer therapy. Jap J Pharmacol 1997; 74: 225-41
-
(1997)
Jap J Pharmacol
, vol.74
, pp. 225-241
-
-
Giacobini, E.1
-
7
-
-
0032426901
-
Alzheimer's disease: Relationship between muscarinic cholinergic receptors, beta-amyloid and tau proteins
-
Pavia J, de Ceballos ML, de la Cuesta FS. Alzheimer's disease: relationship between muscarinic cholinergic receptors, beta-amyloid and tau proteins. Fundam Clin Pharmacol 1998; 12: 473-81
-
(1998)
Fundam Clin Pharmacol
, vol.12
, pp. 473-481
-
-
Pavia, J.1
De Ceballos, M.L.2
De la Cuesta, F.S.3
-
8
-
-
0030734590
-
Potential role of muscarinic agonists in Alzheimer's disease
-
Avery EE, Baker LD. Asthana S, et al. Potential role of muscarinic agonists in Alzheimer's disease. Drugs Aging 1997: 11: 450-9
-
(1997)
Drugs Aging
, vol.11
, pp. 450-459
-
-
Avery, E.E.1
Baker, L.D.2
Asthana, S.3
-
9
-
-
0030813706
-
Muscarinic receptor subtypes: Pharmacology and therapeutic potential
-
Eglen RM, Hegde SS. Muscarinic receptor subtypes: pharmacology and therapeutic potential. DN & P 1997; 10: 462-9
-
(1997)
DN & P
, vol.10
, pp. 462-469
-
-
Eglen, R.M.1
Hegde, S.S.2
-
10
-
-
0030764026
-
Muscarinic agonists for the treatment of Alzheimer's disease: Progress and perspectives
-
Fisher A. Muscarinic agonists for the treatment of Alzheimer's disease: progress and perspectives. Exp Opin Invest Drugs 1997; 6: 1395-411
-
(1997)
Exp Opin Invest Drugs
, vol.6
, pp. 1395-1411
-
-
Fisher, A.1
-
11
-
-
0029761688
-
Treatment development strategies for Alzheimer's disease
-
Wulfert E. Treatment development strategies for Alzheimer's disease. CNS Drug Rev 1996; 2: 238-55
-
(1996)
CNS Drug Rev
, vol.2
, pp. 238-255
-
-
Wulfert, E.1
-
12
-
-
0003294180
-
New perspectives on developing muscarinic agonists for treating Alzheimer's disease
-
Emmerling MR, Schwarz RD, Spiegel K, et al. New perspectives on developing muscarinic agonists for treating Alzheimer's disease [database]. Alzheimer's Dis 1997; 2 (4)
-
(1997)
Alzheimer's Dis
, vol.2
, Issue.4
-
-
Emmerling, M.R.1
Schwarz, R.D.2
Spiegel, K.3
-
13
-
-
0026485448
-
Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists
-
Svensson AL, Alafuzoff I. Nordberg A. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res 1992; 596: 142-8
-
(1992)
Brain Res
, vol.596
, pp. 142-148
-
-
Svensson, A.L.1
Alafuzoff, I.2
Nordberg, A.3
-
15
-
-
0026013698
-
Alzheimer's disease: Specific increases in a G-protein subunit (Gsα) mRNA in hippocampal and cortical neurons
-
Harrison PJ, Barton AJL, McDonald B, et al. Alzheimer's disease: specific increases in a G-protein subunit (Gsα) mRNA in hippocampal and cortical neurons. Mol Brain Res 1991; 10: 71-81
-
(1991)
Mol Brain Res
, vol.10
, pp. 71-81
-
-
Harrison, P.J.1
Barton, A.J.L.2
McDonald, B.3
-
16
-
-
0027950411
-
Discrete activation of transduction pathways associated with acetylcholine M1 receptor by several muscarinic ligands
-
Gurwitz D, Haring R, Heldman E, et al. Discrete activation of transduction pathways associated with acetylcholine M1 receptor by several muscarinic ligands. Eur J Pharmacol (Mol Pharmacol) 1994; 267: 21-31
-
(1994)
Eur J Pharmacol (Mol Pharmacol)
, vol.267
, pp. 21-31
-
-
Gurwitz, D.1
Haring, R.2
Heldman, E.3
-
17
-
-
0026476297
-
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
-
Nitsch RN, Slack BE, Wartman RJ, et al. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 1992; 258: 304-7
-
(1992)
Science
, vol.258
, pp. 304-307
-
-
Nitsch, R.N.1
Slack, B.E.2
Wartman, R.J.3
-
18
-
-
0028267622
-
Neurotransmission the link integrating Alzheimer research?
