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Volumn 10, Issue 2, 1999, Pages 82-92

The potential of neuroprotection in glaucoma treatment

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMINOGUANIDINE; AURINTRICARBOXYLIC ACID; BASIC FIBROBLAST GROWTH FACTOR; BETAXOLOL; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; CYCLOHEXIMIDE; DACTINOMYCIN; DIZOCILPINE; FLUNARIZINE; FLUPIRTINE; GANGLIOSIDE GM1; GLUTAMIC ACID; HYDROCORTISONE; KYNURENINE; MEMANTINE; N(G) NITROARGININE; N5 (1 IMINOETHYL)ORNITHINE; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; NEUROTROPHIN 4; PROTEOCHONDROITIN SULFATE; SELEGILINE; TIRILAZAD; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 0032782221     PISSN: 10408738     EISSN: None     Source Type: Journal    
DOI: 10.1097/00055735-199904000-00002     Document Type: Article
Times cited : (76)

References (137)
  • 1
    • 0031840565 scopus 로고    scopus 로고
    • Changing definition of glaucoma
    • 1 Bathija R, Gupta N, Zangwill L, Weinreb RN: Changing definition of glaucoma. J Glaucoma 1998, 7:165-169. The authors review a selection of literature from the past 15 years concerning open angle glaucoma in an attempt to clarify the definition of this condition. They conclude that there is an urgent need to obtain and adhere to a consensus definition.
    • (1998) J Glaucoma , vol.7 , pp. 165-169
    • Bathija, R.1    Gupta, N.2    Zangwill, L.3    Weinreb, R.N.4
  • 2
    • 0028335151 scopus 로고
    • Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders
    • 2 Hayreh SS, Zimmerman MB, Podhajsky P, Alward WL: Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol 1994, 117:603-624.
    • (1994) Am J Ophthalmol , vol.117 , pp. 603-624
    • Hayreh, S.S.1    Zimmerman, M.B.2    Podhajsky, P.3    Alward, W.L.4
  • 3
    • 0028433377 scopus 로고
    • The vascular concept of glaucoma
    • 3 Flammer J: The vascular concept of glaucoma. Surv Ophthalmol 1994, 38 (suppl):S3-6.
    • (1994) Surv Ophthalmol , vol.38 , Issue.SUPPL.
    • Flammer, J.1
  • 4
    • 0031748266 scopus 로고    scopus 로고
    • Pathogenetic mechanisms of glaucoma not related to intraocular pressure
    • 4 Douglas GR: Pathogenetic mechanisms of glaucoma not related to intraocular pressure. Curr Opin Ophthalmol 1998, 9:34-38.
    • (1998) Curr Opin Ophthalmol , vol.9 , pp. 34-38
    • Douglas, G.R.1
  • 5
    • 0032040434 scopus 로고    scopus 로고
    • Recognizing structural damage to the optic nerve head and nerve fiber layer in glaucoma
    • 5 Quigley HA: Recognizing structural damage to the optic nerve head and nerve fiber layer in glaucoma. Am J Ophthalmol 1998, 125:563.
    • (1998) Am J Ophthalmol , vol.125 , pp. 563
    • Quigley, H.A.1
  • 6
    • 0028038213 scopus 로고
    • Mechanisms of optic nerve damage in primary open angle glaucoma
    • 6 Fechtner RD, Weinreb RN: Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol 1994, 39:23-42.
    • (1994) Surv Ophthalmol , vol.39 , pp. 23-42
    • Fechtner, R.D.1    Weinreb, R.N.2
  • 7
    • 0027275417 scopus 로고
    • Glaucoma: Changes in extracellular matrix in the optic nerve head
    • 7 Hernandez MR, Ye H: Glaucoma: changes in extracellular matrix in the optic nerve head. Ann Med 1993, 25:309-315.
    • (1993) Ann Med , vol.25 , pp. 309-315
    • Hernandez, M.R.1    Ye, H.2
  • 8
    • 0030896890 scopus 로고    scopus 로고
    • The optic nerve head in glaucomatous optic neuropathy
    • 8 Hernandez MR, Pena JD: The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol 1997, 115:389-395.
    • (1997) Arch Ophthalmol , vol.115 , pp. 389-395
    • Hernandez, M.R.1    Pena, J.D.2
  • 9
    • 0029908754 scopus 로고    scopus 로고
    • Retinal ganglion cell death in glaucoma: The how, the why and the maybe
    • 9 Nickells RW: Retinal ganglion cell death in glaucoma: the how, the why and the maybe. J Glaucoma 1996, 5:345-356.
    • (1996) J Glaucoma , vol.5 , pp. 345-356
    • Nickells, R.W.1
  • 10
    • 0009629207 scopus 로고    scopus 로고
    • Apoptosis of retinal ganglion cells in glaucoma: An update of the molecular pathways involved in cell death
    • in press
    • 10 Nickells RW: Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death. Surv Ophthalmol 1998, in press. This paper summarizes the current knowledge on apoptosis and how this process may contribute to retinal ganglion cell death. The author concentrates on the roles of p53 and bcl-2-related genes and caspase enzymes and also discusses the importance of mitochondria in these processes.
    • (1998) Surv Ophthalmol
    • Nickells, R.W.1
  • 11
    • 0030844267 scopus 로고    scopus 로고
    • Glaucoma, apoptosis and neuroprotection
    • 11 McKinnon SJ: Glaucoma, apoptosis and neuroprotection. Curr Opin Ophthalmol 1997, 8:28-37. This review focuses on the role of apoptosis in retinal ganglion cell loss and describes how loss of these neurones constitutes the final common pathway in glaucoma. Mechanisms of death and means of identification of specific apoptosis-related events are discussed.
    • (1997) Curr Opin Ophthalmol , vol.8 , pp. 28-37
    • McKinnon, S.J.1
  • 12
    • 0031730156 scopus 로고    scopus 로고
    • Why do mature CNS neurons of mammals fail to re-establish connections following injury: Functions of Bcl-2
    • 12 Chen DF, Tonegawa S: Why do mature CNS neurons of mammals fail to re-establish connections following injury: functions of Bcl-2. Cell Death Differ 1998, 5:816-822. The authors describe the mechanisms influencing neuronal axon regeneration. Failure of axons to elongate or regenerate is described as being related to both the formation of glial scar and the function of the protooncogene protein product Bcl-2.
    • (1998) Cell Death Differ , vol.5 , pp. 816-822
    • Chen, D.F.1    Tonegawa, S.2
  • 13
    • 0031442851 scopus 로고    scopus 로고
    • Astrocyte responses in human optic nerve head with primary open-angle glaucoma
    • 13 Varela HJ, Hernandez MR: Astrocyte responses in human optic nerve head with primary open-angle glaucoma. J Glaucoma 1997, 6:303-313. By employing paraformaldehyde-fixed, paraffin-embedded sections from both the retinas of both control subjects and patients with primary open-angle glaucoma, these authors describe the existence of two distinct types of astrocytes in the optic nerve head. They show that in primary open-angle glaucoma, type 1B astrocytes exhibit both a greater immunoreactivity to GFAP and N-CAM and an altered morphology. These astrocyte responses are hypothesized to have a pathogenic significance for glaucomatous optic nerve neuropathy.
