Neuroprotection in relation to retinal ischemia and relevance to glaucoma

Survey of Ophthalmology

Volumn 43, Issue 6 SUPPL., 1999, Pages

  Osborne, N N ^a   Ugarte, M ^a   Chao, M ^a   Chidlow, G ^a   Bae, J H ^a   Wood, J P M ^a   Nash, M S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Apoptosis; Excitotoxicity; Ganglion cell death; Glaucoma; Glutamate intraocular pressure; Ischemia; Neuroprotection; Retina

Indexed keywords

21 AMINOSTEROID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ADENOSINE RECEPTOR STIMULATING AGENT; ALPHA TOCOPHEROL; AMINOGUANIDINE; BASIC FIBROBLAST GROWTH FACTOR; BETAXOLOL; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE INHIBITOR; CATALASE; DEFEROXAMINE; DEXTROMETHORPHAN; DIZOCILPINE; DOPAMINE RECEPTOR BLOCKING AGENT; ENDOTHELIAL CELL GROWTH FACTOR; FLUPIRTINE; GANGLIOSIDE; GLUTAMATE AMMONIA LIGASE; HYDROCORTISONE; IBUPROFEN; KETAMINE; MANNITOL; MELATONIN; MEMANTINE; NERVE GROWTH FACTOR; PROTEOGLYCAN; SELEGILINE; SUPEROXIDE DISMUTASE; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

APOPTOSIS; CALCIUM TRANSPORT; CAROTID ARTERY OBSTRUCTION; CONFERENCE PAPER; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; NERVE CELL EXCITABILITY; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; RECEPTOR BLOCKING; RETINA AMACRINE CELL; RETINA GANGLION CELL; RETINA ISCHEMIA; RISK FACTOR; VITREOUS BODY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; ISCHEMIA; NEUROPROTECTIVE AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; RETINAL DISEASES; RETINAL GANGLION CELLS; TREATMENT OUTCOME;

EID: 0032787582     PISSN: 00396257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6257(99)00044-2     Document Type: Conference Paper

References (238)

1. Adachi M., Takahashi K., Nishikawa M.et al. High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats. Graefes Arch Clin Exp Ophthalmol. 234:1996;445-451.
2. Ambati J., Chalam K.V., Chawla D.K.et al. Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch Ophthalmol. 115:1997;1161-1166.
3. Barnett N.L., Osborne N.N. Prolonged bilateral carotid artery occlusion induces electrophysiological and immunohistochemical changes to the rat retina without causing histological damage. Exp Eye Res. 61:1995;83-90.
4. Barnett N.L., Osborne N.N. Redistribution of GABA immunoreactivity following central retinal artery occlusion. Brain Res. 677:1995;337-340.
5. Berkelaar M., Clarke D.B., Wang Y.C.et al. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci. 14:1994;4368-4374.
6. Best M., Rabinovitz A.Z., Masket S. Experimental alpha chymotrypsin glaucoma. Ann Ophthalmol. 7:1975;803-810.
7. Blanks J.C., Hinton D.R., Sadun A.A., Miller C.A. Retinal ganglion cell degeneration in Alzheimer's disease. Brain Res. 501:1989;364-372.
8. Blanks J.C., Torigoe Y., Hinton D.R., Blanks R.H. Retinal pathology in Alzhemier's disease. I. Ganglion cell loss in foveal/parafoveal retina Neurobiol Aging. 17:1996;377-384.
9. Block F., Pergande G., Schwarz M. Flupirtine protects against ischaemic retinal dysfunction in rats. Neuroreport. 5:1994;2630-2632.
10. Block F., Schwarz M. Effects of antioxidants on ischemic retinal dysfunction. Exp Eye Res. 64:1997;559-564.
11. Bonfanti L., Strettoi E., Chierzi S.et al. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci. 16:1996;4186-4194.
12. Brandstatter J.H., Hartveit E., Sassoe-Pognetto M., Wassle H. Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina. Eur J Neurosci. 6:1994;1100-1112.
13. Buchi E.R. Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult. an electron microscopic study. I. Ganglion cell layer and inner nuclear layer Exp Eye Res. 55:1992;605-613.
14. Buys Y.M., Trope G.E., Tatton W.G. -)-Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush. Curr Eye Res. 14:1995;119-126.
15. Cagnoli C.M., Atabay C., Kharlamova E., Manev H. Melatonin protects neurons from singlet oxygen-induced apoptosis. J Pineal Res. 18:1995;222-226.
16. Caprioli J., Kitano S., Morgan J.E. Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity. Invest Ophthalmol Vis Sci. 37:1996;2376-2381.
17. Carmignoto G., Maffei L., Candeo P.et al. Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section. J Neurosci. 9:1989;1263-1272.
18. Castillo B. Jr., del Cerro M., Breakfield X.O.et al. Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF). Brain Res. 647:1994;30-36.
19. Cazevieille C., Osborne N.N. Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not - melatonin counteracts the effects of ischaemia and kainate. Brain Res. 755:1997;91-100.
20. Cellerino A., Kohler K. Brain-derived neurotrophic factor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina. J Comp Neurol. 386:1997;149-160.