-
Bowen DM, Francis PT, Chessell IP, et al. Neurotransmission the link integrating Alzheimer research? TINS 1994; 17: 149-50
-
(1994)
TINS
, vol.17
, pp. 149-150
-
-
Bowen, D.M.1
Francis, P.T.2
Chessell, I.P.3
-
19
-
-
0026448114
-
Cholinergic agonists and interleukin I regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor
-
Buxbaum JD, Oishi M, Chen HJ, et al. Cholinergic agonists and interleukin I regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc Natl Acad Sci U S A 1992; 89: 10075-8
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10075-10078
-
-
Buxbaum, J.D.1
Oishi, M.2
Chen, H.J.3
-
20
-
-
0027059023
-
The cholinergic agonist carbachol reduces intercellular β-amyloid precursor protein in PC12 and C6 cells
-
Lahiri DK, Nall C, Farlow MR. The cholinergic agonist carbachol reduces intercellular β-amyloid precursor protein in PC12 and C6 cells. Biochem Int 1992; 28: 853-60
-
(1992)
Biochem Int
, vol.28
, pp. 853-860
-
-
Lahiri, D.K.1
Nall, C.2
Farlow, M.R.3
-
21
-
-
0028098787
-
Amyloid precursor protein secretion via muscarinic receptors: Reduced desensitization using the M1-selective agonist AF102B
-
Haring R, Gurwitz D, Barg J, et al. Amyloid precursor protein secretion via muscarinic receptors: reduced desensitization using the M1-selective agonist AF102B. Biochem Biophys Res Comm 1994; 203: 652-8
-
(1994)
Biochem Biophys Res Comm
, vol.203
, pp. 652-658
-
-
Haring, R.1
Gurwitz, D.2
Barg, J.3
-
22
-
-
0029166330
-
The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from CHO M1 cells
-
Eckols K, Bymaster FP, Mitch CH, et al. The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from CHO M1 cells. Life Sci 1995; 57: 1183-90
-
(1995)
Life Sci
, vol.57
, pp. 1183-1190
-
-
Eckols, K.1
Bymaster, F.P.2
Mitch, C.H.3
-
23
-
-
0031751761
-
Mitogen-activated kinase-dependent and protein kinase C-dependent pathways link the M1 muscarinic receptor to β-amyloid precursor protein secretion
-
Haring H, Fisher A, Marciano D, et al. Mitogen-activated kinase-dependent and protein kinase C-dependent pathways link the M1 muscarinic receptor to β-amyloid precursor protein secretion. J Neurochem 1998; 71: 2094-103
-
(1998)
J Neurochem
, vol.71
, pp. 2094-2103
-
-
Haring, H.1
Fisher, A.2
Marciano, D.3
-
24
-
-
0027453490
-
Activation of protein kinase C inhibits cellular production of the amyloid β-protein
-
Hung AY, Haass C, Nitsch RT, et al. Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J Biolog Chem 1993; 268: 22959-62
-
(1993)
J Biolog Chem
, vol.268
, pp. 22959-22962
-
-
Hung, A.Y.1
Haass, C.2
Nitsch, R.T.3
-
25
-
-
0028926941
-
Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells
-
Wolf BA, Wertkin AM, Jolly YC, et al. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. J Biol Chem 1995; 270: 4916-22
-
(1995)
J Biol Chem
, vol.270
, pp. 4916-4922
-
-
Wolf, B.A.1
Wertkin, A.M.2
Jolly, Y.C.3
-
26
-
-
0029379605
-
Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease
-
Checler F. Processing of the β-Amyloid precursor protein and its regulation in Alzheimer's disease. J Neurochem 1995; 65: 1431-44
-
(1995)
J Neurochem
, vol.65
, pp. 1431-1444
-
-
Checler, F.1
-
27
-
-
0026539617
-
Growth factor-like effects mediated by muscarinic receptors in PC12M1 cells
-
Pinkas-Kramarski R, Stein R, Lindenboim L, et al. Growth factor-like effects mediated by muscarinic receptors in PC12M1 cells. J Neurochem 1992; 59: 2158-66
-
(1992)
J Neurochem
, vol.59
, pp. 2158-2166
-
-
Pinkas-Kramarski, R.1
Stein, R.2
Lindenboim, L.3
-
28
-
-
0028893462
-
NGF-dependent neurotrophic-like effects of AF102B, an M1 muscarinic agonist, in PC12M1 cells
-
Gurwitz D, Haring R, Pinkas-Kramarski R, et al. NGF-dependent neurotrophic-like effects of AF102B, an M1 muscarinic agonist, in PC12M1 cells. NeuroReport 1995; 6: 485-8
-
(1995)
NeuroReport
, vol.6
, pp. 485-488
-
-
Gurwitz, D.1
Haring, R.2
Pinkas-Kramarski, R.3
-
29
-
-
0028143741
-
Muscarinic stimulation promotes cultured Purkinje cell survival: A role for acetylcholine in cerebellar development?
-
Mount HTJ, Dreyfus CF, Black IB, et al. Muscarinic stimulation promotes cultured Purkinje cell survival: a role for acetylcholine in cerebellar development? J Neurochem 1994; 63: 2065-73
-
(1994)
J Neurochem
, vol.63
, pp. 2065-2073
-
-
Mount, H.T.J.1
Dreyfus, C.F.2
Black, I.B.3
-
30
-
-
0000470396
-
Novel muscarinic M1 receptor agonists promote survival of CNS neurons in primary cell culture
-
Alberch J, Gurwitz D, Fisher A, et al. Novel muscarinic M1 receptor agonists promote survival of CNS neurons in primary cell culture. Soc Neurosci Abstr 1995; 21: 2040
-
(1995)
Soc Neurosci Abstr
, vol.21
, pp. 2040
-
-
Alberch, J.1
Gurwitz, D.2
Fisher, A.3
-
31
-
-
0029117462
-
NGF promotes amyloid protein secretion via muscarinic receptor activation
-
Haring R, Gurwitz D, Barg J, et al. NGF promotes amyloid protein secretion via muscarinic receptor activation. Biochem Biophys Res Comm 1995; 213: 15-23
-
(1995)
Biochem Biophys Res Comm
, vol.213
, pp. 15-23
-
-
Haring, R.1
Gurwitz, D.2
Barg, J.3
-
32
-
-
0029670637
-
Activation of M1-muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells
-
Sadot E, Gurwitz D, Barg J, et al. Activation of M1-muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells. J Neurochem 1996; 66; 877-80
-
(1996)
J Neurochem
, vol.66
, pp. 877-880
-
-
Sadot, E.1
Gurwitz, D.2
Barg, J.3
-
33
-
-
0000248829
-
Muscarinic agonists reduce tau phosphorylation in transfected cells and in neurons
-
Forlenza O, Spink J, Oleson O, et al. Muscarinic agonists reduce tau phosphorylation in transfected cells and in neurons [abstract]. Neurobiol Aging 1998; 19: S218
