메뉴 건너뛰기




Volumn 84, Issue 2, 1999, Pages 158-166

Thrombopoietin: Its role from early hematopoiesis to platelet production

Author keywords

Hematopoiesis; Megakaryopoiesis; Mpl ligand; Stem cells; Thrombopoietin

Indexed keywords

CARBOPLATIN; CD34 ANTIGEN; CD38 ANTIGEN; CYCLOPHOSPHAMIDE; CYTOKINE; FLT3 LIGAND; GROWTH FACTOR; INTERLEUKIN 3; NEUTRALIZING ANTIBODY; PACLITAXEL; RECEPTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR; THROMBOPOIETIN;

EID: 0032832532     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (47)

References (138)
  • 1
    • 0000009286 scopus 로고
    • Demonstration and some properties of human thrombopoietin in thrombocythemic sera
    • Kelemen E, Cserhati I, Tanos B. Demonstration and some properties of human thrombopoietin in thrombocythemic sera. Acta Haematol (Basel) 1958; 20: 350-5.
    • (1958) Acta Haematol (Basel) , vol.20 , pp. 350-355
    • Kelemen, E.1    Cserhati, I.2    Tanos, B.3
  • 2
    • 0026748342 scopus 로고
    • Growth factors affecting human thrombocytopoiesis: Potential agents for the treatment ofthrombocytopenia
    • Gordon MS, Hoffman R. Growth factors affecting human thrombocytopoiesis: potential agents for the treatment ofthrombocytopenia. Blood 1992; 80:302-7.
    • (1992) Blood , vol.80 , pp. 302-307
    • Gordon, M.S.1    Hoffman, R.2
  • 3
    • 0028505160 scopus 로고
    • Platelets and cytokines
    • Burstein SA. Platelets and cytokines. Curr Opin Hematol 1994; 1:373-80.
    • (1994) Curr Opin Hematol , vol.1 , pp. 373-380
    • Burstein, S.A.1
  • 5
    • 0030947892 scopus 로고    scopus 로고
    • Positive and negative regulation of megakaryocytopoiesis
    • Wendling F, Han Z-C. Positive and negative regulation of megakaryocytopoiesis. Ballière's Clin Haematol 1997; 10:29-45.
    • (1997) Ballière's Clin Haematol , vol.10 , pp. 29-45
    • Wendling, F.1    Han, Z.-C.2
  • 6
    • 0022624954 scopus 로고
    • MPLV: A retrovirus complex inducing an acute myeloproliferative disorder in mice
    • Wendling F, Varlet P, Charon M, Tambourin P. MPLV: a retrovirus complex inducing an acute myeloproliferative disorder in mice. Virology 1986; 149:242-6.
    • (1986) Virology , vol.149 , pp. 242-246
    • Wendling, F.1    Varlet, P.2    Charon, M.3    Tambourin, P.4
  • 7
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, Vigon I, Penciolelli J-F, Heard J-M, Tambourin P, Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990; 63:1137-47.
    • (1990) Cell , vol.63 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.-F.3    Heard, J.-M.4    Tambourin, P.5    Wendling, F.6
  • 8
    • 0025102756 scopus 로고
    • Haematopoietic receptors and helical cytokines
    • Bazan JF. Haematopoietic receptors and helical cytokines. Immunol Today 1990; 11:350-4.
    • (1990) Immunol Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 9
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon I, Mornon J-P, Cocault L, et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 1992; 89:5640-4.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.-P.2    Cocault, L.3
  • 10
    • 0027275160 scopus 로고
    • Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: Molecular cloning, chromosomal location and evidence for a function in cell growth
    • Vigon I, Florindo C, Fichelson S, et al. Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 1993; 8:2607-15.
    • (1993) Oncogene , vol.8 , pp. 2607-2615
    • Vigon, I.1    Florindo, C.2    Fichelson, S.3
  • 11
    • 0027245081 scopus 로고
    • Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal
    • Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 1993; 12:2645-53.
    • (1993) EMBO J , vol.12 , pp. 2645-2653
    • Skoda, R.C.1    Seldin, D.C.2    Chiang, M.-K.3    Peichel, C.L.4    Vogt, T.F.5    Leder, P.6
  • 12
    • 0027225872 scopus 로고
    • Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis
    • Methia N, Louache F, Vainchenker W, Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993; 82:1395-401.
    • (1993) Blood , vol.82 , pp. 1395-1401
    • Methia, N.1    Louache, F.2    Vainchenker, W.3    Wendling, F.4
  • 13
    • 0028985426 scopus 로고
    • The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets
    • Debili N, Wendling F, Cosman D, et al.The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 1995; 85:391-401.
    • (1995) Blood , vol.85 , pp. 391-401
    • Debili, N.1    Wendling, F.2    Cosman, D.3
  • 15
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that its a ligand for the cytokine receptor Mpl
    • Bartley TD, Bogenberger J, Hunt P, et al. Identification and cloning of a megakaryocyte growth and development factor that its a ligand for the cytokine receptor Mpl. Cell 1994; 77:1117-24.
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 16
    • 0028302409 scopus 로고
    • Stimulation of megakaryopoiesis and thrombopoiesis by the c-mpl ligand
    • de Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryopoiesis and thrombopoiesis by the c-MPL ligand. Nature 1994; 369:533-8.
    • (1994) Nature , vol.369 , pp. 533-538
    • De Sauvage, F.J.1    Hass, P.E.2    Spencer, S.D.3
  • 17
    • 0028109434 scopus 로고
    • The structure, biology and potential therapeutic applications of recombinant thrombopoietin
    • Lok S, Foster DC. The structure, biology and potential therapeutic applications of recombinant thrombopoietin. Stem Cells 1994; 12:586-98.
    • (1994) Stem Cells , vol.12 , pp. 586-598
    • Lok, S.1    Foster, D.C.2
  • 18
    • 0027992924 scopus 로고
    • Molecular cloning and chromosomal localization of the human thrombopoietin gene
    • Sohma Y, Akahori H, Seki N, et al. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 1994; 353:57-61.
    • (1994) FEBS Lett , vol.353 , pp. 57-61
    • Sohma, Y.1    Akahori, H.2    Seki, N.3
  • 19
    • 0028022980 scopus 로고
    • Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit
    • Kuter DJ, Rosenberg RD. Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994; 84:1464-72.
    • (1994) Blood , vol.84 , pp. 1464-1472
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 20
    • 0028176283 scopus 로고
    • c-Mpl ligand is a humoral regulator of megakaryocytopoiesis
    • Wendling F, Maraskovsky E, Debili N, et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369:571-4.
