Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adult rats

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 12, 1996, Pages 2382-2392

  Vorwerk, Christian K ^a   Kreutz, Michael R ^a   Dreyer, Evan B ^b   Sabel, Bernhard A ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

brightness discrimination; excitotoxicity; glutamate; kainic acid; L kynurenine; N methyl D aspartate; retina; retinal ganglion cells

Indexed keywords

KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRIGHTNESS; CELL DEGENERATION; CELL SURVIVAL; DRUG MECHANISM; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; VISUAL DISCRIMINATION;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL TRANSPORT; CELL COUNT; CELL DEATH; EXCITATORY AMINO ACID AGONISTS; HORSERADISH PEROXIDASE; IMAGE PROCESSING, COMPUTER-ASSISTED; KAINIC ACID; KYNURENINE; LIGHT; N-METHYLASPARTATE; RATS; RETINAL DEGENERATION; RETINAL GANGLION CELLS; VISION DISORDERS; VISUAL PERCEPTION;

EID: 0029824654     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623-634.
2. Dingledine R, Myers SJ, Nicholas RA. Molecular biology of mammalian amino acid receptors. FASEB J. 1990;4:2636-2645.
3. Faden AI, Demediuk P, Panter SS, Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science. 1989;244:798-800.
4. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994;330:613-622.
5. Mosinger JL, Price MT, Bai HY, et al. Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina. Exp Neurol. 1991;113:10-17.
6. Massey SC. Cell types using glutamate as a neurotransmitter in the vertebrate retina. In: Osborne E, Chader G, eds. Progress in Retinal Research. Vol IX. Oxford: Pergamon Press; 1990:399-425.
7. Miller RF, Slaughter MM. Excitatory amino acids receptors of the retina: diversity of subtypes and conductance mechanisms. Trends Neurosci. 1986;9:211-218.
8. Olney JW. Glutamate-induced retinal degeneration in neonatal mice: Electron microscopy of the acutely evolving lesion. J Neuropathol Exp Neurol. 1969;28:455-474.
9. Lucas DR, Newhouse JP. The toxic effect of sodium L-glutamate on the inner layers of the retina. Arch Ophthalmol. 1957;58:193-204.
10. Lei SZ, Zhang D, Abele AE, Lipton SA. Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity. Brain Res. 1992;598: 196-202.
11. Dreyer EB, Pan ZH, Storm S, Lipton SA. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport. 1994;5:629-631.
12. Sabel BA, Sautter J, Stoehr T, Siliprandi R. A behavioral model of excitotoxicity: retinal degeneration, loss of vision, and subsequent recovery after intraocular NMDA-administration in adult rats. Exp Brain Res. 1995;106:93-105.
13. Siliprandi R, Canella R, Carmignoto G, et al. NMDA-induced neurotoxicity in the adult rat retina. Vis Neurosci. 1992;8:567-573.
14. Sucher NJ, Lei SZ, Lipton SE. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Res. 1991;551:1-2:297-302.
15. Dreyer EB, Vorwerk CK. The glaucomas. In: Adelman G, Smith BH, eds. Encyclopedia of Neurosci. Amsterdam: Elsevier; 1996;in press.
16. 2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK 801. Proc Natl Acad Sci USA. 1988;85:6556-6560.
17. Ingham CA, Morgan IG. Dose-dependent effects of intravitreal kainic acid on specific cell types in chicken retina. Neuroscience. 1983;9:165-181.
18. Schwarcz R, Coyle JT. Kainic acid neurotoxic effects after intraocular injection. Invest Ophthalmol Vis Sci. 1977;16:141-148.
19. Redburn DA, Donoso JA, Mitchell CK, et al. Kainic acid-induced denervation supersensitivity of nicotinic, cholinergic receptors in ganglion cells of the rat retina. Exp Eye Res. 1984;38:449-461.
20. Hampton CK, Garcia C, Redburn DA. Localization of kainic acid-sensitive cells in the mammalian retina. J Neurosci Res. 1981;6:99-111.
21. Sucher NJ, Aizenman E, Lipton SE. NMDA antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci. 1991;11:966-971.
22. Swartz KJ, During MJ, Freese A, Beal MF. Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors. J Neurosci. 1990;10:2965-2973.
23. Fukui S, Schwarcz R, Rapoport SI, et al. Blood-Brain barrier transport of kynurenines: Implications for brain synthesis and metabolism. J Neurochem. 1991; 56:2005-2017.
24. Okuno E, Nakamura M, Schwarcz R. Two kynurenine aminotransferases in human brain. Brain Res. 1991; 542:307-312.
25. Okuno E, Schmidt W, Parks DA, Nakamura M, Schwarcz R. Measurement of rat brain kynurenine aminotransferase at physiological kynurenine concentrations. J Neurochem. 1991;57:2:533-540.
26. Minatogawa Y, Noguchi T, Kido R. Kynurenine pyrovate transaminase in rat brain. J Neurochem. 1974;23: 271-272.
27. Turski WA, Nakamura M, Todd WP, et al. Identification and quantification of kynurenic acid in human brain tissue. Brain Res. 1989;545:164-169.
