메뉴 건너뛰기




Volumn 12, Issue 5, 1998, Pages 473-481

Alzheimer's disease: Relationship between muscarinic cholinergic receptors, β-amyloid and tau proteins

Author keywords

Alzheimer's disease; Muscarinic receptors; Tau; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR; PHOSPHATIDYLINOSITIDE; TAU PROTEIN;

EID: 0032426901     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1998.tb00975.x     Document Type: Review
Times cited : (47)

References (99)
  • 2
    • 0000293742 scopus 로고
    • Über eine eigenartige erkrankung der hirnrinde
    • Alzheimer A. Über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psichiatr 1907 ; 64 : 146-8
    • (1907) Allg Z Psichiatr , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 3
    • 0023943181 scopus 로고
    • Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease
    • Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, Quirion R. Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 1988 ; 50 : 1914-23
    • (1988) J Neurochem , vol.50 , pp. 1914-1923
    • Araujo, D.M.1    Lapchak, P.A.2    Robitaille, Y.3    Gauthier, S.4    Quirion, R.5
  • 4
    • 0002503154 scopus 로고    scopus 로고
    • β-Amyloid peptides as direct cholinergic neuromodulators: A missing link?
    • Auld DS, Kar S, Quirion R. β-Amyloid peptides as direct cholinergic neuromodulators: a missing link? Trends Neurosci 1998 ; 21 : 43-9
    • (1998) Trends Neurosci , vol.21 , pp. 43-49
    • Auld, D.S.1    Kar, S.2    Quirion, R.3
  • 5
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RLI, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982 ; 217 : 408-17
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.I.2    Beer, B.3    Lippa, A.S.4
  • 6
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid β protein toxicity
    • Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994 ; 77 : 817-27
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 7
    • 0028301626 scopus 로고
    • Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis
    • Berger-Sweenwy J, Heckers S, Mesulam MM, Wiley RG, Lappi DA, Sharma M. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. J Neurosci 1994 ; 14 : 4507-19
    • (1994) J Neurosci , vol.14 , pp. 4507-4519
    • Berger-Sweenwy, J.1    Heckers, S.2    Mesulam, M.M.3    Wiley, R.G.4    Lappi, D.A.5    Sharma, M.6
  • 9
    • 0029553116 scopus 로고    scopus 로고
    • Acetylcholine: A neurotransmitter for learning and memory?
    • Blokland A. Acetylcholine: a neurotransmitter for learning and memory? Brain Res Rev 1996 ; 21 : 285-300
    • (1996) Brain Res Rev , vol.21 , pp. 285-300
    • Blokland, A.1
  • 10
    • 0028144455 scopus 로고
    • Evidence for a selective decrease in type 1 phosphatidylinositol kinase activity in brains of patients with Alzheimer's disease
    • Bothmer J, Markerink M, Jolles J. Evidence for a selective decrease in type 1 phosphatidylinositol kinase activity in brains of patients with Alzheimer's disease. Dementia 1994 ; 5 : 6-11
    • (1994) Dementia , vol.5 , pp. 6-11
    • Bothmer, J.1    Markerink, M.2    Jolles, J.3
  • 11
    • 0027496789 scopus 로고
    • Muscarinic acetylcholine receptor subtypes: Localization and structure/function
    • Cuello A.C., ed. Amsterdam: Elsevier Science Publishers
    • Brann MR, Ellis J, Jorgensen H, Hill-Eubanks D, Jones SP. Muscarinic acetylcholine receptor subtypes: localization and structure/function. In: Cuello A.C., ed. Progress in Brain Research. Amsterdam: Elsevier Science Publishers; 1993. pp. 121-7
    • (1993) Progress in Brain Research , pp. 121-127
    • Brann, M.R.1    Ellis, J.2    Jorgensen, H.3    Hill-Eubanks, D.4    Jones, S.P.5
  • 13
    • 0028986916 scopus 로고
    • β-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