    • (1994) Nature , vol.369 , pp. 571-574
    • Wendling, F.1    Maraskovsky, E.2    Debili, N.3
  • 21
    • 0028803099 scopus 로고
    • Pegylated megakaryocyte growth and development factor abrogates the lethal thrombopenia associated with carboplatin and irradiation in mice
    • Hokom MM, Lancey D, Kinstler OB, et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombopenia associated with carboplatin and irradiation in mice. Blood 1995; 86:4486-92.
    • (1995) Blood , vol.86 , pp. 4486-4492
    • Hokom, M.M.1    Lancey, D.2    Kinstler, O.B.3
  • 22
    • 0029943307 scopus 로고    scopus 로고
    • Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
    • Harker LA, Marzec UM, Hunt P, et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996; 88:511-21.
    • (1996) Blood , vol.88 , pp. 511-521
    • Harker, L.A.1    Marzec, U.M.2    Hunt, P.3
  • 23
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin and stimulation of platelet production in vivo
    • Lok S, Kaushansky K, Holly RD, et al. Cloning and expression of murine thrombopoietin and stimulation of platelet production in vivo. Nature 1994; 369:564-8.
    • (1994) Nature , vol.369 , pp. 564-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3
  • 24
    • 0028899548 scopus 로고
    • Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
    • Gurney AL, Kuang W-J, Xie M-H, Malloy BE, Eaton DL, de Sauvage FJ. Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Blood 1995; 85:981-8.
    • (1995) Blood , vol.85 , pp. 981-988
    • Gurney, A.L.1    Kuang, W.-J.2    Xie, M.-H.3    Malloy, B.E.4    Eaton, D.L.5    De Sauvage, F.J.6
  • 25
    • 0030461838 scopus 로고    scopus 로고
    • Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246
    • Huffman RC, Andersen H, Walker K, et al. Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from Ser1 to Arg246. Biochemistry 1996; 35:14849-61.
    • (1996) Biochemistry , vol.35 , pp. 14849-14861
    • Huffman, R.C.1    Andersen, H.2    Walker, K.3
  • 26
    • 0031052063 scopus 로고    scopus 로고
    • Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis
    • Eaton DL, de Sauvage FJ. Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis. Exp Hematol 1997; 25:1-7.
    • (1997) Exp Hematol , vol.25 , pp. 1-7
    • Eaton, D.L.1    De Sauvage, F.J.2
  • 27
    • 0028898571 scopus 로고
    • Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene
    • Chang M-S, McNinch J, Basu R, et al. Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene. J Bioch Chem 1995; 270:511-4.
    • (1995) J Bioch Chem , vol.270 , pp. 511-514
    • Chang, M.-S.1    McNinch, J.2    Basu, R.3
  • 28
    • 0030307588 scopus 로고    scopus 로고
    • Biological roles for the second domain of thrombopoietin
    • Foster D, Lok S. Biological roles for the second domain of thrombopoietin. Stem Cells 1996; 14:102-7.
    • (1996) Stem Cells , vol.14 , pp. 102-107
    • Foster, D.1    Lok, S.2
  • 29
    • 0029171091 scopus 로고
    • Structure and function of the cytokine receptor superfamily
    • Drachman JG, Kaushansky K. Structure and function of the cytokine receptor superfamily. Curr Opin Hematol 1995; 2:22-8.
    • (1995) Curr Opin Hematol , vol.2 , pp. 22-28
    • Drachman, J.G.1    Kaushansky, K.2
  • 30
    • 2642679282 scopus 로고    scopus 로고
    • Identification of functionally important residues of human thrombopoietin
    • Park H, Park SS, Jin EH, et al. Identification of functionally important residues of human thrombopoietin. J Biol Chem 1998; 273:256-61.
    • (1998) J Biol Chem , vol.273 , pp. 256-261
    • Park, H.1    Park, S.S.2    Jin, E.H.3
  • 31
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • Cwirla SE, Balasubramanian P, Duffin DJ, et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 1997; 276:1696-9.
    • (1997) Science , vol.276 , pp. 1696-1699
    • Cwirla, S.E.1    Balasubramanian, P.2    Duffin, D.J.3
  • 33
    • 0029086322 scopus 로고
    • The human thrombopoietin gene is located on chromosome 3q26.33-q27, but is not transcriptionally activated in leukemia cells with 3q21 and 3q26 abnormalities (3q21q26 syndrome)
    • Suzukawa K, Satoh H, Taniwaki M, Yokota J, Morishita K. The human thrombopoietin gene is located on chromosome 3q26.33-q27, but is not transcriptionally activated in leukemia cells with 3q21 and 3q26 abnormalities (3q21q26 syndrome). Leukemia 1995; 9:1328-31.
    • (1995) Leukemia , vol.9 , pp. 1328-1331
    • Suzukawa, K.1    Satoh, H.2    Taniwaki, M.3    Yokota, J.4    Morishita, K.5
  • 34
    • 0030465354 scopus 로고    scopus 로고
    • Refined chromosomal localization of the human thrombopoietin gene to 3q27-q28 and exclusion as the responsible gene for thrombocytosis in patients with rearrangements of 3q21 and 3q26
    • Schnittger S, de Sauvage FJ, Le Paslier D, Fonatsch C. Refined chromosomal localization of the human thrombopoietin gene to 3q27-q28 and exclusion as the responsible gene for thrombocytosis in patients with rearrangements of 3q21 and 3q26. Leukemia 1996; 10:1891-6.
    • (1996) Leukemia , vol.10 , pp. 1891-1896
    • Schnittger, S.1    De Sauvage, F.J.2    Le Paslier, D.3    Fonatsch, C.4
  • 35
    • 0028557354 scopus 로고
    • Human thrombopoietin: Gene structure, cDNA sequence, expression and chromosomal localization
    • Foster DC, Sprecher CA, Kramer JM, et al. Human thrombopoietin: gene structure, cDNA sequence, expression and chromosomal localization. Proc Natl Acad Sci USA 1994; 91:13023-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 13023-13027
    • Foster, D.C.1    Sprecher, C.A.2    Kramer, J.M.3
  • 36
    • 0030967202 scopus 로고    scopus 로고
    • Characterization of the human thrombopoietin gene promoter
    • Kamura T, Handa H, Hamasaki N, Kitajima S. Characterization of the human thrombopoietin gene promoter. J Biol Chem 1997; 272:11361-8.