    • (1997) J Glaucoma , vol.6 , pp. 303-313
    • Varela, H.J.1    Hernandez, M.R.2
  • 14
    • 0009609673 scopus 로고    scopus 로고
    • Neuroprotection in relation to retinal ischaemia and relevance to glaucoma
    • in press
    • 14 Osborne NN, Ugarte M, Chao M, Chidlow G, Bae JH, Wood JPM, Nash MS: Neuroprotection in relation to retinal ischaemia and relevance to glaucoma. Surv Ophthalmol 1998, in press. This comprehensive review covers known literature concerning ganglion cell loss in glaucoma and other related conditions. The roles of apoptosis, ischemia, and glutamate in ganglion cell death and optic cupping are discussed and a wideranging review of neuroprotective strategies is presented.
    • (1998) Surv Ophthalmol
    • Osborne, N.N.1    Ugarte, M.2    Chao, M.3    Chidlow, G.4    Bae, J.H.5    Wood, J.P.M.6    Nash, M.S.7
  • 15
    • 0029915446 scopus 로고    scopus 로고
    • Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma
    • 15 Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA: Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 1996, 114:299-305.
    • (1996) Arch Ophthalmol , vol.114 , pp. 299-305
    • Dreyer, E.B.1    Zurakowski, D.2    Schumer, R.A.3    Podos, S.M.4    Lipton, S.A.5
  • 16
    • 0031979758 scopus 로고    scopus 로고
    • Neurotoxic effects of low doses of glutamate on purified rat retinal ganglion cells
    • 16 Otori Y, Wei JY, Bamstable CJ: Neurotoxic effects of low doses of glutamate on purified rat retinal ganglion cells. Invest Ophthalmol Vis Sci 1998, 39:972-981.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 972-981
    • Otori, Y.1    Wei, J.Y.2    Bamstable, C.J.3
  • 17
    • 0030728050 scopus 로고    scopus 로고
    • Molecular basis of glutamate toxicity in retinal ganglion cells
    • 17 Sucher NJ, Lipton SA, Dreyer EB: Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res 1997, 37:3483-3493. This paper describes the involvement of glutamate receptors, particularly of the NMDA type, and calcium in retinal ganglion cell death. The potential use of antagonists for these receptors to prevent glaucomatous damage is also discussed.
    • (1997) Vision Res , vol.37 , pp. 3483-3493
    • Sucher, N.J.1    Lipton, S.A.2    Dreyer, E.B.3
  • 18
    • 0025917356 scopus 로고
    • Accumulation of amino acids and hydroxyl free radicals in brain and retina of gerbil after transient ischemia
    • 18 Delbarre G, Delbarre B, Calinon F, Ferger A: Accumulation of amino acids and hydroxyl free radicals in brain and retina of gerbil after transient ischemia. J Ocul Pharmacol 1991, 7:147-155.
    • (1991) J Ocul Pharmacol , vol.7 , pp. 147-155
    • Delbarre, G.1    Delbarre, B.2    Calinon, F.3    Ferger, A.4
  • 19
    • 0031064041 scopus 로고    scopus 로고
    • The release of amino acids from ischemic retina
    • 19 Müller A, Villain M, Bonne C: The release of amino acids from ischemic retina. Exp Eye Res 1997, 64:291-293.
    • (1997) Exp Eye Res , vol.64 , pp. 291-293
    • Müller, A.1    Villain, M.2    Bonne, C.3
  • 20
    • 0024820051 scopus 로고
    • The benefit of early trabeculectomy versus conventional management in primary open angle glaucoma relative to severity of disease
    • 20 Jay JL, Allan D: The benefit of early trabeculectomy versus conventional management in primary open angle glaucoma relative to severity of disease. Eye 1989, 3:528-535.
    • (1989) Eye , vol.3 , pp. 528-535
    • Jay, J.L.1    Allan, D.2
  • 21
    • 0031890633 scopus 로고    scopus 로고
    • Potential neuroprotective therapy for glaucomatous optic neuropathy
    • 21 Yoles E, Schwartz M: Potential neuroprotective therapy for glaucomatous optic neuropathy. Surv Ophthalmol 1998, 42:367-372. The process of secondary degeneration of neurones after an initial lesion and the possibilities for neuroprotection within this paradigm are discussed.
    • (1998) Surv Ophthalmol , vol.42 , pp. 367-372
    • Yoles, E.1    Schwartz, M.2
  • 22
    • 0032052905 scopus 로고    scopus 로고
    • Optic nerve blood-flow abnormalities in glaucoma
    • 22 Flammer J, Orgul S: Optic nerve blood-flow abnormalities in glaucoma. Prog Retinal Eye Res 1998, 17:267-289. This review describes the importance of the vascular theory of glaucomatous optic nerve damage. The authors conclude that the main cause for the circulation disturbance in glaucoma seems to be a vascular dysregulation leading to local vasospasm and to systemic hypotension.
    • (1998) Prog Retinal Eye Res , vol.17 , pp. 267-289
    • Flammer, J.1    Orgul, S.2
  • 23
    • 0030830310 scopus 로고    scopus 로고
    • Neuroprotection of the optic nerve in glaucoma
    • 23 Caprioli J: Neuroprotection of the optic nerve in glaucoma. Acta Ophthalmol 1997, 75:364-367. The author discusses the importance of both pressure and vascular theories of ganglion cell damage. Neuroprotection strategies outlined include blockade of calcium channels or glutamate receptors, use of antioxidants or stress-response proteins, and inhibition of apoptosis or nitric oxide synthesis.
    • (1997) Acta Ophthalmol , vol.75 , pp. 364-367
    • Caprioli, J.1
  • 24
    • 0009636437 scopus 로고    scopus 로고
    • Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy
    • in press
    • 24 Levin LA: Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy. Surv Ophthalmol 1998, in press. Possible mechanisms of ganglion cell death are described along with the importance of both apoptosis and the timing and degree of optic axon injury. Candidate genes that produce enzymes to counteract reactive oxygen species-induced damage are related to the possibilities of neuroprotection.
    • (1998) Surv Ophthalmol
    • Levin, L.A.1
  • 25
    • 0030694565 scopus 로고    scopus 로고
    • Neuroprotective therapies in stroke
    • discussion 88-89
    • 25 Zivin JA: Neuroprotective therapies in stroke. Drugs 1997, 54(suppl 3):83-88; discussion 88-89.
    • (1997) Drugs , vol.54 , Issue.SUPPL. 3 , pp. 83-88
    • Zivin, J.A.1
  • 26
    • 0031984137 scopus 로고    scopus 로고
    • Neuroprotection as initial therapy in acute stroke
    • Third Report of an Ad Hoc Consensus Group Meeting
    • 26 The European Ad Hoc Consensus Group: Neuroprotection as initial therapy in acute stroke. Third Report of an Ad Hoc Consensus Group Meeting. Cerebrovasc Dis 1998, 8:59-72.
    • (1998) Cerebrovasc Dis , vol.8 , pp. 59-72
  • 27
    • 0031886652 scopus 로고    scopus 로고
    • Duration of neuroprotective treatment for ischemic stroke
    • 27 Dyker AG, Lees KR: Duration of neuroprotective treatment for ischemic stroke. Stroke 1998, 29:535-542.
    • (1998) Stroke , vol.29 , pp. 535-542
    • Dyker, A.G.1    Lees, K.R.2
  • 28
    • 0030820663 scopus 로고    scopus 로고
    • Trends and future developments in the pharmacological treatment of acute ischaemic stroke
    • 28 del Zoppo GJ, Wagner S, Tagaya M: Trends and future developments in the pharmacological treatment of acute ischaemic stroke. Drugs 1997, 54:9-38. The pathologic situations involved in stroke are described along with the latest thoughts on treatment regimens that may be employed, such as neuroprotection, inhibition of inflammation, and arterial recanalization.
