The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 10, 1997, Pages 2038-2044

  Vorwerk, C K ^a   Hyman, B T ^b   Miller, J W ^a   Husain, D ^a   Zurakowski, D ^c   Huang, P L ^b   Fishman, M C ^b   Dreyer, E B ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Endothelial nitric oxide synthase; Excitotoxicity; Glummate; Neuronal nitric oxide synthase; Retinal ganglion cells

Indexed keywords

GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; EYE TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; RETINA INJURY;

ANIMALS; CELL COUNT; CELL SURVIVAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-METHYLASPARTATE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RETINA; RETINAL ARTERY OCCLUSION; RETINAL GANGLION CELLS; RETINAL VESSELS;

EID: 0030963868     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623-634.
2. Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci. 1990;11:379-387.
3. Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med. 1992;326:1464-1468.
4. Lipton SA. Models of neuronal injury in AIDS: Another role for the NMDA receptor? Trends Neurosci. 1992;15:75-79.
5. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994;330:613-622.
6. Choi DW, Maulucci-Gedde MA, Kriegstein AR. Glutamate neurotoxicity in cortical cell culture. J Neurosci. 1987;7:357-368.
7. Lucas DR, Newhouse JP. The toxic effect of sodium L-glutamate on the inner layers of the retina. Am Med Assoc Arch Ophthalmol. 1957;58:193-201.
8. Olney JW. Glutamate-induced retinal degeneration in neonatal mice: Electron microscopy of the acutely evolving lesion. J Neuropathol Exp Neurol. 1969;28:455-474.
9. Sisk DR, Kuwabara T. Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate. Graefes Arch Clin Exp Ophthalmol. 1985;223:250-258.
10. Dreyer EB, Pan ZH, Storm S, Lipton SA. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport. 1994;5:629-631.
11. 2+ toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proc Natl Acad Sci USA. 1988;85:6556-6560.
12. Lipton SA, Choi YB, Pan ZH, et al. A redox-based mechanism for the neuroprotective neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 1993;364:626-631.
13. Aizenman E, Lipton SA, Loring RH. Selective modulation of NMDA responses by reduction and oxidation. Neuron. 1989;2:1257-1263.
14. Sucher NJ, Lei SZ, Lipton SA. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Res. 1991;551:297-302.
15. Iadecola C, Pelligino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab. 1994;14:175-192.
16. Dawson VL, Dawson TM, Snyder SH. A novel neuronal messenger molecule in the brain: The free radical, nitric oxide. Ann Neurol. 1992;32:297-311.
17. Dalkara T, Moskowitz MA. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol. 1994;4:49-57.
18. Nowicki JP, Duval D, Poignet H, Scatton B. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur J Pharmacol. 1991;204:339-340.
19. Zhang J, Snyder SH. Nitric oxide in the nervous system. Annu Rev Pharmacol Toxicol. 1995;35:213-233.
20. Hewett SJ, Csernansky CA, Choi DW. Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron. 1994;13:487-494.
21. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neural nitric oxide synthase gene. Cell. 1993;75:1273-1286.
22. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994;265:1883-1885.
23. Huang PL, Huang Z, Mashimo H, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
24. Lo EH, Hara H, Rogowska J, et al. Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke. 1996;27:1381-1385.
25. Schulz JB, Huang PL, Matthews RT, Passov D, Fishman MC, Beal MF. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. J Neurochem. 1996;67:430-433.
26. Buchi E, Lam T. Injuries induced by diffuse photodynamic action in retina and choroid in albino rats: Morphologic study of an experimental model. Retina. 1994;14:370-378.
27. Miller JW, Adamis AP. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol. 1994;145:574-584.
28. Miller JW, Walsh AW. Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin. Arch Ophthalmol. 1995; 113:810-818.
29. Theodosiadis PG, Moulton RS, Walsh AW, Gragoudas ES, Darnico DJ. Experimental transient exudative retinal detachment in the rat. Arch Ophthalmol 1994; 112:1236-1240.
30. Sautter J, Sabel BA. Recovery of brightness discrimination in adult rats despite progressive loss of retrogradely labelled retinal ganglion cells after controlled optic nerve crush. Eur J Neurosci. 1993;5:680-690.
31. Hanker JS, Yates PE, Metz CB, Rustioni A. A new, specific, sensitive and non-carcinogenic reagent for the demonstration of horseradish peroxidase. Histochem J. 1977;9:789-792.
32. Perry VH, Linden R. Evidence for dendritic competition in the developing retina. Nature. 1982;297:683-685.
33. Sterio D. The unbiased estimation of number and sizes of arbitrary particles using the disector method. J Microsc. 1984;134:127-136.
34. West M. New stereological methods for counting neurons. Neurobiol Aging. 1993;14:275-285.
35. Coggleshall R. A consideration of neural counting methods. Trends Neurosci. 1992;15:9-13.
36. Dräger UR, Olsen JF. Ganglion cell distribution in the retina of the mouse. Invest Ophthalmol Vis Sci. 1981;20:285-293.
37. Armitage P, Berry G. Statistical Methods in Medical Research. Cambridge, MA: Blackwell Science; 1994;207-228.
38. Miller RG. Simultaneous Statistical Inference. 2nd ed. New York: Springer-Verlag; 1981:67-70.
39. Djamgoz MBA, Aguilo R, Greenstreet EH, Reynolds R, Wilkin GP. Histochemistry of NADPH-diaphorase - a marker for neuronal nitric oxide synthase - in the carp retina. Neurochem Int. 1996;28:283-291.
40. Lau KC, So KF, Tay D, Leung M. NADPH-diaphorase neurons in the retina of the hamster. J Comp Neurol. 1994;350:550-558.
41. Liepe BA, Stone C, Koistinaho J, Copenhagen DR. Nitric oxide synthase in Müller cells and neurons of salamander and fish retina. J Neurosci. 1994;14:7641-7654.
42. Osborne NN, Barnett NL, Herrera AJ. NADPH diaphorase localization and nitric oxide synthetase activity in the retina and anterior uvea of the rabbit eye. Brain Res. 1993;610:194-198.
43. Vaccaro TM, Cobcroft MD, Provis JM, Mitrofanis J. NADPH-diaphorase reactivity in adult and developing cat retinae. Cell Tissue Res. 1991;265:371-379.
44. Wässle H, Chun MH, Müller F. Amacrine cells in the ganglion cell layer in the cat retina. J Comp Neurol. 1987;265:391-408.
45. Yamamoto R, Bredt DS, Snyder SH, Stone RA. The localization of nitric oxide synthase in the rat eye and related cranial ganglia Neuroscience. 1993;54:189-200.
46. Irikura K, Huang PL, Ma J, et al. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc Natl Acad Sci USA. 1995; 92:6823-6827.
47. Dreyer EB, Zhang D, Lipton SA. Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death. Neuroreport. 1995;6:942-944.
48. Zeevalk GD, Nicklas WJ. Nitric oxide in retina: Relation to excitatory amino acids and excitotoxicity. Exp Eye Res. 1994;58:343-350.