    • (1997) J Biol Chem , vol.272 , pp. 11361-11368
    • Kamura, T.1    Handa, H.2    Hamasaki, N.3    Kitajima, S.4
  • 37
    • 0028879896 scopus 로고
    • Thrombopoietin is not responsible for the thrombocytosis observed in patients with acute myeloid leukemias and the 3q21q26 syndrome
    • Bouscary D, Fontenay-Roupie M, Chretien S, et al. Thrombopoietin is not responsible for the thrombocytosis observed in patients with acute myeloid leukemias and the 3q21q26 syndrome. Br J Haematol 1995; 91:425-7.
    • (1995) Br J Haematol , vol.91 , pp. 425-427
    • Bouscary, D.1    Fontenay-Roupie, M.2    Chretien, S.3
  • 38
    • 0030753987 scopus 로고    scopus 로고
    • Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization
    • Nomura S, Ogami K, Tsukamoto I, et al. Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization. Exp Haemat 1997; 25:565-72.
    • (1997) Exp Haemat , vol.25 , pp. 565-572
    • Nomura, S.1    Ogami, K.2    Tsukamoto, I.3
  • 39
    • 0032005935 scopus 로고    scopus 로고
    • Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: Evidence of thrombopoietin as a growth factor for liver endothelial cells
    • Cardier JE, Dempsey J. Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: Evidence of thrombopoietin as a growth factor for liver endothelial cells. Blood 1998; 91:923-9.
    • (1998) Blood , vol.91 , pp. 923-929
    • Cardier, J.E.1    Dempsey, J.2
  • 40
    • 0031035555 scopus 로고    scopus 로고
    • Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow and spleen using in situ hybridization
    • Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow and spleen using in situ hybridization. Blood 1996; 89:101-7.
    • (1996) Blood , vol.89 , pp. 101-107
    • Sungaran, R.1    Markovic, B.2    Chong, B.H.3
  • 41
    • 0029587565 scopus 로고
    • Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines
    • Shimada Y, Kato T, Ogami K, et al. Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Exp Hematol 1995; 23:1388-96.
    • (1995) Exp Hematol , vol.23 , pp. 1388-1396
    • Shimada, Y.1    Kato, T.2    Ogami, K.3
  • 44
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • Kuter DJ, Rosenberg RD. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995; 85:2720-30.
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 45
    • 0022751115 scopus 로고
    • Anemia induces accumulation of erythropoietin mRNA in the kidney and liver
    • Bondurant MC, Koury M. Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 1986; 6:2731-9.
    • (1986) Mol Cell Biol , vol.6 , pp. 2731-2739
    • Bondurant, M.C.1    Koury, M.2
  • 47
    • 0030048887 scopus 로고    scopus 로고
    • Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets
    • Stoffer R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996; 87:567-73.
    • (1996) Blood , vol.87 , pp. 567-573
    • Stoffer, R.1    Wiestner, A.2    Skoda, R.C.3
  • 48
    • 0029835344 scopus 로고    scopus 로고
    • Constitutive expression of Mpl ligand transcript during thrombocytopenia and thrombocytosis
    • Cohen-Solal K, Villeval J-L, Titeux M, Lok S, Vainchenker W, Wendling F. Constitutive expression of Mpl ligand transcript during thrombocytopenia and thrombocytosis. Blood 1996; 88:2578-84.
    • (1996) Blood , vol.88 , pp. 2578-2584
    • Cohen-Solal, K.1    Villeval, J.-L.2    Titeux, M.3    Lok, S.4    Vainchenker, W.5    Wendling, F.6
  • 49
    • 0030950319 scopus 로고    scopus 로고
    • Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis
    • Nagata Y, Shozaki Y, Nagahisa H, Nagasawa T, Abe T, Todokaro K. Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thromb Haemost 1997; 77:808-14.
    • (1997) Thromb Haemost , vol.77 , pp. 808-814
    • Nagata, Y.1    Shozaki, Y.2    Nagahisa, H.3    Nagasawa, T.4    Abe, T.5    Todokaro, K.6
  • 50
    • 0029007758 scopus 로고
    • The gene for murine megakaryocyte growth and development factor (Thrombopoietin, Thpo) is located on mouse chromosome 16
    • Chang M-S, Hsu R-Y, McNinch J, Copeland NG, Jenkins NA. The gene for murine megakaryocyte growth and development factor (Thrombopoietin, Thpo) is located on mouse chromosome 16. Genomics 1995; 26:636-7.
    • (1995) Genomics , vol.26 , pp. 636-637
    • Chang, M.-S.1    Hsu, R.-Y.2    McNinch, J.3    Copeland, N.G.4    Jenkins, N.A.5
  • 51
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
    • Fielder PJ, Gurney AL, Stefanich E, et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996; 87:2154-61.
    • (1996) Blood , vol.87 , pp. 2154-2161
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 52
    • 0030024685 scopus 로고    scopus 로고
    • Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
    • de Sauvage FJ, Carver-Moore K, Luoh S-M, et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996; 183:651-6.
    • (1996) J Exp Med , vol.183 , pp. 651-656
    • De Sauvage, F.J.1    Carver-Moore, K.2    Luoh, S.-M.3
  • 54
    • 17744409936 scopus 로고    scopus 로고
    • Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells
    • Hirayama Y, Sakamaki T, Matsunaga T, et al. Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells. Blood 1998; 92:46-52.
    • (1998) Blood , vol.92 , pp. 46-52
    • Hirayama, Y.1    Sakamaki, T.2    Matsunaga, T.3
  • 55
    • 0030968519 scopus 로고    scopus 로고
    • Human platelets display high-affinity receptors for thrombopoietin
    • Broudy V, Lin N, Sabath D, Papayannopoulou T, Kaushansky K. Human platelets display high-affinity receptors for thrombopoietin. Blood 1997; 89:1896-904.
    • (1997) Blood , vol.89 , pp. 1896-1904
    • Broudy, V.1    Lin, N.2    Sabath, D.3    Papayannopoulou, T.4    Kaushansky, K.5
  • 56
    • 0032080016 scopus 로고    scopus 로고
    • Quantitative analysis of thrombopoietin receptors on human megakaryocytes
    • Kuwaki T, Hagiwara T, Yuki C, Kodama I, Kato T, Miyazaki H. Quantitative analysis of thrombopoietin receptors on human megakaryocytes. FEBS Lett 1998; 427:46-50.