    • Busciglio J, Lorenzo A, Yeh J, Yanker BA. β-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 1995 ; 14 : 879-88
    • (1995) Neuron , vol.14 , pp. 879-888
    • Busciglio, J.1    Lorenzo, A.2    Yeh, J.3    Yanker, B.A.4
  • 14
    • 84912818618 scopus 로고
    • Cholinergic system in the central nervous system: Retrospection, anatomic distribution and functions
    • Hanin I, ed. New York: Plenum Press
    • Butcher LL, Wolf NJ. Cholinergic system in the central nervous system: retrospection, anatomic distribution and functions. In: Hanin I, ed. Dynamics of cholinergic function. New York: Plenum Press; 1986. pp. 1-11
    • (1986) Dynamics of Cholinergic Function , pp. 1-11
    • Butcher, L.L.1    Wolf, N.J.2
  • 16
    • 0012723955 scopus 로고
    • Enfermedad de Alzheimer. Bases moleculares, criterios diagnosticos y normativa terapéutica
    • Cacabelos R, Caamaño J, Alvarez XA, Fernandez-Novoa L, Franco A. Enfermedad de Alzheimer. Bases moleculares, criterios diagnosticos y normativa terapéutica. Jano 1994 ; 47 : 39-64
    • (1994) Jano , vol.47 , pp. 39-64
    • Cacabelos, R.1    Caamaño, J.2    Alvarez, X.A.3    Fernandez-Novoa, L.4    Franco, A.5
  • 18
    • 0027324457 scopus 로고
    • 3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine
    • 3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine. J Neurochem 1993 ; 60 : 2296-303
    • (1993) J Neurochem , vol.60 , pp. 2296-2303
    • Calligaro, D.O.1    O'Malley, P.J.2    Monn, J.A.3
  • 19
    • 0344761899 scopus 로고
    • Hippocampal cholinergic (muscarinic, and putative nicotinic) receptors in human cognitive disorders
    • Candy JM, Fairbairn AF, Johnson M, Perry EK, Perry RH, Smith C. Hippocampal cholinergic (muscarinic, and putative nicotinic) receptors in human cognitive disorders. Br J Pharmacol 1986 ; 88 : 359P
    • (1986) Br J Pharmacol , vol.88
    • Candy, J.M.1    Fairbairn, A.F.2    Johnson, M.3    Perry, E.K.4    Perry, R.H.5    Smith, C.6
  • 20
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, De Long MR. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 1983 ; 219 : 1184-90
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    De Long, M.R.3
  • 21
    • 0017740268 scopus 로고
    • Regional distribution of muscarinic acetylcholine receptors in normal and Alzheimer's type dementia brains
    • Davies P, Verth AH. Regional distribution of muscarinic acetylcholine receptors in normal and Alzheimer's type dementia brains. Brain Res 1978 ; 138 : 385-92
    • (1978) Brain Res , vol.138 , pp. 385-392
    • Davies, P.1    Verth, A.H.2
  • 22
    • 0027392982 scopus 로고
    • Epidemiology of Alzheimer's disease: Research trends in the United States
    • De Figueiredo JM. Epidemiology of Alzheimer's disease: Research trends in the United States. Inter J Geriat Psychiat 1993 ; 8 : 59-65
    • (1993) Inter J Geriat Psychiat , vol.8 , pp. 59-65
    • De Figueiredo, J.M.1
  • 23
    • 0029941080 scopus 로고    scopus 로고
    • Synthesis, characterization and pharmacological profile of tropicamide enantiomers
    • Dei S, Bellucci C, Ghelardini C, Romanelli MN, Spampinato S. Synthesis, characterization and pharmacological profile of tropicamide enantiomers. Life Sci 1996 ; 58 : 2147-53
    • (1996) Life Sci , vol.58 , pp. 2147-2153
    • Dei, S.1    Bellucci, C.2    Ghelardini, C.3    Romanelli, M.N.4    Spampinato, S.5
  • 24
    • 0025825073 scopus 로고
    • The role of cholinergic projections from the nucleus basalis in memory
    • Dekker AJAM, Connor DJ, Thai LJ. The role of cholinergic projections from the nucleus basalis in memory. Neurosci Biobehav Revs 1991 ; 15 : 299-317
    • (1991) Neurosci Biobehav Revs , vol.15 , pp. 299-317
    • Dekker, A.J.A.M.1    Connor, D.J.2    Thai, L.J.3
  • 25
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system. A relationship to aging?