    • (1997) Drugs , vol.54 , pp. 9-38
    • Zoppo, G.J.1    Wagner, S.2    Tagaya, M.3
  • 29
    • 0002961637 scopus 로고    scopus 로고
    • Neuroprotection to the retina: Relevance in glaucoma
    • Edited by Drance SM. Amsterdam: Kugler Publications
    • 29 Osborne NN: Neuroprotection to the retina: relevance in glaucoma. In Risk Factors and Neuroprotection in Glaucoma. Edited by Drance SM. Amsterdam: Kugler Publications; 1997:139-155. This overview relates retinal ischemia to glaucoma, describing the selectivity of cellular damage in both cases as weli as reviewing the use of various animal models and discussing therapeutic strategies for the treatment of ischemia/reperfusion injury.
    • (1997) Risk Factors and Neuroprotection in Glaucoma , pp. 139-155
    • Osborne, N.N.1
  • 30
    • 0030960555 scopus 로고    scopus 로고
    • Psychophysical evidence for a selective loss of M ganglion cells in glaucoma
    • 30 Anderson RS, O'Brien C: Psychophysical evidence for a selective loss of M ganglion cells in glaucoma. Vision Res 1997, 37:1079-1083.
    • (1997) Vision Res , vol.37 , pp. 1079-1083
    • Anderson, R.S.1    O'Brien, C.2
  • 31
    • 4243474933 scopus 로고    scopus 로고
    • Glaucoma management: Beyond intraocular pressure
    • 31 Robin AL, Barnebey HS, Harris A, Osborne NN: Glaucoma management: beyond intraocular pressure. Ophthamol Times 1997, 22:S1-S23. This paper relates the round-table discussion of four researchers on the subject of glaucoma management and gives an insight into the possible directions of study for the immediate future.
    • (1997) Ophthamol Times , vol.22
    • Robin, A.L.1    Barnebey, H.S.2    Harris, A.3    Osborne, N.N.4
  • 32
    • 0026777223 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia: Part I: Pathophysiology
    • 32 Siesjo BK: Pathophysiology and treatment of focal cerebral ischemia: part I: pathophysiology. J Neurosurg 1992, 77:169-184.
    • (1992) J Neurosurg , vol.77 , pp. 169-184
    • Siesjo, B.K.1
  • 33
    • 0031425189 scopus 로고    scopus 로고
    • Glutamate in neurologic diseases
    • 33 Bittigau P, Ikonomidou C: Glutamate in neurologic diseases. J Child Neurol 1997, 12:471-485.
    • (1997) J Child Neurol , vol.12 , pp. 471-485
    • Bittigau, P.1    Ikonomidou, C.2
  • 34
    • 0031953601 scopus 로고    scopus 로고
    • Calcium in ischemic cell death
    • 34 Kristian T, Siesjo BK: Calcium in ischemic cell death. Stroke 1998, 29:705-718.
    • (1998) Stroke , vol.29 , pp. 705-718
    • Kristian, T.1    Siesjo, B.K.2
  • 35
    • 0029738468 scopus 로고    scopus 로고
    • Optical recordings of the effects of cholinergic ligands on neurons in the ganglion cell layer of mammalian retina
    • 35 Baldridge WH: Optical recordings of the effects of cholinergic ligands on neurons in the ganglion cell layer of mammalian retina. J Neurosci 1996, 16:5060-5072.
    • (1996) J Neurosci , vol.16 , pp. 5060-5072
    • Baldridge, W.H.1
  • 36
    • 0031558667 scopus 로고    scopus 로고
    • Differential co-localization of nicotinic acetylcholine receptor subunits with calcium-binding proteins in retinal ganglion cells
    • 36 Araki CM, Pires RS, Britto LR, Lindstrom JM, Karten HJ, Hamassaki Britto DE: Differential co-localization of nicotinic acetylcholine receptor subunits with calcium-binding proteins in retinal ganglion cells. Brain Res 1997, 774:250-255.
    • (1997) Brain Res , vol.774 , pp. 250-255
    • Araki, C.M.1    Pires, R.S.2    Britto, L.R.3    Lindstrom, J.M.4    Karten, H.J.5    Hamassaki Britto, D.E.6
  • 37
    • 0030894707 scopus 로고    scopus 로고
    • Localization of gamma-aminobutyric acid (GABA) receptor rho 3 subunit in rat retina
    • 37 Ogurusu T, Eguchi G, Shingai R: Localization of gamma-aminobutyric acid (GABA) receptor rho 3 subunit in rat retina. Neuroreport 1997, 8:925-927.
    • (1997) Neuroreport , vol.8 , pp. 925-927
    • Ogurusu, T.1    Eguchi, G.2    Shingai, R.3
  • 38
    • 0031595433 scopus 로고    scopus 로고
    • C receptors confer distinct temporal properties to retinal synaptic responses
    • C receptors confer distinct temporal properties to retinal synaptic responses. J Neurophysiol 1998, 79:3157-3167.
    • (1998) J Neurophysiol , vol.79 , pp. 3157-3167
    • Lukasiewicz, P.D.1    Shields, C.R.2
  • 39
    • 0030609070 scopus 로고    scopus 로고
    • C receptors to acetylcholine release and directional selectivity in the rabbit retina
    • C receptors to acetylcholine release and directional selectivity in the rabbit retina. Vis Neurosci 1997, 14:939-948.
    • (1997) Vis Neurosci , vol.14 , pp. 939-948
    • Massey, S.C.1    Linn, D.M.2    Kittila, C.A.3    Mirza, W.4
  • 40
    • 0027335503 scopus 로고
    • Localization of D2 dopamine receptors in vertebrate retinae with anti-peptide antibodies
    • 40 Wagner HJ, Luo BG, Ariano MA, Sibley DR, Stell WK: Localization of D2 dopamine receptors in vertebrate retinae with anti-peptide antibodies. J Comp Neurol 1993, 331:469-481.
    • (1993) J Comp Neurol , vol.331 , pp. 469-481
    • Wagner, H.J.1    Luo, B.G.2    Ariano, M.A.3    Sibley, D.R.4    Stell, W.K.5
  • 41
    • 0031148413 scopus 로고    scopus 로고
    • Immunocytochemical localization of dopamine D1 receptors in the retina of mammals
    • 41 Nguyen Legros J, Simon A, Caille I, Bloch B: Immunocytochemical localization of dopamine D1 receptors in the retina of mammals. Vis Neurosci 1997, 14:545-551.
    • (1997) Vis Neurosci , vol.14 , pp. 545-551
    • Nguyen Legros, J.1    Simon, A.2    Caille, I.3    Bloch, B.4
  • 42
    • 0030927539 scopus 로고    scopus 로고
    • Dopaminergic neurons in the rat retina express dopamine D2/3 receptors
    • 42 Veruki ML: Dopaminergic neurons in the rat retina express dopamine D2/3 receptors. Eur J Neurosci 1997, 9:1096-1100.
    • (1997) Eur J Neurosci , vol.9 , pp. 1096-1100
    • Veruki, M.L.1
  • 43
    • 0027472292 scopus 로고
    • The properties of the serotonergic system in the retina
    • Edited by Osborne NN, Chader GJ. Oxford: Pergamon Press
    • 43 Brunken WJ, Jin XT, Pis-Lopez AM: The properties of the serotonergic system in the retina. In Progress in Retinal Research. Edited by Osborne NN, Chader GJ. Oxford: Pergamon Press; 1993:75-100.
