Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice

Blood

Volumn 88, Issue 9, 1996, Pages 3363-3370

  Grossmann, Angelika ^a   Lenox, Joel ^b   Deisher, Theresa A ^b   Ren, Hong Ping ^b   Humes, Jacqueline M ^b   Kaushansky, Kenneth ^b   Sprugel, Katherine H ^b  

^a ZYMOGENETICS INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CELL COUNT; BONE MARROW SUPPRESSION; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA;

EID: 0029992540     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.9.3363.bloodjournal8893363     Document Type: Article

References (49)

1. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
2. Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H: Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 353:57, 1994
3. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu M, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
4. deSauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg LAJ, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
5. Miyazaki H, Kato T, Ogami K, Iwamatsu A, Shimada Y, Souma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kawamura K, Sudo T: Isolation and cloning of a novel human thrombopoietic factor. Exp Hematol 22:838, 1994
6. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
7. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the C-Mpl ligand thrombopoietin. Nature 369:568, 1994
8. Metcalf D: The molecular biology and functions of the granulocyte-macrophage colony stimulating factors. Blood 67:257, 1986
9. Weite K, Bonilla MA, Gillio AP, Boone TC, Potter GK, Gabrilove JL, Moore MA, O'Reilly RJ, Souza LM: Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates. J Exp Med 165:941, 1987
10. Demetri GD, Griffin JD: Granulocyte colony-stimulating factor and its receptor. Blood 78:2791, 1991
11. Gabrilove JL, Jakubowski A, Scher H, Sternberg C, Wong G, Grous J, Yagoda A, Fain K, Moore MA, Clarkson B, Oettgen HF, Alton K, Weite K, Souza L: Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318:1414, 1988
12. Farese AM, Hunt P, Boone T, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 86:54, 1995
13. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P: Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86:971, 1995
14. Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Ren H, Bailey MC, Papayannopoulou T, Forstrom J, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production and enhances erythroid recovery following myelosuppressive therapy. J Clin Invest 96:1683, 1995
15. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC: Thrombopoietin expands erythroid, granulocyte-megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 24:265, 1996
16. Hunt P, Li YS, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C: Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 86:540, 1995
17. Grossmann A, Lenox J, Ping Ren H, Humes JM, Forstrom JW, Kaushansky K, Sprugel KH: Thrombopoietin accelerates platelet, red blood cell and neutrophil recovery in myelosuppressed mice, (in press)
18. Ishikawa M, Okada Y, Satake-Ishikawa R, Kakitani M, Kawagishi M, Matsuki S, Kusaka M, Asano K: Pharmacological effects of recombinant human granulocyte colony-stimulating factor modified by polyethylene glycol on anticancer drug-induced neutropenia in mice. Gen Pharmacol 25:533, 1994
19. Hollingshead LM, Goa KL: Recombinant granulocyte colony-stimulating factor (rG-CSF): A review of its pharmacological properties and prospective role in neutropenic conditions. Drugs 42:300, 1991
20. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
21. Zeigler FC, de Sauvage F, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Hass P, Eaton D, Matthews W: In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045, 1994
22. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (mpl ligand) enhances proliferation of erythroid progenitors. Blood 86:2494, 1995
23. Patchen ML, MacVittie TJ, Williams JL, Schwartz GN, Souza LM: Administration of interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression. Blood 77:472, 1991
24. Leonard JP, Quinto CM, Kozitza MK, Neben TY, Goldman SJ: Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood 83:1499, 1994
25. Foster DC, Sprecher CA, Grant FJ, Kramer JM, Kuijper JL. Holly RD, Whitmore TE, Heipel MD, Bell LA, Ching AF, McGrane V, Hart C, O'Hara PJ, Lok S: Human thrombopoietin: Gene structure, cDNA sequence, expression, and chromosomal localization. Proc Natl Acad Sci USA 91:13023, 1994
26. Hangoc G, Yin T, Cooper S, Schendel P, Yang YC, Broxmeyer HE: In vivo effects of recombinant interleukin-11 on myelopoiesis in mice. Blood 81:965, 1993