    • Drachman DA, Leavitt JL. Human memory and the cholinergic system. A relationship to aging? Arch Neurol 1974 ; 30 : 113-21
    • (1974) Arch Neurol , vol.30 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.L.2
  • 26
    • 0030636350 scopus 로고    scopus 로고
    • Central cholinergic system and cognition
    • Everitt BJ, Robbins TW. Central cholinergic system and cognition. Annu Rev Psychol 1997 ; 48 : 649-84
    • (1997) Annu Rev Psychol , vol.48 , pp. 649-684
    • Everitt, B.J.1    Robbins, T.W.2
  • 27
    • 0026423950 scopus 로고
    • The presence of an M4 subtype muscarinic receptor in the bovine adrenal medulla revealed by mRNA and receptor binding analyses
    • Fernando JC, Abdallah EA, Evinger M, Forray C, El-Fakahany EE. The presence of an M4 subtype muscarinic receptor in the bovine adrenal medulla revealed by mRNA and receptor binding analyses. Eur J Pharmacol 1991 ; 207 : 297-303
    • (1991) Eur J Pharmacol , vol.207 , pp. 297-303
    • Fernando, J.C.1    Abdallah, E.A.2    Evinger, M.3    Forray, C.4    El-Fakahany, E.E.5
  • 28
    • 0025782928 scopus 로고
    • Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence
    • Fibiger HC. Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trend Neurosci 1991 ; 14 : 220-3
    • (1991) Trend Neurosci , vol.14 , pp. 220-223
    • Fibiger, H.C.1
  • 29
    • 0025969654 scopus 로고
    • 1 muscarinic receptor in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies
    • 1 muscarinic receptor in Alzheimer's disease: implications for the failure of cholinergic replacement therapies. Ann Neurol 1991 ; 29 : 256-62
    • (1991) Ann Neurol , vol.29 , pp. 256-262
    • Flynn, D.D.1    Weinstein, D.A.2    Mash, D.C.3
  • 30
    • 0028924664 scopus 로고
    • Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease
    • Flynn DD, Ferrari-DiLeo G, Mash DC, Levey AI. Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease. J Neurochem 1995 ; 64 : 1888-91
    • (1995) J Neurochem , vol.64 , pp. 1888-1891
    • Flynn, D.D.1    Ferrari-DiLeo, G.2    Mash, D.C.3    Levey, A.I.4
  • 32
    • 0029070173 scopus 로고
    • Differential effects of amyloid peptides β-(1-40) and β-(25-35) injections into the rat nucleus basalis
    • Giovannelli L, Casamenti F, Scali L, Bartolini L, Pepeu G. Differential effects of amyloid peptides β-(1-40) and β-(25-35) injections into the rat nucleus basalis. Neuroscience 1995 ; 66 : 781-92
    • (1995) Neuroscience , vol.66 , pp. 781-792
    • Giovannelli, L.1    Casamenti, F.2    Scali, L.3    Bartolini, L.4    Pepeu, G.5
  • 33
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 1987 ; 235 : 877-80
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffiotti, U.4    Gajdusek, D.C.5
  • 34
    • 0024437944 scopus 로고
    • Muscarinic receptor subtypes: Physiology and clinical implications
    • Goyal RK. Muscarinic receptor subtypes: physiology and clinical implications. New Eng J Med 1989 ; 321(15) : 1022-5
    • (1989) New Eng J Med , vol.321 , Issue.15 , pp. 1022-1025
    • Goyal, R.K.1
  • 35
    • 0028981972 scopus 로고
    • Phosphoinositide hydrolysis, Gαq, phospholipase C, and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and Alzheimer's disease
    • Greenwood AF, Powers RE, Jope RS. Phosphoinositide hydrolysis, Gαq, phospholipase C, and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and Alzheimer's disease. Neuroscience 1995 ; 69 : 125-38