    • (1993) Progress in Retinal Research , pp. 75-100
    • Brunken, W.J.1    Jin, X.T.2    Pis-Lopez, A.M.3
  • 44
    • 0031730617 scopus 로고    scopus 로고
    • ICE, neuronal apoptosis and neurodegeneration
    • 44 Friedlander RM, Yuan J: ICE, neuronal apoptosis and neurodegeneration. Cell Death Differ 1998, 5:823-831.
    • (1998) Cell Death Differ , vol.5 , pp. 823-831
    • Friedlander, R.M.1    Yuan, J.2
  • 45
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • 45 Green DR, Reed JC: Mitochondria and apoptosis. Science 1998, 281:1309-1312. This important review encompasses an overview of the central events in the apoptosis cascade that revolve around the mitochondrion. It is seen that this cellular organelle plays an integral part in a number of key apoptotic processes.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 47
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • 47 Ashkenazi A, Dixit VM: Death receptors: signaling and modulation. Science 1998, 281:1305-1308. Another comprehensive review that describes the cellular sequelae that form the initiating mechanisms for apoptosis. A number of the receptor systems known to be involved in apoptotic induction are described.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 49
    • 7144263731 scopus 로고    scopus 로고
    • FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
    • 49 Yen WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, et al.: FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 1998, 279:1954-1958.
    • (1998) Science , vol.279 , pp. 1954-1958
    • Yen, W.C.1    Pompa, J.L.2    McCurrach, M.E.3    Shu, H.B.4    Elia, A.J.5    Shahinian, A.6
  • 50
    • 0031472042 scopus 로고    scopus 로고
    • Cell death: TRAIL and its receptors
    • 50 Golstein P: Cell death: TRAIL and its receptors. Curr Biol 1997, 7:R750-753.
    • (1997) Curr Biol , vol.7
    • Golstein, P.1
  • 51
    • 0031406386 scopus 로고    scopus 로고
    • Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kB pathway
    • 51 Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kB pathway. Immunity 1997, 7:821-830.
    • (1997) Immunity , vol.7 , pp. 821-830
    • Chaudhary, P.M.1    Eby, M.2    Jasmin, A.3    Bookwalter, A.4    Murray, J.5    Hood, L.6
  • 53
    • 0032191132 scopus 로고    scopus 로고
    • Surviving the cytochrome seas
    • 53 Newmeyer DD, Green DR: Surviving the cytochrome seas. Neuron 1998, 21:653-655.
    • (1998) Neuron , vol.21 , pp. 653-655
    • Newmeyer, D.D.1    Green, D.R.2
  • 55
    • 0030755980 scopus 로고    scopus 로고
    • TUNEL-positive ganglion cells in human primary open-angle glaucoma
    • 55 Kerrigan LA, Zack DJ, Quigley HA, Smith SD, Pease ME: TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol 1997, 115:1031-1035. A key research paper that describes the presence, in histologic sections of retinas from patients with primary open-angle glaucoma and age-matched controls, of TUNEL labeling as an indicator of cells undergoing apoptosis in the ganglion cell layer. The conclusion is that apoptosis is a mechanism of ganglion cell loss in glaucoma.
    • (1997) Arch Ophthalmol , vol.115 , pp. 1031-1035
    • Kerrigan, L.A.1    Zack, D.J.2    Quigley, H.A.3    Smith, S.D.4    Pease, M.E.5
  • 56
    • 0030925834 scopus 로고    scopus 로고
    • Apoptosis in retinal ganglion cell decrease in human glaucomatous eyes
    • 56 Okisaka S, Murakami A, Mizukawa A, Ito J: Apoptosis in retinal ganglion cell decrease in human glaucomatous eyes. Jpn J Ophthalmol 1997, 41:84-88.
    • (1997) Jpn J Ophthalmol , vol.41 , pp. 84-88
    • Okisaka, S.1    Murakami, A.2    Mizukawa, A.3    Ito, J.4
  • 57
    • 0029549426 scopus 로고
    • A cautionary note on the use of the TUNEL stain to determine apoptosis
    • 57 Charriaut-Marlangue C, Ben-Ari Y: A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 1995, 7:61-64.
    • (1995) Neuroreport , vol.7 , pp. 61-64
    • Charriaut-Marlangue, C.1    Ben-Ari, Y.2
  • 58
    • 0026555808 scopus 로고
    • Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis
    • 58 Collins RJ, Harmon BV, Gobe GC, Kerr JF: Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radiat Biol 1992, 61:451-453.
    • (1992) Int J Radiat Biol , vol.61 , pp. 451-453
    • Collins, R.J.1    Harmon, B.V.2    Gobe, G.C.3    Kerr, J.F.4
  • 59
    • 0031443822 scopus 로고    scopus 로고
    • Apoptosis and necrosis in toxicology: A continuum or distinct modes of cell death?
    • 59 Raffray M, Cohen GM: Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death? Pharmacol Ther 1997, 75:153-177. With much research attempting to separately classify necrotic and apoptotic cellular death, this paper reminds researchers to keep in perspective the fact that there seems, in many instances, to be a rather undefinable and certainly not complete distinction between the two processes.
    • (1997) Pharmacol Ther , vol.75 , pp. 153-177
    • Raffray, M.1    Cohen, G.M.2
  • 60
    • 0025248516 scopus 로고
    • Cell types using glutamate as a neurotransmitter in the vertebrate retina
    • Edited by Osborne NN, Chader GJ. Oxford: Pergamon Press
    • 60 Massey SC: Cell types using glutamate as a neurotransmitter in the vertebrate retina. In Progress in Retinal Research. Edited by Osborne NN, Chader GJ. Oxford: Pergamon Press; 1990:399-425.
    • (1990) Progress in Retinal Research , pp. 399-425
    • Massey, S.C.1
  • 61
    • 0030300223 scopus 로고    scopus 로고
    • Possible role of the Müller cell in uptake and metabolism of glutamate in the mammalian outer retina
    • 61 Derouiche A: Possible role of the Müller cell in uptake and metabolism of glutamate in the mammalian outer retina. Vision Res 1996, 36:3875-3878.
    • (1996) Vision Res , vol.36 , pp. 3875-3878
    • Derouiche, A.1
  • 62
    • 0031789649 scopus 로고    scopus 로고
    • Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve
    • 62 Yoles E, Schwartz M: Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve. Arch Ophthalmol 1998, 116:906-910.
    • (1998) Arch Ophthalmol , vol.116 , pp. 906-910
    • Yoles, E.1    Schwartz, M.2
  • 63
    • 0030048785 scopus 로고    scopus 로고
    • Modulation of non-vesicular glutamate release by pH
    • 63 Billups B, Attwell D: Modulation of non-vesicular glutamate release by pH. Nature 1996, 379:171-174.
    • (1996) Nature , vol.379 , pp. 171-174
    • Billups, B.1    Attwell, D.2
  • 64
    • 0031027249 scopus 로고    scopus 로고
    • Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: Effect of antioxidants
    • 64 Agostinho P, Duarte CB, Oliveira CR: Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: effect of antioxidants. FASEB J 1997, 11:1 54-163.