-
(1998)
Neurobiol Aging
, vol.19
-
-
Forlenza, O.1
Spink, J.2
Oleson, O.3
-
34
-
-
0032935789
-
Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment
-
Genis I, Fisher A, Michaelson DM. Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment. J Neurochem 1999; 12 (1): 206-13
-
(1999)
J Neurochem
, vol.12
, Issue.1
, pp. 206-213
-
-
Genis, I.1
Fisher, A.2
Michaelson, D.M.3
-
35
-
-
0029051943
-
Activation of muscarinic receptors inhibits apoptosis in PC12M1 cells
-
Lindenboim L, Pinkas-Kramarski R, Sokolovsky M, et al. Activation of muscarinic receptors inhibits apoptosis in PC12M1 cells. J Neurochem 1995; 64: 2491-9
-
(1995)
J Neurochem
, vol.64
, pp. 2491-2499
-
-
Lindenboim, L.1
Pinkas-Kramarski, R.2
Sokolovsky, M.3
-
36
-
-
0032486467
-
Muscarinic acetylcholine receptors activate expression of the Egr gene family of transcription factors
-
von der Kammer H, Mayhaus M, Albrecht C, et al. Muscarinic acetylcholine receptors activate expression of the Egr gene family of transcription factors. J Biolog Chem 1998; 273 (23): 14538-44
-
(1998)
J Biolog Chem
, vol.273
, Issue.23
, pp. 14538-14544
-
-
Von der Kammer, H.1
Mayhaus, M.2
Albrecht, C.3
-
37
-
-
0032105340
-
Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter
-
Nitsch RM, Rossner S, Albrecht C, et al. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. J Physiol (Paris) 1998; 92 (3-4): 257-64
-
(1998)
J Physiol (Paris)
, vol.92
, Issue.3-4
, pp. 257-264
-
-
Nitsch, R.M.1
Rossner, S.2
Albrecht, C.3
-
38
-
-
0000302681
-
Muscarinic receptor agonists under development for the treatment of Alzheimer's disease
-
Schwarz RD. Muscarinic receptor agonists under development for the treatment of Alzheimer's disease. Alzheimer's Dis 1997; 2: 459-65
-
(1997)
Alzheimer's Dis
, vol.2
, pp. 459-465
-
-
Schwarz, R.D.1
-
39
-
-
0030976004
-
Cognitive enhancement therapy for Alzheimer's disease
-
Parnetti L, Senin U, Mecocci P. Cognitive enhancement therapy for Alzheimer's disease. Drugs 1997; 53: 752-68
-
(1997)
Drugs
, vol.53
, pp. 752-768
-
-
Parnetti, L.1
Senin, U.2
Mecocci, P.3
-
40
-
-
0030052086
-
Selective muscarinic receptor agonists and antagonists
-
Eglen RM, Watson N. Selective muscarinic receptor agonists and antagonists. Pharmacol Toxicol 1996; 78: 59-8
-
(1996)
Pharmacol Toxicol
, vol.78
, pp. 59-68
-
-
Eglen, R.M.1
Watson, N.2
-
41
-
-
0028941501
-
Medicinal chemistry of muscarinic agonists: Developments since 1990
-
Moltzen EK, Bjornholm B. Medicinal chemistry of muscarinic agonists: developments since 1990. Drugs Future 1995; 20: 37-54
-
(1995)
Drugs Future
, vol.20
, pp. 37-54
-
-
Moltzen, E.K.1
Bjornholm, B.2
-
44
-
-
0001371544
-
Xanomeline: Preclinical and clinical pharmacology of an M1 muscarinic agonist
-
Fisher A, editor. Austin (TX): RG Landes Company, Medical Intelligence Unit
-
Bymaster EP, Shannon HE, Mitch CH, et al. Xanomeline: preclinical and clinical pharmacology of an M1 muscarinic agonist. In: Fisher A, editor. Muscarinic agonists and Alzheimer's disease. Austin (TX): RG Landes Company, Medical Intelligence Unit. 1996: 155-84
-
(1996)
Muscarinic Agonists and Alzheimer's Disease
, pp. 155-184
-
-
Bymaster, E.P.1
Shannon, H.E.2
Mitch, C.H.3
-
45
-
-
0009673991
-
Determination of the intrinsic functional muscarinic activity of xanomeline. Subtypes of muscarinic receptors
-
Aug 25-29; Danvers (MA), USA
-
Falcone JF, Bymaster FP, Butler T, et al. Determination of the intrinsic functional muscarinic activity of xanomeline. Subtypes of muscarinic receptors. 8th International Symposium; 1998 Aug 25-29; Danvers (MA), USA
-
(1998)
8th International Symposium
-
-
Falcone, J.F.1
Bymaster, F.P.2
Butler, T.3
-
46
-
-
0030927142
-
Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease
-
Bymaster FP, Whitesitt CA, Shannon HE, et al. Xanomeline: a selective muscarinic agonist for the treatment of Alzheimer's disease. Drug Develop Res 1997; 40: 158-70
-
(1997)
Drug Develop Res
, vol.40
, pp. 158-170
-
-
Bymaster, F.P.1
Whitesitt, C.A.2
Shannon, H.E.3
-
47
-
-
0026562756
-
L-687,306: A functionally selective and potent muscarinic M1 receptor agonist
-
Freedman SB, Patel S, Harley EA, et al. L-687,306: a functionally selective and potent muscarinic M1 receptor agonist. Eur J Pharmacol 1992; 215: 135-6
-
(1992)
Eur J Pharmacol
, vol.215
, pp. 135-136
-
-
Freedman, S.B.1
Patel, S.2
Harley, E.A.3
-
48
-
-
0027509178
-
The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vitro and reduced side-effect profile in vivo
-
Freedman SB, Dawson GR, Iversen LL, et al. The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vitro and reduced side-effect profile in vivo. Life Sci 1993; 52: 489-95
-
(1993)
Life Sci
, vol.52
, pp. 489-495
-
-
Freedman, S.B.1
Dawson, G.R.2
Iversen, L.L.3
-
49
-
-
0030998289
-
Pharmacological in vitro characterization of the arecoline bioisostere, Lu 25-109-T, a muscarinic compound with M1-agonistic and M2/M3-antagonistic properties
-
Meier E, Frederiksen K, Nielsen M, et al. Pharmacological in vitro characterization of the arecoline bioisostere, Lu 25-109-T, a muscarinic compound with M1-agonistic and M2/M3-antagonistic properties. Drug Develop Res 1997; 40: 1-16
-
(1997)
Drug Develop Res
, vol.40
, pp. 1-16
-
-
Meier, E.1
Frederiksen, K.2
Nielsen, M.3
-
50
-
-
0031768806
-
Lu 25-109, a combined ml agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease
-
Muller D, Wiegmann H, Langer U, et al. Lu 25-109, a combined ml agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease. J Neural Transm 1998; 105: 1029-43