    • (1995) Neuroscience , vol.69 , pp. 125-138
    • Greenwood, A.F.1    Powers, R.E.2    Jope, R.S.3
  • 38
    • 0031025045 scopus 로고    scopus 로고
    • Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis: Possible role in cholinergic dysfunction in Alzheimer's disease
    • Hoshi M, Takashima A, Murayama M, Yasutake K, Yoshida N, Ishiguro K, Hoshino T, Imahori K. Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis: possible role in cholinergic dysfunction in Alzheimer's disease. J Biol Chem 1997 ; 272: 2038-41
    • (1997) J Biol Chem , vol.272 , pp. 2038-2041
    • Hoshi, M.1    Takashima, A.2    Murayama, M.3    Yasutake, K.4    Yoshida, N.5    Ishiguro, K.6    Hoshino, T.7    Imahori, K.8
  • 40
    • 0030038473 scopus 로고    scopus 로고
    • Dysfunction of cholinergic and dopaminergic neuronal systems in β-amyloid protein-infused rats
    • Itoh A, Nitta A, Nadai M, Nishimura K, Hirose M, Hasegawa T, Nabeshima T. Dysfunction of cholinergic and dopaminergic neuronal systems in β-amyloid protein-infused rats. J Neurochem 1996 ; 66 : 1113-7
    • (1996) J Neurochem , vol.66 , pp. 1113-1117
    • Itoh, A.1    Nitta, A.2    Nadai, M.3    Nishimura, K.4    Hirose, M.5    Hasegawa, T.6    Nabeshima, T.7
  • 41
    • 0002328541 scopus 로고    scopus 로고
    • Tau protein in normal and Alzheimer's disease brain
    • Jonson GVW, Jenkins SM. Tau protein in normal and Alzheimer's disease brain. Alzheimer's Disease Rev 1996 ; 1 : 38-54
    • (1996) Alzheimer's Disease Rev , vol.1 , pp. 38-54
    • Jonson, G.V.W.1    Jenkins, S.M.2
  • 42
    • 0028172796 scopus 로고
    • 3H]PtdInS hydrolysis in postmortem human brain membranes is mediated by the G-proteins Gq/11 and phospholipase C-β
    • 3H]PtdInS hydrolysis in postmortem human brain membranes is mediated by the G-proteins Gq/11 and phospholipase C-β. Biochem J 1994 ; 304 : 655-9
    • (1994) Biochem J , vol.304 , pp. 655-659
    • Jope, R.S.1    Song, L.2    Powers, S.3
  • 43
    • 0028343627 scopus 로고
    • Impaired phosphoinositide hydrolysis in Alzheimer's disease brain
    • Jope RS, Song L, Li X, Powers R. Impaired phosphoinositide hydrolysis in Alzheimer's disease brain. Neurobiol Aging 1994 ; 15 : 221-6
    • (1994) Neurobiol Aging , vol.15 , pp. 221-226
    • Jope, R.S.1    Song, L.2    Li, X.3    Powers, R.4
  • 44
    • 0002463270 scopus 로고    scopus 로고
    • Cholinergic muscarinic receptor signalling by the phosphoinositide signal transduction system in Alzheimer's disease
    • Jope RS. Cholinergic muscarinic receptor signalling by the phosphoinositide signal transduction system in Alzheimer's disease. Alzheimer's Disease Rev 1996 ; 1 : 2-14
    • (1996) Alzheimer's Disease Rev , vol.1 , pp. 2-14
    • Jope, R.S.1
  • 45
    • 0031051353 scopus 로고    scopus 로고
    • Cholinergic activation of phosphoinositide signalling is impaired in Alzheimer's disease brain
    • Jope RS, Song L, Power RE. Cholinergic activation of phosphoinositide signalling is impaired in Alzheimer's disease brain. Neurobiol Aging 1997 ; 18 : 111-20
    • (1997) Neurobiol Aging , vol.18 , pp. 111-120
    • Jope, R.S.1    Song, L.2    Power, R.E.3
  • 47
    • 0029996479 scopus 로고    scopus 로고
    • Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices
    • Kar S, Seto D, Gaudreau P, Quirion R. Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices. J Neurosci 1996 ; 16 : 1034-40
    • (1996) J Neurosci , vol.16 , pp. 1034-1040