    • (1997) FASEB J , vol.11 , pp. 154-163
    • Agostinho, P.1    Duarte, C.B.2    Oliveira, C.R.3
  • 65
    • 0029992779 scopus 로고    scopus 로고
    • Oxidative stress, hypoxia, and ischemialike conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells
    • 65 Rego AC, Santos MS, Oliveira CR: Oxidative stress, hypoxia, and ischemialike conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells. J Neurochem 1996, 66:2506-2516.
    • (1996) J Neurochem , vol.66 , pp. 2506-2516
    • Rego, A.C.1    Santos, M.S.2    Oliveira, C.R.3
  • 66
    • 0345072185 scopus 로고    scopus 로고
    • Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia
    • 66 Lagreze WA, Knorle R, Bach M, Feuerstein TJ: Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci 1998, 39:1063-1066.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1063-1066
    • Lagreze, W.A.1    Knorle, R.2    Bach, M.3    Feuerstein, T.J.4
  • 68
    • 0029824654 scopus 로고    scopus 로고
    • Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adults rats
    • 68 Vorwerk CK, Kreutz MR, Dreyer EB, Sabel BA: Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adults rats. Invest Ophthalmol Vis Sci 1996, 37:2382-2392.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 2382-2392
    • Vorwerk, C.K.1    Kreutz, M.R.2    Dreyer, E.B.3    Sabel, B.A.4
  • 70
    • 0028270348 scopus 로고
    • The effect of experimental ischaemia and excitatory ammo acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina
    • 70 Osborne NN, Herrera AJ: The effect of experimental ischaemia and excitatory ammo acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina. Neuroscience 1994, 59:1071-1081.
    • (1994) Neuroscience , vol.59 , pp. 1071-1081
    • Osborne, N.N.1    Herrera, A.J.2
  • 71
    • 0028865967 scopus 로고
    • The influence of experimental ischaemia on protein kinase C and the GABAergic system in the rabbit retina
    • 71 Osborne NN, Wood J, Muller A: The influence of experimental ischaemia on protein kinase C and the GABAergic system in the rabbit retina. Neuropharmacology 1995, 34:1279-1288.
    • (1995) Neuropharmacology , vol.34 , pp. 1279-1288
    • Osborne, N.N.1    Wood, J.2    Muller, A.3
  • 72
    • 0030041052 scopus 로고    scopus 로고
    • Protection of rabbit retina from ischemic injury by flupirtine
    • 72 Osborne NN, Schwarz M, Pergande G: Protection of rabbit retina from ischemic injury by flupirtine. Invest Ophthalmol Vis Sci 1996, 37:274-280.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 274-280
    • Osborne, N.N.1    Schwarz, M.2    Pergande, G.3
  • 73
    • 0030246958 scopus 로고    scopus 로고
    • Antigens associated with specific retinal cells are affected by ischaemia caused by raised intraocular pressure: Effect of glutamate antagonists
    • 73 Osborne NN, Larsen AK: Antigens associated with specific retinal cells are affected by ischaemia caused by raised intraocular pressure: effect of glutamate antagonists. Neurochem Int 1996, 29:263-270.
    • (1996) Neurochem Int , vol.29 , pp. 263-270
    • Osborne, N.N.1    Larsen, A.K.2
  • 74
    • 0030896545 scopus 로고    scopus 로고
    • Ameliorative effect of MK-801 on retinal ischemia
    • 74 Lam TT, Siew E, Chu R, Tso MO: Ameliorative effect of MK-801 on retinal ischemia. J Ocul Pharmacol Ther 1997, 13:129-137.
    • (1997) J Ocul Pharmacol Ther , vol.13 , pp. 129-137
    • Lam, T.T.1    Siew, E.2    Chu, R.3    Tso, M.O.4
  • 75
    • 0030893958 scopus 로고    scopus 로고
    • Intravitreal injection of gangtioside GM1 after ischemia reduces retinal damage in rats
    • 75 Mohand-Said S, Weber M, Hicks D, Dreyfus H, Sahel JA: Intravitreal injection of gangtioside GM1 after ischemia reduces retinal damage in rats. Stroke 1997, 28:617-621.
    • (1997) Stroke , vol.28 , pp. 617-621
    • Mohand-Said, S.1    Weber, M.2    Hicks, D.3    Dreyfus, H.4    Sahel, J.A.5
  • 76
    • 0031780315 scopus 로고    scopus 로고
    • Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat
    • 76 Shibuki H, Katai N, Kuroiwa S, Kurokawa T, Yodoi J, Yoshimura N: Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat. Invest Ophthalmol Vis Sci 1998, 39:1470-1477.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1470-1477
    • Shibuki, H.1    Katai, N.2    Kuroiwa, S.3    Kurokawa, T.4    Yodoi, J.5    Yoshimura, N.6
  • 78
    • 0030866842 scopus 로고    scopus 로고
    • NMDA-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush
    • 78 Yoles E, Muller S, Schwartz M: NMDA-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush. J Neurotrauma 1997, 14:665-675.
    • (1997) J Neurotrauma , vol.14 , pp. 665-675
    • Yoles, E.1    Muller, S.2    Schwartz, M.3
  • 79
    • 0030826644 scopus 로고    scopus 로고
    • Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury
    • 79 Gao H, Qiao X, Hefti F, Hollyfield JG, Knusel B: Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. Invest Ophthalmol Vis Sci 1997, 38:1840-1847.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 1840-1847
    • Gao, H.1    Qiao, X.2    Hefti, F.3    Hollyfield, J.G.4    Knusel, B.5
  • 80
    • 0028324822 scopus 로고
    • Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
    • 80 Mansour Robaey S, Clarke DB, Wang YC, Bray GM, Aguayo AJ: Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci USA 1994, 91:1632-1636.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1632-1636
    • Mansour Robaey, S.1    Clarke, D.B.2    Wang, Y.C.3    Bray, G.M.4    Aguayo, A.J.5
  • 82
    • 0031267839 scopus 로고    scopus 로고
    • Expression of c-fos and c-jun mRNA following transient retinal ischemia: An approach using ligation of the retinal central artery in the rat
    • 82 Otori Y, Shimada S, Morimura H, Ishimoto I, Tohyama M, Tano Y: Expression of c-fos and c-jun mRNA following transient retinal ischemia: an approach using ligation of the retinal central artery in the rat. Surv Ophthalmol 1997, 42(suppl) 1:S96-104.
    • (1997) Surv Ophthalmol , vol.42 , Issue.1 SUPPL.
    • Otori, Y.1    Shimada, S.2    Morimura, H.3    Ishimoto, I.4    Tohyama, M.5    Tano, Y.6
  • 83
    • 0028079925 scopus 로고
    • Marked increase in glutamate-aspartate transporter (GLAST/GluT-1) mRNA following transient retinal ischemia
    • 83 Otori Y, Shimada S, Tanaka K, Ishimoto I, Tano Y, Tohyama M: Marked increase in glutamate-aspartate transporter (GLAST/GluT-1) mRNA following transient retinal ischemia. Brain Res Mol Brain Res 1994, 27:310-314.
    • (1994) Brain Res Mol Brain Res , vol.27 , pp. 310-314
    • Otori, Y.1    Shimada, S.2    Tanaka, K.3    Ishimoto, I.4    Tano, Y.5    Tohyama, M.6
  • 84
    • 0032536474 scopus 로고    scopus 로고
    • The patterns of retinal ganglion cell death in hypertensive eyes
    • 84 Laquis S, Chaudhary P, Sharma SC: The patterns of retinal ganglion cell death in hypertensive eyes. Brain Res 1998, 784:100-104. This study describes total ganglion cell loss at various times following elevated IOP. The importance of this paper to the current review relates to the experimental paradigm employed. In order to raise the IOP, chronic ocular hypertension is induced, by occlusion of rat episcleral veins. It is argued that this model represents a more realistic system to study glaucomatous pathology.