    • (1998) FEBS Lett , vol.427 , pp. 46-50
    • Kuwaki, T.1    Hagiwara, T.2    Yuki, C.3    Kodama, I.4    Kato, T.5    Miyazaki, H.6
  • 57
    • 0031881317 scopus 로고    scopus 로고
    • Binding and regulation of thrombopoietin to human megakaryocytes
    • Sato T, Fuse A, Niimi H, Fielder PJ, Avraham H. Binding and regulation of thrombopoietin to human megakaryocytes. Br J Haematol 1998; 100:704-11.
    • (1998) Br J Haematol , vol.100 , pp. 704-711
    • Sato, T.1    Fuse, A.2    Niimi, H.3    Fielder, P.J.4    Avraham, H.5
  • 58
    • 0030901558 scopus 로고    scopus 로고
    • Human platelets as a model for the binding and degradation of thrombopoietin
    • Fielder P, Hass P, Nagel M, et al. Human platelets as a model for the binding and degradation of thrombopoietin. Blood 1997; 89:2782-8.
    • (1997) Blood , vol.89 , pp. 2782-2788
    • Fielder, P.1    Hass, P.2    Nagel, M.3
  • 59
    • 0029051295 scopus 로고
    • Transcription factor NF-E2 is required for platelet formation independent of actions of thrombopoietin/ MGDF in megakaryocyte development
    • Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, et al. Transcription factor NF-E2 is required for platelet formation independent of actions of thrombopoietin/ MGDF in megakaryocyte development. Cell 1995; 81:695-704.
    • (1995) Cell , vol.81 , pp. 695-704
    • Shivdasani, R.A.1    Rosenblatt, M.F.2    Zucker-Franklin, D.3
  • 60
    • 0030964546 scopus 로고    scopus 로고
    • Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice
    • Shivdasani RA, Fielder P, Keller G-A, Orkin SH, de Sauvage FJ. Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood 1997; 90:1821-7.
    • (1997) Blood , vol.90 , pp. 1821-1827
    • Shivdasani, R.A.1    Fielder, P.2    Keller, G.-A.3    Orkin, S.H.4    De Sauvage, F.J.5
  • 61
    • 8944258119 scopus 로고    scopus 로고
    • A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haematopoietic disorders
    • Tahara T, Usuki K, Sato H, et al. A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haematopoietic disorders. Br J Haematol 1996; 93:783-8.
    • (1996) Br J Haematol , vol.93 , pp. 783-788
    • Tahara, T.1    Usuki, K.2    Sato, H.3
  • 62
    • 0030695363 scopus 로고    scopus 로고
    • Sensitive measurement of thrombopoietin by a monoclonal antibody based sandwich enzyme-linked immunosorbent assay
    • Folman CC, von dem Borne AE, Rensink IH, et al. Sensitive measurement of thrombopoietin by a monoclonal antibody based sandwich enzyme-linked immunosorbent assay. Thromb Haemostas 1997; 78:1262-7.
    • (1997) Thromb Haemostas , vol.78 , pp. 1262-1267
    • Folman, C.C.1    Von Dem Borne, A.E.2    Rensink, I.H.3
  • 63
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons RVB, Reid DM, Cohen RL, et al. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996; 87:4068-71.
    • (1996) Blood , vol.87 , pp. 4068-4071
    • Emmons, R.V.B.1    Reid, D.M.2    Cohen, R.L.3
  • 64
    • 10544241190 scopus 로고    scopus 로고
    • Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura
    • Mukai HY, Kojima H, Todokoro K, et al. Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura. Thromb Haemost 1996; 76:675-8.
    • (1996) Thromb Haemost , vol.76 , pp. 675-678
    • Mukai, H.Y.1    Kojima, H.2    Todokoro, K.3
  • 65
    • 0029859326 scopus 로고    scopus 로고
    • Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation
    • Meng YG, Martin TG, Peterson ML, Shuman MA, Cohen RL, Wong WL. Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation. Br J Haematol 1996; 95:535-41.
    • (1996) Br J Haematol , vol.95 , pp. 535-541
    • Meng, Y.G.1    Martin, T.G.2    Peterson, M.L.3    Shuman, M.A.4    Cohen, R.L.5    Wong, W.L.6
  • 66
    • 0030472273 scopus 로고    scopus 로고
    • Serum thrombopoietin levels in patients with aplastic anaemia
    • Marsh JCW, Gibson FM, Prue RL, et al. Serum thrombopoietin levels in patients with aplastic anaemia. Br J Haematol 1996; 95:605-10.
    • (1996) Br J Haematol , vol.95 , pp. 605-610
    • Marsh, J.C.W.1    Gibson, F.M.2    Prue, R.L.3
  • 67
    • 9344231924 scopus 로고    scopus 로고
    • Circulating thrombopoietin level in chronic immune thrombocytopenic purpura
    • Kosugi S, Kutara Y, Tomiyama Y, et al. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br J Haematol 1996; 93:704-6.
    • (1996) Br J Haematol , vol.93 , pp. 704-706
    • Kosugi, S.1    Kutara, Y.2    Tomiyama, Y.3
  • 68
    • 0029817844 scopus 로고    scopus 로고
    • Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenia purpura
    • Ichikawa N, Ishida F, Shimodaira S, Tahara T, Kato T, Kitano K. Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenia purpura. Thromb Haemost 1996; 76:156-60.
    • (1996) Thromb Haemost , vol.76 , pp. 156-160
    • Ichikawa, N.1    Ishida, F.2    Shimodaira, S.3    Tahara, T.4    Kato, T.5    Kitano, K.6
  • 69
    • 0031805239 scopus 로고    scopus 로고
    • The diagnostic value of thrombopoietin level measurements in thrombocytopenia
    • Porcelijn L, Folman CC, Bossers B, et al. The diagnostic value of thrombopoietin level measurements in thrombocytopenia. Thromb Haemost 1998; 79:1101-5.
    • (1998) Thromb Haemost , vol.79 , pp. 1101-1105
    • Porcelijn, L.1    Folman, C.C.2    Bossers, B.3
  • 71
    • 0028047591 scopus 로고
    • Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exibits dysfunctional regulation in leukemic cells
    • Steinman RA, Tweardy DJ. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exibits dysfunctional regulation in leukemic cells. Blood 1994; 83:119-27.
    • (1994) Blood , vol.83 , pp. 119-127
    • Steinman, R.A.1    Tweardy, D.J.2
  • 72
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand, thrombopoietin
    • Kaushansky K, Lok S, Holly RD, et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand, thrombopoietin. Nature 1994; 369:568-71.