21. Cenni M.C., Bonfanti L., Martinou J.C.et al. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur J Neurosci. 8:1996;1735-1745.
22. Chang G.Q., Hao Y., Wong F. Apoptosis. final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice Neuron. 11:1993;595-605.
23. Chemtob S., Roy M.S., Abran D.et al. Prevention of postasphyxial increase in lipid peroxides and retinal function deterioration in the newborn pig by inhibition of cyclooxygenase activity and free radical generation. Pediatr Res. 33:1993;335-340.
24. Chen H.S., Pellegrini J.W., Aggarwal S.K.et al. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine. therapeutic advantage against NMDA receptor-mediated neurotoxicity J Neurosci. 12:1992;4427-4436.
25. Chiou G.C., Chen Y.J. Effects of antiglaucoma drugs on ocular blood flow in ocular hypertensive rabbits. J Ocul Pharmacol. 9:1993;13-24.
26. Chiou G.C., Li B.H. Effects of dopamine antagonists on retinal B-wave recovery after retinal ischemia. J Ocul Pharmacol. 9:1993;179-185.
27. Cho S., Joh T.H., Baik H.H.et al. Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats. Brain Res. 755:1997;335-338.
28. Christine C.W., Choi D.W. Effect of zinc on NMDA receptor-mediated channel currents in critical neurons. J Neurosci. 10:1990;108-116.
29. Cohen A., Bray G.M., Aguayo A.J. Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro. J Neurobiol. 25:1994;953-959.
30. Cowan W.M., Fawcett J.W., Stanfield B.B. Regressive events in neurogenesis. Science. 225:1984;1258-1265.
31. Crosson C.E., Willis J.A., Potter D.E. Effect of the calcium antagonist, nifedipine, on ischemic retinal dysfunction. J Ocul Pharmacol. 6:1990;293-299.
32. Cui Q., Harvey A.R. At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats. J Neurosci. 15:1995;8143-8155.
33. Cui Q., Harvey A.R. NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats. Neuroreport. 5:1994;1882-1884.
34. Dawson T.M., Dawson V.L. Nitric oxide synthase. role as a transmitter/mediator in the brain and endocrine system Annu Rev Med. 47:1996;219-227.
35. DeGirolami U., Zivin J.A. Neuropathology of experimental spinal cord ischemia in the rabbit. J Neuropathol Exp Neurol. 41:1982;129-149.
36. Delbarre G., Delbarre B., Calinon F., Ferger A. Accumulation of amino acids and hydroxyl free radicals in brain and retina of gerbil after transient ischemia. J Ocul Pharmacol. 7:1991;147-155.
37. DeSantis L, Dahlin D, Barnes G: A role for the calcium channel blocking-like action of betaxolol for providing therapeutic benefit to glaucoma patients: Update to glaucoma, ocular blood flow and drug treatment, in Drance SM (ed.): Update to Glaucoma Ocular Blood Flow and Treatment. Kugler Publications, 1995, pp 137-143.
38. Draguhn A., Verdorn T.A., Ewert M.et al. Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+. Neuron. 5:1990;781-788.
39. Dreyer E.B., Pan Z.H., Storm S., Lipton S.A. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport. 5:1994;629-631.
40. Dreyer E.B., Zhang D., Lipton S.A. Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death. Neuroreport. 6:1995;942-944.
41. Dreyer E.B., Zurakowski D., Schumer R.A., Podos S.M., Lipton S.A. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol. 114:1996;299-305.
42. Droy Lefaix M.T., Szabo M.E., Doly M. Ischaemia and reperfusion-induced injury in rat retina obtained from normotensive and spontaneously hypertensive rats. effects of free radical scavengers Int J Tissue React. 15:1993;85-91.
43. Du C., Hu R., Csernansky C.A.et al. Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia. Brian Res. 718:1996;233-236.
44. Eschweiler G.W., Bahr M. Flunarizine enhances rat retinal ganglion cell survival after axotomy. J Neurol Sci. 116:1993;34-40.
45. Faberowski N., Stefansson E., Davidson R.C. Local hypothermia protects the retina from ischemia. A quantitative study in the rat Invest Ophthalmol Vis Sci. 30:1989;2309-2313.
46. Fechtner R.D., Weinreb R.N. Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol. 39:1994;23-42.
47. Flammer J. The vascular concept of glaucoma. Surv Ophthalmol. 38(Suppl):1994;S3-S6.
48. Fournier A.E., Beer J., Arregui C.O.et al. Brain-derived neurotrophic factor modulates GAP-43 but not T alpha1 expression in injured retinal ganglion cells of adult rats. J Neurosci Res. 47:1997;561-572.
49. Frade J.M., Barde Y.-A. Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron. 20:1998;35-41.
50. Frade J.M., Bovolenta P., Martinez Morales J.R.et al. Control of early cell death by BDNF in the chick retina. Development. 124:1997;3313-3320.
51. Frederickson C.J. Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol. 31:1989;145-238.
52. Friedel H.A., Fitton A. Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states Drugs. 45:1993;548-569.
53. Gao H., Qiao X., Hefti F.et al. Elevated mRNA expression of brian-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. Invest Ophthalmol Vis Sci. 38:1997;1840-1847.
