Retinal toxicity of nitric oxide released by administration of a nitric oxide donor in the albino rabbit

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 12, 1997, Pages 2540-2544

  Oku, Hidehiro ^a   Yamaguchi, Hitomi ^a   Sugiyama, Tetsuya ^a   Kojima, Shota ^a   Ota, Miyoko ^a   Azuma, Ikuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Electroretinogram; N methyl D aspartate neurotoxicity; Nitric oxide; Nitric oxide donor; Visual evoked potentials

Indexed keywords

CYCLIC GMP; ENDOTHELIUM DERIVED RELAXING FACTOR; GLUTAMIC ACID; NITRIC OXIDE SYNTHASE;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; EYE TOXICITY; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DEGENERATION; TRABECULAR MESHWORK;

ANIMALS; CELL COUNT; ELECTRORETINOGRAPHY; EVOKED POTENTIALS, VISUAL; INJECTIONS; NITRIC OXIDE; PENICILLAMINE; PHOTORECEPTORS; RABBITS; RETINA; S-NITROSO-N-ACETYLPENICILLAMINE; VASODILATOR AGENTS;

EID: 0030729743     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Yao K, Tschudi M, Flammer J, Lüscher TF. Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery. Invest Ophthalmol Vis Sci. 1991;32:1791-1798.
2. Kitamura Y, Okamura T, Kani K, Toda N. Nitric oxide-mediated retinal arteriolar and arterial dilation induced by substance P. Invest Ophthalmol Vis Sci. 1993;34:2859-2865.
3. Widerholt M, Sturm A, Leppel-Wienhues A. Relaxation of trabecular meshwork and ciliary muscle by release of nitric oxide. Invest Ophthalmol Vis Sci. 1994;35:2515-2520.
4. Nathanson JA, Mckee M. Alteration of ocular nitric oxide synthase in human glaucoma. Invest Ophthalmol Vis Sci. 1995;36:1774-1784.
5. Choi DW, Koh J, Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J Neurosci. 1988;8:185-196.
6. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanism of nitric oxide-mediated neurotoxicity in primary brain. J Neurosci. 1993;13:2651-2661.
7. Yamamoto R, Bredt DS, Snyder SH, Stone RA. The localization of nitric oxide synthetase in the rat eye and related cranial ganglia. Neuroscience. 1993;54:189-200.
8. Goureau O, Ballot J, Thillaye B, Courtois Y, Kozak Y. Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase. J Immunol. 1995;154:6518-6523.
9. Lipton SA, Choi YB, Pan ZH, et al. A redox based mechanism for neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds. Nature. 1993;364:626-632.
10. Nawy S, Jah CE. cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. Neuron. 1991;7:677-683.
11. Kashii S. The role of nitric oxide in the ischemic retina [in Japanese]. J Jpn Ophthalmol Soc. 1995;99:1361-1376.
12. Rao NA, Thaete LG, Delmage JM, Savanian A. Superoxide dismutase in ocular structure. Invest Ophthalmol Vis Sci. 1985;26:1779-1781.
13. Behar-Cohen FF, Goureau O, D'Hermies F, Courtois Y. Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Invest Ophthalmol Vis Sci. 1996;37:1711-1715.