Prevention of glutathione depletion-induced apoptosis in cultured human RPE cells by flupirtine

Restorative Neurology and Neuroscience

Volumn 12, Issue 2-3, 1998, Pages 119-125

  Wood, J P M ^a   Pergande, G ^b   Osborne, N N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ASTA MEDICA AG   (Germany)

Author keywords

Apoptosis; Buthionine sulphoxamine; Flupirtine gluconate; Glutathione; Retinal pigmented epithelium

Indexed keywords

BUTHIONINE SULFOXIMINE; FLUPIRTINE; GLUTATHIONE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PIGMENT CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL;

EID: 0031847446     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Abe, M., Reiter, R. J., Orhii, P. B., Hara, M. and Poeggeler, B. Inhibitory effect of melatonin on cataract formation in newborn rats: evidence for an antioxidative role for melatonin, J Pineal Res, 17 (1994) 94-100.
2. Block, F., Pergande, G. and Schwarz, M. Flupirtine protects against ischaemic retinal dysfunction in rats, Neuroreport, 5 (1994) 2630-2.
3. Boulton, M. Ageing of the retinal pigment epithelium, In: Progress in Retinal Research (Osborne N. N. and Chader G., eds) Vol. 11 (1991) pp. 125-151. Pergamon Press, Oxford, UK.
4. Cagnoli, C. M., Atabay, C., Kharlamova, E. and Manev, H. Melatonin protects neurons from singlet oxygen-induced apoptosis, J Pineal Res, 18 (1995) 222-6.
5. Cazevieille, C. and Osborne, N. N. Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not - melatonin counteracts the effects of ischaemia and kainate, Brain Res, 755 (1997) 91-100.
6. Charriaut-Marlangue, C. and Ben-Ari, Y. A cautionary note on the use of the TUNEL stain to determine apoptosis, Neuroreport, 7 (1995) 61-64.
7. Collins, R. J., Harmon, B. V., Gobe, G. C. and Kerr, J. F. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis, Int J Radiat Biol, 61 (1992) 451-3.
8. Dubocovich, M. Role of melatonin in retina, In: Progress in Retinal Research (Osborne N. and Chader G., eds) Vol. 8 (1988) pp. 129-151. Pergamon Press, Oxford.
9. Friedel, H. A. and Fitton, A. Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states, Drugs, 45 (1993) 548-69.
10. Gerschenson, L. E. and Rotello, R. J. Apoptosis: a different type of cell death, Faseb J, 6 (1992) 2450-5.
11. Giusti, P., Franceschini, D., Petrone, M., Manev, H. and Floreani, M. In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin,. J Pineal Res, 20 (1996) 226-31.
12. Hewitt, A. T. and Adler, R. (1994). The retinal pigment epithelium and interphotoreceptor matrix: Structure and specialized functions. In: Retina: Basic science and inherited retinal disease (Ryan, S., ed) Vol. 1, pp. 58-71. Mosby, St Louis, USA.
13. Hockenbery, D. M. Bcl-2, a novel regulator of cell death, Bioessays, 17 (1995) 631-8.
14. Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L. and Korsmeyer, S. J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75 (1993) 241-51.
15. Hyde, H., Borthwick, N., Janossy, G., Salmon, M. and Akbar, A. Upregulation of intracellular glutathione by fibroblast-derived factor(s): enhanced survival of activated T cells in the presence of low Bcl-2, Blood, 89 (1997) 2543-2560.
16. Ishibashi, T., Sorgente, N., Patterson, R. and Ryan, S. J. Pathogenesis of drusen in the primate, Invest Ophthalmol Vis Sci, 27 (1986) 184-93.
17. Jacobson M. D. Reactive oxygen species and programmed cell death, Trends Bioch Sci, 21 (1996) 83-6.
18. Lezoualc'h, F., Skutella, T., Widmann, M. and Behl, C. Melatonin prevents oxidative stress-induced cell death in hippocampal cells, Neuroreport, 7 (1996) 2071-7.