54. Garcia Valenzuela E., Shareef S., Walsh J., Sharma S.C. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res. 61:1995;33-44.
55. Gasser P., Flammer J. Short- and long-term effect of nifedipine on the visual field in patients with presumed vaso spasm. J Int Med Res. 18:1990;334-339.
56. Gehlbach P., Purple R.L. Enhancement of retinal recovery by conjugated deferoxamine after ischemia-reperfusion. Invest Ophthalmol Vis Sci. 35:1994;669-676.
57. Geyer O., Almog J., Lupu-Meiri M.et al. Nitric oxide synthase inhibitors protect rat retina against ischemic injury. FEBS Lett. 374:1995;399-402.
58. Giusti P., Franceschini D., Petrone M.et al. In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin. J Pineal Res. 20:1996;226-231.
59. Giusti P., Gusella M., Lipartiti M.et al. Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity. Exp Neurol. 131:1995;39-46.
60. Gorovits R., Avidan N., Avisar N.et al. Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc Natl Acad Sci U S A. 94:1997;7024-7029.
61. Gupta L.Y., Marmor M.F. Mannitol, dextromethorphan, and catalase minimize ischemic damage to retinal pigment epithelium and retina. Arch Ophthalmol. 111:1993;384-388.
62. Hafezi F., Marti A., Munz K., Reme C.E. Light-induced apoptosis. differential timing in the retina and pigment epithelium Exp Eye Res. 64:1997;963-970.
63. Hafezi F., Steinbach J.P., Marti A.et al. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 3:1997;346-349.
64. Hammes H.P., Federoff H.J., Brownlee M. Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med. 1:1995;527-534.
65. Hangai M., Yoshimura N., Hiroi K.et al. Inducible nitric oxide synthase in retinal ischemia-reperfusion injury. Exp Eye Res. 63:1996;501-509.
66. Harris A., Spaeth G.L., Sergott R.C.et al. Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. Am J Ophthalmol. 120:1995;168-175.
67. Hartveit E., Brandstatter J.H., Sassoe-Pognetto M.et al. Localization and developmental expression of the NMDA receptor subunit NR2A in the mammalian retina. J Comp Neurol. 348:1994;570-582.
68. Hasse R.J. Color Doppler ultrasound measurement of beta-blocker response in normal tension glaucoma. Neuro Ophthalmol. 15:1995;259-263.
69. Hayreh S.S. Anterior Ischemic Optic Neuropathy. 1976;Springer, Berlin.
70. Hayreh S.S., Zimmerman M.B., Podhajsky P., Alward W.L. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol. 117:1994;603-624.
71. Heidinger V., Hicks D., Sahel J., Dreyfus H. Peptide growth factors but not ganglioside protect against excitotoxicity in rat retinal neurons in vitro. Brain Res. 767:1997;279-288.
72. Hester R.K., Chen Z., Becker E.J.et al. The direct vascular relaxing action of betaxolol, carteolol and timolol in porcine long posterior ciliary artery. Surv Ophthalmol. 38(Suppl):1994;S125-S134.
73. Hinton D.R., Sadun A.A., Blanks J.C., Miller C.A. Optic-nerve degeneration in Alzheimer's disease. N Engl J Med. 315:1986;485-487.
74. Hirsch T., Marchetti P., Susin S.A.et al. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death Oncogene. 15:1997;1573-1581.
75. Hoste A.M., Sys S.U. The relaxant action of betaxolol on isolated bovine retinal microarteries. Curr Eye Res. 13:1994;483-487.
76. Huxlin K.R., Carr R., Schulz M.et al. Trophic effect of collicular proteoglycan on neonatal rat retinal ganglion cells in situ. Brain Res Dev Brain Res. 84:1995;77-88.
77. Huxlin K.R., Dreher B., Schulz M.et al. Effect of collicular proteoglycan on the survival of adult rat retinal ganglion cells following axotomy. Eur J Neurosci. 7:1995;96-107.
78. Irak I., Zangwill L., Garden V.et al. Change in optic disk topography after trabeculectomy. Am J Ophthalmol. 122:1996;690-695.
79. Jacobson M.D. Reactive oxygen species and programmed cell death. Trends Biochem Sci. 21:1996;83-86.
80. Johnson E.M.J.R., Greenlund L.J., Akins P.T., Hsu C.Y. Neuronal apoptosis. current understanding of molecular mechanisms and potential role in ischemic brain injury J Neurotrauma. 12:1995;843-852.
81. Jonas J.B., Xu L. Optic disc morphology in eyes after nonarteritic anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci. 34:1993;2260-2265.
82. Kaiser J.H., Flammer J., Stumpfig D., Hendrickson P. Longterm visual field follow-up of glaucoma patients treated with beta-blockers. Surv Ophthalmol. 38(Suppl):1994;S156-S160.
83. Kaiser P.K., Kipton S.A. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron. 5:1990;373-381.
84. Kalvin N.H., Hamasaki D.I., Gass J.D. Experimental glaucoma in monkeys. I. Relationship between intraocular pressure and cupping of the optic disc and cavernous atrophy of the optic nerve Arch Ophthalmol. 76:1966;82-93.