-
(1998)
J Neural Transm
, vol.105
, pp. 1029-1043
-
-
Muller, D.1
Wiegmann, H.2
Langer, U.3
-
51
-
-
4243319232
-
Lu 25-109 - A new muscarinic agent
-
Heisterberg J, Forrest M. Lu 25-109 - a new muscarinic agent. Neurobiol Aging 1996; Suppl. 17: S139
-
(1996)
Neurobiol Aging
, Issue.SUPPL. 17
-
-
Heisterberg, J.1
Forrest, M.2
-
52
-
-
0031566005
-
A bridging study of LU 25-109 in patients with probable Alzheimer's disease
-
Sramek JJ, Forrest M, Mengel H, et al. A bridging study of LU 25-109 in patients with probable Alzheimer's disease. Life Sci 1998; 62: 195-202
-
(1998)
Life Sci
, vol.62
, pp. 195-202
-
-
Sramek, J.J.1
Forrest, M.2
Mengel, H.3
-
53
-
-
0009673459
-
Forest's M1 agonist in Alzheimer's disease fails
-
Aug 26
-
Forest's M1 agonist in Alzheimer's disease fails. SCRIP 1998 Aug 26: 16
-
(1998)
SCRIP
, pp. 16
-
-
-
54
-
-
0027496803
-
Subtype selective muscarinic agonists: Potential therapeutic agents for Alzheimer's disease
-
Davis R, Raby C, Callahan MJ, et al. Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease. Prog Brain Res 1993; 98: 439-45
-
(1993)
Prog Brain Res
, vol.98
, pp. 439-445
-
-
Davis, R.1
Raby, C.2
Callahan, M.J.3
-
55
-
-
0027400004
-
Synthesis and SAR of bulky l-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists
-
Tecle H, Lauffer DJ, Mirzadegan T, et al. Synthesis and SAR of bulky l-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists. Life Sci 1993; 52: 505-11
-
(1993)
Life Sci
, vol.52
, pp. 505-511
-
-
Tecle, H.1
Lauffer, D.J.2
Mirzadegan, T.3
-
56
-
-
0028909699
-
In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832
-
Jaen J, Barrett S, Brann M, et al. In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832. Life Sci 1995; 56: 845-52
-
(1995)
Life Sci
, vol.56
, pp. 845-852
-
-
Jaen, J.1
Barrett, S.2
Brann, M.3
-
57
-
-
1842367290
-
Tetrahydropyrimidine derivatives display functional selectivity for M1 muscarinic receptors in brain
-
Messer WS Jr, Abuh YF, Ryan K, et al. Tetrahydropyrimidine derivatives display functional selectivity for M1 muscarinic receptors in brain. Drug Develop Res 1997; 40: 171-84
-
(1997)
Drug Develop Res
, vol.40
, pp. 171-184
-
-
Messer W.S., Jr.1
Abuh, Y.F.2
Ryan, K.3
-
58
-
-
0026575010
-
Muscarinic activity of the thiolactone, lactam, lactol and thio analogues of pilocarpine and a hypothetical model for the binding of agonists to the M1 receptors
-
Shapiro G, Floersheim P, Boelsterli J, et al. Muscarinic activity of the thiolactone, lactam, lactol and thio analogues of pilocarpine and a hypothetical model for the binding of agonists to the M1 receptors. J Med Chem 1992; 35: 15-27
-
(1992)
J Med Chem
, vol.35
, pp. 15-27
-
-
Shapiro, G.1
Floersheim, P.2
Boelsterli, J.3
-
59
-
-
0027388979
-
SDZ ENS 163 a novel pilocarpine like drug: Pharmacological in vitro and in vivo profile
-
Enz A, Boddeke H, Sauter A, et al. SDZ ENS 163 a novel pilocarpine like drug: pharmacological in vitro and in vivo profile. Life Sci 1993; 52 (5-6): 513-20
-
(1993)
Life Sci
, vol.52
, Issue.5-6
, pp. 513-520
-
-
Enz, A.1
Boddeke, H.2
Sauter, A.3
-
60
-
-
0025077457
-
Pharmacological studies on novel muscarinic agonists, l-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954
-
Wanibuchi F, Konishi T, Harada M, et al. Pharmacological studies on novel muscarinic agonists, l-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur J Pharmacol 1990; 187: 479-86
-
(1990)
Eur J Pharmacol
, vol.187
, pp. 479-486
-
-
Wanibuchi, F.1
Konishi, T.2
Harada, M.3
-
62
-
-
0031011836
-
WAY-131256 is an orally active, efficacious, and in-vivo functionally selective M1 agonist
-
Sabb AL, Stein RP, Vogel RL, et al. WAY-131256 is an orally active, efficacious, and in-vivo functionally selective M1 agonist. Drug Develop Res 1997; 40: 185-92
-
(1997)
Drug Develop Res
, vol.40
, pp. 185-192
-
-
Sabb, A.L.1
Stein, R.P.2
Vogel, R.L.3
-
63
-
-
0031441919
-
SB 202026: A novel muscarinic partial agonist with functional selectivity for M1 receptors
-
Loudon JM, Bromidge SM, Brown F, et al. SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors. J Pharmacol Exp Ther 1997; 283: 1059-68
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 1059-1068
-
-
Loudon, J.M.1
Bromidge, S.M.2
Brown, F.3
-
64
-
-
0009709566
-
Efficacy and safety of SB 202026 as a symptomatic treatment for Alzheimer's disease
-
Iqbal K, Winblad B, Nishimura T, et al., editors. New York (NY): John Wiley and Sons
-
Kumar R, Orgogozo J. Efficacy and safety of SB 202026 as a symptomatic treatment for Alzheimer's disease. In: Iqbal K, Winblad B, Nishimura T, et al., editors. Alzheimer's disease: biology, diagnosis and therapeutics. New York (NY): John Wiley and Sons, 1997: 677-85
-
(1997)
Alzheimer's Disease: Biology, Diagnosis and Therapeutics
, pp. 677-685
-
-
Kumar, R.1
Orgogozo, J.2
-
65
-
-
0030916650
-
WAL 2014 FU (Talsaclidine): A preferentially neuron activating muscarinic agonist for the treatment of Alzheimer's disease
-
Ensinger HA, Bechtel WD, Birke FW, et al. WAL 2014 FU (Talsaclidine): a preferentially neuron activating muscarinic agonist for the treatment of Alzheimer's disease. Drug Develop Res 1997; 40: 144-57
-
(1997)
Drug Develop Res
, vol.40
, pp. 144-157
-
-
Ensinger, H.A.1
Bechtel, W.D.2
Birke, F.W.3
-
66
-
-
0028930910
-
Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease
-
Adamus WS, Leonard JP, Troger W. Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease. Life Sci 1995; 56: 883-90
-
(1995)
Life Sci
, vol.56
, pp. 883-890
-
-
Adamus, W.S.1
Leonard, J.P.2