    • (1998) Brain Res , vol.784 , pp. 100-104
    • Laquis, S.1    Chaudhary, P.2    Sharma, S.C.3
  • 89
    • 0029941302 scopus 로고    scopus 로고
    • The effect of chronically elevated intraocular pressure on the rat optic nerve head extracellular matrix
    • 89 Johnson EC, Morrison JC, Farrell S, Deppmeier L, Moore CG, McGinty MR: The effect of chronically elevated intraocular pressure on the rat optic nerve head extracellular matrix. Exp Eye Res 1996, 62:663-674.
    • (1996) Exp Eye Res , vol.62 , pp. 663-674
    • Johnson, E.C.1    Morrison, J.C.2    Farrell, S.3    Deppmeier, L.4    Moore, C.G.5    McGinty, M.R.6
  • 90
    • 0031887403 scopus 로고    scopus 로고
    • Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma
    • 90 Morrison JC, Nylander KB, Lauer AK, Cepurna WO, Johnson E: Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma. Invest Ophthalmol Vis Sci 1998, 39:526-531. Another research paper that employs a model that, it is argued, may provide a more relevant means of addressing the possibilities of neuroprotection in glaucoma. Episcleral veins are destroyed in rats by injections of saline, thus increasing the IOP.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 526-531
    • Morrison, J.C.1    Nylander, K.B.2    Lauer, A.K.3    Cepurna, W.O.4    Johnson, E.5
  • 91
    • 0029785595 scopus 로고    scopus 로고
    • Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: A quantitative in vivo study
    • 91 Selles Navarro I, Villegas Perez MP, Salvador Silva M, Ruiz Gomez JM, Vidal Sanz M: Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: a quantitative in vivo study. Invest Ophthalmol Vis Sci 1996, 37:2002-2014.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 2002-2014
    • Navarro S. I1    Villegas Perez, M.P.2    Salvador Silva, M.3    Ruiz Gomez, J.M.4    Vidal Sanz, M.5
  • 92
    • 0026483301 scopus 로고
    • Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: An electron microscopic study: I: Ganglion cell layer and inner nuclear layer
    • 92 Buchi ER: Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study: I: ganglion cell layer and inner nuclear layer. Exp Eye Res 1992, 55:605-613.
    • (1992) Exp Eye Res , vol.55 , pp. 605-613
    • Buchi, E.R.1
  • 93
    • 0029893016 scopus 로고    scopus 로고
    • High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats
    • 93 Adachi M, Takahashi K, Nishikawa M, Miki H, Uyama M: High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats. Graefes Arch Clin Exp Ophthalmol 1996, 234:445-451.
    • (1996) Graefes Arch Clin Exp Ophthalmol , vol.234 , pp. 445-451
    • Adachi, M.1    Takahashi, K.2    Nishikawa, M.3    Miki, H.4    Uyama, M.5
  • 94
    • 0029004596 scopus 로고
    • Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells
    • 94 Osborne NN, Larsen A, Barnett NL: Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells. Invest Ophthalmol Vis Sci 1995, 36:1692-1700.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 1692-1700
    • Osborne, N.N.1    Larsen, A.2    Barnett, N.L.3
  • 95
    • 0009592682 scopus 로고    scopus 로고
    • Use of immunohistochemistry to follow the localisation of GABA during retinal ischaemia
    • Edited by Kato S, Osborne NN, Tamai M. Amsterdam: Kugler Publications
    • 95 Osborne NN, Larsen AK, Barnett NL, Wood J, Cazevieille C: Use of immunohistochemistry to follow the localisation of GABA during retinal ischaemia. In Retinal Degeneration and Regeneration. Edited by Kato S, Osborne NN, Tamai M. Amsterdam: Kugler Publications; 1996:23-29.
    • (1996) Retinal Degeneration and Regeneration , pp. 23-29
    • Osborne, N.N.1    Larsen, A.K.2    Barnett, N.L.3    Wood, J.4    Cazevieille, C.5
  • 96
    • 0032932399 scopus 로고    scopus 로고
    • Assessment of Thy-1 mRNA levels as an index of retinal ganglion cell damage
    • in press.
    • 96 Nash MS, Osborne NN: Assessment of Thy-1 mRNA levels as an index of retinal ganglion cell damage. Invest Ophthalmol Vis Sci 1998, in press.
    • (1998) Invest Ophthalmol Vis Sci
    • Nash, M.S.1    Osborne, N.N.2
  • 97
    • 0009592683 scopus 로고    scopus 로고
    • Memantine reduces alterations to the mammalian retina, in situ, induced by ischaemia
    • in press
    • 97 Osborne NN: Memantine reduces alterations to the mammalian retina, in situ, induced by ischaemia. Vis Neurosci 1998, in press.
    • (1998) Vis Neurosci
    • Osborne, N.N.1
  • 98
    • 0029799831 scopus 로고    scopus 로고
    • Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation
    • 98 Grilli M, Pizzi M, Memo M, Spano P: Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 1996, 274:1383-1385.
    • (1996) Science , vol.274 , pp. 1383-1385
    • Grilli, M.1    Pizzi, M.2    Memo, M.3    Spano, P.4
  • 99
    • 0032487869 scopus 로고    scopus 로고
    • A new target for aspirin
    • 99 O'Neill EA: A new target for aspirin. Nature 1998, 396:15-16.
    • (1998) Nature , vol.396 , pp. 15-16
    • O'Neill, E.A.1
  • 100
    • 0032184854 scopus 로고    scopus 로고
    • Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures
    • 100 Ko HW, Park KY, Kim H, Han PL, Kim YU, Gwag BJ, Choi EJ: Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures. J Neurochem 1998, 71:1390-1395.
    • (1998) J Neurochem , vol.71 , pp. 1390-1395
    • Ko, H.W.1    Park, K.Y.2    Kim, H.3    Han, P.L.4    Kim, Y.U.5    Gwag, B.J.6    Choi, E.J.7
  • 101
    • 0031597559 scopus 로고    scopus 로고
    • Inhibition of NF-kB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1
    • 101 Hirano F, Tanaka H, Miura T, Hirano Y, Okamoto K, Makino Y, Makino I: Inhibition of NF-kB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1. Immunopharmacology 1998, 39:31-38.
    • (1998) Immunopharmacology , vol.39 , pp. 31-38
    • Hirano, F.1    Tanaka, H.2    Miura, T.3    Hirano, Y.4    Okamoto, K.5    Makino, Y.6    Makino, I.7
  • 102
    • 0031981981 scopus 로고    scopus 로고
    • N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kB
    • 102 Lezoualc'h F, Sparapani M, Behl C: N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kB. J Pineal Res 1998, 24:168-178.
    • (1998) J Pineal Res , vol.24 , pp. 168-178
    • Lezoualc'h, F.1    Sparapani, M.2    Behl, C.3
  • 103
    • 0030935915 scopus 로고    scopus 로고
    • Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not: Melatonin counteracts the effects of ischaemia and kainate
    • 103 Cazevieille C, Osborne NN: Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not: melatonin counteracts the effects of ischaemia and kainate. Brain Res 1997, 755:91-100.