    • Kar, S.1    Seto, D.2    Gaudreau, P.3    Quirion, R.4
  • 48
    • 0022616654 scopus 로고
    • Alzheimer's disease
    • Katzman R. Alzheimer's disease. New Eng J Med 1986 ; 314 : 964-73
    • (1986) New Eng J Med , vol.314 , pp. 964-973
    • Katzman, R.1
  • 49
    • 0023521793 scopus 로고
    • Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex
    • Kellar KJ, Whitehouse PJ, Martino-Barrows AM, Marcus K, Price DL. Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain Res 1987 ; 436 : 62-8
    • (1987) Brain Res , vol.436 , pp. 62-68
    • Kellar, K.J.1    Whitehouse, P.J.2    Martino-Barrows, A.M.3    Marcus, K.4    Price, D.L.5
  • 51
    • 0027517624 scopus 로고
    • Central cholinergic mechanisms and function
    • Krnjevic K. Central cholinergic mechanisms and function. Prog Brain Res 1993 ; 98 : 285-92
    • (1993) Prog Brain Res , vol.98 , pp. 285-292
    • Krnjevic, K.1
  • 52
    • 0020574683 scopus 로고
    • Cholinergic receptor binding and autoradiography in brains of non-neurological and senile dementia of Alzheimer-type patients
    • Lang W, Henke H. Cholinergic receptor binding and autoradiography in brains of non-neurological and senile dementia of Alzheimer-type patients. Brain Res 1983 ; 267 : 278-80
    • (1983) Brain Res , vol.267 , pp. 278-280
    • Lang, W.1    Henke, H.2
  • 53
    • 0029092685 scopus 로고
    • Alzheimer disease, attention, and the cholinergic system
    • Lawrence AD, Sahakian BJ. Alzheimer disease, attention, and the cholinergic system. Alzheimer Dis Assoc Disord 1995 ; 9 (suppl 2) : 43-9
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , Issue.SUPPL. 2 , pp. 43-49
    • Lawrence, A.D.1    Sahakian, B.J.2
  • 54
    • 0025572697 scopus 로고
    • Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells
    • Lazareno S, Buckley NJ, Roberts FF. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol 1990 ; 38 : 805-15
    • (1990) Mol Pharmacol , vol.38 , pp. 805-815
    • Lazareno, S.1    Buckley, N.J.2    Roberts, F.F.3
  • 55
    • 0029762386 scopus 로고    scopus 로고
    • Effects of neonatal lesions of the basal forebrain cholinergic system by 192 immunoglobulin G-saporin: Biochemical, behavioral and morphological characterization
    • Leanza G, Nilsson OG, Nikkhah G, Wiley RG. Björklund A. Effects of neonatal lesions of the basal forebrain cholinergic system by 192 immunoglobulin G-saporin: biochemical, behavioral and morphological characterization. Neuroscience 1996 ; 74 : 119-41
    • (1996) Neuroscience , vol.74 , pp. 119-141
    • Leanza, G.1    Nilsson, O.G.2    Nikkhah, G.3    Wiley, R.G.4    Björklund, A.5
  • 56
    • 0029145757 scopus 로고
    • Isolation of a phosphorilated soluble tau fraction from Alzheimer's disease brain
    • Ledesma MD, Avila J, Correas I. Isolation of a phosphorilated soluble tau fraction from Alzheimer's disease brain. Neurobiol Aging 1995 ; 16 : 515-22
    • (1995) Neurobiol Aging , vol.16 , pp. 515-522
    • Ledesma, M.D.1    Avila, J.2    Correas, I.3
  • 57
    • 0030467247 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer's Disease
    • Levey AI. Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer's Disease. Proc Natl Acad Sci USA 1996 ; 93 : 13541-6
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13541-13546
    • Levey, A.I.1
  • 58
    • 0343168248 scopus 로고
    • Relation-ship between choline acetyltransferase and muscarinic binding in aging rodent brain and Alzheimer's disease