Troger, W.3
-
67
-
-
0024473267
-
(+/-)cis-2-methyl-spiro (1,3-oxathiolane-5,3′) quinuclidine (AF102B): A new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats
-
Fisher A, Brandeis R, Pittel Z, et al. (+/-)Cis-2-methyl-spiro (1,3-oxathiolane-5,3′) quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats. Neurosci Lett 1989; 102: 325-31
-
(1989)
Neurosci Lett
, vol.102
, pp. 325-331
-
-
Fisher, A.1
Brandeis, R.2
Pittel, Z.3
-
68
-
-
0025924916
-
Cis-2-methyl-spiro(1,3-oxathiolane-5,3′) quinuclidine an M1 selective cholinergic agonist attenuates cognitive dysfunctions in an animal model of Alzheimer's disease
-
Fisher A, Brandeis R, Karton Y, et al. Cis-2-methyl-spiro(1,3-oxathiolane-5,3′) quinuclidine an M1 selective cholinergic agonist attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther 1991; 257: 392-403
-
(1991)
J Pharmacol Exp Ther
, vol.257
, pp. 392-403
-
-
Fisher, A.1
Brandeis, R.2
Karton, Y.3
-
69
-
-
0026657437
-
Rigid analogs of acetylcholine can be M1-selective agonists: Implications for a rational treatment strategy in Alzheimer's disease
-
Fisher A, Gurwitz D, Barak D, et al. Rigid analogs of acetylcholine can be M1-selective agonists: implications for a rational treatment strategy in Alzheimer's disease. Biorg Med Chem Lett 1992; 2: 839-44
-
(1992)
Biorg Med Chem Lett
, vol.2
, pp. 839-844
-
-
Fisher, A.1
Gurwitz, D.2
Barak, D.3
-
70
-
-
0027312143
-
Progress in medicinal chemistry of novel selective muscarinic agonists
-
Fisher A, Karton Y, Heldman E, et al. Progress in medicinal chemistry of novel selective muscarinic agonists. Drug Des Discov 1993; 9: 221-35
-
(1993)
Drug Des Discov
, vol.9
, pp. 221-235
-
-
Fisher, A.1
Karton, Y.2
Heldman, E.3
-
71
-
-
0029007153
-
AF150(S): A new functionally selective M1 agonist improves cognitive performance in rats
-
Brandeis R, Sapir M, Hatif N, et al. AF150(S): a new functionally selective M1 agonist improves cognitive performance in rats. Pharmacol Biochem Behav 1995; 51: 667-74
-
(1995)
Pharmacol Biochem Behav
, vol.51
, pp. 667-674
-
-
Brandeis, R.1
Sapir, M.2
Hatif, N.3
-
72
-
-
0031596743
-
M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice
-
Fisher A, Brandeis R, Chapman S. M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice. J Neurochem 1998; 70: 1991-7
-
(1998)
J Neurochem
, vol.70
, pp. 1991-1997
-
-
Fisher, A.1
Brandeis, R.2
Chapman, S.3
-
73
-
-
0032105415
-
The effects of the acetylcholinesterase inhibitor ENA713 and the M1 agonist AF150(S) on apolipoprotein E deficient mice
-
Chapman S, Fisher A, Weinstock M, et al. The effects of the acetylcholinesterase inhibitor ENA713 and the M1 agonist AF150(S) on apolipoprotein E deficient mice. J Physiol (Paris) 1998; 92: 299-303
-
(1998)
J Physiol (Paris)
, vol.92
, pp. 299-303
-
-
Chapman, S.1
Fisher, A.2
Weinstock, M.3
-
74
-
-
0024501089
-
Different agonist-receptor active conformations for rat brain M1 and M2 muscarinic receptors that are separately coupled to two biochemical effector systems
-
McKinney A, Anderson D, Vella-Rountree L. Different agonist-receptor active conformations for rat brain M1 and M2 muscarinic receptors that are separately coupled to two biochemical effector systems. Mol Pharmacol 1988; 35: 39-47
-
(1988)
Mol Pharmacol
, vol.35
, pp. 39-47
-
-
McKinney, A.1
Anderson, D.2
Vella-Rountree, L.3
-
75
-
-
0023726578
-
Heterogeneity of muscarinic autoreceptors and heteroreceptors in the rat brain: Effects of a novel M1 agonist, AF102B
-
Ono S, Saito Y, Ohgane N, et al. Heterogeneity of muscarinic autoreceptors and heteroreceptors in the rat brain: effects of a novel M1 agonist, AF102B. Eur J Pharmacol 1989; 155: 77-84
-
(1989)
Eur J Pharmacol
, vol.155
, pp. 77-84
-
-
Ono, S.1
Saito, Y.2
Ohgane, N.3
-
76
-
-
0023928204
-
Dual synaptic effects of activating M1-receptors, in superior cervical ganglia of rabbits
-
Mochida S, Mizobe F, Fisher A, et al. Dual synaptic effects of activating M1-receptors, in superior cervical ganglia of rabbits. Brain Res 1988; 455 (1): 9-17
-
(1988)
Brain Res
, vol.455
, Issue.1
, pp. 9-17
-
-
Mochida, S.1
Mizobe, F.2
Fisher, A.3
-
77
-
-
0027367765
-
β-amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease
-
Mattson MP, Barger SW, Cheng B, et al. β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease. TINS 1993; 16: 409-14
-
(1993)
TINS
, vol.16
, pp. 409-414
-
-
Mattson, M.P.1
Barger, S.W.2
Cheng, B.3
-
78
-
-
0009741573
-
Muscarinic receptors regulate amyloid precursor protein processing
-
Fisher A, editor. Austin (TX): RG Landes Company, Medical Intelligence Unit
-
Nitsch RM. Muscarinic receptors regulate amyloid precursor protein processing. In: Fisher A, editor. Muscarinic agonists and Alzheimer's Disease, Austin (TX): RG Landes Company, Medical Intelligence Unit, 1996: 45-54
-
(1996)
Muscarinic Agonists and Alzheimer's Disease
, pp. 45-54
-
-
Nitsch, R.M.1
-
79
-
-
0343811715
-
Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ecrodomain
-
Muller DM, Mendla K, Farber SA. Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ecrodomain. Life Sci 1997; 60: 985-91
-
(1997)
Life Sci
, vol.60
, pp. 985-991
-
-
Muller, D.M.1
Mendla, K.2
Farber, S.A.3
-
80
-
-
1842399364
-
SB 202026: A functionally M1 selective partial agonist alters processing of amyloid precursor protein at the cell surface
-
Gray C, Hawkins J, Clark MSG, et al. SB 202026: a functionally M1 selective partial agonist alters processing of amyloid precursor protein at the cell surface [abstract]. Neurobiol Aging 1996; 17 Suppl.: 118
-
(1996)
Neurobiol Aging
, vol.17
, Issue.SUPPL.