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 73
    • 0029035985 scopus 로고
    • Thrombopoietin: The primary regulator of platelet production
    • Kaushansky K. Thrombopoietin: The primary regulator of platelet production. Blood 1995; 86:419-31.
    • (1995) Blood , vol.86 , pp. 419-431
    • Kaushansky, K.1
  • 74
    • 0028985594 scopus 로고
    • Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development
    • Kaushansky K, Broudy VC, Lin N, et al. Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 1995; 92:3234-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3234-3238
    • Kaushansky, K.1    Broudy, V.C.2    Lin, N.3
  • 75
    • 0028114123 scopus 로고
    • In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells
    • Zeigler FC, de Sauvage F, Widmer HR, et al. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994; 84:4045-52.
    • (1994) Blood , vol.84 , pp. 4045-4052
    • Zeigler, F.C.1    De Sauvage, F.2    Widmer, H.R.3
  • 76
    • 0028928884 scopus 로고
    • Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional
    • Choi ES, Nichol JL, Hokom MM, Hornkohl AC, Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995; 85:402-13.
    • (1995) Blood , vol.85 , pp. 402-413
    • Choi, E.S.1    Nichol, J.L.2    Hokom, M.M.3    Hornkohl, A.C.4    Hunt, P.5
  • 77
    • 0029022246 scopus 로고
    • Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro
    • Choi ES, Hokom M, Bartley T. Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro. Stem cells 1995; 13:317-22.
    • (1995) Stem Cells , vol.13 , pp. 317-322
    • Choi, E.S.1    Hokom, M.2    Bartley, T.3
  • 78
    • 0029037953 scopus 로고
    • The Mpl-ligand or thrombopoietin or megakaryocyte growth and development factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors
    • Debili N, Wendling F, Katz A, et al. The Mpl-Ligand or thrombopoietin or megakaryocyte growth and development factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 1995; 86:2516-25.
    • (1995) Blood , vol.86 , pp. 2516-2525
    • Debili, N.1    Wendling, F.2    Katz, A.3
  • 79
    • 0008487105 scopus 로고    scopus 로고
    • Regulation of proplatelet and platelet formation in vitro
    • Kuter DJ, Hunt P, Sheridan W, Zucker-Franklin D, eds. Totowa, N J Humana Press
    • Choi E. Regulation of proplatelet and platelet formation in vitro. In: Kuter DJ, Hunt P, Sheridan W, Zucker-Franklin D, eds. Thrombopoiesis and thrombopoietins. Totowa, N J Humana Press, 1996. p. 271-84.
    • (1996) Thrombopoiesis and Thrombopoietins , pp. 271-284
    • Choi, E.1
  • 80
    • 0029837329 scopus 로고    scopus 로고
    • Effects of thrombopoietin on the development of megakaryocytes and platelets
    • Zucker-Franklin D, Kaushansky K. Effects of thrombopoietin on the development of megakaryocytes and platelets. Blood 1996; 88:1632-40.
    • (1996) Blood , vol.88 , pp. 1632-1640
    • Zucker-Franklin, D.1    Kaushansky, K.2
  • 81
    • 0029804163 scopus 로고    scopus 로고
    • The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis
    • Choi ES, Hokom MM, Chen J-L, et al. The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis. Br J Haematol 1996; 95:227-33.
    • (1996) Br J Haematol , vol.95 , pp. 227-233
    • Choi, E.S.1    Hokom, M.M.2    Chen, J.-L.3
  • 82
    • 0030982911 scopus 로고    scopus 로고
    • Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand
    • Cramer E, Norol F, Guichard J, et al. Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood 1997; 89:2326-46.
    • (1997) Blood , vol.89 , pp. 2326-2346
    • Cramer, E.1    Norol, F.2    Guichard, J.3
  • 83
    • 0032005215 scopus 로고    scopus 로고
    • Effects of cytokines on platelet production from blood and marrow cd34+ cells
    • Norol F, Vitrat N, Cramer E, et al. Effects of cytokines on platelet production from blood and marrow CD34+ cells. Blood 1998; 91:830-4.
    • (1998) Blood , vol.91 , pp. 830-834
    • Norol, F.1    Vitrat, N.2    Cramer, E.3
  • 84
    • 0029949455 scopus 로고    scopus 로고
    • Recombinant human c-mpl ligand is not a direct stimulator of proplatelet formation in mature human megakaryocytes
    • Ito T, Ishida Y, Kuriya S-I. Recombinant human c-mpl ligand is not a direct stimulator of proplatelet formation in mature human megakaryocytes. Br J Haematol 1996; 94:387-90.
    • (1996) Br J Haematol , vol.94 , pp. 387-390
    • Ito, T.1    Ishida, Y.2    Kuriya, S.-I.3
  • 85
    • 0030788804 scopus 로고    scopus 로고
    • Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin
    • Bunting S, Widmer R, Lipari T, et al. Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin. Blood 1997; 90:3423-9.
    • (1997) Blood , vol.90 , pp. 3423-3429
    • Bunting, S.1    Widmer, R.2    Lipari, T.3
  • 86
    • 0029052479 scopus 로고
    • Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus Kinase 2 and Shc in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, et al. Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus Kinase 2 and Shc in human blood platelets. Blood 1995; 86:23-7.
    • (1995) Blood , vol.86 , pp. 23-27
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3
  • 87
    • 0030052617 scopus 로고    scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation of stat3 and stat5 in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, et al. Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood 1996; 87:439-46.
    • (1996) Blood , vol.87 , pp. 439-446
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3
  • 88
    • 0030945262 scopus 로고    scopus 로고
    • Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets
    • Miyakawa Y, Oda A, Drucker B, et al. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood 1997; 89:2789-98.
    • (1997) Blood , vol.89 , pp. 2789-2798
    • Miyakawa, Y.1    Oda, A.2    Drucker, B.3
  • 89
    • 9344225757 scopus 로고    scopus 로고
    • Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists
    • Oda A, Miyakawa Y, Druker BJ, et al. Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists. Blood 1996; 87:4664-70.
    • (1996) Blood , vol.87 , pp. 4664-4670
    • Oda, A.1    Miyakawa, Y.2    Druker, B.J.3
  • 90
    • 0028820319 scopus 로고
    • Regulation of platelets activation in vitro by the c-Mpl ligand, thrombopoietin
    • Chen J, Herced-Harjacek L, Groopman JE, Grabarek J. Regulation of platelets activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 1995; 86:4054-62.