85. Kendell K.R., Quigley H.A., Kerrigan L.A.et al. Primary open-angle glaucoma is not associated with photoreceptor loss. Invest Ophthalmol Vis Sci. 36:1995;200-205.
86. Kermer P., Klocker N., Labes M., Bahr M. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci. 18:1998;4656-4662.
87. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis. a basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer. 26:1972;239-257.
88. Kerrigan L.A., Zack D.J., Quigley H.A.et al. TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol. 115:1997;1031-1035.
89. Kitano S., Morgan J., Caprioli J. Hypoxic and excitotoxic damage to cultured rat retinal ganglion cells. Exp Eye Res. 63:1996;105-112.
90. Kitazawa Y., Shirai H., Go F.J. The effect of Ca2(+)-antagonist on visual field in low-tension glaucoma. Graefes Arch Clin Exp Ophthalmol. 227:1989;408-412.
91. Koh J.Y., Suh S.W., Gwag B.J.et al. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science. 272:1996;1013-1016.
92. Konigsreuther K.A., Jonas J.B. Optic disc morphology in diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 233:1995;200-204.
93. Kornhuber J., Weller M. Psychotogenicity and N-methyl-D-aspartate receptor antagonism. implications for neuroprotective pharmacotherapy Biol Psychiatry. 41:1997;135-144.
94. Korth M., Horn F., Storck B., Jonas J. The pattern-evoked electroretinogram (PERG). age-related alterations and changes in glaucoma Graefes Arch Clin Exp Ophthalmol. 227:1989;123-130.
95. Kristian T., Siesjo B.K. Calcium-related damage in ischemia. Life Sci. 59:1996;357-367.
96. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med. 3:1997;614-620.
97. Kroemer G., Petit P., Zamzami N.et al. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
98. Kroemer G., Zamzami N., Susin S.A. Mitochondrial control of apoptosis. Immunol Today. 18:1997;44-51.
99. Lam T.T. The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina. Res Commun Mol Pathol Pharmacol. 95:1997;241-252.
100. Lam T.T., Fu J., Hrynewycz M., Tso M.O. The effect of aurintricarboxylic acid, an endonuclease inhibitor, on ischemia/reperfusion damage in rat retina. J Ocul Pharmacol Ther. 11:1995;253-259.
101. Lam T.T., Siew E., Chu R., Tso M.O. Ameliorative effect of MK-801 on retinal ischemia. J Ocul Pharmacol Ther. 13:1997;129-137.
102. Lam T.T., Takahashi K., Tso M.O. The effects of naloxone on retinal ischemia in rats. J Ocul Pharmacol. 10:1994;481-492.
103. Larsen A.K., Osborne N.N. Involvement of adenosine in retinal ischemia. Studies on the rat Invest Ophthalmol Vis Sci. 37:1996;2603-2611.
104. Lehwalder D., Jeffrey P.L., Unsicker K. Survival of purified embryonic chick retinal ganglion cells in the presence of neurotrophic factors. J Neurosci Res. 24:1989;329-337.
105. Leske M.C. The epidemiology of open-angle glaucoma. a review Am J Epidemiol. 118:1983;166-191.
106. Levin L.A., Clark J.A., Johns L.K. Effect of lipid peroxidation inhibition on retinal ganglion cell death. Invest Ophthalmol Vis Sci. 37:1996;2744-2749.
107. Levin L.A., Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol. 114:1996;488-491.
108. Levin L.A., Schlamp C.L., Spieldoch R.L.et al. Identification of the bcl-2 family of genes in the rat retina. Invest Ophthalmol Vis Sci. 38:1997;2545-2553.
109. Levy D.I., Lipton S.A. Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death. Neurology. 40:1990;852-855.
110. Levy D.I., Sucher N.J., Lipton S.A. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neurosci Lett. 110:1990;291-296.
111. Levy D.I., Sucher N.J., Lipton S.A. Glutathione prevents N-methyl-D-aspartate receptor-mediated neurotoxicity. Neuroreport. 2:1991;345-347.
112. Linnik M.D., Zobrist R.H., Hatfield M.D. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke. 24:1993;2002-2008.
113. Lipton S.A., Choi Y.B., Sucher N.J.et al. Redox state, NMDA receptors and NO-related species. Trends Pharmacol Sci. 17:1996;186-187.
114. Liu S., Araujo S.V., Spaeth G.L.et al. Lack of effect of calcium channel blockers on open-angle glaucoma. J Glaucoma. 5:1996;187-190.
115. Louzada P. Jr., Dias J.J., Santos W.F.et al. Glutamate release in experimental ischaemia of the retina. an approach using microdialysis J Neurochem. 59:1992;358-363.
116. MacManus J.P., Linnik M.D. Gene expression induced by cerebral ischemia. an apoptotic perspective J Cereb Blood Flow Metab. 17:1997;815-832.
117. Majno G., Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death [see comments] Am J Pathol. 146:1995;3-15.
118. Manev H., Uz T., Kharlamov A., Joo J.Y. Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. FASEB J. 10:1996;1546-1551.