28. Turski WA, Gramsbergen JBP, Traitler H, Schwarcz R. Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine. J Neurochem. 1989;52:5:1629-1636.
29. Jannson R. Glutamate neurotoxicity in the developing rat cochlea is antagonized by kynurenic acid and MK-801. Brain Res. 1992;590:201-206.
30. Perry VH, Linden R. Evidence for dendritic competition in the developing retina. Nature. 1982;297:683-685.
31. Hanker JS, Yates PE, Metz CB, Rustioni A. A new specific, sensitive and non carcinogenic reagent for the demonstration of horseradish peroxidase. Histochem J. 1977;9:789-792.
32. Sautter J, Sabel BA. Recovery of brightness discrimination in adult rats despite progressive loss of retrogradely labeled retinal ganglion cells after controlled optic nerve crush. Eur J Neurosci. 1993;5:680-690.
33. Sautter J, Schwartz M, Duvdevani R, Sabel BA. GM1 ganglioside treatment reduces visual deficits after graded crush of the rat optic nerve. Brain Res. 1991; 565:23-33.
34. Dreher B, Potts RA, Bennett MR. Evidence that the early postnatal reduction in the number of rat retinal ganglion cells is due to a wave of ganglion cell death. Neurosci Lett. 1983;36:255-259.
35. Schober W, Gruschka H. Zur Projektion der einzelnen Ganglienzellklassen der Retina der Albinoratte. Eine Studie mit Meerrettich-Peroxidase. Z mikrosk-anat Forschung. 1978;92:2:283-297.
36. Stone TW, Connick JH. Quinolic acid and other kynurenines in the central nervous system. Neuroscience. 1985;15:597-617.
37. Hughes TE, Hermans-Borgmeyer I, Heinemann S. Differential expression of glutamate receptor genes (GluR1-5) in the rat retina. Visual Neurosci. 1992; 8:49-55.
38. Sisk DR, Kuwabara T. Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate. Graefe's Arch Clin Exp Ophthalmol. 1985;223:250-258.
39. Choi DW, Maulucci Gedde M, Kriegstein AR. Glutamate neurotoxicity in cortical cell culture. J Neurosci. 1987;7:357-368.
40. Choi DW, KohJ, Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J Neurosci. 1988;8:185-196.
41. Brandstätter JH, Hartveit E, Sassoe-Pognetto M, Wässle H. Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina. Eur J Neurosci. 1994;6:1100-1112.
42. Vorwerk CK, Kreutz MR, Sabel BA. Systemic L-Kynurenine protects against NMDA but not Kainate induced lesions in the adult rat retina. Soc Neurosci Abs. 20:1994:121.1.
43. Ferrari R, Biral G. Pattern of the retinal afferent distribution in the rat superior colliculus after intravitreal kainic acid injection. Med Sci Res. 1989;17:49-50.
44. Gomez-Ramos P, Estrada C, Perez-Rico C. Choline acetyltransferase deplation in the rat retina after intraocular injection of neurotoxins. J Neurochem. 1985;44: 993-995.
45. Goto M, Inomata N, Ono H, Saito KI, Fukuda H. Ghanges of electroretinogram and neurochemical aspects of GABAergic neurons of retina after intraocular injection of kainic acid in rats. Brain Res. 1981; 211:305-314.
46. Sattayasai J, Rogers LJ, Ehrlich D. Sequential treatment with lower doses of kainic acid alters sensitivity of retinal cell types. Neurosci Lett. 1985;54:277-281.
47. Rogers BC, Tilson HA. Kainate-induced functional deficits are not blocked by MK-801. Neurosci Lett. 1990;109:335-340.
48. Foster AC, Gill R, Woodruff GN. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. J Neurosci. 1988;8:4745-4754.
49. Guarnieri T, Virgili M, Villani L, et al. Pharmacological manipulation of the NMDA receptor differentially protects from systemic kainic acid neuropathology: Evaluation immunohistochemistry. Restor Neurol Neurosci. 1993;5:327-335.
50. Speciale C, Schwarcz R. Uptake of kynurenine into rat brain slices. J Neurochem. 1990;54:156-163.
51. Heyes MP, Quearry BJ. Quantification of kynurenic acid in cerebrospinal fluid: Effects of systemic and central L-kynurenine administration. J Chromatogr Biomed Appl. 1990;530:108-115.
52. Foster AC, Willis CL, Tridgett R. Protection against N-methyl-D-aspartate receptor-mediated neuronal degeneration in rat brain by 7-chlorokynurenate and 3-amino-1-hydroxypryrolid-2-one, antagonists at the allosteric site for glycine. Eur J Neurosci. 1988;2:270-277.
53. Kessler M, Terramani T, Lynch G, Baudry M. A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists. J Neurochem. 1989;52:1319-1332.
54. Foster AC, Vezzani A, French ED, Schwarcz R. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolic acid. Neurosci Lett. 1984;48:273-278.
55. Nozaki K, Beal MF. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992;12:400-407.
56. Smith DH, Okiyama K, Thomas MJ, McIntosh TK. Effects of the excitatory amino acid receptor antagonists Kynurenate and Indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury. J Neurosci. 1993;13:5383-5392.