    • (1995) Blood , vol.86 , pp. 4054-4062
    • Chen, J.1    Herced-Harjacek, L.2    Groopman, J.E.3    Grabarek, J.4
  • 91
    • 0029080417 scopus 로고
    • Recombinant human megakaryocyte growth and development factor (MGDF) moderately enhances ex vivo platelet aggregation by a receptor dependent mechanism
    • Toombs CF, Young CH, Glaspy JA, Varnum BC. Recombinant human megakaryocyte growth and development factor (MGDF) moderately enhances ex vivo platelet aggregation by a receptor dependent mechanism. Thromb Res 1995; 80:23-33.
    • (1995) Thromb Res , vol.80 , pp. 23-33
    • Toombs, C.F.1    Young, C.H.2    Glaspy, J.A.3    Varnum, B.C.4
  • 92
    • 0029912139 scopus 로고    scopus 로고
    • Effects of recombinant human megakaryocyte growth and development factor on platelet activation
    • Montrucchio G, Brizzi MF, Calosso G, Marengo S, Pegoraro L, Camussi G. Effects of recombinant human megakaryocyte growth and development factor on platelet activation. Blood 1996; 87:2762-8.
    • (1996) Blood , vol.87 , pp. 2762-2768
    • Montrucchio, G.1    Brizzi, M.F.2    Calosso, G.3    Marengo, S.4    Pegoraro, L.5    Camussi, G.6
  • 93
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl
    • Alexander WS, Roberts AW, Nicola NA, Ll R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl. Blood 1996; 87:2162-70.
    • (1996) Blood , vol.87 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3    Ll, R.4    Metcalf, D.5
  • 94
    • 0029684417 scopus 로고    scopus 로고
    • Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice
    • Carver-Moore K, Broxmeyer HE, Luoh S-M, et al. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood 1996; 88: 803-8.
    • (1996) Blood , vol.88 , pp. 803-808
    • Carver-Moore, K.1    Broxmeyer, H.E.2    Luoh, S.-M.3
  • 95
    • 0032126638 scopus 로고    scopus 로고
    • Role of c-mpl in early hematopoiesis
    • Solar GP, Kerr WG, Ziegler FC, et al. Role of c-mpl in early hematopoiesis. Blood 1998; 92:4-10.
    • (1998) Blood , vol.92 , pp. 4-10
    • Solar, G.P.1    Kerr, W.G.2    Ziegler, F.C.3
  • 96
    • 0032125714 scopus 로고    scopus 로고
    • Thrombopoietin and the hematopoietic stem cell
    • Kaushansky K. Thrombopoietin and the hematopoietic stem cell. Blood 1998; 92:1-3.
    • (1998) Blood , vol.92 , pp. 1-3
    • Kaushansky, K.1
  • 97
    • 0030039567 scopus 로고    scopus 로고
    • Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
    • Ku H, Yonemura Y, Kaushansky K, Ogawa M. Thrombopoietin, the ligand for the Mpl receptor, synergizes with Steel Factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996; 87:4544-51.
    • (1996) Blood , vol.87 , pp. 4544-4551
    • Ku, H.1    Yonemura, Y.2    Kaushansky, K.3    Ogawa, M.4
  • 98
    • 0030014681 scopus 로고    scopus 로고
    • The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
    • Sitnicka E, Lin N, Priestley GV, et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996; 87:4998-5005.
    • (1996) Blood , vol.87 , pp. 4998-5005
    • Sitnicka, E.1    Lin, N.2    Priestley, G.V.3
  • 99
    • 0029900227 scopus 로고    scopus 로고
    • Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3
    • Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M. Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3. Blood 1996; 88:429-36.
    • (1996) Blood , vol.88 , pp. 429-436
    • Kobayashi, M.1    Laver, J.H.2    Kato, T.3    Miyazaki, H.4    Ogawa, M.5
  • 100
    • 0029977501 scopus 로고    scopus 로고
    • Differential cytokine effects on primitive (CD34+ CD38-) human hematopoietic cells: Novel response to flt-3 ligand and thrombopoietin
    • Petzer AL, Zanstra PW, Piret JM, Eaves CJ. Differential cytokine effects on primitive (CD34+ CD38-) human hematopoietic cells: novel response to flt-3 ligand and thrombopoietin. J Exp Med 1996; 183:2551-7.
    • (1996) J Exp Med , vol.183 , pp. 2551-2557
    • Petzer, A.L.1    Zanstra, P.W.2    Piret, J.M.3    Eaves, C.J.4
  • 101
    • 0029912731 scopus 로고    scopus 로고
    • Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3
    • Ramsfjell V, Borge OJ, Veiby OP, et al. Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3. Blood 1996; 88:4481-92.
    • (1996) Blood , vol.88 , pp. 4481-4492
    • Ramsfjell, V.1    Borge, O.J.2    Veiby, O.P.3
  • 102
    • 0030905059 scopus 로고    scopus 로고
    • Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand
    • Ohmizono Y, Sakabe H, Kimura T, et al. Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand. Leukemia 1997; 11:524-30.
    • (1997) Leukemia , vol.11 , pp. 524-530
    • Ohmizono, Y.1    Sakabe, H.2    Kimura, T.3
  • 103
    • 0031000903 scopus 로고    scopus 로고
    • Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
    • Piacibello W, Sanavio SF, Garetto L, et al. Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood 1997; 89:2644-53.
    • (1997) Blood , vol.89 , pp. 2644-2653
    • Piacibello, W.1    Sanavio, S.F.2    Garetto, L.3
  • 104
    • 0031157028 scopus 로고    scopus 로고
    • Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells
    • Ramsfjell V, Borge OJ, Cui L, Jacobsen SEW. Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells. J Immunol 1997; 158:5169-74.
    • (1997) J Immunol , vol.158 , pp. 5169-5174
    • Ramsfjell, V.1    Borge, O.J.2    Cui, L.3    Jacobsen, S.E.W.4
  • 105
    • 0030823542 scopus 로고    scopus 로고
    • Ability of early acting cytokine to directly promote survival and suppress apoptosis of human primitive CD34+ CD38-bone marrow cells with multilineage potential at the single cell level: Key role of thrombopoietin
    • Borge OJ, Ramsfjell V, Cui L, Jacobsen SEW. Ability of early acting cytokine to directly promote survival and suppress apoptosis of human primitive CD34+ CD38-bone marrow cells with multilineage potential at the single cell level: Key role of thrombopoietin. Blood 1997; 90:2282-9.