119. Mansour Robaey S., Clarke D.B., Wang Y.C.et al. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci U S A. 91:1994;1632-1636.
120. Marchetti P., Castedo M., Susin S.A.et al. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med. 184:1996;1155-1160.
121. Martinou J.C., Dubois Dauphin M., Staple J.K.et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 13:1994;1017-1030.
122. Massey S.C., Miller R.F. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 63:1990;16-30.
123. Matini P., Moroni F., Lombardi G.et al. Ultrastructural and biochemical studies on the neuroprotective effects of excitatory amino acid antagonists in the ischemic rat retina. Exp Neurol. 146:1997;419-434.
124. McConkey D.J., Orrenius S. The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun. 239:1997;357-366.
125. Melchiorri D., Reiter R.J., Sewerynek E., Chen L.D., Nistico G. Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB J. 9:1995;1205-1210.
126. Mey J., Thanos S. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res. 602:1993;304-317.
127. Mohand-Said S., Weber M., Hicks D.et al. Intravitreal injection of ganglioside GM1 after ischemia reduces retinal damage in rats. Stroke. 28:1997;617-621.
128. Mori H., Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology. 34:1995;1219-1237.
129. Morizane C., Adachi K., Furutani I.et al. N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo. Eur J Pharmacol. 328:1997;45-49.
130. Mosinger J.L., Olney J.W. Photothrombosis-induced ischemic neuronal degeneration in the rat retina. Exp Neurol. 105:1989;110-113.
131. Mosinger J.L., Price M.T., Bai H.Y.et al. Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina. Exp Neurol. 113:1991;10-17.
132. Muller A., Pietri S., Villain M.et al. Free radicals in rabbit retina under ocular hyperpressure and functional consequences. Exp Eye Res. 64:1997;637-743.
133. Muller W.E., Pergande G., Ushijima H.et al. Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1. induction and pharmacological intervention Prog Mol Subcell Biol. 16:1996;44-57.
134. Nakajima M., Nambu H., Shikata N.et al. Pigmentary degeneration induced by N-methyl-N-nitrosourea and the fate of pigment epithelial cells in the rat retina. Pathol Int. 46:1996;874-882.
135. Nash MS, Osborne NN: Assessment of Thy-1 mRNA levels as an index of ganglion cell damage. Invest Ophthalmol Vis Sci 1999 (in press).
136. Nayak M.S., Kita M., Marmor M.F. Protection of rabbit retina from ischemic injury by superoxide dismutase and catalase. Invest Ophthalmol Vis Sci. 34:1993;2018-2022.
137. Neufeld A., Hernandez M., Gonzalez M., Geller A. Cyclooxygenase-1 and cyclooxygenase-2 in the human optic nerve head. Exp Eye Res. 65:1997;739-745.
138. Nichol K.A., Schulz M.W., Bennett M.R. Nitric oxide-mediated death of cultured neonatal retinal ganglion cells. neuroprotective properties of glutamate and chondroitin sulfate proteoglycan Brain Res. 697:1995;1-16.
139. Nickells R.W. Retinal ganglion cell death in glaucoma. the how, the why, and the maybe J Glaucoma. 5:1996;345-356.
140. Nickells R.W., Zack D.J. Apoptosis in ocular disease. a molecular overview Ophthalmic Genet. 17:1996;145-165.
141. Okisaka S., Murakami A., Mizukawa A., Ito J. Apoptosis in retinal ganglion cell decrease in human glaucomatous eyes. Jpn J Ophthalmol. 41:1997;84-88.
142. Oku H., Yamaguchi H., Sugiyama T.et al. Retinal toxicity of nitric oxide released by administration of a nitric oxide donor in the albino rabbit. Invest Ophthalmol Vis Sci. 38:1997;2540-2544.
143. Ophir A., Berenshtein E., Kitrossky N., Averbukh E. Protection of the transiently ischemic cat retina by zinc-desferrioxamine. Invest Ophthalmol Vis Sci. 35:1994;1212-1222.
144. Ophir A., Berenshtein E., Kitrossky N.et al. Hydroxyl radical generation in the cat retina during reperfusion following ischemia. Exp Eye Res. 57:1993;351-357.
145. Orgul S., Cioffi G.A., Wilson D.J.et al. An endothelin-1 induced model of optic nerve ischemia in the rabbit. Invest Ophthalmol Vis Sci. 37:1996;1860-1869.
146. Orgul S., Gass A., Flammer J. Optic disc cupping in arteritic anterior ischemic optic neuropathy. Ophthalmologica. 208:1994;336-338.
147. Osborne N.N. Memantine reduces alterations to the mammalian retina, in situ, induced by ischaemia. Vis Neurosci. 16:1999;45-52.
148. Osborne NN: Neuroprotection to the retina: Relevance in glaucoma, in Drance SM (ed): Vascular Risk Factors and Neuroprotection in Glaucoma - Update 1996. 139-155, 1997.
149. Osborne N.N., Block F., Sontag K.H. Reduction of ocular blood flow results in glial fibrillary acidic protein (GFAP) expression in rat retinal Muller cells. Vis Neurosci. 7:1991;637-639.