19. Majno, G. and Joris, I. Apoptosis, oncosts, and necrosis. An overview of cell death, Am J Pathol, 146 (1995) 3-15.
20. McConkey, D. J., Orrenius, S. and Jondal, M. Cellular signalling in programmed cell death (apoptosis), Immunol Today, 11 (1990) 120-1.
21. Meister, A. Glutathione deficiency produced by inhibition of its synthesis and its reversal; applications in research and therapy, Pharmacol Ther, 51 (1991) 155-194.
22. Muller, W., Romero, F., Perovic, S., Pergande, G. and Pialoglou, P. Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion, J Neurochem, 68 (1997) 2371-2377.
23. Muller, W. E., Pergande, G., Ushijima, H., Schleger, C., Kelve, M. and Perovic, S. Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention, Prog Mol Subcell Biol, 16 (1996) 44-57.
24. Nagai, H. and Kalnins, V. I. Normally occurring loss of single cells and repair of resulting defects in retinal pigment epithelium in situ, Exp Eye Res, 62 (1996) 55-61.
25. Nash, M. S. and Osborne, N. N. Pertussis toxin-sensitive melatonin receptors negatively coupled to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells, Invest Ophthalmol Vis Sci, 36 (1995) 95-102.
26. Osborne, N. N., Cazevieille, C., Pergande, G. and Wood, J. P. M. Induction of apoptosis in cultured human retinal pigmented epithelial cells is counteracted by flupirtine, Invest Ophthal Vis Sci, 38 (1997) 1390-1400.
27. Osborne, N. N., Nash, M. S. and Wood, J. P. M. Melatonin counteracts apoptosis in cultured human retinal pigment epithelium cells induced by experimental ischaemia, Invest Ophthalmol Vis Sci (1997) submitted.
28. Osborne, N. N., Pergande, G., Block, F. and Schwarz, M. Immunohistochemical evidence for flupirtine acting as an antagonist on the N-methyl-D-aspartate and homocysteic acid-induced release of GABA in the rabbit retina, Brain Res, 667 (1994) 291-4.
29. Osborne, N. N., Schwarz, M. and Pergande, G. Protection of rabbit retina from ischaemic injury by flupirtine, Invest Ophthalmol Vis Sci, 37 (1996) 274-80.
30. Pablos, M. I., Chuang, J., Reiter, R. J., Ortiz, G. G., Daniels, W. M., Sewerynek, E., Melchiorri, D. and Poeggeler, B. Time course of the melatonin-induced increase in glutathione peroxidase activity in chick tissues, Biol Signals, 4 (1995) 325-30.
31. Perovic, S., Pialoglou, P., Schroder, H., Pergande, G. and Muller, W. Flupirtine increases the levels of glutathione and Bcl-2 in hNT (human Ntera/d1) neurons: mode of action of the drug-mediated anti-apoptotic effect, Eur J Pharmacol, 317 (1996) 157-164.
32. Pieri, C., Marra, M., Moroni, F., Recchioni, R. and Marcheselli, F. Melatonin: a peroxyl radical scavenger more effective than vitamin E, Life Sci, 55 (1994) 1271-6.
33. Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S., Ishizaki, Y. and Jacobson M. D. Programmed cell death and the control of cell survival, Philos Trans R Soc Lond B Biol Sci, 345 (1994) 265-8.
34. Reiter, R. J. Antioxidant actions of melatonin, Adv Pharmacol, 38 (1997) 103-17.
35. Reiter, R. J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow Walden, L., Chuang, J., Ortiz, G. G. and Acuna Castroviejo, D. A review of the evidence supporting melatonin's role as an antioxidant, J Pineal Res, 18 (1995) 1-11.
36. 2+ concentration, Eur J Pharmacol, 294 (1995) 469-73.
37. Wood, J. P. M. and Osborne, N. N. Induction of Apoptosis in Cultured Human Retinal Pigmented Epithelial Cells: The Effect Of Protein Kinase C Activation and Inhibition, Neurochemistry Int, 31 (1997) 261-274.