    • (1997) Blood , vol.90 , pp. 2282-2289
    • Borge, O.J.1    Ramsfjell, V.2    Cui, L.3    Jacobsen, S.E.W.4
  • 107
    • 0031803784 scopus 로고    scopus 로고
    • Cytokines in hematopoiesis
    • Alexander WS. Cytokines in hematopoiesis. Int Rev Immunol 1998; 16:651-82.
    • (1998) Int Rev Immunol , vol.16 , pp. 651-682
    • Alexander, W.S.1
  • 108
    • 0031827478 scopus 로고    scopus 로고
    • Update on thrombopoietin in preclinical and clinical trials
    • Miyazaki H. Update on thrombopoietin in preclinical and clinical trials. Curr Opin Hematol 1998; 5:197-202.
    • (1998) Curr Opin Hematol , vol.5 , pp. 197-202
    • Miyazaki, H.1
  • 109
    • 0030942587 scopus 로고    scopus 로고
    • A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size and ploidy
    • Arnold JT, Daw NC, Stenberg PE, Jayawardene D, Srivastava DK, Jackson CW. A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size and ploidy. Blood 1997; 89:1683-7.
    • (1997) Blood , vol.89 , pp. 1683-1687
    • Arnold, J.T.1    Daw, N.C.2    Stenberg, P.E.3    Jayawardene, D.4    Srivastava, D.K.5    Jackson, C.W.6
  • 110
    • 0031973576 scopus 로고    scopus 로고
    • A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration
    • Daw NC, Arnold JT, Abushullaih BA, et al. A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration. Blood 1998; 91:466-74.
    • (1998) Blood , vol.91 , pp. 466-474
    • Daw, N.C.1    Arnold, J.T.2    Abushullaih, B.A.3
  • 111
    • 0029051730 scopus 로고
    • Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice
    • Ulich TR, del Castillo J, Yin S, et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995; 86:971-6.
    • (1995) Blood , vol.86 , pp. 971-976
    • Ulich, T.R.1    Del Castillo, J.2    Yin, S.3
  • 112
    • 0004493180 scopus 로고    scopus 로고
    • In vivo biological effects of various forms of thrombopoietin in a murine model of transient thrombocytopenia
    • Thomas GR, Thibodeaux H, Erret CJ, et al. In vivo biological effects of various forms of thrombopoietin in a murine model of transient thrombocytopenia. Stem Cells 1996; 14:244-51.
    • (1996) Stem Cells , vol.14 , pp. 244-251
    • Thomas, G.R.1    Thibodeaux, H.2    Erret, C.J.3
  • 113
    • 0028787175 scopus 로고
    • Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice
    • Fibbe WE, Heemskerk DPM, Laterveer L, et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995; 86:3308-13.
    • (1995) Blood , vol.86 , pp. 3308-3313
    • Fibbe, W.E.1    Heemskerk, D.P.M.2    Laterveer, L.3
  • 114
    • 0029839244 scopus 로고    scopus 로고
    • Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation
    • Molineux G, Hartley CA, McElroy P, McCrea C, McNiece IK. Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation. Blood 1996; 88:1509-14.
    • (1996) Blood , vol.88 , pp. 1509-1514
    • Molineux, G.1    Hartley, C.A.2    McElroy, P.3    McCrea, C.4    McNiece, I.K.5
  • 115
    • 0029999474 scopus 로고    scopus 로고
    • Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients
    • Molineux G, Hartley C, McElroy P, McCrea C, McNiece IK. Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients. Blood 1996; 88:366-76.
    • (1996) Blood , vol.88 , pp. 366-376
    • Molineux, G.1    Hartley, C.2    McElroy, P.3    McCrea, C.4    McNiece, I.K.5
  • 116
    • 0029062371 scopus 로고
    • Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates
    • Farese AM, Hunt P, Boone T, MacVittie TJ. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 1995; 86:54-9.
    • (1995) Blood , vol.86 , pp. 54-59
    • Farese, A.M.1    Hunt, P.2    Boone, T.3    MacVittie, T.J.4
  • 117
    • 0029963122 scopus 로고    scopus 로고
    • Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia
    • Farese AM, Hunt P, Grab LB, MacVittie TJ. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. J Clin Invest 1996; 97:2145-51.
    • (1996) J Clin Invest , vol.97 , pp. 2145-2151
    • Farese, A.M.1    Hunt, P.2    Grab, L.B.3    MacVittie, T.J.4
  • 118
    • 0030068687 scopus 로고    scopus 로고
    • Regulation of platelet production and function by megakaryocyte growth and development factor in nonnuman primates
    • Harker LA, Hunt P, Marzec UM, et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonnuman primates. Blood 1996; 87:1833-44.
    • (1996) Blood , vol.87 , pp. 1833-1844
    • Harker, L.A.1    Hunt, P.2    Marzec, U.M.3
  • 119
    • 0031019748 scopus 로고    scopus 로고
    • Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor
    • Harker LA, Marzec UM, Kelly AB, et al. Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor. Blood 1997; 89:155-65.
    • (1997) Blood , vol.89 , pp. 155-165
    • Harker, L.A.1    Marzec, U.M.2    Kelly, A.B.3
  • 120
    • 0029150347 scopus 로고
    • Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
    • Kaushansky K, Broudy VC, Grossmann A, et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 1995; 96:1683-7.
    • (1995) J Clin Invest , vol.96 , pp. 1683-1687
    • Kaushansky, K.1    Broudy, V.C.2    Grossmann, A.3
  • 121
    • 0029992540 scopus 로고    scopus 로고
    • Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice
    • Grossmann A, Lenox J, Deisher TA, et al. Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. Blood 1996; 88:3363-70.
    • (1996) Blood , vol.88 , pp. 3363-3370
    • Grossmann, A.1    Lenox, J.2    Deisher, T.A.3
  • 122
    • 0030836514 scopus 로고    scopus 로고
    • Clinical studies with megakaryocyte growth and development factor (Mpl-ligand)
    • Begley CG. Clinical studies with megakaryocyte growth and development factor (Mpl-ligand). Thromb Haemostas 1997; 78:42-6.
    • (1997) Thromb Haemostas , vol.78 , pp. 42-46
    • Begley, C.G.1
  • 123
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHUMGDF) in patients with advanced cancer
    • Basser RL, Rasko JEJ, Clarke K, et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHUMGDF) in patients with advanced cancer. Lancet 1996; 348:1279-81.