    • (1997) Brain Res , vol.755 , pp. 91-100
    • Cazevieille, C.1    Osborne, N.N.2
  • 104
    • 0031733003 scopus 로고    scopus 로고
    • Melatonin counteracts apoptosis in cultured human retinal pigment epithelium cells induced by experimental ischaemia
    • 104 Osborne N, Nash M, Wood J: Melatonin counteracts apoptosis in cultured human retinal pigment epithelium cells induced by experimental ischaemia. Invest Ophthalmol Vis Sci 1998, 39:2374-2383.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 2374-2383
    • Osborne, N.1    Nash, M.2    Wood, J.3
  • 105
    • 0031955535 scopus 로고    scopus 로고
    • The efficacy of vitamin E and melatonin as antioxidants against lipid peroxidation in rat retinal homogenates
    • 105 Siu AW, Reiter RJ, To CH: The efficacy of vitamin E and melatonin as antioxidants against lipid peroxidation in rat retinal homogenates. J Pineal Res 1998, 24:239-244.
    • (1998) J Pineal Res , vol.24 , pp. 239-244
    • Siu, A.W.1    Reiter, R.J.2    To, C.H.3
  • 107
    • 0032546662 scopus 로고    scopus 로고
    • Acetylsalicylate administered during simulated ischemia reduces the recovery of neuronal function in the in vitro rabbit retina
    • 107 Maynard KI, Arango PM, Chen D, Ogilvy CS: Acetylsalicylate administered during simulated ischemia reduces the recovery of neuronal function in the in vitro rabbit retina. Neurosci Lett 1998, 249:159-162.
    • (1998) Neurosci Lett , vol.249 , pp. 159-162
    • Maynard, K.I.1    Arango, P.M.2    Chen, D.3    Ogilvy, C.S.4
  • 108
    • 0031068491 scopus 로고    scopus 로고
    • Melatonin: Media hype or therapeutic breakthrough?
    • 108 Kendler BS: Melatonin: media hype or therapeutic breakthrough? Nurse Pract 1997, 22:66-67.
    • (1997) Nurse Pract , vol.22 , pp. 66-67
    • Kendler, B.S.1
  • 109
    • 0031307984 scopus 로고    scopus 로고
    • Toxicology of melatonin
    • 109 Guardiola Lemaitre B: Toxicology of melatonin. J Biol Rhythms 1997, 12:697-706.
    • (1997) J Biol Rhythms , vol.12 , pp. 697-706
    • Guardiola Lemaitre, B.1
  • 110
    • 0031435993 scopus 로고    scopus 로고
    • Is melatonin associated with the development of autoimmune hepatitis?
    • 110 Hong YG, Riegler JL: Is melatonin associated with the development of autoimmune hepatitis? J Clin Gastroenterol 1997, 25:376-378.
    • (1997) J Clin Gastroenterol , vol.25 , pp. 376-378
    • Hong, Y.G.1    Riegler, J.L.2
  • 111
    • 0026769497 scopus 로고
    • Melatonin increases photoreceptor susceptibility to light-induced damage
    • 111 Wiechmann AF, O'Steen WK: Melatonin increases photoreceptor susceptibility to light-induced damage. Invest Ophthalmol Vis Sci 1992, 33:1894-1902.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , pp. 1894-1902
    • Wiechmann, A.F.1    O'Steen, W.K.2
  • 112
    • 0009644790 scopus 로고    scopus 로고
    • The Chinese restauranteur's role in glaucoma: An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy
    • in press
    • 112 Vorwerk CK, Gorla MSR, Dreyer EB: The Chinese restauranteur's role in glaucoma: an experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy. Surv Ophthalmol 1998, in press. The finding that glutamate levels are elevated in the vitreous humors of glaucoma patients and the implications of this are discussed in detail in this review.
    • (1998) Surv Ophthalmol
    • Vorwerk, C.K.1    Gorla, M.S.R.2    Dreyer, E.B.3
  • 113
    • 0029068549 scopus 로고
    • Protective role of excitatory amino acid antagonists in experimental retinal ischemia
    • 113 Weber M, Bonaventure N, Sahel JA: Protective role of excitatory amino acid antagonists in experimental retinal ischemia. Graefes Arch Clin Exp Ophthalmol 1995, 233:360-365.
    • (1995) Graefes Arch Clin Exp Ophthalmol , vol.233 , pp. 360-365
    • Weber, M.1    Bonaventure, N.2    Sahel, J.A.3
  • 115
    • 0032482130 scopus 로고    scopus 로고
    • MK801: A neuroprotectant in rat hypertensive eyes
    • 115 Chaudhary P, Ahmed F, Sharma SC: MK801: a neuroprotectant in rat hypertensive eyes. Brain Res 1998, 792:154-158.
    • (1998) Brain Res , vol.792 , pp. 154-158
    • Chaudhary, P.1    Ahmed, F.2    Sharma, S.C.3
  • 116
    • 0026806960 scopus 로고
    • Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones
    • 116 Osborne N, Quack G: Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones. Neurochem Int 1992, 21:329-336.
    • (1992) Neurochem Int , vol.21 , pp. 329-336
    • Osborne, N.1    Quack, G.2
  • 118
    • 0027933671 scopus 로고
    • New medical and surgical treatments for Parkinson's disease
    • 118 Klockgether T, Loschmann PA, Wullner U: New medical and surgical treatments for Parkinson's disease. Curr Opin Neurol 1994, 7:346-352.
    • (1994) Curr Opin Neurol , vol.7 , pp. 346-352
    • Klockgether, T.1    Loschmann, P.A.2    Wullner, U.3
  • 120
    • 0026632865 scopus 로고
    • Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
    • 120 Lei SZ, Pan ZH, Aggarwal SK, Chen HS, Hartman J, Sucher NJ, Lipton SA: Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 1992, 8:1087-1099.
    • (1992) Neuron , vol.8 , pp. 1087-1099
    • Lei, S.Z.1    Pan, Z.H.2    Aggarwal, S.K.3    Chen, H.S.4    Hartman, J.5    Sucher, N.J.6    Lipton, S.A.7
  • 121
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • 121 Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA: Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995, 92:7162-7166.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Krainc, D.2    Ankarcrona, M.3    Nicotera, P.4    Lipton, S.A.5
  • 122
    • 0025287446 scopus 로고
    • Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity
    • 122 Zeevalk GD, Nicklas WJ: Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity. Brain Res 1990, 522:135-139.
    • (1990) Brain Res , vol.522 , pp. 135-139
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 123
    • 0026520866 scopus 로고
    • Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil
    • 123 Zeevalk GD, Nicklas WJ: Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil. Brain Res Dev Brain Res 1992, 65:147-155.
    • (1992) Brain Res Dev Brain Res , vol.65 , pp. 147-155
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 124
    • 1842405463 scopus 로고    scopus 로고
    • Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia
    • 124 Dogan A, Rao AM, Baskaya MK, Rao VL, Rastl J, Donaldson D, Dempsey Rj: Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. J Neurosurg 1997, 87:921-926.
    • (1997) J Neurosurg , vol.87 , pp. 921-926
    • Dogan, A.1    Rao, A.M.2    Baskaya, M.K.3    Rao, V.L.4    Rastl, J.5    Donaldson, D.6    Dempsey, R.J.7
  • 125
    • 0001106361 scopus 로고
    • Thirty-month visual field follow-up of glaucoma patients treated with beta-blockers
    • 125 Kaiser HJ, Flammer J, Messmer C, Stumpfig D, Hendrickson P: Thirty-month visual field follow-up of glaucoma patients treated with beta-blockers. J Glaucoma 1992, 1:153-155.
