Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation

Blood

Volumn 88, Issue 4, 1996, Pages 1509-1514

  Molineux, Graham ^a   Hartley, Cynthia A ^a   McElroy, Patricia ^a   McCrea, Clay ^a   McNiece, Ian K ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL GROWTH; FEMALE; HEMATOPOIESIS; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE COUNT; TREATMENT OUTCOME;

EID: 0029839244     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.4.1509.bloodjournal8841509     Document Type: Article

References (35)

1. Sheridan WP, Morstyn G, Wolf M, Dodds A, Lusk J, Maher D, Layton JE, Green MD, Souza L, Fox RM: Granulocyle colony-stimulating factor and neutrophil recovery after high dose chemotherapy and autologous bone marrow transplantation. Lancet 2:891, 1989
2. Taylor KM, Jagannath S, Spitzer G: Recombinant human granulocyte colony-stimulating factor hastens granulocyte recovery after high-dose chemotherapy and autologous bone marrow transplantation in Hodgkin's disease. J Clin Oncol 7:1791, 1989
3. Devereauz S, Linch DC, Gribben JG, McMillan A, Petterson K, Goldstone AH: GM-CSF accelerates neutrophil recovery after autologous bone marrow transplantation for Hodgkin's disease. Bone Marrow Transplant 4:49, 1989
4. Nemunaitis J, Rabinowe SN, Singer JW, Bierman PJ, Vose JM, Freedman AS, Onetto N, Gillis S, Oette D, Gold M, Buckner CD, Hansen JA, Ritz J, Appelbaum FR, Armitage JO, Nadler LM: Recombinant granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid cancer. N Engl J Med 32:1773, 1991
5. Gabrilove JL, Jakubowski A, Scher H, Sternberg C, Wong G, Grous J, Yagoda A, Fain K, Moore MA, Clarkson B, Oettgen MF, Alton K, Weite K, Souza L: Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318:1414, 1988
6. de Sauvage F, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
7. Wendung F, Maraskovsky E, Debill N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryopoiesis. Nature 369:571, 1994
8. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
9. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliot G, Izumi R, Covey T, Grouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl. Cell 77:1117, 1994
10. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li YS, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp G, Hunt P: Megakaryocyte growth and development factor. Analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 95:2973, 1995
11. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennet L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P: Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 96:971, 1995
12. Farese AM, Hunt P, Boone T, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman-primates. Blood 86:54, 1995
13. Morstyn G, Dexter TM (eds): Filgrastim (r-met HuG-CSF) in Clinical Practice. New York, NY, Marcel Dekker, 1994
14. Souza L, Boone T, Gabrilove J, Lai P, Zsebo K, Murdock D, Cahzin V, Brusewski J, Lu H, Chen K, Barendt J, Platzer E, Moore M, Mertelsmann R, Weite K: Recombinant granulocyte colony-stimulating factor effects on normal and leukemic myeloid cells. Science 232:61, 1986
15. Molineux G, Hartley C, McCrea C, McElroy T, McNiece IK: Continuous subcutaneous infusion (CSI) of hematopoietic growth factors in mice. Exp Hematol 23:880, 1995 (abstr)
16. Hokom MM, Lacey D, Kinstler OB. Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486, 1995
17. Yan XQ, Lacey D, Fletcher F, Hartley C, McElroy P, Sun Y, Xia M, Mu S, Saris C, Hill D. Hawley RG, McNiece IK: Chronic exposure to retroviral vector encoded mgdf (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 86:4025, 1995
18. Kanz L, Lindemann A, Oster W, Herrmann F, Mertelsmann R: Hemopoietins in clinical oncology. Am J Clin Oncol 14:S27, 1991
