Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist

General Pharmacology

Volumn 30, Issue 3, 1998, Pages 255-263

  Osborne, N N ^a   Cazevieille, C ^a   Wood, J P M ^a   Nash, M S ^a   Pergande, G ^b   Block, F ^c   Kosinski, C ^a   Schwarz, M ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ASTA MEDICA AG   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Antagonist; Flupirtine; Ischemia; Neuroprotection; NMDA receptor

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; 5,7 DICHLOROKYNURENIC ACID; DIZOCILPINE; EXCITATORY AMINO ACID RECEPTOR; FLUPIRTINE; GLUTAMATE RECEPTOR; MEMANTINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; REACTIVE OXYGEN METABOLITE;

BINDING SITE; CONFERENCE PAPER; DRUG MECHANISM; DRUG RECEPTOR BINDING; ELECTRORETINOGRAM; HUMAN; ISCHEMIA; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RETINA;

AMINOPYRIDINES; ANALGESICS; ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; RECEPTORS, N-METHYL-D-ASPARTATE; RETINA;

EID: 0032033290     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(97)00355-8     Document Type: Conference Paper

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