    • Hanin I, ed. New York: Plenum Press
    • London ED, Waller SB. Relation-ship between choline acetyltransferase and muscarinic binding in aging rodent brain and Alzheimer's disease. In: Hanin I, ed. Dynamics of Cholinergic Function. New York: Plenum Press; 1986. pp. 215-24
    • (1986) Dynamics of Cholinergic Function , pp. 215-224
    • London, E.D.1    Waller, S.B.2
  • 59
    • 0021962590 scopus 로고
    • 2 muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation
    • 2 muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science 1985 ; 228 : 1115-7
    • (1985) Science , vol.228 , pp. 1115-1117
    • Mash, D.C.1    Flynn, D.D.2    Potter, L.T.3
  • 60
    • 0026570528 scopus 로고
    • β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992 ; 12 : 367-89
    • (1992) J Neurosci , vol.12 , pp. 367-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 61
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 1993 ; 10 : 243-54
    • (1993) Neuron , vol.10 , pp. 243-254
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 62
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson MP. Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 1997 ; 77 : 1081-132
    • (1997) Physiol Rev , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 63
    • 0345624429 scopus 로고
    • Cholinergic neurons and cholinergic projections in the mammalian C.N.S.
    • Hanin I, ed. New York: Plenum Press
    • McGeer PL, McGeer EG, Kimura H, Peng JF. Cholinergic neurons and cholinergic projections in the mammalian C.N.S. In: Hanin I, ed. Dynamics of Cholinergic Function. New York: Plenum Press; 1986. pp. 11-22
    • (1986) Dynamics of Cholinergic Function , pp. 11-22
    • McGeer, P.L.1    McGeer, E.G.2    Kimura, H.3    Peng, J.F.4
  • 64
    • 0027431176 scopus 로고
    • Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems
    • McKinney M. Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems. Prog Brain Res 1993 ; 98 : 330-40
    • (1993) Prog Brain Res , vol.98 , pp. 330-340
    • McKinney, M.1
  • 65
    • 0028316603 scopus 로고
    • AMPA-induced excitotoxic lesions of the basal forebrain: A significant role for the cortical cholinergic system in attentional function
    • Muir JL, Everitt BJ, Robbins TW. AMPA-induced excitotoxic lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function. J Neurosci 1994 ; 14 : 2312-26
    • (1994) J Neurosci , vol.14 , pp. 2312-2326
    • Muir, J.L.1    Everitt, B.J.2    Robbins, T.W.3
  • 67
    • 0026441546 scopus 로고
    • Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system
    • Nilsson OG, Leanza G, Rosenblad C, Lappi DA, Wiley RG, Bjorklund A. Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system. Neuroreport 1992 ; 3 : 1005-8
    • (1992) Neuroreport , vol.3 , pp. 1005-1008
    • Nilsson, O.G.1    Leanza, G.2    Rosenblad, C.3    Lappi, D.A.4    Wiley, R.G.5    Bjorklund, A.6
  • 68
    • 0026476297 scopus 로고
    • Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
    • Nitsch RM, Slack BE, Wurtman RJ, Gordon JH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 1992 ; 258 : 304-7
    • (1992) Science , vol.258 , pp. 304-307
    • Nitsch, R.M.1    Slack, B.E.2    Wurtman, R.J.3    Gordon, J.H.4
  • 69
    • 0029936426 scopus 로고    scopus 로고
    • Regulation of APP processing: Potential for the therapeutical reduction of brain amyloid burden