19. Crown J, Jakubowski A, Kemeny N, Gordon M, Gasparetto C, Wong G, Sheridan C, Toner G, Meisenberg B, Botet J, Applewhite J, Sinha S, Moore M, Kelsen D, Buhles N, Gabrilove J: A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer. Blood 78:1420, 1991
20. Nimer SD, Paquette RL, Ireland P, Resta D, Young D, Golde DW: A phase I/II study of interleukin-3 in patients with aplastic anemia and myelodysplasia. Exp Hematol 22:875, 1994
21. Weber J, Yang JC, Toplian SL, Parkinson DR, Schwartzentruber DS, Ettinghausen SE, Gunn H, Mixon A, Kim H, Cole D, Levin R, Rosenberg SA: Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J Clin Oncol 11:499, 1993
22. Yonemura Y, Kawakita M, Masuda T, Fujimoto K, Takatsuki K: Effect of human interleukin-11 on rat megakaryopoiesis and thrombopoiesis in vivo: Comparative study with interleukin-6. Br J Haematol 84:16, 1993
23. Klaesson S, Ringden O, Ljungman P, Loennqvist B, Wennberg L: Reduced blood transfusions requirements after allogeneic bone marrow transplantation: Results of a randomised, double-blind study with high-dose erythropoietin. Bone Marrow Transplant 13:397, 1994
24. de Campos E, Radford J, Steward W, Milroy R, Dougal M, Swindell R, Testa N, Thatcher N: Clinical and in vitro effects of recombinant human erythropoietin in patients receiving intensive chemotherapy for small-cell lung cancer. J Clin Oncol 13:1623, 1995
25. Biggs JC, Atkinson KA, Booker V, Concannon A, Dart GW, Dodds A, Downs K, Szer J, Turner J, Worthington R: Prospective randomised double-blind trial of the in vivo use of recombinant human erythropoietin in bone marrow transplantation from HLA-identical sibling donors. The Australian Bone Marrow Transplant Study Group. Bone Marrow Transplant 15:129, 1995
26. Malyszko J, Malyszko JS, Borawski J, Rydzewski A, Kalinowski M, Azzadin A, Mysliwiec M, Buczko W: A study of platelet functions, some hemostatic and fibrinolytic parameters in relation to serotonin in hemodialyzed patients under erythropoietin therapy. Thromb Res 77:133, 1995
27. Baer MR, Bernstein SH, Brunetto VL, Heinonen K, Mrozek K, Swann VL, Minderman H, Block A-MW, Pixley LA, Christiansen NP, Fay JW, Barcos M, Rustum Y, Herzig GP, Bloomfield CD: Biological effects of recombinant human granulocyte colony-stimulating factor in patients with untreated acute myeloid leukemia. Blood 87:1484, 1996
28. Molineux G, Hartley CA, McElroy P, McCrea DC, McNiece IK: MGDF accelerates platelet recovery in peripheral blood progenitor cell (PBPC) transplant recipients. Blood (in press)
29. Molineux G, Hartley C, McCrea C, McNiece IK: MGDF (mpl ligand) enhances platelet recovery after bone marrow transplantation. Exp Hematol 23:829, 1995 (abstr)
30. Molineux G, Pojda Z, Dexter TM: A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor. Blood 75:563, 1990
31. Molineux G, Dexter TM: The suppression of erythropoiesis by rhG-CSF in mice. Exp Hematol 20:774, 1992
32. Udupa KB, Sharma BG: Response of erythropoietin and granulocyte/macrophage colony-stimulating factor in exhypoxic polycythemic mice. Exp Hematol 20:793, 1992
33. Cronkite EP, Burlington H, Shimosaka A, Bullis JE, Pappas N: Anemia induced in splenectomized mice by administration of rhG-CSF. Exp Hematol 21:319, 1993
34. de Haan G, Engel C, Dontje B, Nijhof W, Loeffler M: The mutual inhibition of erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colony-stimulating factor and stem cell factor administration; in vivo interactions and dose response surfaces. Blood 84:4157, 1994
35. Sheridan WP, Begley CG, To LB, Grigg A, Szer J, Maher D, Green MD, Rowlings PA, McGrath KM, Cebon J, Dyson P, Watson D, Bayly J, Deluca E, Tomita D, Hoffman E, Morstyn G, Juttner CA, Fox RM: Phase II study of autologous filgrastim (GCSF)-mobilized peripheral-blood progenitor cells to restore hematopoiesis after high-dose chemotherapy for lymphoid malignancies. Bone Marrow Transplant 14:105, 1994