, pp. 118
-
-
Gray, C.1
Hawkins, J.2
Clark, M.S.G.3
-
81
-
-
0030566744
-
Muscarinic control of amyloid precursor protein secretion in rat cerebral cortex and cerebellum
-
Pittel Z, Heldman E, Barg J, et al. Muscarinic control of amyloid precursor protein secretion in rat cerebral cortex and cerebellum. Brain Res 1996: 742: 299-304
-
(1996)
Brain Res
, vol.742
, pp. 299-304
-
-
Pittel, Z.1
Heldman, E.2
Barg, J.3
-
82
-
-
0032441386
-
Novel M1 muscarinic agonists in treatment and delaying the progression of Alzheimer's disease: A unifying hypothesis
-
Fisher A, Brandeis R, Haring R, et al. Novel M1 muscarinic agonists in treatment and delaying the progression of Alzheimer's disease: a unifying hypothesis. J Physiol (Paris) 1998; 92: 337-40
-
(1998)
J Physiol (Paris)
, vol.92
, pp. 337-340
-
-
Fisher, A.1
Brandeis, R.2
Haring, R.3
-
83
-
-
0028971033
-
Regulated secretion of β-amyloid precursor protein in rat brain
-
Farber SA, Nitsch RM, Schulz JG, et al. Regulated secretion of β-amyloid precursor protein in rat brain. J Neurosci 1995; 15: 7442-51
-
(1995)
J Neurosci
, vol.15
, pp. 7442-7451
-
-
Farber, S.A.1
Nitsch, R.M.2
Schulz, J.G.3
-
84
-
-
0030956630
-
Muscarinic agonists in Alzheimer's disease
-
Growdon JH. Muscarinic agonists in Alzheimer's disease. Life Sci 1997: 60: 993-8
-
(1997)
Life Sci
, vol.60
, pp. 993-998
-
-
Growdon, J.H.1
-
85
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal tau
-
Lee VM-Y, Balin BJ, Otvos L, et al. A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 1991: 251: 675-8
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.-Y.1
Balin, B.J.2
Otvos, L.3
-
86
-
-
0028790904
-
Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
-
Gordon I, Grauer E, Genis I, et al. Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. Neurosci Lett 1995; 199: 1-4
-
(1995)
Neurosci Lett
, vol.199
, pp. 1-4
-
-
Gordon, I.1
Grauer, E.2
Genis, I.3
-
87
-
-
0024234819
-
Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B
-
Nakahara N, Iga Y, Mizobe F, et al. Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B. Jpn J Pharmacol 1988; 48: 502-6
-
(1988)
Jpn J Pharmacol
, vol.48
, pp. 502-506
-
-
Nakahara, N.1
Iga, Y.2
Mizobe, F.3
-
88
-
-
0024408321
-
Beneficial effects of FKS-508 (AP102B) a selective M1 muscarinic agonist, on the impaired working memory in AF64A-treated rats
-
Nakahara N, Iga Y, Saito Y, et al. Beneficial effects of FKS-508 (AP102B) a selective M1 muscarinic agonist, on the impaired working memory in AF64A-treated rats. Jpn J Pharmacol 1989; 51: 539-47
-
(1989)
Jpn J Pharmacol
, vol.51
, pp. 539-547
-
-
Nakahara, N.1
Iga, Y.2
Saito, Y.3
-
89
-
-
0025348842
-
Reversal of age-related cognitive impairments by an M1 cholinergic agonist - AF102B
-
Brandeis R, Dachir S, Sapir M, et al. Reversal of age-related cognitive impairments by an M1 cholinergic agonist - AF102B. Pharmacol Biochem Behav 1990; 36: 89-95
-
(1990)
Pharmacol Biochem Behav
, vol.36
, pp. 89-95
-
-
Brandeis, R.1
Dachir, S.2
Sapir, M.3
-
91
-
-
0026615760
-
AF102B, a novel M1 agonist, enhanced spatial learning in C57BL/10 mice with a long duration of action
-
Vincent GP, Sepinwall J. AF102B, a novel M1 agonist, enhanced spatial learning in C57BL/10 mice with a long duration of action. Brain Res 1992; 597: 264-8
-
(1992)
Brain Res
, vol.597
, pp. 264-268
-
-
Vincent, G.P.1
Sepinwall, J.2
-
92
-
-
0027936838
-
Apolipoprotein E affects the rate of Alzheimer disease expression: Beta-amyloid burden is of secondary consequence dependent on APOE genotype and duration of disease
-
Roses AD. Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is of secondary consequence dependent on APOE genotype and duration of disease. J Neuropathol Exp Neurol 1994; 53: 429-37
-
(1994)
J Neuropathol Exp Neurol
, vol.53
, pp. 429-437
-
-
Roses, A.D.1
-
93
-
-
0007691164
-
Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
-
Poirier J. Delisle MC, Quirion R, et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proc Natl Acad Sci U S A 1995; 92 (26): 12260-4
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.26
, pp. 12260-12264
-
-
Poirier, J.1
Delisle, M.C.2
Quirion, R.3
-
94
-
-
0023177967
-
Induction of depression with oxotremorine in patients with Alzheimer's disease
-
Davis KL, Hollander, E. Davidson M, et al. Induction of depression with oxotremorine in patients with Alzheimer's disease. Am J Psychiatry 1987; 144: 468-71
-
(1987)
Am J Psychiatry
, vol.144
, pp. 468-471
-
-
Davis, K.L.1
Hollander, E.2
Davidson, M.3
-
95
-
-
0025933055
-
Cholinergic drugs, affective disorders and dementia: Problems of clinical research
-
Spiegel R. Cholinergic drugs, affective disorders and dementia: problems of clinical research. Acta Psychiatr Scand 1991; 366 Suppl.: 66-9
-
(1991)
Acta Psychiatr Scand
, vol.366
, Issue.SUPPL.