    • (1992) J Glaucoma , vol.1 , pp. 153-155
    • Kaiser, H.J.1    Flammer, J.2    Messmer, C.3    Stumpfig, D.4    Hendrickson, P.5
  • 126
    • 0028433068 scopus 로고
    • Longterm effect of topical beta-blockers on intraocular pressure and visual field sensitivity in ocular hypertension and chronic open-angle glaucoma
    • 126 Collignon Brach J: Longterm effect of topical beta-blockers on intraocular pressure and visual field sensitivity in ocular hypertension and chronic open-angle glaucoma. Surv Ophthalmol 1994, 38(suppl):S149-155.
    • (1994) Surv Ophthalmol , vol.38 , Issue.SUPPL.
    • Collignon Brach, J.1
  • 127
    • 0028435195 scopus 로고
    • Longterm visual field follow-up of glaucoma patients treated with beta-blockers
    • discussion S160
    • 127 Kaiser HJ, Fiammer J, Stumpfig D, Hendrickson P: Longterm visual field follow-up of glaucoma patients treated with beta-blockers. Surv Ophthalmol 1994, 38(suppl):S156-159; discussion S160.
    • (1994) Surv Ophthalmol , vol.38 , Issue.SUPPL.
    • Kaiser, H.J.1    Fiammer, J.2    Stumpfig, D.3    Hendrickson, P.4
  • 128
    • 85041108608 scopus 로고    scopus 로고
    • A comparison of the effects of betaxolol, timolol and pilocarpine on visual function in patients with open-angle glaucoma
    • 128 Drance SM: A comparison of the effects of betaxolol, timolol and pilocarpine on visual function in patients with open-angle glaucoma. J Glaucoma 1998, 7:247-252.
    • (1998) J Glaucoma , vol.7 , pp. 247-252
    • Drance, S.M.1
  • 129
    • 4243568763 scopus 로고
    • The direct vascular relaxing action of betaxolol, carteolol and timolol in porcine long posterior ciliary artery
    • 129 Hester RK, Chen Z, Becker EJ, McLaughlin M, DeSantis L: The direct vascular relaxing action of betaxolol, carteolol and timolol in porcine long posterior ciliary artery. Surv Ophthalmol 1994, 38(suppl):S125-134.
    • (1994) Surv Ophthalmol , vol.38 , Issue.SUPPL.
    • Hester, R.K.1    Chen, Z.2    Becker, E.J.3    McLaughlin, M.4    DeSantis, L.5
  • 130
    • 0001255492 scopus 로고
    • Differences in the longterm effect of timolol and betaxolol on the pulsatile ocular blood flow
    • 130 Carenini AB, Sibour G, Boles Carenini B: Differences in the longterm effect of timolol and betaxolol on the pulsatile ocular blood flow. Surv Ophthalmol 1994, 38(suppl):S118-124.
    • (1994) Surv Ophthalmol , vol.38 , Issue.SUPPL.
    • Carenini, A.B.1    Sibour, G.2    Boles Carenini, B.3
  • 131
    • 0029164594 scopus 로고
    • Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma
    • 131 Harris A, Spaeth GL, Sergott RC, Katz LJ, Cantor LB, Martin BJ: Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. Am J Ophthalmol 1995, 120:168-175.
    • (1995) Am J Ophthalmol , vol.120 , pp. 168-175
    • Harris, A.1    Spaeth, G.L.2    Sergott, R.C.3    Katz, L.J.4    Cantor, L.B.5    Martin, B.J.6
  • 132
    • 0032128081 scopus 로고    scopus 로고
    • Effect of betaxolol. Timolol and nimodipine on human and pig retinal arterioles
    • 132 Yu DY, Su EN, Cringle SJ, Alder VA, Yu PK, Desantis L: Effect of betaxolol. timolol and nimodipine on human and pig retinal arterioles. Exp Eye Res 1998, 67:73-81.
    • (1998) Exp Eye Res , vol.67 , pp. 73-81
    • Yu, D.Y.1    Su, E.N.2    Cringle, S.J.3    Alder, V.A.4    Yu, P.K.5    Desantis, L.6
  • 133
    • 0031595789 scopus 로고    scopus 로고
    • Calcium channel-blocking activity of propanolol and betaxolol in isolated bovine retinal microartery
    • 133 Hoste AM, Sys SU: Calcium channel-blocking activity of propanolol and betaxolol in isolated bovine retinal microartery. J Cardiovasc Pharmacol 1998, 32:390-396.
    • (1998) J Cardiovasc Pharmacol , vol.32 , pp. 390-396
    • Hoste, A.M.1    Sys, S.U.2
  • 134
    • 0030894739 scopus 로고    scopus 로고
    • In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent
    • 134 Osborne NN, Cazevieille C, Carvalho AL, Larsen AK, DeSantis L: In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent. Brain Res 1997, 751:113-123. In vivo experiments were performed in rats by elevating the IOP for 45 minutes to induce ischemia. The retina was assessed to be damaged after 3 days of reperfusion by electroretinography and immunohistochemistry and these effects were counteracted by intraperitoneal injection of betaxolol before ischemia. In vitro experiments showed that betaxolol also prevented changes to rabbit retinas induced by ionotropic glutamate receptor agonists and oxygen/glucose deprivation.
    • (1997) Brain Res , vol.751 , pp. 113-123
    • Osborne, N.N.1    Cazevieille, C.2    Carvalho, A.L.3    Larsen, A.K.4    DeSantis, L.5
  • 135
    • 0029670345 scopus 로고    scopus 로고
    • Betaxolol, a beta 1-adrenoceptor antagonist, inhibits Ca(2+)-induced contraction in skinned renal artery of the dog
    • 135 Kitada Y: Betaxolol, a beta 1-adrenoceptor antagonist, inhibits Ca(2+)-induced contraction in skinned renal artery of the dog. Jpn J Pharmacol 1996, 70:191-194.
    • (1996) Jpn J Pharmacol , vol.70 , pp. 191-194
    • Kitada, Y.1
  • 136
    • 0029041707 scopus 로고
    • Inhibitory action of betaxolol, a beta 1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea-pig artery and vein
    • 136 Setoguchi M, Ohya Y, Abe I, Fujishima M: Inhibitory action of betaxolol, a beta 1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea-pig artery and vein. Br J Pharmacol 1995, 115:198-202.
    • (1995) Br J Pharmacol , vol.115 , pp. 198-202
    • Setoguchi, M.1    Ohya, Y.2    Abe, I.3    Fujishima, M.4
  • 137
    • 13144267708 scopus 로고    scopus 로고
    • Functions of the two glutamate transporters GLAST and GLT-1 in the retina
    • 137 Harada T, Harada C, Watanabe M, Inoue Y, Sakagawa T, Nakayama N, et al.: Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci U S A 1998, 95:4663-4666. This is a very useful study describing the occurrence of multiple functions for GLAST and GLT-1 glutamate transporters in mice retinas. The authors demonstrate that GLAST is required for normal signal transduction between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4663-4666
    • Harada, T.1    Harada, C.2    Watanabe, M.3    Inoue, Y.4    Sakagawa, T.5    Nakayama, N.6


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