    • Nitsch RM, Wurtman RJ, Growdon JH. Regulation of APP processing: potential for the therapeutical reduction of brain amyloid burden. Ann N Y Acad Sci 1996 ; 777 : 175-82
    • (1996) Ann N Y Acad Sci , vol.777 , pp. 175-182
    • Nitsch, R.M.1    Wurtman, R.J.2    Growdon, J.H.3
  • 70
    • 0019968550 scopus 로고
    • Autoradiographic localization of muscarinic cholinergic receptors in the hippocampus of patients with senile dementia
    • Palacios JM. Autoradiographic localization of muscarinic cholinergic receptors in the hippocampus of patients with senile dementia. Brain Res 1982 ; 243 : 173-5
    • (1982) Brain Res , vol.243 , pp. 173-175
    • Palacios, J.M.1
  • 72
    • 85038174030 scopus 로고
    • Alois Alzheimer
    • Perez JM. Alois Alzheimer. Jano 1994 ; 47 : 57-61
    • (1994) Jano , vol.47 , pp. 57-61
    • Perez, J.M.1
  • 73
    • 0017360731 scopus 로고
    • Necropsy evidence of central cholinergic deficits in senile dementia
    • Perry EK, Perry RH, Blessedd G, Tomlinson BE. Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1977 ; 1 : 189
    • (1977) Lancet , vol.1 , pp. 189
    • Perry, E.K.1    Perry, R.H.2    Blessedd, G.3    Tomlinson, B.E.4
  • 75
    • 0022558388 scopus 로고
    • New perspectives in Alzheimer's disease
    • Price DL. New perspectives in Alzheimer's disease. Ann Rev Neurosci 1986 ; 9 : 489-512
    • (1986) Ann Rev Neurosci , vol.9 , pp. 489-512
    • Price, D.L.1
  • 76
    • 0023875310 scopus 로고
    • Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: An autoradiographic study
    • Probst A, Cortes R, Ulrich J, Palacios JM. Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: an autoradiographic study. Brain Res 1988 ; 450 : 190-201
    • (1988) Brain Res , vol.450 , pp. 190-201
    • Probst, A.1    Cortes, R.2    Ulrich, J.3    Palacios, J.M.4
  • 77
    • 0021358533 scopus 로고
    • Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain
    • Raiteri M, Leardi R, Marchi M. Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. J Pharmacol Exp Ther 1984 ; 228 : 209-14
    • (1984) J Pharmacol Exp Ther , vol.228 , pp. 209-214
    • Raiteri, M.1    Leardi, R.2    Marchi, M.3
  • 79
    • 84886617908 scopus 로고
    • Pre- and post-synaptic neurochemical alterations in Alzheimer's disease
    • Reisine TD, Yamamura HI, Bird ED, Spokes E, Enna SJ. Pre- and post-synaptic neurochemical alterations in Alzheimer's disease. Brain Res 1978 ; 159 : 477-80
    • (1978) Brain Res , vol.159 , pp. 477-480
    • Reisine, T.D.1    Yamamura, H.I.2    Bird, E.D.3    Spokes, E.4    Enna, S.J.5
  • 82
    • 0024709982 scopus 로고
    • Signal sorting and amplification through G-protein coupled receptors
    • Ross BM. Signal sorting and amplification through G-protein coupled receptors. Neuron 1989 ; 3 : 141-52
    • (1989) Neuron , vol.3 , pp. 141-152
    • Ross, B.M.1
  • 84
    • 0024556348 scopus 로고
    • Biochemistry of altered brain proteins in Alzheimer's disease
    • Selkoe DJ. Biochemistry of altered brain proteins in Alzheimer's disease. Ann Rev Neurosci 1989 ; 12 : 463-90
    • (1989) Ann Rev Neurosci , vol.12 , pp. 463-490
    • Selkoe, D.J.1
  • 85
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the beta-amyloid precursor protein
    • Selkoe DJ. Normal and abnormal biology of the beta-amyloid precursor protein. Ann Rev Neurosci 1994 ; 17 : 489-517
    • (1994) Ann Rev Neurosci , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 89