, pp. 66-69
-
-
Spiegel, R.1
-
96
-
-
0023837692
-
Intraventricular beth anechol infusion for Alzheimer's disease
-
Penn RD, Martin EM, Wilson RS, et al. Intraventricular beth anechol infusion for Alzheimer's disease. Neurology 1988; 38: 219-22
-
(1988)
Neurology
, vol.38
, pp. 219-222
-
-
Penn, R.D.1
Martin, E.M.2
Wilson, R.S.3
-
97
-
-
0027340758
-
Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer's disease
-
Sonerant TT, Raffaele KC, Asthana S, et al. Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer's disease. Psychopharmacol 1993; 112: 421-7
-
(1993)
Psychopharmacol
, vol.112
, pp. 421-427
-
-
Sonerant, T.T.1
Raffaele, K.C.2
Asthana, S.3
-
98
-
-
0028795476
-
The utility of salivary amylase as an evaluation of M3 muscarinic agonist activity in Alzheimer's disease
-
Sramek JJ, Cutler NR, Hurley DJ, et al. The utility of salivary amylase as an evaluation of M3 muscarinic agonist activity in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 1995; 19: 85-91
-
(1995)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.19
, pp. 85-91
-
-
Sramek, J.J.1
Cutler, N.R.2
Hurley, D.J.3
-
100
-
-
10544229530
-
Absorption distribution, metabolism and elimination of radiolabeled xanomeline in healthy male subjects
-
Hanin I, Yoshida M, Fisher A, editors. New York (NY): Plenum Press
-
Delong AF, Bonate PL, Gillespie T, et al. Absorption distribution, metabolism and elimination of radiolabeled xanomeline in healthy male subjects. In: Hanin I, Yoshida M, Fisher A, editors. Alzheimer's and Parkinson diseases: recent developments. New York (NY): Plenum Press, 1995: 463-8
-
(1995)
Alzheimer's and Parkinson Diseases: Recent Developments
, pp. 463-468
-
-
Delong, A.F.1
Bonate, P.L.2
Gillespie, T.3
-
101
-
-
0030902127
-
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease
-
Bodick NC, Offen WW, Levey AI, et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol 1997; 54: 465-73
-
(1997)
Arch Neurol
, vol.54
, pp. 465-473
-
-
Bodick, N.C.1
Offen, W.W.2
Levey, A.I.3
-
102
-
-
0009711739
-
Lilly to develop Alzheimer's patch
-
[online]. [Accessed 1999 Jun 20]
-
Lilly to develop Alzheimer's patch. SCRIP 1996; 2144: 22 [online]. Available from: URL: http://www.alzforum.org/members/research/drugs/xanomeline.html [Accessed 1999 Jun 20]
-
(1996)
SCRIP
, vol.2144
, pp. 22
-
-
-
103
-
-
0031026661
-
Effects of central muscarinic-1 receptor stimulation on blood pressure regulation
-
Medina A, Bodick N, Goldberger AL, et al. Effects of central muscarinic-1 receptor stimulation on blood pressure regulation. Hypertension 1997; 29: 828-34
-
(1997)
Hypertension
, vol.29
, pp. 828-834
-
-
Medina, A.1
Bodick, N.2
Goldberger, A.L.3
-
104
-
-
0342818556
-
-
April 27; [online]. [Accessed 1999 Jun 20]
-
Marketletter. April 27, 1998; Alzheimer Research Forum [online]. Available from: URL: http://www.alzforum.org/members/research/drugs/memric.html [Accessed 1999 Jun 20]
-
(1998)
Marketletter
-
-
-
105
-
-
4243235708
-
Bridging study in the clinical development of milameline (CI-979/RU 35926), a novel muscarinic agonist
-
Hoover T, Breslin E, Bridging study in the clinical development of milameline (CI-979/RU 35926), a novel muscarinic agonist [abstract]. Neurobiol Aging 1996; Suppl. 17: S139
-
(1996)
Neurobiol Aging
, Issue.SUPPL. 17
-
-
Hoover, T.1
Breslin, E.2
-
106
-
-
0009749974
-
-
Alzheimer Research Forum [online]. Available from: URL: alzforum.org/members/research/drugs/milameline.html [Accessed 1999 Jun 20]
-
Alzheimer Research Forum [online]. Available from: URL: alzforum.org/members/research/drugs/milameline.html [Accessed 1999 Jun 20]
-
-
-
-
107
-
-
0029263518
-
Cholinergic therapies for Alzheimer's disease. Palliative or disease altering?