    • (1996) Lancet , vol.348 , pp. 1279-1281
    • Basser, R.L.1    Rasko, J.E.J.2    Clarke, K.3
  • 124
    • 10344238601 scopus 로고    scopus 로고
    • Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vitro activation
    • O'Malley CJ, Rasko RL, Basser RL, et al. Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vitro activation. Blood 1996; 88:3288-98.
    • (1996) Blood , vol.88 , pp. 3288-3298
    • O'Malley, C.J.1    Rasko, R.L.2    Basser, R.L.3
  • 125
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
    • Vadjan-Raj S, Murray LJ, Bueso-Ramos C, et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Intern Med 1997; 126: 673-81.
    • (1997) Ann Intern Med , vol.126 , pp. 673-681
    • Vadjan-Raj, S.1    Murray, L.J.2    Bueso-Ramos, C.3
  • 126
    • 8544258752 scopus 로고    scopus 로고
    • Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG-rHuMGDF
    • Rasko JE, Basser RL, Boyd J, et al. Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG-rHuMGDF. Br J Haematol 1997; 97:871-88.
    • (1997) Br J Haematol , vol.97 , pp. 871-888
    • Rasko, J.E.1    Basser, R.L.2    Boyd, J.3
  • 127
    • 0344073863 scopus 로고    scopus 로고
    • Safety and biological effects of pegylated megakaryocyte growth and development factor in lung cancer patients receiving carboplatin and paclitaxel: Randomised, placebo-controlled phase I study
    • Fanucchi M, Glapsy J, Crawfold J, et al. Safety and biological effects of pegylated megakaryocyte growth and development factor in lung cancer patients receiving carboplatin and paclitaxel: Randomised, placebo-controlled phase I study. Proc Am Soc Clin Oncol 1996; 15:720-6.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 720-726
    • Fanucchi, M.1    Glapsy, J.2    Crawfold, J.3
  • 128
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi MG, Glapsy J, Crawford J, et al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997; 336:404-9.
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucchi, M.G.1    Glapsy, J.2    Crawford, J.3
  • 129
    • 0344073862 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled study using PEG-rhuMGDF as an adjunct to chemotherapy for adults with de-novo acute myeloid leukemia (AML): Early results
    • Archimbaud E, Ottmann O, Lui Yin JA, et al. A randomised, double-blind, placebo-controlled study using PEG-rhuMGDF as an adjunct to chemotherapy for adults with de-novo acute myeloid leukemia (AML): early results. Blood 1996; 88 (Suppl 1):447.
    • (1996) Blood , vol.88 , Issue.SUPPL. 1 , pp. 447
    • Archimbaud, E.1    Ottmann, O.2    Lui Yin, J.A.3
  • 130
    • 0004522568 scopus 로고    scopus 로고
    • Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I)
    • Vadhan-Raj S, Patel S, Broxmeyer HE, et al. Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I). Blood 1996; 88(suppl 1):448.
    • (1996) Blood , vol.88 , Issue.SUPPL. 1 , pp. 448
    • Vadhan-Raj, S.1    Patel, S.2    Broxmeyer, H.E.3
  • 131
    • 17944389931 scopus 로고    scopus 로고
    • Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryoctyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
    • Basser RL, Rasko JE, Clarke K, et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryoctyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 1997; 89:3118-28.
    • (1997) Blood , vol.89 , pp. 3118-3128
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 132
    • 0003350616 scopus 로고    scopus 로고
    • Analysis of the thrombopoietin receptor (Mpl) on platelets from normal and essential thrombocythemic (ET) patients
    • Li J, Xia Y, Kuter DJ. Analysis of the thrombopoietin receptor (Mpl) on platelets from normal and essential thrombocythemic (ET) patients. Blood 1996; 88:545-52.
    • (1996) Blood , vol.88 , pp. 545-552
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 133
    • 0030732423 scopus 로고    scopus 로고
    • Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia
    • Horikawa Y, Matsumura I, Hashimoto K, et al. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood 1997; 90: 4031-8.
    • (1997) Blood , vol.90 , pp. 4031-4038
    • Horikawa, Y.1    Matsumura, I.2    Hashimoto, K.3
  • 134
    • 2642609475 scopus 로고    scopus 로고
    • Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera
    • Moliterno AR, Hankins WD, Spivak JL. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. N Engl J Med 1998; 338:572-80.
    • (1998) N Engl J Med , vol.338 , pp. 572-580
    • Moliterno, A.R.1    Hankins, W.D.2    Spivak, J.L.3
  • 135
    • 0031975482 scopus 로고    scopus 로고
    • An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia
    • Wiestner A, Schlemper RJ, van der Maas APC, Skoda RC. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nature Genetics 1998; 18:49-52.
    • (1998) Nature Genetics , vol.18 , pp. 49-52
    • Wiestner, A.1    Schlemper, R.J.2    Van Der Maas, A.P.C.3    Skoda, R.C.4
  • 136
    • 0032227150 scopus 로고    scopus 로고
    • Myelofibrosis: Experimental models and human studies
    • Taksin A-L, Cohen-Solal K, Le Couedic J-P, et al. Myelofibrosis: Experimental models and human studies. Stem Cells 1998; 16 (suppl 2):155-64.
    • (1998) Stem Cells , vol.16 , Issue.SUPPL. 2 , pp. 155-164
    • Taksin, A.-L.1    Cohen-Solal, K.2    Le Couedic, J.-P.3
  • 137
    • 0032913316 scopus 로고    scopus 로고
    • Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L
    • Taksin A-L, Le Couedic J-P, Massé A, et al. Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L. Blood 1999; 93:125-39.
    • (1999) Blood , vol.93 , pp. 125-139
    • Taksin, A.-L.1    Le Couedic, J.-P.2    Massé, A.3
  • 138
    • 0030962275 scopus 로고    scopus 로고
    • Polycythemia vera. V. Enhanced proliferation and phosphorylation due to vanadate are diminished in polycythemia vera erythroid progenitor cells: A possible defect of phosphatase activity in polycythemia vera
    • Dai CH, Krantz SB, Sawyer ST. Polycythemia vera. V. Enhanced proliferation and phosphorylation due to vanadate are diminished in polycythemia vera erythroid progenitor cells: A possible defect of phosphatase activity in polycythemia vera. Blood 1997; 89:3574-81.
    • (1997) Blood , vol.89 , pp. 3574-3581
    • Dai, C.H.1    Krantz, S.B.2    Sawyer, S.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.