27. Patchen ML, MacVittie TJ, Williams JL, Schwartz GN, Souza LM: Administration of interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression. Blood 77:472, 1991
28. Burstein SA, Downs T, Friese P, Lynam S, Anderson S, Henthorn J, Epstein RB, Savage K: Thrombocytopoiesis in normal and sublethally irradiated dogs: Response to human interleukin-6. Blood 80:420, 1992
29. Winton EF, Srinivasiah J, Kim BK, Hillyer CD, Strobert EA, Orkin JL, Swenson RB, McClure HM, Myers LA, Saral R: Effect of recombinant human interleukin-6 (rhIL-6) and rhIL-3 on hematopoietic regeneration as demonstrated in a nonhuman primate chemotherapy model. Blood 84:65, 1994
30. D'Hondt V, Humblet Y, Guillaume T, Baatout S, Chatelain C, Berliere M, Longueville J, Feyens AM, de Greve J, Van Oosterom A: Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: A multicentric placebo-controlled, randomized phase Ib study. Blood 85:2347, 1995
31. Gordon MS, Nemunaitis J, Huffman R, Paquette RL, Rosenfeld C, Manfreda S, Isaacs R, Nimer SD: A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia. Blood 85:3066, 1995
32. Ulich TR, Yi ES, Yin S, del Castillo J, McNiece I, Pang Yung Y, Zsebo KM: Hematologic effects of stem cell factor alone and in combination with G-CSF and GM-CSF in vivo and in vitro in rodents. Int Rev Exp Pathol 34A:215, 1993
33. Tanikawa S, Nakao I, Tsuneoka K, Nara N: Effects of recombinant granulocyte colony-stimulating factor (rG-CSF) and recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) on acute radiation hematopoietic injury in mice. Exp Hematol 17:883, 1989
34. Kikebuchi K, Ihle JN, Hirai Y, Wong GG, Clark SC, Ogawa M: Synergistic factors for stem cell proliferation: Further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor. Blood 72:2007, 1988
35. Kohgo Y, Hirayama Y, Sakamaki S, Matsunaga T, Ohi S, Kuga T, Kato J, Niitsu Y: Improved recovery of myelosuppression following chemotherapy in mice by combined administration of PSK and various cytokines. Acta Haematol 92:130, 1994
36. Krumwieh D, Weinmann E, Siebold B, Seiler FR: Preclinical studies on synergistic effects of IL-1, IL-3, G-CSF and GM-CSF in cynomolgus monkeys. Int J Cell Cloning 8:229, 1990 (suppl 1)
37. Shimosaka A, Akahori H, Shibuya K, Kabaya K, Obuchi M, Kato M, Kato T, Miyazaki H, Kusaka M: In vivo effect of recombinant human thrombopoietin (rhtpo) on ACNU-induced thrombocytopenia: Results of animal models. Acta Haematol 93:211, 1995
38. Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720, 1995
39. Hokom MM, Lacey D, Kinstler OB, Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486, 1995
40. Nash RA, McSweeney PA, Storb R, Abrams K, Bolles L, Deeg HJ, Feng Z, Hart C, Schuening FG, Slichter S, Grossmann A: Effects of thrombopoietin (rhTPO) in normal dogs and after nonlethal total body irradiation (TBI) (200 cGy). Blood 86:904a, 1995 (abstr, suppl 1)
41. Farese AM, Hunt P, Grab LB, MacVittie TJ: Evaluation of administration protocols of pegylated megakaryocyte growth and development factor on platelet recovery in a primate model of radiation-induced bone marrow aplasia. Blood 86:497a, 1995 (abstr, suppl 1)
42. Akahori H, Kabaya K, Shibuya K, Obuchi M, Kato T, Miyazaki H: Effects of recombinant human thrombopoietin (rhTPO) and granulocyte colony-stimulating factor (rhG-CSF) on pancytopenia induced by chemotherapy. Blood 86:892a, 1995 (abstr, suppl 1)
43. Neelis KJ, Wognum AW, Eaton D, Thomas R, Wagemaker G: Preclinical evaluation of thrombopoietin in rhesus monkeys. Blood 86:256a, 1995 (abstr, suppl 1)
44. Ikebuchi K, Clark SC, Ihle JN, Souza LM, Ogawa M: Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 85:3445, 1988
45. Shieh JH, Peterson RHF, Moore MAS: Granulocyte colony-stimulating factor modulation of cytokine receptors on murine bone marrow cells: In vivo and in vitro studies. J Immunol 147:2984, 1991
46. Molineux G, Projda Z, Dexter TM: A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor. Blood 75:563, 1990
47. Molineux G, Hartley CA, McElroy P, McCrea C, McNiece IK: Effects of treatment with MGDF and G-CSF on the acceleration of simultaneous neutrophil and platelet recovery after bone marrow transplant in mice. Blood 86:227a, 1995 (abstr, suppl 1)
48. Farese AM. Hunt P, Grab LB, MacVittie TJ: Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte-colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman-primates after radiation-induced marrow aplasia. J Clin Invest 97:2145, 1996
49. Harker LA, Marzec UM, Kelly AB, Hanson SR: Enhanced hematopoietic regeneration in primate model of myelosuppressive chemotherapy by pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in combination with granulocyte colony stimulating factor (G-CSF). Blood 86:497a, 1995 (abstr, suppl 1)