-
Davis RE, Doyle PD, Carroll RT, et al. Cholinergic therapies for Alzheimer's disease. Palliative or disease altering? Arncimittelforschung 1995; 45: 425-31
-
(1995)
Arncimittelforschung
, vol.45
, pp. 425-431
-
-
Davis, R.E.1
Doyle, P.D.2
Carroll, R.T.3
-
108
-
-
0029050694
-
Safety and tolerability of CI-979 in patients with Alzheimer's disease
-
Sramek JJ, Sedman AJ, Reece PA, et al. Safety and tolerability of CI-979 in patients with Alzheimer's disease. Life Sci 1995; 57: 503-10
-
(1995)
Life Sci
, vol.57
, pp. 503-510
-
-
Sramek, J.J.1
Sedman, A.J.2
Reece, P.A.3
-
109
-
-
0029990456
-
Toxicological comparison of a muscarinic agonist given to rats by gavage or in the diet
-
Dethloff LA, Chang T, Courtney CL. Toxicological comparison of a muscarinic agonist given to rats by gavage or in the diet. Food Chem Toxicol 1996; 34: 407-22
-
(1996)
Food Chem Toxicol
, vol.34
, pp. 407-422
-
-
Dethloff, L.A.1
Chang, T.2
Courtney, C.L.3
-
110
-
-
0009743452
-
Alzheimer's disease drug status update
-
Alzheimer's disease drug status update. ID Research Alerts 1997; 2 (8): 383-91
-
(1997)
ID Research Alerts
, vol.2
, Issue.8
, pp. 383-391
-
-
-
111
-
-
0029081632
-
The safety and tolerance of xanomeline tartrate in patients with Alzheimer's disease
-
Sramek JJ, Hurley DJ, Wardle TS, et al. The safety and tolerance of xanomeline tartrate in patients with Alzheimer's disease. J Clin Pharmacol 1995; 35: 800-6
-
(1995)
J Clin Pharmacol
, vol.35
, pp. 800-806
-
-
Sramek, J.J.1
Hurley, D.J.2
Wardle, T.S.3
-
112
-
-
0002463270
-
Cholinergic muscarinic receptor signalling by phosphoinositides signal transduction system in Alzheimer's disease
-
Jope RS. Cholinergic muscarinic receptor signalling by phosphoinositides signal transduction system in Alzheimer's disease. Alzheimer's Dis Rev 1996; 1: 2-14
-
(1996)
Alzheimer's Dis Rev
, vol.1
, pp. 2-14
-
-
Jope, R.S.1
-
113
-
-
0028946296
-
Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons
-
Yan GM, Lin SZ, Irwin RP, et al. Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol Pharmacol 1996; 47: 257
-
(1996)
Mol Pharmacol
, vol.47
, pp. 257
-
-
Yan, G.M.1
Lin, S.Z.2
Irwin, R.P.3
-
114
-
-
0031738197
-
The time course of nerve growth factor content in different neuropsychiatric disease - A unifying hypothesis
-
Hellweg R, von Richthofen S, Anders D, et al. The time course of nerve growth factor content in different neuropsychiatric disease - a unifying hypothesis. J Neural Transm 1988; 105: 871-903
-
(1988)
J Neural Transm
, vol.105
, pp. 871-903
-
-
Hellweg, R.1
Von Richthofen, S.2
Anders, D.3
-
115
-
-
0032439950
-
Long term tacrine treatment in three mild Alzheimer patients: Effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities
-
Nordberg A. Amberla K, Shigeta M. Long term tacrine treatment in three mild Alzheimer patients: effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities. Alzheimer Dis Assoc Disord 1998; 12: 228-37
-
(1998)
Alzheimer Dis Assoc Disord
, vol.12
, pp. 228-237
-
-
Nordberg, A.1
Amberla, K.2
Shigeta, M.3
-
116
-
-
7844222807
-
Clinical neurochemistry: Developments in dementia research based on brain bank material
-
Perry E, Court J, Goodchild R, et al. Clinical neurochemistry: developments in dementia research based on brain bank material. J Neural Transm 1998; 105: 915-33
-
(1998)
J Neural Transm
, vol.105
, pp. 915-933
-
-
Perry, E.1
Court, J.2
Goodchild, R.3
-
117
-
-
0028973318
-
Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease
-
Lander CJ, Celesia GG, Magnuson DJ, et al. Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease. J Neuropath Exp Neurol 1995; 54: 783-9
-
(1995)
J Neuropath Exp Neurol
, vol.54
, pp. 783-789
-
-
Lander, C.J.1
Celesia, G.G.2
Magnuson, D.J.3
-
118
-
-
0029900084
-
Amyloid β-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons
-
Kelly JF, Furukawa K, Barger SW, et al. Amyloid β-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons. Proc Natl Acad Sci 1996; 96: 6753-8
-
(1996)
Proc Natl Acad Sci
, vol.96
, pp. 6753-6758
-
-
Kelly, J.F.1
Furukawa, K.2
Barger, S.W.3
-
119
-
-
0031051353
-
Cholinergic activation of phosphoinositide signalling is impaired in Alzheimer's disease brain
-
Jope RS, Song L, Powers RE. Cholinergic activation of phosphoinositide signalling is impaired in Alzheimer's disease brain. Neurobiol Aging 1997; 18: 111-20
-
(1997)
Neurobiol Aging
, vol.18
, pp. 111-120
-
-
Jope, R.S.1
Song, L.2
Powers, R.E.3
-
120
-
-
0028919316
-
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease
-
Ferrari-DiLeo G, Mash DC, Flynn DD. Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease. Mol Chem Neuropathol 1995; 24: 69-91
-
(1995)
Mol Chem Neuropathol
, vol.24
, pp. 69-91
-
-
Ferrari-DiLeo, G.1
Mash, D.C.2
Flynn, D.D.3
-
121
-
-
0031025045
-
Nontoxic amyloid β peptide 1-42 suppresses acetylcholine synthesis
-
Hoshi M, Takashima A, Murayama M, et al. Nontoxic amyloid β peptide 1-42 suppresses acetylcholine synthesis. J Biol Chem 1997; 272: 2038-41
-
(1997)
J Biol Chem
, vol.272
, pp. 2038-2041
-
-
Hoshi, M.1
Takashima, A.2
Murayama, M.3
-
122
-
-
0028179063
-
Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo
-
Abe E, Casamenti F, Giovannelli L, et al. Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo. Brain Res 1994; 636: 162-4
-
(1994)
Brain Res
, vol.636
, pp. 162-164
-
-
Abe, E.1
Casamenti, F.2
Giovannelli, L.3
-
123
-
-
12644264304
-
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C
-
Walter J, Grunberg J, Capell A, et al. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proc Natl Acad Sci U S A 1997; 94: 5349-54
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5349-5354
-
-
Walter, J.1
Grunberg, J.2
Capell, A.3
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