150. Osborne N.N., Cazevieille C., Carvalho A.L.et al. In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent. Brain Res. 751:1997;113-123.
151. Osborne N.N., Cazevieille C., Pergande G., Wood J.P. Induction of apoptosis in cultured human retinal pigment epithelial cells is counteracted by flupirtine. Invest Ophthalmol Vis Sci. 38:1997;1390-1400.
152. Osborne N.N., Cazevielle C., Wood J.P.M.et al. Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen Pharmacol. 30:1998;255-263.
153. Osborne N.N., Herrera A.J. The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina. Neuroscience. 59:1994;1071-1081.
154. Osborne N.N., Larsen A., Barnett N.L. Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells. Invest Ophthalmol Vis Sci. 36:1995;1692-1700.
155. Osborne N.N., Larsen A.K. Antigens associated with specific retinal cells are affected by ischaemia caused by raised intraocular pressure. effect of glutamate antagonists Neurochem Int. 29:1996;263-270.
156. Osborne N.N., Pergande G., Block F., Schwarz M. Immunohistochemical evidence for flupirtine acting as an antagonist on the N-methyl-D-aspartate and homocysteic acid-induced release of GABA in the rabbit retina. Brain Res. 667:1994;291-294.
157. Osborne N.N., Quack G. Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones. Neurochem Int. 21:1992;329-336.
158. Osborne N.N., Schwarz M., Pergande G. Protection of rabbit retina from ischemic injury by flupirtine. Invest Ophthalmol Vis Sci. 37:1996;274-280.
159. Osborne N.N., Wood J., Muller A. The influence of experimental ischaemia on protein kinase C and the GABAergic system in the rabbit retina. Neuropharmacology. 34:1995;1279-1288.
160. Osborne NN, Safa R, Nash MS: Photoreceptors are preferentially affected in rat retina following permanent occlusion of the carotid arteries. Vision Res 1999 (in press).
161. Osborne NN, DeSantis L, Bae JH, et al: Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the retina. Exp Eye Res 1999 (in press).
162. Osborne N.N., Chidlow G., Nash M.S., Wood J.P.M. The potential of neuroprotection in glaucoma treatment. Curr Opin Ophthalmol. 10:1999;82-92.
163. Panda S., Jonas J.B. Decreased photoreceptor count in human eyes with secondary angle-closure glaucoma. Invest Ophthalmol Vis Sci. 33:1992;2532-2536.
164. Papermaster D.S. Necessary but insufficient. Nat Med. 1:1995;874-875.
165. Papermaster D.S., Windle J. Death at an early age. Apoptosis in inherited retinal degenerations Invest Ophthalmol Vis Sci. 36:1995;977-983.
166. Parsons C.G., Gruner R., Rozental J.et al. Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyl adamantan). Neuropharmacology. 32:1993;1337-1350.
167. Peachey N.S., Green D.J., Ripps H. Ocular ischemia and the effects of allopurinol on functional recovery in the retina of the arterially perfused cat eye. Invest Ophthalmol Vis Sci. 34:1993;58-65.
168. Peinado Ramon P., Salvador M., Villegas Perez M.P., Vidal Sanz M. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study Invest Ophthalmol Vis Sci. 37:1996;489-500.
169. Peng Y.W., Blackstone C.D., Huganir R.L., Yau K.W. Distribution of glutamate receptor subtypes in the vertebrate retina. Neuroscience. 66:1995;483-497.
170. Pieri C., Marra M., Moroni F.et al. Melatonin. a peroxyl radical scavenger more effective than vitamin E Life Sci. 55:1994;P1271-P1276.
171. Porciatti V., Pizzorusso T., Cenni M.C., Maffei L. The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2. Proc Natl Acad Sci U S A. 93:1996;14955-14959.
172. Quigley H.A., Addicks E.M., Green W.R. Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy Arch Ophthalmol. 100:1982;135-146.
173. Quigley H.A., Addicks E.M., Green W.R., Maumenee A.E. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage Arch Ophthalmol. 99:1981;635-649.
174. Quigley H.A., Dunkelberger G.R., Green W.R. Chronic human glaucoma causing selectively greater loss of large optic nerve fibers. Ophthalmology. 95:1988;357-363.
175. Quigley H.A., Dunkelberger G.R., Green W.R. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol. 107:1989;453-464.
176. Quigley H.A., Green W.R. The histology of human glaucoma cupping and optic nerve damage. clinicopathologic correlation in 21 eyes Ophthalmol. 86:1979;1803-1830.
177. Quigley H.A., Miller N.R., Green W.R. The pattern of optic nerve fiber loss in anterior ischemic optic neuropathy. Am J Ophthalmol. 100:1985;769-776.
178. Quigley H.A., Nickells R.W., Kerrigan L.A.et al. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci. 36:1995;774-786.
179. Quigley H.A., Sanchez R.M., Dunkelberger G.R.et al. Chronic glaucoma selectively damages large optic nerve fibers. Invest Ophthalmol Vis Sci. 28:1987;913-920.
180. Rabacchi S.A., Bonfanti L., Liu X.H., Maffei L. Apoptotic cell death induced by optic nerve lesion in the neonatal rat. J Neurosci. 14:1994;5292-5301.