    • 0024592268 scopus 로고
    • 3H-oxotremorine-M binding in normal and Alzheimer's disease parietal cortex: An index of muscarinic receptor-G-protein coupling
    • 3H-oxotremorine-M binding in normal and Alzheimer's disease parietal cortex: an index of muscarinic receptor-G-protein coupling. Biochem Soc Trans 1989; 17 : 202-3
    • (1989) Biochem Soc Trans , vol.17 , pp. 202-203
    • Smith, C.J.1    Perry, E.K.2    Birdsall, N.J.M.3
  • 90
    • 0028958833 scopus 로고
    • Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: Role of the septohippocampal projection
    • Steckler T, Keith AB, Wiley RG, Sahgal A. Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: Role of the septohippocampal projection. Neuroscience 1995 ; 66 : 101-14
    • (1995) Neuroscience , vol.66 , pp. 101-114
    • Steckler, T.1    Keith, A.B.2    Wiley, R.G.3    Sahgal, A.4
  • 91
    • 0030855949 scopus 로고    scopus 로고
    • Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes
    • Svensson AL, Warpman U, Hellstrom-Lindahl E, Bogdanovic N, Lannfelt L, Nordberg A. Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes. Neurosci Lett 1997 ; 232 : 37-40
    • (1997) Neurosci Lett , vol.232 , pp. 37-40
    • Svensson, A.L.1    Warpman, U.2    Hellstrom-Lindahl, E.3    Bogdanovic, N.4    Lannfelt, L.5    Nordberg, A.6
  • 92
    • 0030044463 scopus 로고    scopus 로고
    • Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the activation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I glycogen synthase kinase-3β
    • Takashima A, Noguchi K, Michel G, Mercken M, Hoshi M, Ishiguro K, Imahori K. Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the activation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I glycogen synthase kinase-3β. Neurosci Lett 1996 ; 203 : 33-6
    • (1996) Neurosci Lett , vol.203 , pp. 33-36
    • Takashima, A.1    Noguchi, K.2    Michel, G.3    Mercken, M.4    Hoshi, M.5    Ishiguro, K.6    Imahori, K.7
  • 93
    • 0028090036 scopus 로고
    • Behavioral, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system
    • Torres EM, Perry TA, Blokland A, Wilkinson LS, Wiley RG, Lappi DA, Dunnett SB. Behavioral, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 1994 ; 63 : 95-122
    • (1994) Neuroscience , vol.63 , pp. 95-122
    • Torres, E.M.1    Perry, T.A.2    Blokland, A.3    Wilkinson, L.S.4    Wiley, R.G.5    Lappi, D.A.6    Dunnett, S.B.7
  • 94
    • 0024822431 scopus 로고
    • Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons
    • Toselli N, Lang J, Coeta T, Lux HD. Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons. Pfluegers Arch 1989 ; 415 : 255-61
    • (1989) Pfluegers Arch , vol.415 , pp. 255-261
    • Toselli, N.1    Lang, J.2    Coeta, T.3    Lux, H.D.4
  • 95
    • 0028872596 scopus 로고
    • 192 Immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar purkinje cells
    • Waite JJ, Chen AD, Wardlow ML, Wiley RG, Lappi DA, Thal LJ. 192 Immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar purkinje cells. Neuroscience 1995 ; 65 : 463-76
    • (1995) Neuroscience , vol.65 , pp. 463-476
    • Waite, J.J.1    Chen, A.D.2    Wardlow, M.L.3    Wiley, R.G.4    Lappi, D.A.5    Thal, L.J.6
  • 98
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides
    • Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 1990 ; 250 : 279-82
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.