181. Rabacchi S.A., Ensini M., Bonfanti L.et al. Nerve growth factor reduces apoptosis of axotomized retinal ganglion cells in the neonatal rat. Neuroscience. 63:1994;969-973.
182. Reiter R.J. antioxidant actions of melatonin. Adv Pharmacol. 38:1997;103-117.
183. Reiter R.J., Melchiorri D., Sewerynek E.et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res. 18:1995;1-11.
184. Robin L.N., Kalloniatis M. Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA. Doc Ophthalmol. 80:1992;273-300.
185. Ross G.M., Shamovsky I.L., Lawrance G.et al. Zinc alters conformation inhibits biological activities of nerve growth factor and related neurotrophins. Nat Med. 3:1997;872-878.
186. Rothman S.M., Olney J.W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol. 19:1986;105-111.
187. Russelakis Carneiro M., Silveira L.C., Perry V.H. Factors affecting the survival of cat retinal ganglion cells after optic nerve injury. J Neurocytol. 25:1996;393-402.
188. Sabel B.A., Sautter J., Stoehr T., Siliprandi R. A behavioral model of excitotoxicity. retinal degeneration, loss of vision, and subsequent recovery after intraocular NMDA administration in adult rats Exp Brain Res. 106:1995;93-105.
189. Sawai H., Clarke D.B., Kittlerova P.et al. Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells. J Neurosci. 16:1996;3887-3894.
190. Schmidt Kastner R., Eysel U.T. Ischemic damage visualized in flat mounts of rat retina after photochemically induced thrombosis. Brain Res Bull. 34:1994;487-491.
191. Schmitt U., Sabel B.A. MK-801 reduces retinal ganglion cell survival but improves visual performance after controlled optic nerve crush. J Neurotrauma. 13:1996;791-800.
192. Schwartz M., Belkin M., Yoles E., Solomon A. Potential treatment modalities for glaucomatous neuropathy. neuroprotection and neuroregeneration J Glaucoma. 5:1996;427-432.
193. Schwarz M., Block F., Pergande G. N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats. Neuroreport. 5:1994;1981-1984.
194. Sebag J., Thomas J.V., Epstein D.L., Grant W.M. Optic disc cupping in arteritic anterior ischemic optic neuropathy resembles glaucomatous cupping. Ophthalmology. 93:1986;357-361.
195. Selles-Navarro I., Villegas Perez M.P., Salvador-Silva M.et al. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals. A quantitative in vivo study Invest Ophthalmol Vis Sci. 37:1996;2002-2014.
196. Siesjo B.K. Pathophysiology and treatment of focal cerebral ischemia. Part II. Mechanisms of damage and treatment J Neurosurg. 77:1992;337-354.
197. Siesjo B.K. A new perspective on ischemic brain damage? Prog Brain Res. 96:1993;1-9.
198. Siesjo B.K. Pathophysiology and treatment of focal cerebral ischemia. Part I. Pathophysiology J Neurosurg. 77:1992;169-184.
199. Siliprandi R., Canella R., Carmignoto G. Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia. Invest Ophthalmol Vis Sci. 34:1993;3232-3245.
200. Siliprandi R., Canella R., Carmignoto G.et al. N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina. Vis Neurosci. 8:1992;567-573.
201. Sonty S., Schwartz B. Development of cupping and pallor in posterior ischemic optic neuropathy. Int Ophthalmol. 6:1983;213-220.
202. Steinsapir K.D., Goldberg R.A. Traumatic optic neuropathy. Surv Ophthalmol. 38:1994;487-518.
203. Sucher N.J., Aizenman E., Lipton S.A. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci. 11:1991;966-971.
204. Szabo M.E., Droy Lefaix M.T., Doly M. Modification of reperfusion-induced ionic imbalance by free radical scavengers in spontaneously hypertensive rat retina. Free Radic Biol Med. 13:1992;609-620.
205. Szabo M.E., Droy Lefaix M.T., Doly M.et al. Ischaemia- and reperfusion-induced Na+, K+, Ca2+, and MG2+ shifts in rat retina. effects of two free radical scavengers. SOD and EGB 761 Exp Eye Res. 55:1992;39-45.
206. Szabo M.E., Droy-Lefaix M.T., Doly M., Braquet P. Modification of ischemia/reperfusion-induced ion shifts (Na+, K+, Ca2+, and Mg2+) by free radical scavengers in the rat retina. Ophthalmic Res. 25:1993;1-9.
207. Szabo M.E., Droy-Lefaix M.T., Doly M.et al. Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism Invest Ophthalmol Vis Sci. 32:1991;1471-1478.
208. Takahashi K., Lam T.T., Edward D.P.et al. Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol. 110:1992;862-870.
209. Tamai K., Toumoto E., Majima A. Local hypothermia protects the retina from ischaemic injury in vitrectomy. Br J Ophthalmol. 81:1997;789-794.
210. Thanos S., Moore S., Hong Y.-M. retinal microglia. Prog Retina Eye Res. 15:1996;331-361.
211. Tonder N., Johansen F.F., Frederickson C.J.et al. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat. Neurosci Lett. 109:1990;247-252.
212. Trick G.L. Pattern reversal retinal potentials in ocular hypertensives at high and low risk of developing glaucoma. Doc Ophthalmol. 65:1987;79-85.
213. Trobe J.D., Glaser J.S., Cassady J.C. Optic atrophy. Differential diagnosis by fundus observation alone Arch Ophthalmol. 98:1980;1040-1045.
214. Tuulonen A., Airaksinen P.J. Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and their progression. Am J Ophthalmol. 111:1991;485-490.
215. Ugarte M., Osborne N.N. The localization of endogenous zinc and the in vitro effect of exogenous zinc on the GABA immunoreactivity and formation of reactive oxygen species in the retina. Gen Pharmacol. 30:1998;297-303.
216. Unoki K., LaVail M.M. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest Ophthalmol Vis Sci. 35:1994;907-915.
217. Uz T., Giusti P., Franceschini D.et al. Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats. Neuroscience. 73:1996;631-636.
218. Varma R., Minckler D.S. Anatomy and pathophysiology of the retina and optic nerve. The glaucomas Clin Sci. 1:1996;139-178.
219. Veriac S., Tissie G., Bonne C. Oxygen free radicals adversely affect the regulation of vascular tone by nitric oxide in the rabbit retina under high intraocular pressure. Exp Eye Res. 56:1993;85-88.
220. Vickers J.C., Schumer R.A., Podos S.M.et al. Differential vulnerability of neurochemically identified subpopulations of retinal neurons in a monkey model of glaucoma. Brain Res. 680:1995;23-35.
221. Vorwerk C.K., Hyman B.T., Miller J.W.et al. The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity. Invest Ophthalmol Vis Sci. 38:1997;2038-2044.
222. Vorwerk C.K., Kreutz M.R., Dreyer E.B., Sabel B.A. Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adults rats. Invest Ophthalmol Vis Sci. 37:1996;2382-2392.
223. Vorwerk C.K., Lipton S.A., Zurakowski D.et al. Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine Invest Ophthalmol Vis Sci. 37:1996;1618-1624.
224. Weber M., Bonaventure N., Sahel J.A. Protective role of excitatory amino acid antagonists in experimental retinal ischemia. Graefes Arch Clin Exp Ophthalmol. 233:1995;360-365.
225. Weber M., Mohand-Said S., Hicks D.et al. Monosialoganglioside GM1 reduces ischemia-reperfusion-induced injury in the rat retina. Invest Ophthalmol Vis Sci. 37:1996;267-273.
226. Weibel D., Kreutzberg G.W., Schwab M.E. Brain-derived neurotrophic factor (BDNF) prevents lesion-induced axonal die-back in young rat optic nerve. Brain Res. 679:1995;249-254.
227. Wood J, Pergande G, Osborne NN: Prevention of glutathione-depletion induced apoptosis in cultured human RPE cells by flupirtine. Restor Neurol Neurosci In Press: 1998.
228. Wu K.K. Cyclooxygenase 2 induction. molecular mechanism and pathophysiologic roles J Lab Clin Med. 128:1996;242-245.
229. Wygnanski T., Desatnik H., Quigley H.A., Glovinsky Y. Comparison of ganglion cell loss and cone loss in experimental glaucoma. Am J Ophthalmol. 120:1995;184-189.
230. Wyllie A.H., Beattie G.J., Hargreaves A.D. Chromatin changes in apoptosis. Histochem J. 13:1981;681-692.
231. Wyllie A.H., Kerr J.F., Currie A.R. Cell death. the significance of apoptosis Int Rev Cytol. 68:1980;251-306.
232. Xu L., Liu L., Yang H.et al. Characteristics of reversal optic cupping in adults glaucoma after reduction of intraocular pressure. Yen Ko Hsueh Pao. 11:1995;155-160.
233. Yamamoto T., Kitazawa Y. Vascular pathogenesis of normal-tension glaucoma. a possible pathogenic factor, other than intraocular pressure, of glaucomatous optic neuropathy Prog Retina Eye Res. 17:1998;127-143.
234. Yoon Y.H., Marmor M.F. Dextromethorphan protects retina against ischemic injury in vivo. Arch Ophthalmol. 107:1989;409-411.
235. 2+ entry blockers on ocular vessels, in Drance SM (ed): Vascular Risk Factors and Neuroprotection in Glaucoma - Update 1996. Kugle Publication, 1997, pp. 123-134.
236. Zeevalk G.D., Hyndman A.G., Nicklas W.J. Excitatory amino acid-induced toxicity in chick retina. amino acid release, histology, and effect of chloride channel blockers J Neurochem. 53:1989;1610-1619.
237. Zhang C., Takahashi K., Lam T.T., Tso M.O. Effects of basic fibroblast growth factor in retinal ischemia. Invest Ophthalmol Vis Sci. 35:1994;3163-3168.
238. Zhang H., Agardh C.D., Agardh E. Increased catalase levels and hypoxanthine-enhanced nitro-blue tetrazolium staining in rat retina after ischemia followed by recirculation. Curr Eye Res. 14:1995;47-54.